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Medewerkers met het vakgebied Biochemie & Moleculaire Biologie

Wetenschap ontwikkelt zich waar verschillende vakgebieden samenkomen. Alleen al daarom bestaat er binnen de RUG een grote verscheidenheid aan vakgebieden, met daarbinnen een groot aantal vakspecialisten. Met behulp van onderstaand overzicht, gebaseerd op een vaststaande indeling van wetenschapsgebieden, vindt u op elk vakgebied de juiste deskundige. Komt de deskundige die u zoekt niet voor in deze lijst? Via een vergelijkbaar vakgebied of een gerelateerde faculteit vindt u mogelijk alsnog de juiste persoon.

Overzicht van alle vakgebieden

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Functie
PhD student
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Functie
Research Analist
Main interest: Fibrosis; Foreign body reaction; Tissue engineering of cartilage; role of fibroblasts and macrophages in tissue repair; role of mesenchymal stem cells in tissue repair. Expertise in collagen (synthesis and degradation; fibrosis) and cell/matrix interactions.
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Functie
Hoogleraar
Structural Biology
cryo Electron Microscopy (cryo-EM)
Membrane Proteins
V.W. (Vincent) Bloks
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Functie
Onderzoeksmedewerker
Protein engineering
Therapeutic proteins
Directed evolution
Molecular biology
Cell-based assays
dr. Y.L. (Ykelien) Boersma
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Functie
Rosalind Franklin Fellow / assistant professor
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Functie
onderwijscoördinator Farmacie/Farmaceutische Wetenschappen
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Functie
Bijzonder hoogleraar Synthetic Biology and Cell Engineering
dr. S.W.M. (Sophia) Bruggeman
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Functie
Rosalind Franklin fellow (scientist, junior group leader)
Transcriptional, translational and post-translational control of gene regulation.

prof. dr. C.F. (Cor) Calkhoven
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Functie
Professor
Epigenetic Editing
D. (David) Cano Rodriguez
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Functie
Molecular diagnostics of infectious diseases -Molecular Biology - Cell biology - Microbiology - Genomics - Next Generation Sequencing - Genotyping
dr. M.A. Chlebowicz
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Functie
PostDoc
L. (Linda) Dijkshoorn, MSc
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Functie
Promovendus
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Functie
Hoogleraar Medische Microbiologie
Neurodegeneration, Mitochondrial function, Inflammation, Potassium channels
A.M. (Amalia M.) Dolga, PhD
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Functie
Assistant Professor
Membraan biologie, Eiwittranslocatie en membraaneiwit biogenese, Multidrugresistentie, Biotechnologie van Filamenteuze Schimmels en Gisten, Membraan biologie van hyperthermofiele Archaea
prof. dr. A.J.M. (Arnold J M) Driessen
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Functie
Hoogleraar Moleculaire Microbiologie
Molecular mechanisms involved in neuroinflammatory and neurodegenerative diseases are a result of evolutionary processes like all other biological phenomena. Therefore understanding how these mechanisms may have evolved will eventually lead to a deeper understanding of these processes.
We investigate in depths the function of the cytokine Tumor Necrosis Factor in neurodegenerative diseases in the last years. This cytokine belongs to a large family of molecules, which are able to induce apoptotic cell death but also proliferation and other cellular responses like tissue remodeling. Apoptosis plays an important role in the elimination of infected or transformed cells but also during embryonic development. TNF was found to play a major role in many neurodegenerative diseases such as Alzheimer’s disease (AD) or Multiple Sclerosis (MS) but also in Depression and many other diseases.
In both neurodegenerative diseases AD and MS apoptosis seems to play a major role and therefore the pro-apoptotic function was for a long time at the center of interest to many researchers in the field. We have used an evolutionary driven approach and detected that the TNF and TNF receptor system is mainly a protective and sensory system guiding the tissue response to various forms of cellular stress. Apoptosis is just one of the potential responses, which can be induced by TNF. We have followed some of these molecular signaling mechanisms in the brain and specific brain cells in response to TNF. We have detected various signaling molecules downstream of either TNF receptor 1 or TNF receptor 2 and their signaling being either neuroprotective or degenerative like small conductance potassium channels, cAMP Epac-, PKB/Akt- signaling, Nuclear Factor kappa B or lipocalin-2 and investigated those in more detail. By that we were able to get a clearer picture about the role of TNF and especially TNF receptor signaling in more detail. In part this has also led to the development of a new generation of new drugs by some of our co-operation partners, which are tested right now in some of our model systems.
prof. dr. U.L.M. (Ulrich L. M.) Eisel
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Functie
Adjunct Hoogleraar
A. (Arja) ter Elst
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Functie
Klinisch Moleculair Bioloog in de pathologie
In my lab, we are interested in the consequences of aneuploidy, an abnormal DNA content affecting 2 out of 3 cancers. By understanding how cancer cells make use of the advantages of aneuploidy and cope with the disadvantages of aneuploidy, we hope to get to therapies that can eradicatel aneuploid cancers.
dr. F. (Floris) Foijer
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Functie
Associate professor
Enzyme engineering, redox enzymology, biocatalysis
Celbeweging
Signaaltransductie
prof. dr. P.J.M. (Peter) van Haastert
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Functie
Hoogleraar Cel Biochemie
microbial metabolism, systems biology, single cell analysis, modeling
prof. dr. M. (Matthias) Heinemann
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Functie
Hoogleraar
Toegepaste Biotechnologie/Moleculairebiologie/Microbiologie/
Eiwitkristallografie/ Proteomics (LC-MS)

Proteomics services zijn  beschikbaar voor instituten en bedrijven 
ing. J. (Johan) Hekelaar
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Functie
Coördinator Proteomics Faciliteit (onderdeel van GBB instituut)
Stamcellen m.b.t. hartfalen
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Functie
PhD student
Membrane Biophysics, Fluorescence Spectroscopy, Lipid-protein interactions, Super-resolution microscopy
Enzyme discovery and engineering, biocatalysis, biotransformation, protein engineering
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Functie
Hoogleraar in Chemical Biotechnology
Understanding chemosensitivity of testicular germ cell tumors, Inducing apoptosis and inhibiting pro-survival to enhance drug efficacy in cancer, Identifying novel drugable pathways in ovarian and cervical cancer.
prof. dr. S. (Steven) de Jong
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Functie
Professor
Protein X-ray crystallography
dr. I.K. (Ilona) Jozwik
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Functie
Guest researcher
S.P. (Sebastiaan) van Kessel, MSc
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Functie
PhD-Student in Host-Microbiota Group (see projects)
Cell Biology, Biochemistry & Molecular Biology, Microscopy
prof. dr. I.J. (Ida) van der Klei
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Functie
Hoogleraar
Ion channels, chemical biology, biochemistry, biophysics, electrophysiology, nanotechnology
prof. dr. A. (Armagan) Kocer
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Functie
Tenure-Track Associate Professor
Molecular Genetics, Genomics
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Functie
Professor in Molecular Genetics
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Functie
Universitair Hoofddocent
Endosomal transport, autophagy, behavioural neurogenetics, genetics, mitochondria, neurodegeneration
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Functie
microRNA, endothelial dysfunction, endothelial-mesenchymal transition, epigenetics, Ezh2, MAPK7, Erk5, inflammation, endothelial cell, cardiac fibrosis, atherosclerosis, diabetic retinopathy.
Targeted therapy: Apoptosis, Biology of cancer stem cells: novel therapeutic opportunities
prof. dr. F.A.E. (Frank) Kruyt
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Functie
Professor
Biochemie, fysiologie van gewrichtskraakbeen. Kennis van manieren om gewrichtskraakbeen te herstellen. Meer algemeen: kennis van extracellulaire matrix. Ruime ervaring met Orthopedisch onderzoek, van laboratoriumonderzoek met kraakbeen, chondrocyten, tot heupprotheses en infecties van implantaten.
dr. R. (Roel) Kuijer
Functie
Emeritus Universitair hoofddocent
Galzouten, Cholesterol, Lipiden, Nucleaire receptoren, Fluxomics
prof. dr. F. (Folkert) Kuipers
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Functie
Professor Kindergeneeskunde, Hoofd Laboratorium Kindergeneeskunde
Moleculaire Celbiologie
dr. M.H.K. (Maarten H K) Linskens
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Functie
Universitair hoofddocent Cel Biochemie
M. (Mark) Loznik
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Functie
Research Technician
Biotechnology & Applied Microbiology, Microbiology, Food Science & Technology, Biobased Economy, Enzymology, Intellectual Property and Patents, Applied Biocatalysis, Starch, Carbohydrates
prof. dr. M.J.E.C. (Marc) van der Maarel
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Functie
Hoogleraar Aquatische Biotechnologie en Bioproduct Technologie (ITM)
Electrophysiology, Single-molecule Nanopore Technology
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Functie
systems biology, mathematical modelling, machine learning, probability & statistics
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Functie
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Functie
Hoogleraar Experimentele Hepatologie en Gastro-enterologie
Gene Regulation with emphasis on the control of translation
Molecular mechanisms in life span determination, ageing and age related diseases
Molecular mechanisms in cancer development
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Functie
Research Associate
Development and use of biophysical tools to study complex biochemical processes at the single-molecule level.
prof. dr. A.M. (Antoine) van Oijen
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Functie
Professor of Molecular Microscopy and Spectroscopy
Computational Physics, Molecular Biophysics, Applied Physics, Materials Science
nutrient sensing
stable isotope-based fluxomics
transcriptional regulation
metabolic diseases
dr. H.P. (Hjalmar) Permentier
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Functie
Hoofd Interfacultair Massaspectrometriecentrum
biokatalyse
enzym cascades
enzym engineering
directed evolution
enzym remmers
synthetische biologie
C-N en C-C lyases
prof. dr. G.J. (Gerrit) Poelarends
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Functie
Hoogleraar Farmaceutische Biotechnologie
Synthetische biologie, Enzymologie, Membraanbiologie, Transport en Signaaltransductie
prof. dr. B. (Bert) Poolman
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Functie
Hoogleraar Biochemie
ing. C.P. (Christiaan) Postema
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Functie
Onderzoeksanalist
in vivo metabolism, stable isotopes, metabolomics
prof. dr. D.J. (Dirk-Jan) Reijngoud
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Functie
Hoogleraar Erfelijke Varieteit van het Metabolisme, emeritus
biomoleculaire chemie & katalyse
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Functie
hoogleraar
Molecular diagnostics of infectious diseases - Real-time PCR -
Molecular Biology - Virology - Cell biology - Microbiology - Genomics - Next Generation Sequencing - Genotyping
dr. J.W.A. (John) Rossen
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Functie
Hoofd Moleculaire Unit MMB / Principal Investigator Genomics for Infection Prevention
Transfectie technology
Gerichte afgifte van biologische actieve componenten
Epigenetica
Genetica
Celbiology
Moleculaire Ontwikkelingsbiologie
dr. M.H.J. (Marcel) Ruiters
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Functie
Hoofd onderafdeling Medische Biologie Afdeling Pathologie en Medische Biologie UHD
Complex traits Genetics, Complex traits mapping, Genetics in Isolates, Genome-wide association studies, Quantitative genetics, Genotype Imputation Methods
prof. dr. D.J. (Dirk-Jan) Scheffers
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Functie
Associate Professor - Molecular Microbiology
Membraan biologie, Eiwittranslocatie en membraaneiwit biogenese
Regulation of inflammation, vesicular transport, mouse transgenesis, liver disease
Medische biologie
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Functie
Promovendus
Bioinformatic specialization: datamining, sequence analysis and gene regulation
Metabolic Signaling
Eiwitkristallografie
Enzym katalyse
Structuurbiologie
Kernporiecomplex, kernmembraan
cellulaire veroudering; replicative ageing in bakkers gist
Cell cycle regulation and cellular responses to genotoxic stress, DNA damage and repair pathways and their relevance for cancer treatment
prof. dr. M.A.T.M. (Marcel) van Vugt
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Functie
Tenure Track Professor Moleculaire Oncologie
B. (Barbora) Waclawiková, MSc
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Functie
PhD student in Host-Microbiota Group
Carbohydrate chemistry
Glycobiology
M.T.C. (Marthe) Walvoort, PhD
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Functie
Assistant Professor (Rosalind Franklin fellow)
DNA damage response, cell cycle regulation, DNA damage checkpoints, DNA repair, CRISPR-Cas9, iPSC
dr. D.O. (Daniël) Warmerdam
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Functie
Scientist
Peroxisomal Membrane Protein degradation, Ubiquitination.
dr. C.P. (Chris) Williams
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Functie
Group Leader (VIDI laureate)
dr. M.D. (Martin) Witte
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Functie
Assistant Professor
Biological Chemistry
Mass spectrometry
Solid phase peptide synthesis
Peptide Chemistry

Proteomics/Massa spectrometrie/Biochemie
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