Molecular biology (cloning, mutagenesis)
Enzymology (kinetics, structural analysis)
Expression and purification of enzymes
Analytical chemistry (GC-MS, HPLC, NMR)

Synthetic biology

Postdoc position in the Recon4IMD project
I am searching for a postdoc with skills in genome-scale metabolic modelling, who likes to collaborate in an interdisciplinary team to solve inherited metabolic diseases.

Vacancy: https://werkenbijumcg.nl/-/vacatures/postdoctoral-researcher-in-computational-systems-medicine/10419-02s00084jp

Recon4IMD project: https://www.recon4imd.org/

My group is specialised in: Systems Biology of Metabolic Networks and Metabolic Disease; Computational models of metabolic networks; Fluxomics; Metabolomics; Enzyme kinetics

Main interest: issue engineering and use of stem cells in wound repair. Expertise in collagen (connective tissue diseases; fibrosis) and cell/matrix interactions.

Structural Biology
cryo Electron Microscopy (cryo-EM)
Membrane Proteins

My research interest is the role that membrane proteins and lipids play as antigens in T cell activation, and their potential as vaccination agents. 

iGEM - International Genetically Engineered Machine competition . Please find additional information in the links  below.

policy/strategy, academic & industrial partnerships, staff development & recruiting, quality management, technology transfer and public relations

Rnaseq / Microarray analysis

Antigen presenting cells, macrophages, dendritic cells

Hematology, Leukemia, Epigenetic regulation of gene expression

Aging, cellular senescence, cancer

Next generation probiotics
Gut microbiome interaction with host
Anaerobic bacterium

research

Biomolecular Chemistry

Transcriptional, translational and post-translational control of gene regulation.
Moelcular mechansims in ageing, lifespan determination and age-related diseases.
Molecular mechanims and metabolic alterations in tumour development.

Organic chemistry, enzyme kinetics, bioorthogonal reactions, cell-based studies

Bacterial gene expression, protein localization, protein secretion, bacteria-host interactions, bacterial pathogenesis, imaging of bacterial infections

Neurodegeneration, Mitochondrial function, Inflammation, Potassium channels

Membrane biology, Protein translocation and membrane protein biogenesis, multidrug resistance, biotechnology of filamentous fungi and yeast, membrane biology of hyperthermophilic Archaea, Synthetic cells

Neuroscience, molecular biology, neuroinflammation, gene expression, epigenetics, cellbiology, development, multiple sclerosis, Alzheimer's disease

Professor in Molecular Neurobiology and Neuroimmunology

Background:
Our group is working at the cross roads of inflammation and neuronal function with molecular, cellular and behavioural approaches in various neuronal disease models. 

Molecular mechanisms involved in neuroinflammatory and neurodegenerative diseases are a result of evolutionary processes like all other biological phenomena. Therefore understanding how these mechanisms may have evolved will eventually lead to a deeper understanding of these processes. We investigate in depths the function of the cytokine Tumor Necrosis Factor in neurodegenerative diseases. This pleotropic master cytokine belongs to a large family of molecules, which are able to induce apoptotic cell death but also proliferation and other cellular responses like tissue remodeling. Apoptosis plays an important role in the elimination of infected or transformed cells but also during embryonic development. TNF was found to play a major role in many neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson's disease, stroke or Multiple Sclerosis (MS) but also in Depression and many other brain diseases. In neurodegenerative diseases apoptosis seems to play a major role and therefore the pro-apoptotic function was for a long time at the center of interest to many researchers in this field. We and others have demonstrated that the TNF and TNF receptor system is mainly a protective and sensory system guiding the tissue response to various forms of cellular stress. Apoptosis is just one of the potential responses, which can be induced by TNF. We are following some of these molecular signaling mechanisms in the brain and specific brain cells in response to TNF and detected various signaling molecules downstream of either TNF receptor 1 or TNF receptor 2 and their neuromodulatory signaling e.g. glutamate receptor function, small conductance potassium channels, cAMP Epac-, PKB/Akt- signaling, Nuclear Factor kappa B or lipocalin-2 and iron metabolism.

Please visit the Research Group Webpage : https://www.elaidylab.com/

Molecular diagnostics of infectious diseases -Molecular Biology - Cell biology - Microbiology - Genomics - Next Generation Sequencing - Genotyping

We are interested in the consequences of aneuploidy, an abnormal DNA content affecting 2 out of 3 cancers. By understanding how cancer cells make use of the advantages of aneuploidy and cope with the disadvantages of aneuploidy, we hope to get to therapies that can eradicate aneuploid cancers.

Enzyme discovery, enzyme engineering, biocatalysis, redox enzymology

Corinna Glasner is scientific project manager for the leadpartner of the two INTERREG V projects EurHealth-1Health and health-i-care and research associate at the Department of Medical Microbiology and Infection Prevention. Her expertise lies in molecular microbiology and local, national and international epidemiology of pathogens. She successfully completed her PhD at the end of 2014 with numerous publications on the subtyping and genomic population structure of major pathogens of hospital infections, such as Staphylococcus aureus. Here she led u.a. Europe-wide prevalence of S. aureus and carbapenemase-producing Enterobacteriaceae (CPE). The avoidance of antibiotic resistance and the strengthening of infection prevention are also her area of ​​interest during this time. Since 2016, Corinna Glasner has been a central part of German-Dutch cooperation in the current INTERREG project EurHealth-1Health and health-i-care and is learning and living the opportunities of this exciting border region every single day.

Autophagy, phagophore, autophagosome, yeast, microscopy

Cell movement
Signal transduction

- Carbohydrate Active Enzymes (CAZymes)
- Structural analytics of carbohydrates (HPAEC-PAD, MS)
- Enzyme characterization & engineering
- Biomass degradation & valorization research

Engineering of microbial cell factories
Enzyme discovery and characterization
Structural Biology, macromolecular X-ray crystallography

Inflammation, lipid metabolism, cholesterol transport, liver disease

microbial metabolism, systems biology, single cell analysis, modeling

Applied Biotechnology/Microbiology/Molecularbiology/
Protein X-ray Crystallography/ Proteomics (LC-MS)/ Mass spectrometry Analytical Chemistry

Stemcells in relation to cardiomyopathy

RNA structure determination in living cells

Membrane Biophysics, Fluorescence Spectroscopy, Lipid-protein interactions, Super-resolution microscopy

Enzyme discovery and engineering, biocatalysis, biotransformation, protein engineering

Molecular genetics, (meta-)genomics, (meta-)transcriptomics, microbiology, DNA-seq, RNA-seq, bacteriocins, lantibiotics, anti-microbial peptides, gene expressions and regulation, Bioinformatics, Statistics, R, Perl, Python, JavaScript, PHP, Linux (server), High Performance Computing, Machine Learning.

Understanding chemosensitivity of testicular germ cell tumors, Inducing apoptosis and inhibiting pro-survival to enhance drug efficacy in cancer, Identifying novel drugable pathways in ovarian and cervical cancer.

Molecular Biology, Physiology, Endocrinology, Nuclear Hormone Receptors, Energy Metabolism, Type 2 diabetes, NAFLD, ABC transporters

Analytical chemistry. Carbohydrate & enzyme characterization. Protein and DNA analysis, gene expression and protein purification. Plant biomass.

cell cycle regulation and dynamics, post-translational modifications, Xenopus laevis, live cell microscopy

Clinical Chemist

Inborn errors of metabolism, GSD-I, Cell signalling, metabolism, autophagy and cell biology

Cell Biology, Biochemistry & Molecular Biology, Microscopy

Molecular Genetics, Genomics

Endosomal transport, autophagy, behavioural neurogenetics, genetics, mitochondria, neurodegeneration

Endothelial cells, endothelial dysfunction, endothelial-mesenchymal transition, mitochondrial dysfunction, mitochondrial medicines, microRNA, epigenetics,  inflammation, heart failure, cardiac fibrosis, atherosclerosis, vascular calcification, (diabetic) retinopathy, kidney disease.

Biology of cancer stem cells: novel therapeutic opportunities

Bile acids, Cholesterol, Lipids, Nuclear receptors, Fluxomics

Molecular Genetics

Molecular Cell Biology

Biotechnology & Applied Microbiology, Microbiology, Food Science & Technology, Intellectual Property and Patents , Applied Biocatalysis, Starch, Carbohydrates

Electrophysiology, Single-molecule Nanopore Technology

Evolutionary Biochemistry, Enzymes, Bioinformatics, Biocatalisis

Autophagy, aggrephagy, autophagosome, virus, neurodegenerative diseases

Chemical Biology, Biomolecular Chemistry, Biotechnology, (Bio)catalysis

Biotechnical proceedings and moleculair/genetic biology, as well as field work assitance.

systems biology, TOR signaling, cell growth, cell cycle, mathematical modelling, machine learning, probability & statistics

Gene Regulation with emphasis on the control of translation
Molecular mechanisms in life span determination, ageing and age related diseases
Molecular mechanisms in cancer development

Therapy resistance; Bioengineering; Tumour microenvironment; 3D cell culture; Extracellular Vesicles.

Dimerization of LRRK2, a protein involved in Parkinon's Disease

Research in the Onck group aims at understanding the micromechanical and functional behavior of (biological) materials based on an accurate description of the underlying (bio-) physical mechanisms. Computational techniques (e.g. molecular dynamics, finite element methods and solid-fluid interaction techniques) are being used to explicitly account for the physical mechanisms at the relevant length scales.

Primary focus at the moment is on:
(i) Transport through the nuclear pore complex
(ii) Phase separation and aggregation of disordered proteins
(iii) Molecular chaperones in neurodegenerative diseases
(iii) Soft-robotic nature-inspired microswimmers and magnetic artificial cilia.

For more details, visit the group's web-page.

(genetic) metabolic diseases
translational research
nutrient sensing
stable isotope-based metabolic flux analysis
transcriptional regulation

Molecular biology, protein biochemistry and bioinformatics.

Type 1 Diabetes pathophysiology, pancreatic islets, biomaterials

Biocatalysis, enzymology, protein engineering, directed evolution, enzyme inhibitors, synthetic biology

Membrane Transport, Synthetic Biology, Enzymology, Membrane Biology, Fluorescence Microscopy, Membrane Reconstitution, Structure-Function of Proteins

in vivo metabolism, stable isotopes, metabolomics

biomolecular chemistry & catalysis

Antibiotica
Lanthipeptides
Posstranslationele Modification Enzymes
Peptide Design

Complex traits Genetics, Complex traits mapping, Genetics in Isolates, Genome-wide association studies, Quantitative genetics, Genotype Imputation Methods

Biocatalysis, Redox enzymes, Biocatalytic cascades, Protein engineering, Synthetic biology, Strain engineering

Inflammation, vesicular transport, lipid metabolism, cholesterol transport, mouse transgenesis, liver disease

Artikel 9
Stralingsbescherming 5B

Cryo-Electron Microscopy

Medical biology

Computational protein nanopore design

Bioinformatic specialization: datamining, sequence analysis and gene regulation

Metabolic Signaling

Protein X-ray crystallography
Structural enzymology
Structural biology

• Plant specialized metabolism
• Functional genomics
• Bioenergy crops
• Abiotic stress
• Nectar production

Evolutionary Cell Biology
Comparative genomics of Eukaryotes
Chromosome/Nuclear Biology

Immunoblotting, Cloning, Confocal Microscopy, Chromatography

Nuclear Pore Complex, Nuclear envelope, cellular ageing, intrinsic disorder, liquid-liquid phase separation, Baker's yeast

STED super resolution microscopy, image-analysis, single-molecule biofysics, cell biology

Strategie & beleid

Cell cycle regulation and cellular responses to genotoxic stress, DNA damage and repair pathways and their relevance for cancer treatment.

Carbohydrate chemistry
Glycobiology

Gynecologic Oncology

Proteomics/Mass Spectrometry/Biochemistry

Molecular Microbiology, Microscopy techniques

Yeast (Saccharomyces cerevisiae) and nematode worm (Caenorhabditis elegans) ageing studies
RNA-seq