Staff members with discipline Neurosciences
Academia develops at the interface of different fields. This is one reason why the University of Groningen is home to a wide range of fields, each with a great number of subject specialists. The overview below, which is based on a standard categorization of fields, will help you find the right expert for each field. If you cannot find the expert you are looking for in this list, try searching via a related field or faculty; you may find him or her there.
Please see elkanakyurek.com for more information.
-Obesity and co-morbidities
Molecular mechanisms involved in neuroinflammatory and neurodegenerative diseases are a result of evolutionary processes like all other biological phenomena. Therefore understanding how these mechanisms may have evolved will eventually lead to a deeper understanding of these processes. We investigate in depths the function of the cytokine Tumor Necrosis Factor in neurodegenerative diseases. This pleotropic master cytokine belongs to a large family of molecules, which are able to induce apoptotic cell death but also proliferation and other cellular responses like tissue remodeling. Apoptosis plays an important role in the elimination of infected or transformed cells but also during embryonic development. TNF was found to play a major role in many neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson's disease, stroke or Multiple Sclerosis (MS) but also in Depression and many other brain diseases. In neurodegenerative diseases apoptosis seems to play a major role and therefore the pro-apoptotic function was for a long time at the center of interest to many researchers in this field. We and others have demonstrated that the TNF and TNF receptor system is mainly a protective and sensory system guiding the tissue response to various forms of cellular stress. Apoptosis is just one of the potential responses, which can be induced by TNF. We are following some of these molecular signaling mechanisms in the brain and specific brain cells in response to TNF and detected various signaling molecules downstream of either TNF receptor 1 or TNF receptor 2 and their neuromodulatory signaling e.g. glutamate receptor function, small conductance potassium channels, cAMP Epac-, PKB/Akt- signaling, Nuclear Factor kappa B or lipocalin-2 and iron metabolism.
Methods: reaction times studies and functional Magnetic Resonance Imaging (fMRI) experiments
Manual and automated scoring of behavior (The Observer XT and EthoVision XT),
Ziekte van Huntington
Erfelijke Spastische Paraparese
Pain and Ageing
Pain and Cognition
Pain Assessment and Pain Management in Dementia
Facial Expression Research
Organisation of complex treatments related to Parkinson's disease
Dynamics of the Healthy Brain
See http://www.temporalcognition.org for a more extensive overview.
Topics: Temporal Cognition; Cognitive Science; Interval Timing; Optimalization of Learning; Adaptive Learning.
Methods: comptuational modeling; mathematical modeling; experimentation; EEG; fMRI; MEG; eyetracking; pupil dilation
Animal models for body-brain interaction (depression after myocardial infarction; postoperative cognitive decline)