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Boterman, M., Smits, R.J.G., Meurs, H., Zaagsma. J. Protein kinase C potentiates homologous desensitization of the ß2-adrenoceptor in bovine tracheal smooth muscle. Eur.J.Pharmacol., 529: 151-156.

Gosens, R., Grootte Bromhaar, M.M., Maarsingh, H., Damme ten, A., Meurs, H., Zaagsma, J., Nelemans, S.A., Bradykinin augments EGF-induced airway smooth muscle proliferation by activation of conventional protein kinase C isoenzymes. Eur.J.Pharmacol., 535(1-3): 253-262.

Gosens, R., Schaafsma, D., Nelemans, S.A., Halayko, A.J. Rho-kinase as a drug target for the treatment of airway hyperrespon-siveness in asthma. Med.Chem., 6: 339-348.

Gosens, R., Stelmack, G.L., Dueck, G., McNeill, K.D., Yamasaki, A., Gerthoffer, W.T., Unruh, H., Soussi Gounni, A., Zaagsma, J., Halayko, A.J. Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle. Am.J.Physiol.Lung Cell Mol.Physiol. 291(3): L523-534.

Gosens, R., Zaagsma, J., Meurs, H., Halayko, A.J. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir.Res., 7: 73.

Halayko, A.J., Tran, T., Ji, S.Y., Yamasaki, A., Gosens, R. Airway smooth muscle phenotype and function: interactions with current asthma therapies. Curr.Drug Targets, 7(5): 525-540.

Hennenberg, H., Biecker, E., Trebicka, J., Jochem, K., Zhou, Q., Schmidt, M., Jakobs, K.H., Sauerbruch, T., Heller, J. Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats. Gastroenterol., 130(12): 838-854.

Lopez de Jesus, M ., Stope, M.B., Oude Weernink, P.A., Mahlke, Y., Borgermann, C., Annana, V.N., Rimmbach, C., Rosskopf, D., Michel, M.C., Jakobs, K.H., Schmidt, M. Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation. J.Biol.Chem., 281: 21837-21847.

Maarsingh, H., Leusink, J., Bos, I.S.T., Zaagsma, J., Meurs, H. Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma. Respir.Res., 7: 1-7.

Maarsingh, H., Leusink, J., Zaagsma, J., Meurs, H. Role of the l-citrulline/l-arginase cycle in iNANC nerve-mediated nitric oxide production and airway smooth muscle relaxation in allergic asthma. Eur.J.Pharmacol., 546: 171-176.

Meurs, H., Santing, R., Remie, R., Mark van der, T.W., Westerhof, F.J., Zuidhof, A.B., Bos, I.S.T., Zaagsma, J. A guinea pig model of acute and chronic asthma using permanently instrumented and unrestrained animals. Nature Protocols., 1: 840-847.

Peters, S.L ., Schmidt, M., Michel, M.C. Rho kinase: a target for treating urinary bladder dysfunction? Trends Pharmacol.Sci., 27: 492-497.

Schaafsma, D., Zuidhof, A.B., Nelemans, S.A., Zaagsma, J., Meurs, H. Inhibition of Rho-kinase normalizes nonspecific hyperresponsiveness in passively sensitized airway smooth muscle preparations. Eur.J.Pharmacol., 531: 145-150.

Schaafsma, D., Boterman, M., Jong de, A.-M., Hovens, I., Penninks, J.-M., Nelemans, S.A., Meurs, H., Zaagsma, J. Differential Rho-kinase dependency of full partial muscarinic receptor agonists in airway smooth muscle contraction. Br.J.Pharmacol., 147: 737-743.

Schaafsma, D., Bos, I.S.T., Zuidhof, A.B., Zaagsma, J., Meurs, H. Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction. Respir.Res., 7: 121.

National publication:

Dekhuijzen, P.N., Schayck van, C.P., Wesseling, G., Aalbers, R., Aalderen van, W.M. Zaagsma, J., Molen van der, T. The treatment of asthma: indications for a change in approach. Nederlands Tijdschrift voor Geneeskunde, 150(5):225-229.

Chapter in books:

Meurs, H., Maarsingh, H., Zaagsma, J. Nitric oxide and nitrogen oxides. In: Encyclopedia of Respiratory Medicine. Ed: Laurent, G.F., Shapiro, S.D. (Academic Press), pp. 161-169.

Nelemans, S.A. Measurement of [Ca2+] in cell suspensions using indo-1. In: Calcium Signalling Protocols (second edition). Ed: D.G. Lambert, (Totowa, NJ, USA: Humana Press), pp. 47-54.

Zaagsma, J., Meurs, H. Acetylcholine. In: Encyclopedia of Respiratory Medicine. Ed: Laurent, G.F., Shapiro, S.D. (Academic Press), pp. 1-5.


Boterman, M. Heterologous amplification of homologous ß-adrenoceptor desensitization in airway smooth muscle: implications for asthma? Promotores: Zaagsma, J., Meurs, H. Rijksuniversiteit Groningen, 24 maart, 2006. 175 pp. ISBN:90-367-2548-8.

Maarsingh, H. Arginase: a novel key enzyme in the pathophysiology of allergic asthma. Promotores: Meurs, H., Zaagsma, J. Rijksuniversiteit Groningen, 15 december, 2006. 209 pp.

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