Synthetic biology

Marine Microbiologist with an interest in phytoplankton, algal physiology, primary production, DMSP production and sea ice habitats.

Antimicrobial resistance analysis, data analysis & visualisation

Microbiology (studies and previous work experience),  neuroscience (studies and research projects), teaching in practicals

Cell Biology, Electron microscopy, Fluorescence microscopy,

Molcular Genetics, Bacteriology, Medical Microbiology, Infection prevention

Former chair: Ecophysiology of marine microalgae.
Key words: marine phytoplankton, marine carbon cycle, marine polar ecology, global change, harmful algal blooms, (micro)algal applications.

I am interested in all factors that control the growth and diversity of marine phytoplankton. In practice I was involved in projects that deal with climate change and (Ant)Arctic algal productivity and diversity, harmful algal blooms and algal applications. We executed experimental work in the lab, based on our extensive culture collection. Furthermore, we participated in field campaigns, for example to the open Atlantic, both polar regions, or Indonesia.

Biomaterial-associated infections
- how they develop
- how to prevent
- how to evaluate preventive measures

Bacterial gene expression, protein localization, protein secretion, bacteria-host interactions, bacterial pathogenesis, imaging of bacterial infections

Membrane biology, Protein translocation and membrane protein biogenesis, multidrug resistance, biotechnology of filamentous fungi and yeast, membrane biology of hyperthermophilic Archaea, Synthetic cells

Please visit the Research Group Webpage : https://www.elaidylab.com/

Experimental evolution; Microbiology; Antibiotic resistance; Theoretical biology; Computational biology; Paleontology

Microbial Ecology, Genetics

biotechnology, microbiology, separation technology, water technology, high througput screening, biochemistry, enzymology

The intestinal mucosa is exposed to fluctuations in oxygen levels due to constantly changing rates of oxygen demand and supply and its juxtaposition with the anoxic environment of the intestinal lumen. This frequently results in a state of hypoxia in the healthy mucosa even in the physiologic state. Furthermore, pathophysiologic hypoxia (which is more severe and extensive) is associated with chronic inflammatory diseases including inflammatory bowel disease (IBD). The hypoxia-inducible factor-1α (HIF-1α), a ubiquitously expressed regulator of cellular adaptation to hypoxia, is central to both the adaptive and the inflammatory responses of cells of the intestinal mucosa in IBD patients. In my PhD, I was interested in studying how microenvironmental factors in the intestine modulate intestinal epithelial HIF-1α activation and influence epithelial homeostasis. Currently, as a PostDoc, I study the KEAP1:NFR2 pathway in the context of mucosal inflammation, in which we apply scRNAseq to intestinal biopsies and patient-derived intestinal organoids to better understand cell-type specific responses to oxidative stress and antioxidant therapy.

Microbial Community Ecology

Molecular diagnostics of infectious diseases -Molecular Biology - Cell biology - Microbiology - Genomics - Next Generation Sequencing - Genotyping

Methicillin-resistant S. aureus (MRSA)
Prevention of Antibiotic Resistance and Healthcare-associated infections
Crossborder (NL/DE) comparative research of health systems
Network analysis and transmission dynamics for infection prevention 

Microbial Community Ecology

Corinna Glasner is scientific project manager for the leadpartner of the two INTERREG V projects EurHealth-1Health and health-i-care and research associate at the Department of Medical Microbiology and Infection Prevention. Her expertise lies in molecular microbiology and local, national and international epidemiology of pathogens. She successfully completed her PhD at the end of 2014 with numerous publications on the subtyping and genomic population structure of major pathogens of hospital infections, such as Staphylococcus aureus. Here she led u.a. Europe-wide prevalence of S. aureus and carbapenemase-producing Enterobacteriaceae (CPE). The avoidance of antibiotic resistance and the strengthening of infection prevention are also her area of ​​interest during this time. Since 2016, Corinna Glasner has been a central part of German-Dutch cooperation in the current INTERREG project EurHealth-1Health and health-i-care and is learning and living the opportunities of this exciting border region every single day.

Microbiology; especially gastrointestinal ecology , pre- and probiotic.

Engineering of microbial cell factories
Enzyme discovery and characterization
Structural Biology, macromolecular X-ray crystallography

microbial metabolism, systems biology, single cell analysis, modeling

Vaccinology

Mitochondrial epigenetics, Functional genomics, LFQ Proteomics, Microbe-host interaction

Enzyme discovery and engineering, biocatalysis, biotransformation, protein engineering

Molecular Genetics, Genomics

Microscopy, Cell Biology, Yeast, Research, Education, Peroxisomes

Molecular Genetics

Data analysis & visualization | Teaching R

Biotechnology & Applied Microbiology, Microbiology, Food Science & Technology, Intellectual Property and Patents , Applied Biocatalysis, Starch, Carbohydrates

My main field is biomaterials associated infections in the human body by studying the effect of a modified biomaterial surface  on bacterial adhesion and biofilm formation.

Evolutionary systems biology, Theoretical biology, Microbial ecology, Experimental evolution, Population genetics, Dynamical systems, Stochastic processes 

Development and implementation of molecular diagnostics in clinical virology. Implementation of international quality control programmes. Implementation of Point-of-Impact technologies. Cost/benefits studies. MiddleWare solutions in molecular diagnostics.

Molecular biology, protein biochemistry and bioinformatics.

Bacterial culturomics, spezialized in anaerobic bacteria.
Host-Microbe interaction models.

Membrane Transport, Synthetic Biology, Enzymology, Membrane Biology, Fluorescence Microscopy, Membrane Reconstitution, Structure-Function of Proteins

BiotechnologyPharmaceutical BiologyMolecular BiologyAntibiotics 
For more details See Publications in Google Scolar

Development and implementation of molecular tools for diagnosing infectious diseases. Focus on the use of sequence-based technologies for infection control, detection and understanding of antimicrobial resistance, and the role of the host in the disease course of an infection.

Biocatalysis, Redox enzymes, Biocatalytic cascades, Protein engineering, Synthetic biology, Strain engineering

Research project: de klinische toepasbaarheid van Next-Generation Sequencing technieken om interventies in het pathogene orale microbioom aan te tonen

Antibioticabeleid binnen de Tandheelkunde

Research unit: Microbes in Health and Disease (MHD)
Research unit: Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
Research Institute: GUIDE

Bio-optical imaging, foreign body reaction, bacterial adhesion, biofilms, colloid and interface science

marine phytoplankton, ecophysiology, biogeochemistry, climate gases, DMS, pigments, pelagic and sea ice habitats

Animal Ecology, Physiological Ecology, Wild Immunology

Physiology and ecology of seaweeds

I am a community microbial ecologist with expertise in community composition of a variety of different soil organisms. My primary interest is in assessing the relationship between microbial and above-ground plant communities in semi-natural ecosystems and low-input agriculture.

I have a broad knowledge in plant and microbial (bacteria and fungi) ecology and have competence in bioinformatics and data analysis of molecular data.

The group investigates ecological and evolutionary processes in (infectious) microbial communities. We aim to understand the genotype-phenotype-fitness relationships within (evolving) communities, and aim to elucidate the ecological drivers of evolution. 
We study these eco-evolutionary processes using molecular biological tools, by performing phenotypic and growth measurements, and modeling.
By unveiling the fundamental ecological and evolutionary microbial processes in infectious disease, we hope to improve and contribute to strategies that can alleviate infectious diseases and limit the spread of antibiotic resistance.

Infectiepreventie

Molecular Microbiology, Microscopy techniques