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Publications 2010

Below you will find the publications of the department of Pharmaceutical Biology for 2010. The title of the publication links automatically to the PDF-file (when available)

Nadal Jimenez, P., Koch, G., Papaioannou, E., Wahjudi, M., Krzeslak, J., Coenye, T., Cool, R.H., Quax, W.J. The role of PvdQ in Pseudomonas aeruginosa virulence under iron-limiting conditions. Microbiology 156(Pt 1):49-59 .

Kouwen T.R., Nielsen, A.K., Denham, E.L., Dubois, J.Y., Dorenbos, R., Rasmussen, M.D., Quax, W.J., Freudl, R., van Dijl, J.M. Contributions of the pre- end pro-regions of Staphylococcus hyicus lipase to secretion of a heterologous protein by Bacillus subtilis. Appl Environ Microbiol . 76(3):659-669.

Staniek, A., Muntendam, R., Woerdenbag, H.J., Kayser, O. Essential oil constituents derived from different organs of a relictual conifer Wollemia nobilis. Biochemical Systematics and Ecology, DOI 10.1016/j.bse.2009.12.022. Accepted for publication December 31, 2009.

Staniek, A., Woerdenbag, H.J., Kayser, O. Screening the endophytic flora of Wollemia nobilis for alternative paclitaxel sources. Jourmal of Plant Interactions. Accepted for publication December 31, 2009.

Bokhove, M., Nadal Jimenez, P., Quax, W.J., Dijkstra, B.W. The quorum quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket. Proc Natl Acad Sci U S A. 107(2):686-91.

Kayser, O. Metabolic engineering strategies for the optimization of medicinal and aromatic plants: expectations and realities.  Acta Horticulturae (ISHS).860:199-204.

Lemke, A., Petri, B, Kiderlen, A.F., Kayser, O. Delivery of amphotericin B nanosuspensions to the brain and determination of activity against Balamuthia mandrillaris amebae. Nanomedicine: Nanotechnology, Biology, and Medicine. in press.

Vrielink, J., Heins, M., Setroikromo, R., Szegezdi, E., Mullally, M.M., Samali, A. & Quax, W.J. Synthetic constrained peptide selectively binds and antagonizes death receptor DR5., FEBS Journal. in press.

Rana, A, Siudeja, K., Seinen E., Reijngoud, DJ; Kayser O., Hayflick, S. Muntendam, R., Srinivasan, B., van der Want, JJL, Sibon O. Pantethine rescues a Drosophila model for Pantothenate Kinase-Associated Neurodegeneration, Proc.Natl.Acad.Sci. 107, 6988-6993

Wu, B., Szymanski, W., Wijma, H.J., Crismaru, C.G., de Wildeman, S., Poelarends, G.J., Feringa, B.L., Janssen, D.B.  Engineering of an enantioselective tyrosine aminomutase by mutation of a single active site residue in phenylalanine aminomutase. Chem. Commun. 46:8157-8159.

Wu, B., Szymanski, W., de Wildeman, S., Poelarends, G.J., Feringa, B.L., and Janssen, D.B. Efficient tandem biocatalytic process for the kinetic resolution of aromatic ß-amino acids. Adv. Synth. Catal. 352:1409-1412.

Reis, C.R., Sloot, A.M. van der., Natoni, A., Szegezdi, E., Setroikromo, R., Meijer, M., Sjollema, K., Stricher, F., Cool, R.H., Samali, A., Serrano, L., Quax, W.J. Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants. Edited by R Johnstone. Cell Death and Disease 1 , e83; doi:10.1038/cddis.2010.61, Published online 21 October 2010.

Rydén, A-M., Ruyter-Spira, C., Quax, W. J., Osada, H., Muranaka, T., Kayser, O., Bouwmeester, H. J., Molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis.  DOI Published online Planta Med.

Ryden, A.M., Ruyter-Spira, C., Quax, W.J., Osada, H., Muranaka, T., Kayser, O. and Bouwmeester, H. (2010) The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua. Planta Med. Germany 76, 1778-1783.

Rydén, A-M., Ruyter-Spira, C., Litjens, R., Takahashi, S., Quax, W. J., Osada, H., Bouwmeester, H. J., Kayser, O., Molecular cloning and characterization of a broad substrate terpenoid oxidoreductase from Artemisia annua. Plant Cell Physiol. 51(7): 1219–1228.

Rydén, A-M., Ruyter-Spira, C., Van den End, F., Verstappen, F., Quax, W. J., Bouwmeester, H. J., Kayser, O. Oxygen dependent biosynthesis of artemisinin precursors in yeast. Submitted, Journal of biotechnology, 2010.

Hendrawati, O., Woerdenbag, H., Hille, J., Quax, W. and Kayser, O. Plant Regeneration and Transformation of Anthriscus sylvestris L (HOFFM). In Vitro Cellular & Developmental Biology-Animal. 46, S121-S121.

Insanu, M., Anggadireja, J. and Kayser, O. Isolation of curcacycline A from latex of Jatropha curcas and its antibiotic and cytotoxic effect. Planta Med. 76, 1302-1302 .

Ryden, A., Melillo, E., Czepnik, M. and Kayser, O. Metabolic engineering for improved heterologous terpenoid biosynthesis. Planta Med. 76, 1176-1176  

Chapter in book:

Poelarends, G.J., and Whitman, C.P. Mechanistic and structural studies of microbial dehalogenases: How Nature cleaves a carbon-halogen bond. In L.N. Mander and H.-W. Liu (eds.), Comprehensive Natural Products II: Chemistry and Biology volume 8: 89-123, Elsevier, Oxford, UK.


Staniek, A., Endophytes as alternative paclitaxel sources: chemistry and genetics of Taxomyces andreanae & the endophytic flora of Wollemia nobilis. April 16, 2010.

ISBN printed version: 978-90-367-4296-2

ISBN digital version: 978-90-367-4297-9

Rodrigues dos Reis, C.R., Selectivity and Efficacy in TRAIL-mediated apoptosis. April 16, 2010.

ISBN printed version: 978-90-367-4249-8

ISBN digital version: 978-90-367-4250-4

Rydén, A-M., Identification, characterisation and expression of early biosynthetic genes from Artemisia annua for the heterologous biosynthesis of diydroartemisinic acid as a first step towards artemisinin production. September 10, 2010.

ISBN printed version: 978-90-367-4493-5

ISBN digital version: 978-90-367-4494-2


Last modified:14 August 2013 10.51 a.m.
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