prof. dr. P.C.A. (Patrick) van der Wel

Our main expertise is in the application of advanced methods of NMR spectroscopy to various types of solids, supramolecular assemblies, and (semi/soft) materials. Using the versatile tools of modern solid-state NMR spectroscopy we dissect dynamics as well as structure on the atomic scale. Most of our measurements employ magic-angle-spinning NMR methods, which are applicable to a wide array of materials of both biological and human-made origins. 

In a biological and biomedical context we have developed a particular interest in using the above techniques (along with other biophysical experiments) to probe the molecular mechanisms of human disease. A particular focus has been on the protein misfolding and aggregation behind Huntington's disease and related neurodegenerative disorders. Moreover, we have a strong interest in study the behavior of lipid membranes and how they are modulated by protein/peptide-lipid interactions.

We are increasingly applying similar experiments to determine the structure-function relationship of various functional materials. A particular interest in this area is the increasing use of bio-inspired principles to design bio-mimetic functional materials. These include responsive hydrogels, functionalized nanomaterials and other nano-assemblies. 

Academic Editor for the journal PLOS ONE
Scientific reviewer for national & international funding agencies.
Scientific reviewer for international scientific journals.