Skip to ContentSkip to Navigation
About us Latest news News News articles

STW grants for antibiotics research

21 November 2011

In addition to three ALW grants from the Netherlands Organisation for Scientific Research (NWO), in November three grants from the Technology Foundation STW were also awarded to the Groningen Biomolecular Sciences and Biotechnology Institute (GBB). This brings the total project grant amount for GBB researchers to EUR 2.3 million, thus ensuring that progress can be made in the coming years in research on new antibiotics (4 research projects), peroxisome biology (1 research project) and protein translocation (1 research project).

The antibiotics research is also part of the STW Perspective programme GenBiotics ; the relevant projects are:

1. CRYPTON II – a genome-based generalized strategy to activate cryptic antibiotic biosynthesis gene clusters in Actinomycetales.

Contact : , Microbial Physiology, GBB

Prof. E. Takano (University of Groningen), Prof. W. Bitter (VU Medical Center), Prof. R. Breitling (University of Groningen), Prof. Vandenbroucke-Grauls (VU Medical Center) Industrial partner(s): DSM and KtedoGen.

Grant awarded: € 500,000

The aim of the project is to activate a systematically identified gene cluster for the production of secondary metabolites in order to determine the antibiotic function and the structure of new components. Another aim is to try to construct new bioactive substances by means of more complex synthesis and derivatization.

2. Combinatorial strategies for the production of antimicrobials by advanced fungal host strains.

Contact : , Molecular Microbiology, GBB

Prof. A.J.M. Driessen (University of Groningen), Prof. T. Hankemeijer (Leiden University), Prof. H.S. Overkleeft (Leiden University), Dr R. Vreeken (Leiden University).

Industrial partner(s): DSM

Grant awarded: € 540,000

The aim of the research is to link the superior fermentation characteristics of the mould Penicillium chrysogenum to synthetic-chemical approaches. The intended ‘deliverables’ are new fermentation-based and synthetic routes to create natural and unnatural roquefortine-related metabolites, including an overview of their antimicrobial activity and toxicity.

3. Lanthexpress

Contact : , Molecular Genetics, GBB

Prof. G.P. van Wezel (Leiden University), Prof. O.P. Kuipers (University of Groningen).

Industrial partner(s): Bruker, Novacta and BioMade

Grant awarded: € 200,000

The project aims to develop new bacterial expression systems for lantibiotics and derivatives so that >40 new types of lantibiotics from actinomycetes can be screened for activity against familiar multi-drug-resistant pathogenic microorganisms. The expectation is that new antimicrobial drugs will be discovered.

Technology Foundation STW promotes knowledge transmission between the technical sciences and users. To this end, STW links researchers and potential users to each other and finances excellent technical-scientific research.

Last modified:07 August 2020 11.55 a.m.
View this page in: Nederlands

More news

  • 13 May 2024

    ‘The colourful cells of petals never get boring!’

    Most people will enjoy colours in nature. However, the interest of evolutionary biologist Casper van der Kooi goes much further: he studies how flowers, birds, butterflies, and beetles get their colours. He also studies how these colours are used...

  • 13 May 2024

    Trapping molecules

    In his laboratory, physicist Steven Hoekstra is building an experimental set-up made of two parts: one that produces barium fluoride molecules, and a second part that traps the molecules and brings them to an almost complete standstill so they can...

  • 07 May 2024

    Lecture with soon to be Honorary Doctor Gerrit Hiemstra on May 24

    In celebration of his honorary doctorate, FSE has invited Hiemstra to give a lecture entitled ‘Science, let's talk about it’ on the morning of 24 May