Staff members with discipline Biochemistry & Molecular Biology
Academia develops at the interface of different fields. This is one reason why the University of Groningen is home to a wide range of fields, each with a great number of subject specialists. The overview below, which is based on a standard categorization of fields, will help you find the right expert for each field. If you cannot find the expert you are looking for in this list, try searching via a related field or faculty; you may find him or her there.
Enzymology (kinetics, structural analysis)
Expression and purification of enzymes
Analytical chemistry (GC-MS, HPLC, NMR)



I am searching for a postdoc with skills in genome-scale metabolic modelling, who likes to collaborate in an interdisciplinary team to solve inherited metabolic diseases.
Vacancy: https://werkenbijumcg.nl/-/vacatures/postdoctoral-researcher-in-computational-systems-medicine/10419-02s00084jp
Recon4IMD project: https://www.recon4imd.org/
My group is specialised in: Systems Biology of Metabolic Networks and Metabolic Disease; Computational models of metabolic networks; Fluxomics; Metabolomics; Enzyme kinetics




cryo Electron Microscopy (cryo-EM)
Membrane Proteins












Gut microbiome interaction with host
Anaerobic bacterium





Moelcular mechansims in ageing, lifespan determination and age-related diseases.
Molecular mechanims and metabolic alterations in tumour development.











Background:
Our group is working at the cross roads of inflammation and neuronal function with molecular, cellular and behavioural approaches in various neuronal disease models.
Molecular mechanisms involved in neuroinflammatory and neurodegenerative diseases are a result of evolutionary processes like all other biological phenomena. Therefore understanding how these mechanisms may have evolved will eventually lead to a deeper understanding of these processes. We investigate in depths the function of the cytokine Tumor Necrosis Factor in neurodegenerative diseases. This pleotropic master cytokine belongs to a large family of molecules, which are able to induce apoptotic cell death but also proliferation and other cellular responses like tissue remodeling. Apoptosis plays an important role in the elimination of infected or transformed cells but also during embryonic development. TNF was found to play a major role in many neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson's disease, stroke or Multiple Sclerosis (MS) but also in Depression and many other brain diseases. In neurodegenerative diseases apoptosis seems to play a major role and therefore the pro-apoptotic function was for a long time at the center of interest to many researchers in this field. We and others have demonstrated that the TNF and TNF receptor system is mainly a protective and sensory system guiding the tissue response to various forms of cellular stress. Apoptosis is just one of the potential responses, which can be induced by TNF. We are following some of these molecular signaling mechanisms in the brain and specific brain cells in response to TNF and detected various signaling molecules downstream of either TNF receptor 1 or TNF receptor 2 and their neuromodulatory signaling e.g. glutamate receptor function, small conductance potassium channels, cAMP Epac-, PKB/Akt- signaling, Nuclear Factor kappa B or lipocalin-2 and iron metabolism.










Signal transduction

- Structural analytics of carbohydrates (HPAEC-PAD, MS)
- Enzyme characterization & engineering
- Biomass degradation & valorization research

Enzyme discovery and characterization
Structural Biology, macromolecular X-ray crystallography



Protein X-ray Crystallography/ Proteomics (LC-MS)/ Mass spectrometry Analytical Chemistry












































Molecular mechanisms in life span determination, ageing and age related diseases
Molecular mechanisms in cancer development







Primary focus at the moment is on:
(i) Transport through the nuclear pore complex
(ii) Phase separation and aggregation of disordered proteins
(iii) Molecular chaperones in neurodegenerative diseases
(iii) Soft-robotic nature-inspired microswimmers and magnetic artificial cilia.
For more details, visit the group's web-page.

translational research
nutrient sensing
stable isotope-based metabolic flux analysis
transcriptional regulation














Lanthipeptides
Posstranslationele Modification Enzymes
Peptide Design








Stralingsbescherming 5B








Structural enzymology
Structural biology

• Functional genomics
• Bioenergy crops
• Abiotic stress
• Nectar production


Comparative genomics of Eukaryotes
Chromosome/Nuclear Biology






Glycobiology






RNA-seq

