Skip to ContentSkip to Navigation
About us Faculty of Science and Engineering

Prof Schmidt receives grant from BAYER

17 November 2020

Prof. Martina Schmidt of the Groningen Research Institute of Pharmacy ( GRIP ) has been awarded a grant of the company BAYER GmbH. The grant worth EUR 175,000 is for her research project ‘ Evaluation of the P2RX4 antagonist BR11595 in experimental guinea pig models of allergen-induced acute and chronic asthma and ATP/citric acid-induced cough’. Schmidt conducts this project together with Prof. Reinoud Gosens and Dr. Loes Kistemaker.

Asthma is a common chronic lung disease, affecting over 300 million people worldwide. Patients with asthma suffer from airway obstruction and reduced bronchodilation by deep breathing due to remodeling of the bronchial tree. Episodes with worsening of particularly severe asthma (so-called exacerbations), in addition to airway obstruction, are often characterized by coughing. In the current studies, the researchers will investigate the potential of the P2X4 purinergic ion channel receptor as a novel anti-asthma drug, targeting airway obstruction and in particular cough.

The goal is to develop in vivo cough models in guinea pigs to investigate an intervention strategy taking place when the exacerbation and the burden of coughing is maximal. By combining this with classical asthma models investigating effects on lung function, airway remodeling and airway inflammation, the researchers aim to elucidate the potential of the novel P2RX4 antagonist in asthma and thereby contribute to improved therapy for (severe) asthma patients.

Grant from BAYER for Prof. Martina Schmidt
Grant from BAYER for Prof. Martina Schmidt
Last modified:17 November 2020 10.45 a.m.

More news

  • 22 May 2024

    Raffaella Carloni and Jonas Göbel winners Ben Feringa Impact Award 2024

    Raffaella Carloni and Jonas Göbel received the Ben Feringa Impact Awards 2024 for the categories of researchers and students on Tuesday 21 May.

  • 13 May 2024

    ‘The colourful cells of petals never get boring!’

    Most people will enjoy colours in nature. However, the interest of evolutionary biologist Casper van der Kooi goes much further: he studies how flowers, birds, butterflies, and beetles get their colours. He also studies how these colours are used...

  • 13 May 2024

    Trapping molecules

    In his laboratory, physicist Steven Hoekstra is building an experimental set-up made of two parts: one that produces barium fluoride molecules, and a second part that traps the molecules and brings them to an almost complete standstill so they can...