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Publications 2007

Below you will find the publications of the department of Pharmaceutical Biology for 2007. The title of the publication links automatically to the PDF-file (when available).


de Jong, R.M., Bazzacco, P., Poelarends, G.J., Johnson Jr.,W.H., Kim, Y.J., Burks, E.A., Serrano, H., Thunnissen, A.M., Whitman, C.P., Dijkstra, B.W. Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase. Structural basis for substrate specificity and inactivation by (R)-oxirane-2-carboxylate. J. Biol. Chem 282(4):2440-9.


Julsing, M.K., Rijpkema, M., Woerdenbag, H.J., Quax, W.J., Kayser, O. Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis. Appl Microbiol Biotechnol 2007 Jul;75(6):1377-84.


Bos, R., Windono, T., Woerdenbag, H.J.,Boersma,Y.L., Koulman, A., Kayser,O. HPLC-photodiode array detection analysis of curcuminoids in Curcuma species indigenous to Indonesia. Phytochem. Anal. 2007 Mar;18(2):118-22.


Kouwen, T.R., van der Goot, A., Dorenbos, R., Winter, T., Antelmann, H., Plaisier, M.C., Quax, W.J., van Dijl, J.M., Dubois, J.Y. Thiol-disulphide oxidoreductase modules in the low-GC Gram-positive bacteria. Mol Microbiol. 2007 May; 64(4): 984-99.


Boersma,Y.L.; Droge,M.J.; Quax,W.J. Selection strategies for improved biocatalysts. FEBS J. 2007 May; 274(9): 2181-95.


Bos,R.; Woerdenbag,H.J.; Kayser,O.; Quax,W.J.; Ruslan,K.; Elfahmi. Essential oil constituents of Piper cubeba L. fils. from Indonesia. Journal of Essential Oil Research 19 (1): 14-17 (available online at


Otten,L.G.; Sio,C.F.; Reis,C.R.; Koch,G.; Cool,R.H.; Quax,W.J. A highly active adipyl-cephalosporin acylase obtained via rational randomization. Febs J. 2007 Nov; 274(21):5600-10.


Wassenaar,T.A.; Quax,W.J.; Mark,A.E. The conformation of the extracellular binding domain of Death Receptor 5 in the presence and absence of the activating ligand TRAIL: A molecular dynamics study . Proteins 2007 Aug 1; [Epub ahead of print]


Seifert,K.; Lemke,A.; Croft,S.L.; Kayser,O. Anti-leishmanial structure-activity-relationships of synthetic phospholipids: in vitro and in vivo activity of selected derivatives. Antimicrob. Agents Chemother 2007 Dec;51(12):4525-8.


Poelarends,G.J.; Johnson,W.H.,Jr.; Serrano,H.; Whitman,C.P. Phenylpyruvate tautomerase activity of trans-3-chloroacrylic acid dehalogenase: evidence for an enol intermediate in the dehalogenase reaction? Biochemistry 46(33):9596- 9604.


Elfahmi, Ruslan, K., Batterman, S., Bos, R., Kayser, O., Woerdenbag, H.J., Quax, W.J. Lignan profile of Piper cubeba, an Indonesian medicinal plant. Biochemical Systematics and Ecology 35: 397-402.


Staniek, A.; Woerdenbag, H.J.; Czepnik, M.; Szamalek, M.; Baer-Dubowska,W.; Krawczyk, K.; Budzianowski, J.; Zwart, J.W.; Kayser, O. Endophytic paclitaxel synthesizers - search and investigation. PLANTA MEDICA 73 (9): 1021-1021 P641 AUG. (Meeting abstract)


Koulman, A.; Hendrawati, O.; Batterman, S.; Van Putten, F.M.S.; Bos, R.; Kayser, O. The seasonal variations of lignan profiles in Anthriscus sylvestris (L.) Hoffm. PLANTA MEDICA 73 (9): 858-858 P112 AUG  (Meeting abstract)


Tarrus,M., van der Sloot,A.M., Temming,K., Lacombe,M., Opdam,F., Quax,W.J., Molema,G., Poelstra,K., Kok,R.J.. RGD-avidin-biotin pretargeting to alpha(v)beta (3) integrin enhances the proapoptotic activity of TNFalpha related apoptosis inducing ligand (TRAIL). Apoptosis. Dec 11 [Epub ahead of print]


Julsing,M.K., Vasilev,N.P., Schneidman-Duhovny,D., Muntendam,R.,Woerdenbag,H.J.,Quax,W.J.,Wolfson,H.J., Ionkova,I.,Kayser,O. Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation. Eur. J. Med.Chem. Sep 19 [Epub ahead of print]


Duarte N, Kayser O, Abreu P, Ferreira MJ. Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds. Phytother Res. Dec 31; [Epub ahead of print]


Setroikromo,R.; Wierenga,P.K.; van Waarde,M.A.; Brunsting,J.F.; Vellenga,E.; Kampinga,H.H. Heat shock proteins and Bcl-2 expression and function in relation to the differential hyperthermic sensitivity between leukemic and normal hematopoietic cells. Cell Stress Chaperones. 12(4):320-30.


Chapters in books:


Joanna Krzeslak,Mariana Wahjudi and Wim J. Quax
Chapter:Quorum-Quenching Acylases in Pseudomonas aeruginosa.

In: Pseudomonas Volume 5: A Model System in Biology, p 429-449.
Springer Netherlands, 2007.

ISBN: 978-1-4020-6096-0 (Print) 978-1-4020-6097-7 (Online)


A.-M. Rydén, O. Kayser.

Chapter: Chemistry, Biosynthesis and Biological Activity of Artemisinin and Related Natural Peroxides.

In Book Series: Topics in Heterocyclic Chemistry,

Volume 9/2007, p 1-31.
Book: Bioactive Heterocycles III
Khan, M.T.H. (Ed.), Publisher Springer Berlin / Heidelberg
ISSN 1861-9282 (Print) 1861-9290 (Online)     
ISBN 978-3-540-73401-7

T. Flemming, R. Muntendam, C. Steup, O. Kayser.

Chapter: Chemistry and Biological Activiy of Tetrahydrocannabinol and its Derivatives

In Book Series: Topics in Heterocyclic Chemistry,

Volume 10/2007, p 1-42.
Book: Bioactive Heterocycles IV
Khan, M.T.H. (Ed.), Springer-Verlag Berlin / Heidelberg
ISSN 1861-9282      
ISBN 978-3-540-73403-1


Magazine articles :


Boersma, Y.L., Dröge, M.J., Quax, W.J.. Evolutie in vitro. Biokatalysator produceert enantiozuivere geneesmiddelen. Pharmaceutisch Weekblad, 9 november 2007, p 22-24.


Julsing MK, Woerdenbag HJ, Kayser O. Combinatori ë le biosynthese. Plantenstoffen staan weer volop in de belangstelling. Conceptuur 2007; no. 51: 6-7.




Boersma, Y.L. Evolution of Enantioselectivity. Selection of Improved Hydrolase Variants. 29 juni 2007.

ISBN printed version:90-367-3085-3. ISBN digital version:90-367-3086-0.



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