Molecular Pharmacology
- Bachelor projects Molecular Pharmacology
- Master projects Molecular Pharmacology
- Pharmacology of Chronic Diseases and Aging
- MG: Endocrine system, Respiratory tract and Digestive Tract
- MG: Circulatory Tract- Collected Medicine Groups
- Academic research and communication skills (1, 2 and 3)

Correlated light and electron microscopy. Type 1 Diabetes

Cell Biology, Electron microscopy, Fluorescence microscopy,

Antigen presenting cells, macrophages, dendritic cells

Hematology, Leukemia, Epigenetic regulation of gene expression

Aging, cellular senescence, cancer

-antibody engineering
-immunotherapy
-tumor immunology

Transcriptional, translational and post-translational control of gene regulation.
Moelcular mechansims in ageing, lifespan determination and age-related diseases.
Molecular mechanims and metabolic alterations in tumour development.

Molecular Biology
Ageing Biology
Stem Cell Biology
Cardiovascular Regenerative Medicine

Aging, cancer, age-related disease, cellular senescence

Neuroscience, molecular biology, neuroinflammation, gene expression, epigenetics, cellbiology, development, multiple sclerosis, Alzheimer's disease

The intestinal mucosa is exposed to fluctuations in oxygen levels due to constantly changing rates of oxygen demand and supply and its juxtaposition with the anoxic environment of the intestinal lumen. This frequently results in a state of hypoxia in the healthy mucosa even in the physiologic state. Furthermore, pathophysiologic hypoxia (which is more severe and extensive) is associated with chronic inflammatory diseases including inflammatory bowel disease (IBD). The hypoxia-inducible factor-1α (HIF-1α), a ubiquitously expressed regulator of cellular adaptation to hypoxia, is central to both the adaptive and the inflammatory responses of cells of the intestinal mucosa in IBD patients. In my PhD, I was interested in studying how microenvironmental factors in the intestine modulate intestinal epithelial HIF-1α activation and influence epithelial homeostasis. Currently, as a PostDoc, I study the KEAP1:NFR2 pathway in the context of mucosal inflammation, in which we apply scRNAseq to intestinal biopsies and patient-derived intestinal organoids to better understand cell-type specific responses to oxidative stress and antioxidant therapy.

We are interested in the consequences of aneuploidy, an abnormal DNA content affecting 2 out of 3 cancers. By understanding how cancer cells make use of the advantages of aneuploidy and cope with the disadvantages of aneuploidy, we hope to get to therapies that can eradicate aneuploid cancers.

Autophagy, phagophore, autophagosome, yeast, microscopy

Cell movement
Signal transduction

Inflammation, lipid metabolism, cholesterol transport, liver disease

Respiratory System, Cell and Molecular Biology, Immunology, Asthma, COPD

Stemcells in relation to cardiomyopathy

cell biology, intracellular transport of proteins and lipids, cell polarity, intestinal and liver diseases

cell cycle regulation and dynamics, post-translational modifications, Xenopus laevis, live cell microscopy

Inborn errors of metabolism, GSD-I, Cell signalling, metabolism, autophagy and cell biology

Cell Biology, Biochemistry & Molecular Biology, Microscopy

Microsurgery, Hepatocyte isolation, Microinjection, Histology

Non-coding RNAs, microRNAs, long non-coding RNAs (lncRNAs), B-cell lymphoma

Neurowetenschappen, moleculaire biologie, neuroinflammatie, gen expressie, epigenetica, histon (de)methylatie, celbiologie, ontwikkeling, multiple sclerose,

Endosomal transport, autophagy, behavioural neurogenetics, genetics, mitochondria, neurodegeneration

Microscopy, Cell Biology, Yeast, Research, Education, Peroxisomes

Vascular Grafts
Regenerative Medicine
Tissue Engineering
Mesenchymal Stem/Stromal Cells
Extracellular Matrix
Hydrogels
Biomaterials

Autophagy, aggrephagy, autophagosome, virus, neurodegenerative diseases

Molecular neurobiology. Microglia immune memory. Epigenetics, neuroinflammation, and demyelination in the context of multiple sclerosis.

Gene Regulation with emphasis on the control of translation
Molecular mechanisms in life span determination, ageing and age related diseases
Molecular mechanisms in cancer development

Therapy resistance; Bioengineering; Tumour microenvironment; 3D cell culture; Extracellular Vesicles.

Dimerization of LRRK2, a protein involved in Parkinon's Disease

Hematopoietic stem cells

Zebrafish genetics, mouse embryology, neurogenesis, neural stem cell, asymmetric cell division, organelle assembly, molecular biology, centrosome and cilium biology

Molecular biology, protein biochemistry and bioinformatics.

Type 1 Diabetes pathophysiology, pancreatic islets, biomaterials

BiotechnologyPharmaceutical BiologyMolecular BiologyAntibiotics 
For more details See Publications in Google Scolar

I work on the early secretory pathway in Drosophila cells and tissues, and we have recently focused our research on the response of this pathway to nutrient stress.
Please check
PMID: 21847093; PMID: 25386913; PMID: 26054799; PMID: 27874829; PMID:28342303; PMID: 28377034; PMID: 28746877

PostDoctoral Researcher at Center for Liver, Digestive and Metabolic Diseases. PhD/University of Groningen, the Netherlands. PhD/University of Antioquia, Colombia. Extensive experience and knowledge in Biomedical Sciences: Cellular and Molecular Biology, Oncology, Immunology and Virology. My research is focused in Endoplasmic Reticulum Stress and UPR activation in the context of fatty liver disease or/and liver inflammation. I have a scientific-oriented profile with competencies in science construction and divulgation, analysis and interpretation of scientific literature, situational leadership, multidisciplinary team work, assertive communication and results-orientated.

Stem Cells
Flow cytometry
Molecular biology
Cellular Biology

Biophysics, diamond, nanotechnology, magnetometry, equipment development

Human hematopoietic stem cells, Leukemic stem cells

(Confocal) Microscopy, Electron Microscopy, Imageprocessing 

Inflammation, vesicular transport, lipid metabolism, cholesterol transport, mouse transgenesis, liver disease

Artikel 9
Stralingsbescherming 5B

Metabolic Signaling

Peripheral auditory system
Hearing loss and tinnitus
Neuroscience

Immunoblotting, Cloning, Confocal Microscopy, Chromatography

Nuclear Pore Complex, Nuclear envelope, cellular ageing, intrinsic disorder, liquid-liquid phase separation, Baker's yeast

Strategie & beleid

Cardiovascular Diseases, Atherosclerosis, Lipoprotein Metabolism, Cholestrol Efflux Pathways, Inflammation

drug delivery, non-viral gene delivery, nanocarrier-cell interactions, endocytosis, endosomal escape, blood-brain barrier, transcytosis