2014

Articles:

Alkhouri H., Poppinga, W. J., Tania, N. P., Ammit, A. & Schuliga, M. Regulation of pulmonary inflammation by mesenchymal cells. In : Pulmonary Pharmacology & Therapeutics. 29, 2, p. 156-165.

Baker K. E., Bonvini, S. J., Donovan, C., Foong, R. E., Han, B., Jha, A., Shaifta, Y., Smit, M., Johnson, J. R. & Moir, L. M. Novel drug targets for asthma and COPD: lessons learned from in vitro and in vivo models. Dec-2014 In : Pulmonary Pharmacology & Therapeutics. 29, 2, p. 181-198.

Boardman C., Chachi, L., Gavrila, A., Keenan, C. R., Perry, M. M., Xia, Y. C., Meurs, H. & Sharma, P. Mechanisms of glucocorticoid action and insensitivity in airways disease. Dec-2014 In : Pulmonary Pharmacology & Therapeutics. 29, 2, p. 129-143.

Boorsma C. E., Dekkers, B. G., van Dijk, E. M., Kumawat, K., Richardson, J., Burgess, J. K. & John, A. E. Beyond TGFβ--novel ways to target airway and parenchymal fibrosis. Dec-2014 In : Pulmonary Pharmacology & Therapeutics. 29, 2, p. 166-180.

Burgess J. K. & Gosens, R. Airway Smooth Muscle and Fibroblast Biology still a leading research focus for Young Investigators in the field. Dec-2014 In : Pulmonary Pharmacology & Therapeutics. 29, 2, p. 91-92.

Cernecka H., Pradidarcheep, W., Lamers, W. H., Schmidt, M., Michel, M. C. Rat β ₃ -adrenoceptor protein expression: antibody validation and distribution in rat gastrointestinal and urogenital tissues. Aug-2014 In: Naunyn Schmiedebergs Archives of Pharmacology. 387, 11, p. 1117-27.

Dale P. R., Cernecka, H., Schmidt, M., Dowling, M. R., Charlton, S. J., Pieper, M. P. & Michel, M. C. The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease. Mar-2014 In: Current Opinion in Pharmacology. 16, p. 31-42.

Kistemaker L. E. M., Bos, S. T., Mudde, W. M., Hylkema, M. N., Hiemstra, P. S., Wess, J., Meurs, H., Kerstjens, H. A. M. & Gosens, R. Muscarinic M3 receptors contribute to allergen-induced airway remodeling in miceApr-2014 In : American Journal of Respiratory Cell and Molecular Biology. 50, 4, p. 690-698.

Kolahian S., Shahbazfa, R. A. A., Tayefi-Nasrabadi, H., Keyhanmanesh, R., Ansarin, K., Ghasemi, H., Rashidi, A.H., Gosens, R. & Hanifeh, M. Tiotropium effects on airway inflammatory events in the cat as an animal model for acute cigarette smoke-induced lung inflammation . Aug-2014 In: Experimental Lung Research. 40, 6, p. 272-87.

Koopmans T. , Anaparti, V., Castro-Piedras, I., Yarova, P., Irechukwu, N., Nelson, C., Perez-Zoghbi, J., Tan X, Ward, J. P. & Wright, D. B. Ca2+ handling and sensitivity in airway smooth muscle: emerging concepts for mechanistic understanding and therapeutic targeting. Dec-2014 In: Pulmonary Pharmacology & Therapeutics. 29, 2, p. 108-120.

Kumawat K., Koopmans, T. & Gosens, R. β-catenin as a regulator and therapeutic target for asthmatic airway remodeling. Sep-2014 In : EXPERT OPINION ON THERAPEUTIC TARGETS. 18, 9, p. 1023-1034.

Kumawat K., Menzen, M. H., Slegtenhorst, R. M., Halayko, A. J., Schmidt, M. & Gosens, R. TGF-β-activated kinase 1 (TAK1) signaling regulates TGF-β-induced WNT-5A expression in airway smooth muscle cells via Sp1 and β-catenin. 11-Apr-2014 In : PLoS ONE. 9, 4, e94801

Noble P. B., Pascoe, C. D., Lan, B., Ito, S., Kistemaker, L. E. M., Tatler, A. L., Pera, T., Brook, B. S., Gosens, R. & West, A. R. Airway smooth muscle in asthma: Linking contraction and mechanotransduction to disease pathogenesis and remodelling. Dec-2014 In : Pulmonary Pharmacology & Therapeutics. 29, 2, p. 96-107.

Oldenburger A., Timens, W., Bos, S., Smit, M., Smrcka, A. V., Laurent, A-C., Cao, J., Hylkema, M., Meurs, H., Maarsingh, H., Lezoualc'h, F. & Schmidt, M. Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke. Nov-2014 In: FASEB Journal 28, 11, p. 4617-4628.

Oldenburger A., Poppinga, W. J., Kos, F., de Bruin, H. G., Rijks, W. F., Heijink, H., Timens, W., Meurs, H., Maarsingh, H. & Schmidt, M. A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke. 15-Mar-2014 In : American Journal of Physiology - Cell Physiology. 306, 6, p. C585-C597.

Oldenburger A., van Basten, B., Kooistra, W., Meurs, H., Maarsingh, H., Krenning, G., Timens, W. & Schmidt, M. Interaction between Epac1 and miRNA-7 in airway smooth muscle cells. Aug-2014 In : Naunyn-Schmiedebergs Archives of Pharmacology. 387, 8, p. 795-797.

Pera T., Zuidhof, A. B., Smit, M., Menzen, M. H., Klein, T., Flik, G., Zaagsma, J., Meurs, H. & Maarsingh, H. Arginase inhibition prevents inflammation and remodeling in a guinea pig model of chronic obstructive pulmonary disease. May-2014 In : Journal of Pharmacology and Experimental Therapeutics. 349, 2, p. 229-238.

Poppinga W. J., Muñoz-Llancao, P., González-Billault, C. & Schmidt, M. A-kinase anchoring proteins: Cyclic AMP compartmentalization in neurodegenerative and obstructive pulmonary diseases. 18-Aug-2014 In : British Journal of Pharmacology 171, 24, p. 5603-5623.

Smit M., Zuidhof, A. B., Bos, S. I. T., Maarsingh, H., Gosens, R., Zaagsma, J. & Meurs, H. Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a guinea pig model of allergic asthma. Feb-2014 In : Journal of Pharmacology and Experimental Therapeutics. 348, 2, p. 303-10.

Tania N. P., Schmidt, M. & Gosens, R. Activin-A: active in inflammation in COPD. 1-Apr-2014 In : European Respiratory Journal. 43, 4, p. 954-955.

Wright D. B., Meurs, H. & Dekkers, B. G. J. Integrins: therapeutic targets in airway hyperresponsiveness and remodelling? Nov-2014 In : Trends in Pharmacological Sciences. 35, 11, p. 567-574.

Dissertations:

Cernecka H., β₃-Adrenoceptor detection and signal transduction: Focus on antibody validation and urinary bladder. 2014, P1-191. Promotores: Schmidt M., Michel M.C., Maarsingh H.

Oldenburger A., New avenues for Epac in inflammation and tissue remodeling in COPD. 2014, P1-278. Promotores: Schmidt M., Timens W., Meurs H., Maarsingh H.