Dermatogenetics
Genetics
Epidermolysis bullosa

Epidemiology, congenital anomalies, mediaction use in pregnancy, prenatal screening

Evolutionary Genetics; Fundamental and Applied Entomology, Ecological and Evolutionary Genomics, Evolution of reproductive modes, Genetics of sex determination, Life history evolution, Insect pest control

My main field of research is conservation genetics that studies the consequences of habitat fragmentation and particularly the accompanying genetic process of genetic drift, which causes loss of fitness (inbreeding depression) and loss of genetic variation. The main question addressed is how this so called process of genetic erosion affects the adaptability and persistence of small fragmented populations of endangered species. This includes both applied aspects, studying the genetic structures of endangered species in their natural habitat, and more fundamental aspects by doing decisive experiments using Drosophila melanogaster (banana fly, vinegar fly, fruitvlieg) as model organism.

Neurogenetics, Pheromonal communication, social and sexual behaviours, reproduction, Drosophila.

Heart Failure
Translational cardiology

Perinatale Genetica, Stollingsstoornissen. 

Dupuytren's disaese, hand surgery, methodology

Epilepsy, Epidemiology, Clinical trials, Genetics, Neurology

Developmental psychopathology; Psychiatric genetics; Reward sensitivity; Personality.

Inherited cardiac diseases

Computational genetics, RNA sequencing, Bioinformatics

Viral biomarkers and epigenetic

Inborn errors of metabolism
Neonatal screening
Hepatic glycogen storage diseases (GSD)
Medium-chain acyl-CoA dehydrogenase deficiency (MCADD)
Multiple acyl-CoA dehydrogenase deficiency (MADD)

Senescence; Genomics; Evolution of personalities; Cooperative breeding; Pedigree reconstruction; Quantitative genetics; Social effects; Women in science

Microbial Ecology, Genetics

Keywords: Molecular Ecology | Population genetics / genomics | Bioinformatics | Phylogeography | Speciation | Evolutionary Biology

My research group works on the identification of molecular effects that disease-causing mutations have. More information on my work can be found on http://www.ludesign.nl/frankelab

Computatiional biology, genomics, biology of ageing 

I am an interventional cardiologist and scientist. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction.

My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website: www.cardiomics.net

In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/mHealth to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; www.early-synergy.nl) studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies.

Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Clinical chemistry
Inborn errors of metabolism
Fatty acid oxidation defects
Defects in amino acid metabolism

classificatie en codering van aangeboren afwijkingen, klinische genetica, teratologie

genetica
immunology

Microsurgery, Hepatocyte isolation, Microinjection, Histology

Non-coding RNAs, microRNAs, long non-coding RNAs (lncRNAs), B-cell lymphoma

Npehrogenetics

Molecular Genetics, Genomics

Dynamics of parental behaviour
Early-life environment, social stress and individual behaviour
Physiology of life histories and senescence
Fitness consequences and heritability of life-history decisions
Conserving threatened species

Innovations in genetic counselling, ELSI-aspects of clinical genetics and genetic screening, cardiogenetics

Genetic data management, Bioinformatics, Genetic ancestry, Cervical cancer, HPV genetics and epidemiology.

Bayesian statistics
Statistical genetics
Functional Genomics
Machine Learning
Evolutionary biology

demographics; high-dimensional data; health; labour market

Ik ben opgeleid als wetenschappelijk onderzoeker met een sterke focus op cellulair en moleculair immunologisch onderzoek, waarbij ik een steeds sterkere interesse heb ontwikkeld in het doen van translationeel onderzoek in een multidisciplinaire setting. Mijn unieke expertise is het ontwikkelen van experimentele en preklinische modellen waarin mechanismes van complexe ziektes van het ademhalingsstelsel worden onderzocht, met als doel nieuwe interventies te ontwikkelen gebaseerd op de persoonlijke aanleg voor de aandoening. Naast het wetenschappelijk onderzoek draag ik met veel plezier bij aan het Geneeskunde en Immunologie onderwijs binnen het UMCG en de Rijksuniversiteit Groningen. Ik ben als Immunoloog erkend volgens de SMBWO criteria.

Mijn onderzoek kent twee thema’s, die allebei een sterk translationeel karakter hebben:Ten eerste heb ik een onderzoekslijn functionele genetica van chronische longaandoeningen , waarbinnen wij de biologische effecten proberen te ontrafelen van de genetische variatie die bijdraagt aan de gevoeligheid van de patiënt voor astma of COPD.  Ten tweede heb ik een onderzoekslijn translationeel onderzoek naar de mechanismen van allergeen immunotherapie , waarbinnen we in een combinatie van basaal onderzoek in muismodellen en patient-gebonden onderzoek het werkingsmechanisme van allergeen immunotherapie proberen te achterhalen, met als doel de effectiviteit van deze behandeling te kunnen verbeteren.

Population genetics, Conservation genetics, Evolutionary genetics, Genomics,
Molecular ecology,
Marine mammals

CHARGE syndrome, Phelan-McDermid syndrome, Chromosome 6 aberrations, Clinical Cytogenetics

Epigenetics, gene expression modulation, Epigenetic Editing, mitochondrial DNA methylation, CRISPR/dCas

Complex traits Genetics, Complex traits mapping, Genetics in Isolates, Genome-wide association studies, Quantitative genetics, Genotype Imputation Methods

Inflammation, vesicular transport, lipid metabolism, cholesterol transport, mouse transgenesis, liver disease

Genetic Epidemiology of (risk factors for) cardiovascular disease and type 2 diabetes

Data science, Bioinformatics, Next-generation sequencing, Patient and mutation registies, Genomics, Biobank data integration, data catalogue, High performance computing, databases, FAIR data, semantic harmonization

Bioinformatic specialization: datamining, sequence analysis and gene regulation

Molecular DNA techniques
DNA lab

Functional genetics of rare movement disorders: ataxia, dystonia & familial Parkinson's disease

Obesity; Type 2 Diabetes; Genetic epidemiology; Human Genetics; Epigenetics; Gene x Environment interactions, Endocrine Disruptors 

Theoretical Biology; Behaviour, Ecology, Evolution; Evolutionary Game Theory; Dynamical Systems; Cultural Evolution; Evolutionary Systems Biology.

Ecological and evolutionary genomics
Host-parasite interactions
Innate immunity in insects

PCR, molecular cloning, Crispr Cas9, western blot, flowcytometry.

Genetics of auto-immune diseasesSee  http://www.rug.nl/research/genetics/staff/cisca-wijmenga and www.systemsgenetics.nl

Biochemistry; Human Genetics; Non-coding RNAs; miRNAs; lncRNAs; Molecular Immunology; Disease Models for Complex Genetic Immunediseases; Celiac disease; iPS Technology; Organoids; Organ-on-chip Technology.

Bioinformatics, biostatistics

Populatiegenetica, bioinformatica, moleculaire ecologie, kwantitatieve ecologie, mariene vertebraten

genetics of complex diseases, system genetics, diseases of gastrointestinal trait, aging, microbiome