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Publications 2006

Below you will find the publications of the department of Pharmaceutical Biology for 2006. The title of the publication links automatically to the PDF-file (when available).

Droge, M. J., Boersma, Y. L., van, P. G., Vrenken, T. E., Ruggeberg, C. J., Reetz, M. T., Dijkstra, B. W., and Quax, W. J. Directed evolution of Bacillus subtilis lipase A by use of enantiomeric phosphonate inhibitors: crystal structures and phage display selection, Chembiochem. 7, 149-157.

Elfahmi, Batterman, S., Koulman, A., Hackl, T., Bos, R., Kayser, O., Woerdenbag, H. J., and Quax, W. J. Lignans from cell suspension cultures of Phyllanthus niruri, an Indonesian medicinal plant, J. Nat. Prod. 69, 55-58.

Sio, C. F., Otten, L. G., Cool, R. H., Diggle, S. P., Braun, P. G., Bos, R., Daykin, M., Camara, M., Williams, P., and Quax, W. J. Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1 , Infect. Immun. 74, 1673-1682.

Westers, L., Dijkstra D.S., Westers, H., van Dijl, J.M., Quax, W.J. Secretion of functional human interleukin-3 from Bacillus subtilis. J. Biotechnol. 123: 211-224

Zanen, G., Antelmann, H., Meima, R., Jongbloed, J.D.H., Kolkman, M., Hecker, M., Van Dijl, J.M., Quax, W.J. Proteomic dissection of potential signal recognition particle dependence in protein secretion by Bacillus subtilis. Proteomics,  2006,  (12): 3636-48

Vasilev, N.P., Julsing, M.K., Koulman, A., Clarkson, C., Woerdenbag, H.J., Ionkova, I., Bos, R., Jaroszewski, J.W., Kayser, O., Quax, W.J. Bioconversion of deoxypodophyllotoxin into epipodophyllotoxin in E. coli using human cytochrome P450 3A4. J Biotechnol. 2006 Nov 10;126(3):383-393

Droge, M.J., Boersma, Y.L., Braun, P.G., Buining, R.J., Julsing, J.K., Selles, K.G.A., Van Dijl, J.M., Quax, W.J., Phage display of an intracellular carboxylesterase of Bacillus subtilis: a comparison of the Sec and Tat pathway export capabilities. Appl Environ Microbiol, 2006, 72 (7):4589-4595.

Lemke, A., Kayser, O. HPLC detection of miltefosine using an evaporative light scattering detector. Pharmazie, 2006 May;61(5):406-8.

Sloot, A.M. van der, Tur, V., Szegezdi, E., Mullally, M.M., Cool, R.H., Samali, A., Serrano, L., Quax, W.J. Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor. PNAS, 2006 June, 103(23): 8634-8639.

Darmon, E., Dorenbos, R., Meens J., Freudl, R., Antelmann, H., Hecker, M., Kuipers, O.P., Bron, S., Quax, W.J., Dubois, J.Y., Van Dijl, J.M. A Disulfide Bond -Containing Alkaline Phosphatase Triggers a BdbC-Dependent Secretion Stress Response in Bacillus subtilis. Appl. Envoron Microbiol. 2006 November; 72(11): 6876-85

Julsing, M.K. , Koulman, A., Woerdenbag, H.J. , Quax, W.J. , Kayser, O. Combinatorial biosynthesis of medicinal plant secondary metabolites. Biomol Eng. 2006 Aug 22, (in press)

Vasilev,N., Elfahmi, Bos, R., Kayser, O., Momekov, G., Konstantinov, S., Ionkova, I. Production of justicidin B, a cytotoxic arylnaphthalene lignan from genetically transformed root cultures of Linum leonii. J. Nat. Prod. 2006, 69, 1014-1017.

Westers, H., Westers, L., Darmon, E., Van Dijl , J.M. , Quax, W.J. , Zanen,G. The CssRS two-component regulatory system controls a general secretion stress response in Bacillus subtilis. FEBS Journal (2006) 273, 3816-3827.

Kaneshiro, E.S. , Basselin, M. , Merali, S., Kayser, O. Ubiquinone Synthesis and its Regulation in Pneumocystis carinii.  J. Eukaryot. Microbiol. (2006), 53(6):435-44.


Elfahmi. Phytochemical and Biosynthetic Studies of Lignans. With a Focus on Indonesian Medicinal Plants. June 26, 2006. ISBN 90-902-0771-6

Julsing, M.K. Bioconversion and combinatorial biosynthesis of selected terpenoids and lignans. October 13, 2006.

ISBN printed version: 90-367-2762-6. ISBN electronical version: 90-367-2763-4.

Sloot, A.M. van der. Design and Engineering of human TRAIL Variants. November 24, 2006.

ISBN printed version:90-367-2878-9. ISBN digital version:90-367-2879-7.


Kayser, O, Quax, W (2006)

Medicinal Plant Biotechnology. 2 vols. From Basic Research to Industrial Applications

Wiley-VCH, Heidelberg (ISBN: 3527314431)

Kayser, O. (2006)

Podstawy Biotechnologii Farmaceuttycznej

B.G. Teubner Verlag, GWV Verlagsgesellschaft, Wiesbaden

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