Wijmenga, Prof. Cisca
Prof. Cisca Wijmenga has been Professor of Human Genetics at the University of Groningen and head of the Genetics Department of the University Medical Center Groningen since 2007. The aim of her research is to understand the role that genes play in the development of chronic diseases. Her research group focuses on the genetics of inflammation-related conditions, such as coeliac disease (gluten allergy) and inflammatory intestinal disease (e.g. Crohn’s disease, ulcerative colitis). Research led by Wijmenga has discovered several genes that are involved in causing such immune-related disorders. This knowledge is leading to new insights into the disease process, and could possibly result in new treatments for patients.
Prof. Wijmenga has been elected a member of the Royal Netherlands Academy of Arts and Sciences (KNAW) in 2012. Members of KNAW are all prominent academics from all disciplines and are chosen on the basis of nominations from within and outside the Academy. In the same year she received a prestigious ERC Advanced Grant for her research project on Celiac disease. The BBMRI-NL2.0 project, a collaboration led by Wijmenga between biobanks in the Netherlands, received EUR 9.8 million from NWO in 2014. In 2015 Wijmenga has been awarded a Spinoza Prize, also referred to as the 'Dutch Nobel Prize'.
In 2019 Wijmenga has been appointed as Rector Magnificus of the University of Groningen. She is the first female rector in the 405-year history of the UG.
More video's
- 'Een ontzettende erkenning voor mijn werk' (Wijmenga in Nieuwsuur, vanaf 39.00)
- Grant for biobanks
- Wijmenga on her research and KNAW membership
- Wat krijgen we mee en wat laten we na? (‘What are we given, and what do we leave behind?’)
- Kunnen we ons een fout permitteren? (‘Can we afford to make a mistake?’)
Previously in the news
- 'The women in my family are my example'
- Wijmenga Rector Magnificus of the University of Groningen
- Lifestyle has a strong impact on intestinal bacteria
- Spinoza Prize for Wijmenga
- Five gene variants play important role in development coeliac disease
- Grant for biobanks (in Dutch)
- Red wine and butter milk are good for your gut (NOS, in Dutch)
- The genome of the Netherlands
- Wijmenga appointed member of KNAW
- Plastisch chirurgen en genetici brengen genen ziekte van Dupuytren in kaart
Contact and further information
Publications
2023
Palasantzas,
V. E. J. M., Tamargo-Rubio, I., Le,
K., Slager, J., Wijmenga,
C., Jonkers, I. H., Kumar,
V., Fu, J., & Withoff, S.
(2023). iPSC-derived organ-on-a-chip models for personalized
human genetics and pharmacogenomics studies.
Trends in Genetics. https://doi.org/10.1016/j.tig.2023.01.002
eQTLGen
Consortium, Dai, Q., Zhou, G., Zhao, H., Võsa,
U., Franke, L., Battle, A., Teumer, A.,
Lehtimäki, T., Raitakari, O. T., Esko, T., Epstein, M. P.,
& Yang, J. (2023). OTTERS: a powerful TWAS framework
leveraging summary-level reference data. Nature
Communications, 14, [1271]. https://doi.org/10.1038/s41467-023-36862-w
Bourgonje,
A. R., Andreu-Sánchez, S., Vogl, T.,
Hu, S., Vich Vila, A., Gacesa, R.,
Leviatan, S., Kurilshchikov, A., Klompus, S., Kalka,
I. N., van Dullemen, H. M., Weinberger, A.,
Visschedijk, M. C., Festen, E. A. M.,
Faber, K. N., Wijmenga, C., Dijkstra,
G., Segal, E., Fu, J., ... Weersma, R.
K. (2023). Phage-display immunoprecipitation
sequencing of the antibody epitope repertoire in inflammatory bowel
disease reveals distinct antibody signatures.
Immunity, 56(6). https://doi.org/10.1016/j.immuni.2023.04.017
Lifelines
Cohort Study (2023). Phage display sequencing reveals that
genetic, environmental, and intrinsic factors influence variation
of human antibody epitope repertoire.
Immunity, 56(6). https://doi.org/10.1016/j.immuni.2023.04.003
Lifelines
Corona Research initiative, Mobach, M. P., Boezen, H.
M., Mierau, J. O., Franke, H.
L., Dekens, J., Deelen, P.,
Lanting, P., Vonk, J. M., Nolte,
I., Ori, A. P. S., Claringbould,
A., Boulogne, F., Dijkema, M. X. L.,
Wiersma, H. H., Warmerdam, R.,
Jankipersadsing, S. A., van Blokland, I.,
de Bock, G. T. H., ... Wijmenga, C. (2023).
Workplace impact on employees: A Lifelines Corona Research
Initiative on the return to work. PLoS
ONE, 18(1), [e0279902]. https://doi.org/10.1371/journal.pone.0279902
2022
Chu,
X., Janssen, A. W. M., Koenen, H., Chang, L., He, X.,
Joosten, I., Stienstra, R., Kuijpers, Y., Wijmenga,
C., Xu, C-J., Netea, M. G., Tack, C. J., Li,
Y., & Buettner, C. (2022). A genome-wide
functional genomics approach uncovers genetic determinants of
immune phenotypes in type 1 diabetes.
eLife, 11, [73709]. https://doi.org/10.7554/eLife.73709
Lifelines
Cohort Study, Lopera-Maya, E. A., Kurilshikov,
A., van der Graaf, A., Hu,
S., Andreu-Sánchez, S., Chen,
L., Vila, A. V., Gacesa, R.,
Sinha, T., Collij, V., Klaassen, M. A.
Y., Bolte, L. A., Gois, M. F. B.,
Neerincx, P. B. T., Swertz, M. A.,
Harmsen, H. J. M., Wijmenga, C., Fu,
J., ... Sanna, S. (2022). Author
Correction: Effect of host genetics on the gut microbiome in 7,738
participants of the Dutch Microbiome Project (Nature Genetics,
(2022), 54, 2, (143-151), 10.1038/s41588-021-00992-y).
Nature genetics, 54(9), 1448. https://doi.org/10.1038/s41588-022-01164-2
Gulyaeva,
A., Garmaeva, S., Ruigrok, R. A. A. A.,
Wang, D., Riksen, N. P., Netea, M. G., Wijmenga,
C., Weersma, R. K., Fu, J.,
Vila, A. V., Kurilshikov, A., &
Zhernakova, A. (2022). Discovery, diversity, and
functional associations of crAss-like phages in human gut
metagenomes from four Dutch cohorts. Cell
reports, 38(2), [110204]. https://doi.org/10.1016/j.celrep.2021.110204
Lopera-Maya,
E. A., Kurilshikov, A., van der Graaf,
A., Hu, S., Lifelines Cohort Study,
Andreu-Sánchez, S., Chen, L., Vila,
A. V., Gacesa, R., Sinha,
T., Collij, V., Klaassen, M. A. Y.,
Bolte, L. A., Brandao Gois, M. F.,
Neerincx, P. B. T., Swertz, M. A.,
Harmsen, H. J. M., Wijmenga, C., Fu,
J., ... Sanna, S. (2022). Effect of host
genetics on the gut microbiome in 7,738 participants of the Dutch
Microbiome Project. Nature genetics,
54, 143-151. https://doi.org/10.1038/s41588-021-00992-y
Lifelines
Cohort Study, Lopera-Maya, E. A., Kurilshikov,
A., van der Graaf, A., Hu,
S., Andreu-Sánchez, S., Chen,
L., Vich-Vila, A., Gacesa,
R., Sinha, T., Collij, V.,
Klassen, M. A. Y., Bolte, L. A., Brandao-Gois,
M. F., Neerincx, P. B. T., Swertz, M.
A., Harmsen, H. J. M., Wijmenga,
C., Fu, J., ... Sanna, S. (2022).
Effect of host genetics on the gut microbiome in 7,738
participants of the Dutch Microbiome Project.
European Journal of Human Genetics,
30(SUPPL 1), 589-589.
Gacesa,
R., Kurilshikov, A., Vich Vila,
A., Sinha, T., Klaassen, M. A. Y., Bolte,
L. A., Andreu-Sánchez, S., Chen,
L., Collij, V., Hu, S.,
Dekens, J. A. M., Lenters, V. C., Björk, J.
R., Swarte, J. C., Swertz, M.
A., Jansen, B. H., Gelderloos-Arends, J.,
Jankipersadsing, S., Hofker, M., ... Weersma, R.
K. (2022). Environmental factors shaping the gut
microbiome in a Dutch population.
Nature, 732–739. https://doi.org/10.1038/s41586-022-04567-7
Andreu-Sánchez,
S., Aubert, G., Ripoll-Cladellas, A., Henkelman, S.,
Zhernakova, D. V., Sinha, T.,
Kurilshikov, A., Cenit, M. C., Jan Bonder,
M., Franke, L., Wijmenga,
C., Fu, J., van der Wijst, M. G.
P., Melé, M., Lansdorp, P., &
Zhernakova, A. (2022). Genetic, parental and lifestyle
factors influence telomere length. Communications
biology, 5(1), [565]. https://doi.org/10.1038/s42003-022-03521-7
BIOS
Consortium, Brain MEND Consortium, Hop, P. J., Zwamborn, R. A. J.,
Hannon, E., Shireby, G. L., Nabais, M. F., Walker, E. M., van
Rheenen, W., van Vugt, J. J. F. A., Dekker, A. M., Westeneng, H.
J., Tazelaar, G. H. P., van Eijk, K. R., Moisse, M., Baird, D., Al
Khleifat, A., Iacoangeli, A., Ticozzi, N., ... Veldink, J. H.
(2022). Genome-wide study of DNA methylation shows
alterations in metabolic, inflammatory, and cholesterol pathways in
ALS. Science Translational Medicine,
14(633), [eabj0264]. https://doi.org/10.1126/scitranslmed.abj0264
deCODE
Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes
& Health Research Team, LifeLines, Mass General Brigham
Biobank, Michigan Genomics Initiative, National Biobank of Korea,
Penn Medicine BioBank, Qatar Biobank, The QSkin Sun and Health
Study, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health
Initiative, Uganda Genome Resource, UK Biobank, Biobank of the
Americas, BioBank Japan Project, ... Sanna, S. (2022).
Global Biobank Meta-analysis Initiative: Powering genetic
discovery across human disease. Cell
Genomics, 2(10), [100192]. https://doi.org/10.1016/j.xgen.2022.100192
Swarte,
J. C., Li, Y., Hu, S.,
Björk, J. R., Gacesa, R., Vich Vila,
A., Douwes, R. M., Collij,
V., Kurilshikov, A., Post, A.,
Klaassen, M. A. Y., Eisenga, M. F., Gomes-Neto,
A. W., Kremer, D., Jansen, B.
H., Knobbe, T. J., Berger, S.
P., Sanders, J-S. F., Heiner-Fokkema, M.
R., ... Weersma, R. K. (2022). Gut
microbiome dysbiosis is associated with increased mortality after
solid organ transplantation. Science Translational
Medicine, 14(660), [eabn7566]. https://doi.org/10.1126/scitranslmed.abn7566
Bourgonje,
A. R., Andreu-Sánchez, S., Vogl, T.,
Hu, S., Vich Vila, A., Leviatan, S.,
Kurilshchikov, A., Klompus, S., Kalka, I. N., van
Dullemen, H. M., Weinberger, A., Visschedijk, M.
C., Festen, E. A. M., Faber, K.
N., Wijmenga, C., Dijkstra, G.,
Segal, E., Fu, J., Zhernakova, A.,
& Weersma, R. K. (2022). In-depth characterisation
of the serum antibody epitope repertoire in Inflammatory Bowel
Disease by high-throughput phage-displayed immunoprecipitation
sequencing. Journal of Crohn's and
Colitis, 16(Suppl(1)), S100-S102. https://doi.org/10.1093/ecco-jcc/jjab232.092
Lifelines
Cohort Study, Chen, L., Zhernakova, D.
V., Kurilshikov, A., Andreu-Sánchez,
S., Wang, D., Augustijn, H. E., Vich
Vila, A., Weersma, R. K., Medema, M. H., Netea,
M. G., Kuipers, F., Wijmenga, C.,
Zhernakova, A., & Fu, J. (2022).
Influence of the microbiome, diet and genetics on
inter-individual variation in the human plasma metabolome.
Nature Medicine, 28,
2333–2343. https://doi.org/10.1038/s41591-022-02014-8
Mujagic,
Z., Kasapi, M., Jonkers, D. M. A. E., Garcia-Perez, I., Vork, L.,
Weerts, Z. Z. R. M., Serrano-Contreras, J. I., Zhernakova,
A., Kurilshikov, A., Scotcher, J., Holmes,
E., Wijmenga, C., Keszthelyi, D., Nicholson, J. K.,
Posma, J. M., & Masclee, A. A. M. (2022). Integrated
fecal microbiome–metabolome signatures reflect stress and
serotonin metabolism in irritable bowel syndrome.
Gut Microbes, 14(1), [2063016]. https://doi.org/10.1080/19490976.2022.2063016
Estonian
Biobank Research Team, Lepamets, M., Auwerx, C., Nõukas,
M., Claringbould, A., Porcu, E., Kals, M.,
Jürgenson, T., Morris, A. P., Võsa, U.,
Bochud, M., Stringhini, S., Wijmenga, C.,
Franke, L., Peterson, H., Vilo, J., Lepik, K., Mägi,
R., & Kutalik, Z. (2022). Omics-informed CNV calls reduce
false-positive rates and improve power for CNV-trait
associations. Human Genetics and Genomics
Advances, 3(4), [100133]. https://doi.org/10.1016/j.xhgg.2022.100133
Ramírez-Sánchez,
A. D., Chu, X., Modderman, R., Kooy-Winkelaar,
Y., Koletzko, S., Korponay-Szabó, I. R., Troncone, R.,
Wijmenga, C., Mearin, L., Withoff, S.,
Jonkers, I. H., & Li, Y. (2022). Single-Cell RNA
Sequencing of Peripheral Blood Mononuclear Cells From Pediatric
Coeliac Disease Patients Suggests Potential Pre-Seroconversion
Markers. Frontiers in Immunology,
13, [843086]. https://doi.org/10.3389/fimmu.2022.843086
Doestzada,
M., Zhernakova, D. V., C L van den Munckhof,
I., Wang, D., Kurilshikov, A.,
Chen, L., Bloks, V. W., van Faassen,
M., Rutten, J. H. W., Joosten, L. A. B., Netea, M. G.,
Wijmenga, C., Riksen, N. P., Zhernakova,
A., Kuipers, F., & Fu, J.
(2022). Systematic analysis of relationships between plasma
branched-chain amino acid concentrations and cardiometabolic
parameters: an association and Mendelian randomization
study. BMC Medicine, 20(1),
[485]. https://doi.org/10.1186/s12916-022-02688-4
TANDEM
Consortium, van Doorn, C. L. R., Eckold, C., Ronacher, K., Ruslami,
R., van Veen, S., Lee, J-S., Kumar, V., Kerry-Barnard,
S., Malherbe, S. T., Kleynhans, L., Stanley, K., Hill, P. C.,
Joosten, S. A., van Crevel, R., Wijmenga, C.,
Critchley, J. A., Walzl, G., Alisjahbana, B., ... Cliff, J. M.
(2022). Transcriptional profiles predict treatment outcome in
patients with tuberculosis and diabetes at diagnosis and at two
weeks after initiation of anti-tuberculosis treatment.
EBioMedicine, 82, [104173]. https://doi.org/10.1016/j.ebiom.2022.104173
2021
Moorlag,
S. J. C. F. M., Matzaraki, V., van Puffelen Heijden,
J. H., van der Heijden, C., Keating, S., Groh, L., Bakker, O.
B., Koeken, V. A. C. M., de Bree, L. C. J., Smeekens, S. P.,
Oosting, M., Gamboa, R. A., Riksen, N. P., Xavier, R.
J., Wijmenga, C., Kumar, V., van Crevel,
R., Novakovic, B., Joosten, L. A. B., ... Netea, M. G. (2022).
An integrative genomics approach identifies KDM4 as a
modulator of trained immunity. European Journal of
Immunology, 52(3), 431-446. https://doi.org/10.1002/eji.202149577
Brandao
Gois, M. F., Sinha, T., Spreckels, J.
E., Vich Vila, A., Bolte, L.
A., Weersma, R. K., Wijmenga,
C., Fu, J., Zhernakova, A.,
& Kurilshikov, A. (2022). Role of the gut
microbiome in mediating lactose intolerance symptoms.
Gut, 71(1), 215-217. https://doi.org/10.1136/gutjnl-2020-323911
Gacesa,
R., Vich Vila, A., Collij, V.,
Mujagic, Z., Kurilshikov, A., Voskuil, M.
D., Festen, E. A. M., Wijmenga,
C., Jonkers, D. M. A. E., Dijkstra, G.,
Fu, J., Zhernakova, A., Imhann,
F., & Weersma, R. K. (2021). A
combination of fecal calprotectin and human beta-defensin 2
facilitates diagnosis and monitoring of inflammatory bowel
disease. Gut Microbes, 13(1),
[1943288]. https://doi.org/10.1080/19490976.2021.1943288
Tan,
I. L., Barisani, D., Panceri, R., Modderman, R.,
Visschedijk, M., Weersma, R. K.,
Wijmenga, C., Jonkers, I., Coutinho de Almeida,
R., & Withoff, S. (2021). A Combined mRNA-
and miRNA-Sequencing Approach Reveals miRNAs as Potential
Regulators of the Small Intestinal Transcriptome in Celiac
Disease. International Journal of Molecular
Sciences, 22(21), [11382]. https://doi.org/10.3390/ijms222111382
Wang,
D., Doestzada, M., Chen, L.,
Andreu-Sánchez, S., van den Munckhof, I. C. L.,
Augustijn, H. E., Koehorst, M., Ruiz-Moreno, A.
J., Bloks, V. W., Riksen, N. P., Rutten, J. H.
W., Joosten, L. A. B., Netea, M. G., Wijmenga,
C., Zhernakova, A., Kuipers,
F., & Fu, J. (2021). Characterization
of gut microbial structural variations as determinants of human
bile acid metabolism. Cell Host &
Microbe, 29(12), 1802-1814.e5. https://doi.org/10.1016/j.chom.2021.11.003
Tan,
I. L., Coutinho de Almeida, R., Modderman, R., Stachurska,
A., Dekens, J., Barisani, D., Meijer, C. R., Roca, M.,
Martinez-Ojinaga, E., Shamir, R., Auricchio, R.,
Korponay-Szabó, I. R., Castillejo, G., Szajewska, H.,
Koletzko, S., Zhernakova, A., Kumar,
V., Li, Y., Visschedijk, M.
C., ... Withoff, S. (2021). Circulating
miRNAs as Potential Biomarkers for Celiac Disease
Development. Frontiers in Immunology,
12, [734763]. https://doi.org/10.3389/fimmu.2021.734763
Wijmenga,
C. (2021). From LD-based mapping to GWAS.
Nature Reviews Genetics, 22(8). https://doi.org/10.1038/s41576-021-00366-4
Ortiz
Fernández, L., Coit, P., Yilmaz, V., Yentür, S. P.,
Alibaz-Oner, F., Aksu, K., Erken, E., Düzgün, N., Keser,
G., Cefle, A., Yazici, A., Ergen, A., Alpsoy, E., Salvarani, C.,
Casali, B., Kısacık, B., Kötter, I., Henes, J.,
Çınar, M., ... Sawalha, A. H. (2021). Genetic
Association of a Gain-of-Function IFNGR1 Polymorphism and the
Intergenic Region LNCAROD/DKK1 With Behcet's Disease.
Arthritis & Rheumatology, 73(7),
1244-1252. https://doi.org/10.1002/art.41637
Peters,
V., Tigchelaar-Feenstra, E. F., Imhann,
F., Dekens, J. A. M., Swertz, M.
A., Franke, L. H., Wijmenga,
C., Weersma, R. K., Alizadeh, B.
Z., Dijkstra, G., &
Campmans-Kuijpers, M. J. E. (2021). Habitual dietary
intake of IBD patients differs from population controls: a
case-control study. European Journal of
Nutrition. https://doi.org/10.1007/s00394-020-02250-z
Brand,
E. C., Klaassen, M. A. Y., Gacesa, R., Vila, A.
V., Ghosh, H., de Zoete, M. R., Boomsma, D. I.,
Hoentjen, F., Horjus Talabur Horje, C. S., van de Meeberg, P. C.,
Willemsen, G., Fu, J., Wijmenga, C., van
Wijk, F., Zhernakova, A., Oldenburg, B.,
Weersma, R. K., & Dutch TWIN-IBD consortium and the
Dutch Initiative on Crohn and Colitis (2021). Healthy Cotwins
Share Gut Microbiome Signatures With Their Inflammatory Bowel
Disease Twins and Unrelated Patients.
Gastroenterology, 160(6), 1970-1985.
https://doi.org/10.1053/j.gastro.2021.01.030
Matzaraki,
V., Le, K. T. T., Jaeger, M.,
Aguirre-Gamboa, R., Johnson, M. D., Sanna, S.,
Rosati, D., Franke, L., Zhernakova,
A., Fu, J., Withoff, S.,
Jonkers, I., Li, Y., Joosten, L. A. B., Netea,
M. G., Wijmenga, C., & Kumar, V.
(2021). Inflammatory Protein Profiles in Plasma of
Candidaemia Patients and the Contribution of Host Genetics to Their
Variability. Frontiers in Immunology,
12, [662171]. https://doi.org/10.3389/fimmu.2021.662171
Chu,
X., Jaeger, M., Beumer, J., Bakker, O.
B., Aguirre-Gamboa, R., Oosting, M., Smeekens,
S. P., Moorlag, S., Mourits, V. P., Koeken, V. A. C. M., de Bree,
C., Jansen, T., Mathews, I. T., Dao, K., Najhawan, M., Watrous, J.
D., Joosten, I., Sharma, S., Koenen, H. J. P. M., ... Li,
Y. (2021). Integration of metabolomics, genomics, and
immune phenotypes reveals the causal roles of metabolites in
disease. Genome Biology,
22(1), [198]. https://doi.org/10.1186/s13059-021-02413-z
MiBioGen
Consortium Initiative, Kurilshikov, A., Medina-Gomez,
C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan,
A., Le Roy, C. I., Raygoza Garay, J. A., Finnicum, C. T.,
Liu, X., Zhernakova, D. V., Bonder, M.
J., Hansen, T. H., Frost, F., Ruehlemann, M. C., Turpin, W.,
Moon, J-Y., Kim, H-N., ... Zhernakova, A. (2021).
Large-scale association analyses identify host factors
influencing human gut microbiome composition.
Nature Genetics, 53, 156-165. https://doi.org/10.1038/s41588-020-00763-1
BIOS
Consortium, i2QTL Consortium, Võsa, U.,
Claringbould, A., Westra, H-J., Bonder,
M. J., Deelen, P., Zeng, B., Kirsten, H., Saha,
A., Kreuzhuber, R., Yazar, S., Brugge, H.,
Oelen, R., de Vries, D. H., van der
Wijst, M. G. P., Kasela, S., Pervjakova, N., Alves,
I., ... Franke, L. (2021). Large-scale cis- and
trans-eQTL analyses identify thousands of genetic loci and
polygenic scores that regulate blood gene expression.
Nature Genetics, 53(9), 1300-1310.
https://doi.org/10.1038/s41588-021-00913-z
Mc
Intyre, K., Lanting, P., Deelen,
P., Wiersma, H. H., Vonk, J.
M., Ori, A. P. S., Jankipersadsing, S.
A., Warmerdam, R., van Blokland,
I., Boulogne, F., Dijkema, M. X. L.,
Herkert, J. C., Claringbould, A., Bakker,
O., Lopera Maya, E. A., Bültmann,
U., Zhernakova, A., Reijneveld, S.
A., Zijlstra, E., ... Franke, L.
(2021). Lifelines COVID-19 cohort: investigating COVID-19
infection and its health and societal impacts in a Dutch
population-based cohort. BMJ Open,
11(3), [e044474]. https://doi.org/10.1136/bmjopen-2020-044474
Atanasovska,
B., Rensen, S. S., Marsman, G., Shiri-Sverdlov, R., Withoff,
S., Kuipers, F., Wijmenga,
C., van de Sluis, B., & Fu, J.
(2021). Long Non-Coding RNAs Involved in Progression of
Non-Alcoholic Fatty Liver Disease to Steatohepatitis.
Cells, 10(8), 1-15. [1883]. https://doi.org/10.3390/cells10081883
Bolte,
L. A., Vich Vila, A., Imhann,
F., Collij, V., Gacesa, R.,
Peters, V., Wijmenga, C., Kurilshikov,
A., Campmans-Kuijpers, M. J. E., Fu,
J., Dijkstra, G., Zhernakova,
A., & Weersma, R. K. (2021).
Long-term dietary patterns are associated with
pro-inflammatory and anti-inflammatory features of the gut
microbiome. Gut, 70(7),
1287-1298. https://doi.org/10.1136/gutjnl-2020-322670
Bolte,
L. A., Klaassen, M. A. Y., Collij, V.,
Vich Vila, A., Fu, J., van der Meulen, T.
A., de Haan, J. J., Versteegen, G.
J., Dotinga, A., Zhernakova,
A., Wijmenga, C., Weersma, R.
K., & Imhann, F. (2021). Patient
attitudes towards faecal sampling for gut microbiome studies and
clinical care reveal positive engagement and room for
improvement. PLoS ONE, 16(4),
[e0249405]. https://doi.org/10.1371/journal.pone.0249405
Vogl,
T., Klompus, S., Leviatan, S., Kalka, I. N., Weinberger, A.,
Wijmenga, C., Fu, J., Zhernakova,
A., Weersma, R. K., & Segal, E. (2021).
Population-wide diversity and stability of serum antibody
epitope repertoires against human microbiota.
Nature Medicine, 27(8), 1442-1450.
https://doi.org/10.1038/s41591-021-01409-3
Bakker,
O. B., Ramírez-Sánchez, A. D., Borek,
Z. A., de Klein, N., Li, Y., Modderman,
R., Kooy-Winkelaar, Y., Johannesen, M. K., Matarese, F., Martens,
J. H. A., Kumar, V., van Bergen, J., Qiao, S-W.,
Lundin, K. E. A., Sollid, L. M., Koning, F., Wijmenga,
C., Withoff, S., & Jonkers, I.
H. (2021). Potential impact of celiac disease genetic
risk factors on T cell receptor signaling in gluten-specific CD4+ T
cells. Scientific Reports,
11(1), 1-15. [9252]. https://doi.org/10.1038/s41598-021-86612-5
Garmaeva,
S., Gulyaeva, A., Sinha, T.,
Shkoporov, A. N., Clooney, A. G., Stockdale, S. R.,
Spreckels, J. E., Sutton, T. D. S., Draper, L. A., Dutilh,
B. E., Wijmenga, C., Kurilshikov,
A., Fu, J., Hill, C., & Zhernakova,
A. (2021). Stability of the human gut virome and
effect of gluten-free diet. Cell
reports, 35(7), 1-21. [109132]. https://doi.org/10.1016/j.celrep.2021.109132
BIOS
Consortium, van der Graaf, A., Zorro, M.
M., Claringbould, A., Vosa,
U., Aguirre-Gamboa, R., Li,
C., Mooiweer, J., Ricano-Ponce,
I., Borek, Z., Koning, F., Kooy-Winkelaar, Y., Sollid, L.
M., Qiao, S-W., Kumar, V., Li, Y.,
Franke, L., Withoff, S., Wijmenga,
C., ... Jonkers, I. (2021). Systematic
Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1
as a Master Regulator of IFN gamma Signaling in Celiac
Disease. Frontiers in Genetics,
11, 562434. [562434]. https://doi.org/10.3389/fgene.2020.562434
Ruigrok,
R. A. A. A., Collij, V., Sureda, P., Klaassen, M. A.
Y., Bolte, L. A., Jansen, B. H.,
Voskuil, M. D., Fu, J., Wijmenga,
C., Zhernakova, A., Weersma, R.
K., & Vich Vila, A. (2021). The
composition and metabolic potential of the human small intestinal
microbiota within the context of inflammatory bowel disease.
Journal of Crohn's and Colitis,
15(8), 1326-1338. https://doi.org/10.1093/ecco-jcc/jjab020
Lifelines
Cohort Study, Chen, L., Wang, D.,
Garmaeva, S., Kurilshikov, A., Vich Vila,
A., Gacesa, R., Sinha, T., Segal,
E., Weersma, R. K., Wijmenga, C.,
Zhernakova, A., & Fu, J. (2021). The
long-term genetic stability and individual specificity of the human
gut microbiome. Cell, 184(9),
2302-+. https://doi.org/10.1016/j.cell.2021.03.024
2020
TANDEM
Consortium, Eckold, C., Kumar, V., Weiner Rd, J.,
Alisjahbana, B., Riza, A-L., Ronacher, K., Coronel,
J., Kerry-Barnard, S., Malherbe, S. T., Kleynhans, L., Stanley, K.,
Ruslami, R., Ioana, M., Ugarte-Gil, C., Walzl, G., van Crevel,
R., Wijmenga, C., Critchley, J. A., ... Cliff, J. M.
(2021). Impact of intermediate hyperglycaemia as well as
diabetes on immune dysfunction in tuberculosis.
Clinical Infectious Diseases, 72(1),
69-78. [ciaa751]. https://doi.org/10.1093/cid/ciaa751
Tan,
I. L., Withoff, S., Kolkman, J.
J., Wijmenga, C., Weersma, R.
K., & Visschedijk, M. C. (2021).
Non-classical clinical presentation at diagnosis by male
celiac disease patients of older age. European
Journal of Internal Medicine, 83, 28-33. https://doi.org/10.1016/j.ejim.2020.09.020
BIOS
Consortium, Xu, C-J., Gruzieva, O., Qi,
C., Esplugues, A., Gehring, U., Bergstroem, A., Mason, D.,
Chatzi, L., Porta, D., Carlsen, K. C. L., Baiz, N., Madore, A-M.,
Alenius, H., van Rijkom, B., Jankipersadsing, S. A.,
van der Vlies, P., Kull, I., van Hage, M., ... Koppelman, G.
H. (2021). Shared DNA methylation signatures in
childhood allergy: The MeDALL study. Journal of
Allergy and Clinical Immunology, 147(3),
1031-1040. https://doi.org/10.1016/j.jaci.2020.11.044
Hu,
S., Vich Vila, A., Gacesa,
R., Collij, V., Stevens, C., Fu, J. M., Wong,
I., Talkowski, M. E., Rivas, M. A., Imhann, F.,
Bolte, L., van Dullemen, H., Dijkstra,
G., Visschedijk, M. C., Festen, E.
A., Xavier, R. J., Fu, J., Daly, M. J.,
Wijmenga, C., ... Weersma, R. K. (2021).
Whole exome sequencing analyses reveal gene-microbiota
interactions in the context of IBD.
Gut, 70(2), 285-296. [319706]. https://doi.org/10.1136/gutjnl-2019-319706
BIOS
Consortium, Ouwens, K. G., Jansen, R., Nivard, M. G., van Dongen,
J., Frieser, M. J., Hottenga, J-J., Arindrarto, W.,
Claringbould, A., van Iterson, M., Mei, H., &
Franke, L. (2020). A characterization of cis- and
trans-heritability of RNA-Seq-based gene expression.
European Journal of Human Genetics,
28(2), 253-263. https://doi.org/10.1038/s41431-019-0511-5
BIOS
Consortium, Aguirre-Gamboa, R., de Klein,
N., di Tommaso, J., Claringbould, A., van
der Wijst, M. G. P., de Vries, D.,
Brugge, H., Oelen, R., Vosa,
U., Zorro, M. M., Chu, X.,
Bakker, O. B., Borek, Z., Ricano-Ponce,
I., Deelen, P., Xu, C-J., Swertz,
M., Jonkers, I., ... Li, Y.
(2020). Deconvolution of bulk blood eQTL effects into immune
cell subpopulations. Bmc
Bioinformatics, 21(1), [243]. https://doi.org/10.1101/548669
Chu,
X., Janssen, A. W. M., Koenen, H., Chang, L., He, X.,
Joosten, I., Xu, C., Wijmenga, C., Netea, M., Tack, C.
J., & Li, Y. (2020). Differential genetic and
environmental effects on immune parameters and functions in type 1
diabetes and health. European Journal of Human
Genetics, 28(SUPPL 1), 735-736.
Chen,
L., Schraa, K., van den Munckhof, I. C. L., Ter Horst,
R., Koehorst, M., van Faassen, M., van
der Ley, C., Doestzada, M., Zhernakova, D.
V., Kurilshikov, A., Bloks, V.
W., Groen, A. K., Human Functional Genomics
Project, Riksen, N. P., Rutten, J. H. W., Joosten, L. A. B.,
Wijmenga, C., Zhernakova, A., Netea, M.
G., ... Kuipers, F. (2020). Genetic and
Microbial Associations to Plasma and Fecal Bile Acids in Obesity
Relate to Plasma Lipids and Liver Fat Content.
Cell reports, 33(1), [108212]. https://doi.org/10.1016/j.celrep.2020.108212
BBMRI
Metabol Consortium, Pool, R., Hagenbeek, F. A., Hendriks, A. M.,
van Dongen, J., Willemsen, G., de Geus, E., van Dijk, K. W.,
Verhoeven, A., Suchiman, H. E. D., Beekman, M., Slagboom, P. E.,
Harms, A. C., Hankemeier, T., & Boomsma, D. (2020).
Genetics and Not Shared Environment Explains Familial
Resemblance in Adult Metabolomics Data. Twin
research and human genetics, 23(3), 145-155.
https://doi.org/10.1017/thg.2020.53
Kannambath,
S., Jarvis, J. N., Wake, R. M., Longley, N., Loyse, A.,
Matzaraki, V., Aguirre-Gamboa, R.,
Wijmenga, C., Doyle, R., Paximadis, M., Tiemessen, C.
T., Kumar, V., Pittman, A., Meintjes, G., Harrison, T.
S., Netea, M. G., & Bicanic, T. (2020). Genome-Wide
Association Study Identifies Novel Colony Stimulating Factor 1
Locus Conferring Susceptibility to Cryptococcosis in Human
Immunodeficiency Virus-Infected South Africans.
Open Forum Infectious Diseases,
7(11), ofaa489. [ofaa489]. https://doi.org/10.1093/ofid/ofaa489
Chen,
L., Collij, V., Jaeger, M., van den Munckhof,
I. C. L., Vich Vila, A., Kurilshikov,
A., Gacesa, R., Sinha, T.,
Oosting, M., Joosten, L. A. B., Rutten, J. H. W., Riksen, N. P.,
Xavier, R. J., Kuipers, F., Wijmenga,
C., Zhernakova, A., Netea, M. G.,
Weersma, R. K., & Fu, J. (2020). Gut
microbial co-abundance networks show specificity in inflammatory
bowel disease and obesity. Nature
Communications, 11(1), 4018. [4018]. https://doi.org/10.1038/s41467-020-17840-y
BBMRI
Metabolomics Consortium, Hagenbeek, F. A., Pool, R., van Dongen,
J., Draisma, H. H. M., Jan Hottenga, J., Willemsen, G., Abdellaoui,
A., Fedko, I. O., den Braber, A., Visser, P. J., de Geus, E. J. C.
N., Willems van Dijk, K., Verhoeven, A., Suchiman, H. E., Beekman,
M., Slagboom, P. E., van Duijn, C. M., Harms, A. C., ... Boomsma,
D. I. (2020). Heritability estimates for 361 blood
metabolites across 40 genome-wide association studies.
Nature Communications, 11(1), [39].
https://doi.org/10.1038/s41467-019-13770-6
Vich
Vila, A., Collij, V., Sanna,
S., Sinha, T., Imhann, F.,
Bourgonje, A. R., Mujagic, Z., Jonkers, D. M. A. E.,
Masclee, A. A. M., Fu, J., Kurilshikov,
A., Wijmenga, C., Zhernakova,
A., & Weersma, R. K. (2020). Impact
of commonly used drugs on the composition and metabolic function of
the gut microbiota. Nature
Communications, 11(1), [362]. https://doi.org/10.1038/s41467-019-14177-z
Lifelines
Cohort Study, Lopera Maya, E. A., van der Graaf,
A., Lanting, P., van der Geest,
M., Fu, J., Swertz, M.,
Franke, L., Wijmenga, C., Deelen,
P., Zhernakova, A., & Sanna,
S. (2020). Lack of Association Between Genetic
Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection
and Human Quantitative Phenotypes. Frontiers in
Genetics, 11, [613]. https://doi.org/10.3389/fgene.2020.00613
Warmink-Perdijk,
W. D. B., Peters, L. L., Tigchelaar, E.
F., Dekens, J. A. M., Jankipersadsing, S.
A., Zhernakova, A., Bossers, W. J. R.,
Sikkema, J., de Jonge, A., Reijneveld, S.
A., Verkade, H. J., Koppelman, G.
H., Wijmenga, C., Kuipers,
F., & Scherjon, S. A. (2020).
Lifelines NEXT: a prospective birth cohort adding the next
generation to the three-generation Lifelines cohort study.
European Journal of Epidemiology,
35(2), 157-168. https://doi.org/10.1007/s10654-020-00614-7
BIOS
Consortium, van der Graaf, A., Claringbould,
A., Rimbert, A., Westra,
H-J., Li, Y., Wijmenga, C.,
Sanna, S., & Franke, L. (2020).
Mendelian randomization while jointly modeling cis genetics
identifies causal relationships between gene expression and
lipids. Nature Communications,
11(1), [4930]. https://doi.org/10.1038/s41467-020-18716-x
van
den Akker, E. B., Trompet, S., Barkey Wolf, J. J. H., Beekman, M.,
Suchiman, H. E. D., Deelen, J., Asselbergs, F. W., Boersma, E.,
Cats, D., Elders, P. M., Geleijnse, J. M., Ikram, M. A.,
Kloppenburg, M., Mei, H., Meulenbelt, I., Mooijaart, S. P.,
Nelissen, R. G. H. H., Netea, M. G., Penninx, B. W. J. H., ...
Slagboom, P. E. (2020). Metabolic Age Based on the BBMRI-NL
1H-NMR Metabolomics Repository as Biomarker of Age-related
Disease. Circulation. Genomic and precision
medicine, 13(5), 541-547. [e002610]. https://doi.org/10.1161/CIRCGEN.119.002610
Lanting,
P., Drenth, E., Boven, L., van
Hoek, A., Hijlkema, A., Poot, E., van der Vries, G.,
Schoevers, R., Horwitz, E., Gans,
R., Kosterink, J., Plantinga,
M., van Langen, I., Ranchor,
A., Wijmenga, C., Franke,
L., Wilffert, B., & Sijmons,
R. (2020). Practical Barriers and Facilitators
Experienced by Patients, Pharmacists and Physicians to the
Implementation of Pharmacogenomic Screening in Dutch Outpatient
Hospital Care-An Explorative Pilot Study. Journal
of personalized medicine, 10(4), 1-13. [293].
https://doi.org/10.3390/jpm10040293
Li,
C. M., Zhernakova, A., Engstrand, L., Wijmenga,
C., & Brusselaers, N. (2020). Systematic review
with meta-analysis: the risks of proton pump inhibitors during
pregnancy. Alimentary Pharmacology &
Therapeutics, 51(4), 410-420. https://doi.org/10.1111/apt.15610
Zorro,
M. M., Aguirre-Gamboa, R., Mayassi, T.,
Ciszewski, C., Barisani, D., Hu, S., Weersma, R.
K., Withoff, S., Li, Y.,
Wijmenga, C., Jabri, B., & Jonkers, I. H.
(2020). Tissue alarmins and adaptive cytokine induce dynamic
and distinct transcriptional responses in tissue-resident
intraepithelial cytotoxic T lymphocytes. Journal
of Autoimmunity, 108, [102422]. https://doi.org/10.1016/j.jaut.2020.102422
2019
Consortium
for the study of genetic associations of celiac disease in
Latin-America, Ricaño-Ponce, I.,
Gutierrez-Achury, J., Costa, A. F., Deelen, P.,
Kurilshikov, A., Zorro, M. M., Platteel,
M., van der Graaf, A., Sanna, S.,
Daffra, O., Zhernakova, A., Fu, J.,
Trynka, G., Smecuol, E., Niveloni, S. I., Bai, J. C., Kumar,
V., & Wijmenga, C. (2020). Immunochip
meta-analysis in European and Argentinian populations identifies
two novel genetic loci associated with celiac disease.
EJHG, 28(3), 313-323. https://doi.org/10.1038/s41431-019-0520-4
Jaeger,
M., Matzaraki, V., Aguirre-Gamboa, R.,
Gresnigt, M. S., Chu, X., Johnson, M. D., Oosting, M.,
Smeekens, S. P., Withoff, S., Jonkers,
I., Perfect, J. R., van de Veerdonk, F. L., Kullberg, B-J.,
Joosten, L. A. B., Li, Y., Wijmenga, C.,
Netea, M. G., & Kumar, V. (2019). A
Genome-Wide Functional Genomics Approach Identifies Susceptibility
Pathways to Fungal Bloodstream Infection in Humans.
The Journal of Infectious Diseases,
220(5), 862-872. https://doi.org/10.1093/infdis/jiz206
Sinha,
T., Vila, A. V., Garmaeva,
S., Jankipersadsing, S. A., Imhann,
F., Collij, V., Bonder, M. J.,
Jiang, X., Gurry, T., Alm, E. J., D'Amato, M., Weersma, R.
K., Scherjon, S., Wijmenga,
C., Fu, J., Kurilshikov, A.,
& Zhernakova, A. (2019). Analysis of 1135 gut
metagenomes identifies sex-specific resistome profiles.
Gut Microbes, 10(3), 358-366. https://doi.org/10.1080/19490976.2018.1528822
Klaassen,
M. A. Y., Imhann, F., Collij, V.,
Fu, J., Wijmenga, C., Zhernakova,
A., Dijkstra, G., Festen, E. A.
M., Gacesa, R., Vich Vila,
A., & Weersma, R. K. (2019).
Anti-inflammatory Gut Microbial Pathways Are Decreased During
Crohn's Disease Exacerbations. Journal of Crohn's
and Colitis, 13(11), 1439-1449. https://doi.org/10.1093/ecco-jcc/jjz077
Clark,
D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin,
I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H.,
Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini,
F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., ... Wilson,
J. F. (2019). Associations of autozygosity with a broad range
of human phenotypes. Nature
Communications, 10(1), [4957]. https://doi.org/10.1038/s41467-019-12283-6
Jaeger,
M., Pinelli, M., Borghi, M., Constantini, C., Dindo, M., van Emst,
L., Puccetti, M., Pariano, M., Ricaño-Ponce, I.,
Büll, C., Gresnigt, M. S., Wang, X., Gutierrez Achury, J.,
Jacobs, C. W. M., Xu, N., Oosting, M., Arts, P., Joosten, L. A. B.,
van de Veerdonk, F. L., ... Netea, M. G. (2019). A systems
genomics approach identifies SIGLEC15 as a susceptibility factor in
recurrent vulvovaginal candidiasis. Science
Translational Medicine, 11(496), [3558]. https://doi.org/10.1126/scitranslmed.aar3558
Franzosa,
E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H.
J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L.
J., Sauk, J. S., Wilson, R. G., Stevens, B. W., Scott, J. M.,
Pierce, K., Deik, A. A., Bullock, K., Imhann, F.,
Porter, J. A., ... Xavier, R. J. (2019). Author Correction:
Gut microbiome structure and metabolic activity in inflammatory
bowel disease. Nature Microbiology,
4(5), 898. https://doi.org/10.1038/s41564-019-0442-5
Sanna,
S., van Zuydam, N. R., Mahajan, A., Kurilshikov,
A., Vich Vila, A., Võsa, U.,
Mujagic, Z., Masclee, A. A. M., Jonkers, D. M. A. E., Oosting, M.,
Joosten, L. A. B., Netea, M. G., Franke, L.,
Zhernakova, A., Fu, J., Wijmenga,
C., & McCarthy, M. I. (2019). Causal relationships
among the gut microbiome, short-chain fatty acids and metabolic
diseases. Nature Genetics,
51(4), 600-605. https://doi.org/10.1038/s41588-019-0350-x
Moerkens,
R., Mooiweer, J., Withoff,
S., & Wijmenga, C. (2019). Celiac
disease-on-chip: Modeling a multifactorial disease in vitro.
United European Gastroenterology Journal,
7(4), 467-476. https://doi.org/10.1177/2050640619836057
Mayassi,
T., Ladell, K., Gudjonson, H., McLaren, J. E., Shaw, D. G., Tran,
M. T., Rokicka, J. J., Lawrence, I., Grenier, J-C., van Unen, V.,
Ciszewski, C., Dimaano, M., Sayegh, H. E., Kumar,
V., Wijmenga, C., Green, P. H. R., Gokhale, R.,
Jericho, H., Semrad, C. E., ... Jabri, B. (2019). Chronic
Inflammation Permanently Reshapes Tissue-Resident Immunity in
Celiac Disease. Cell, 176(5),
967-981,e19. https://doi.org/10.1016/j.cell.2018.12.039
BIOS
Consortium, van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E.
J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran,
D. L., Moffitt, T. E., Poulton, R., Franke, B., & Boomsma, D.
(2019). Epigenome-wide Association Study of
Attention-Deficit/Hyperactivity Disorder Symptoms in Adults.
Biological Psychiatry, 86(8),
599-607. https://doi.org/10.1016/j.biopsych.2019.02.016
Le,
K. T. T., Matzaraki, V., Netea, M. G.,
Wijmenga, C., Moser, J., & Kumar,
V. (2019). Functional Annotation of Genetic Loci
Associated With Sepsis Prioritizes Immune and Endothelial Cell
Pathways. Frontiers in Immunology,
10, [1949]. https://doi.org/10.3389/fimmu.2019.01949
Myositis
Genetics Consortium, Scleroderma Genetics Consortium,
Acosta-Herrera, M., Kerick, M., Gonzalez-Serna, D., Wijmenga,
C., Franke, A., Gregersen, P. K., Padyukov, L., Worthington,
J., Vyse, T. J., Eugenia Alarcon-Riquelme, M., Mayes, M. D., &
Martin, J. (2019). Genome-wide meta-analysis reveals shared
new loci in systemic seropositive rheumatic diseases.
Annals of the Rheumatic Diseases,
78(3), 311-319. https://doi.org/10.1136/annrheumdis-2018-214127
Edwards,
R. A., Vega, A. A., Norman, H. M., Ohaeri, M., Levi, K., Dinsdale,
E. A., Cinek, O., Aziz, R. K., McNair, K., Barr, J. J., Bibby, K.,
Brouns, S. J. J., Cazares, A., de Jonge, P. A., Desnues, C.,
Díaz Muñoz, S. L., Fineran, P. C., Kurilshikov,
A., Lavigne, R., ... Dutilh, B. E. (2019). Global
phylogeography and ancient evolution of the widespread human gut
virus crAssphage. Nature Microbiology,
4(10), 1727-1736. https://doi.org/10.1038/s41564-019-0494-6
Kurilshikov,
A., van den Munckhof, I. C., Chen, L.,
Bonder, M. J., Schraa, K., Rutten, J., Riksen, N. P., de
Graaf, J., Oosting, M., Sanna, S., Joosten, L. A., van
der Graaf, M., Brand, T., Koonen, D. P., van
Faassen, M. J., Slagboom, P. E., Xavier, R. J.,
Kuipers, F., Hofker, M., ... Fu, J. (2019).
Gut Microbial Associations to Plasma Metabolites Linked to
Cardiovascular Phenotypes and Risk: A Cross-Sectional Study.
Circulation research, 124(12),
1808-1820. https://doi.org/10.1161/CIRCRESAHA.118.314642
Franzosa,
E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H.
J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L.
J., Sauk, J. S., Wilson, R. G., Stevens, B. W., Scott, J. M.,
Pierce, K., Deik, A. A., Bullock, K., Imhann, F.,
Porter, J. A., ... Xavier, R. J. (2019). Gut microbiome
structure and metabolic activity in inflammatory bowel
disease. Nature Microbiology,
4(2), 293-305. https://doi.org/10.1038/s41564-018-0306-4
European
Scleroderma Group† (2019). GWAS for systemic sclerosis
identifies multiple risk loci and highlights fibrotic and
vasculopathy pathways. Nature
Communications, 10(1), [4955]. https://doi.org/10.1038/s41467-019-12760-y
Hu,
S., Vila, A. V., Gacesa, R.,
Collij, V., Xavier, R., Stevens, C., Daly, M. J.,
Wijmenga, C., van Dullemen, H., Dijkstra,
G., Visschedijk, M. C., Festen, E.
A., Fu, J., Kurilshikov, A.,
Zhernakova, A., & Weersma, R. K. (2019).
In-depth characterization of host-genetics and gut microbiome
unravels novel host-microbiome interactions in inflammatory bowel
disease. Gastroenterology,
156(6), S34.
FREX
Consortium, GoNL Consortium, Kim, A., Savary, C., Dubourg, C.,
Carre, W., Mouden, C., Guyodo, H., Le Douce, J., Pasquier, L.,
Flori, E., Gonzales, M., Beneteau, C., Boute, O., Attie-Bitach, T.,
Roume, J., Goujon, L., Akloul, L., Odent, S., ... David, V. (2019).
Integrated clinical and omics approach to rare diseases:
novel genes and oligogenic inheritance in holoprosencephaly.
Brain, 142(1), 35-49. https://doi.org/10.1093/brain/awy290
Chu,
X., Jaeger, M., Bakker, O. B., Aguirre-Gamboa,
R., Oosting, M., Smeekens, S. P., Withoff, S.,
Netea-Maier, R. T., Koenen, H. J. P. M., Joosten, I., Xavier, R.
J., Franke, L., Joosten, L. A. B.,
Sanna, S., Kumar, V., Wijmenga,
C., Netea, M. G., & Li, Y. (2019).
Integration of similar to 10,000 metabolite features with
genotype data and immune phenotypes reveals genetic determinants
and common regulatory modules. European Journal of
Human Genetics, 27, 787-787.
BBMRI
Metabolomics Consortium (2019). Large-scale plasma metabolome
analysis reveals alterations in HDL metabolism in migraine.
Neurology, 92(16), E1899-E1911. https://doi.org/10.1212/WNL.0000000000007313
Le,
K. T. T., Chu, X., Jaeger, M., Plantinga,
J. A., Matzaraki, V., Withoff, S.,
Joosten, L. A. B., Netea, M. G., Wijmenga, C.,
Li, Y., Moser, J., & Kumar, V.
(2019). Leukocyte-Released Mediators in Response to Both
Bacterial and Fungal Infections Trigger IFN Pathways, Independent
of IL-1 and TNF-alpha, in Endothelial Cells.
Frontiers in Immunology, 10, [2508].
https://doi.org/10.3389/fimmu.2019.02508
Porcu,
E., Rueger, S., Lepik, K., eQTLgen Consortium, & BIOS
Consortium (2019). Mendelian randomization integrating GWAS
and eQTL data reveals genetic determinants of complex and clinical
traits. Nature Communications,
10, [3300]. https://doi.org/10.1038/s41467-019-10936-0
Marquez,
A., Kerick, M., Zhernakova, A., Gutierrez-Achury, J.,
Chen, W-M., Onengut-Gumuscu, S., Gonzalez-Alvaro, I.,
Rodriguez-Rodriguez, L., Gonzalez-Gay, M. A., Mayes, M.,
Raychaudhuri, S., Rich, S. S., Wijmenga, C., &
Martin Ibanez, J. (2019). Meta-analysis of immunochip data of
four autoimmune diseases reveals novel single-disease and
cross-phenotype associations. Annals of the
Rheumatic Diseases, 78, 170. https://doi.org/10.1136/annrheumdis-2019-eular.402
Kilpelainen,
T. O., Nolte, I. M., van der Most, P.
J., Verweij, N., Snieder, H., van
der Ende, M. Y., Oldehinkel, A. J., van der
Harst, P., Van Vliet-Ostaptchouk, J. V.,
Lifelines Cohort Study, & Wang, Y. X. (2019).
Multi-ancestry study of blood lipid levels identifies four
loci interacting with physical activity. Nature
Communications, 10(1), [376]. https://doi.org/10.1038/s41467-018-08008-w
Vojinovic,
D., Radjabzadeh, D., Kurilshikov, A., Amin, N.,
Wijmenga, C., Franke, L., Ikram, M. A.,
Uitterlinden, A. G., Zhernakova, A., Fu,
J., Kraaij, R., & van Duijn, C. M. (2019).
Relationship between gut microbiota and circulating
metabolites in population-based cohorts. Nature
Communications, 10(1), [5813]. https://doi.org/10.1038/s41467-019-13721-1
Peters,
V., Tigchelaar, E., Imhann, F., Dekens,
J., Swertz, M., Franke, L.,
Wijmenga, C., Weersma, R. K., Alizadeh,
B., Dijkstra, G., &
Campmans-Kuijpers, M. J. (2019). Sa2029 –
Habitual dietary intake of dutch IBD patients differs from
population controls: A case-control study.
Gastroenterology, 156(6), S477-S478.
https://doi.org/10.1016/S0016-5085(19)38052-7
Abstract
van
der Meulen, T. A., Harmsen, H. J. M.,
Vich Vila, A., Kurilshikov, A., Liefers,
S. C., Zhernakova, A., Fu,
J., Wijmenga, C., Weersma, R.
K., de Leeuw, K., Bootsma,
H., Spijkervet, F. K. L., Vissink,
A., & Kroese, F. G. M. (2019). Shared
gut, but distinct oral microbiota composition in primary
Sjögren's syndrome and systemic lupus erythematosus.
Journal of Autoimmunity, 97, 77-87.
https://doi.org/10.1016/j.jaut.2018.10.009
BIOS
Consortium, & GoNL Consortium (2019). Skewed
X-inactivation is common in the general female population.
European Journal of Human Genetics,
27(3), 455-465. https://doi.org/10.1038/s41431-018-0291-3
Collij,
V., Imhann, F., Vich Vila,
A., Fu, J., Dijkstra, G.,
Festen, E. A. M., Voskuil, M. D., Daly, M. J.,
Xavier, R. J., Wijmenga, C., Zhernakova,
A., & Weersma, R. K. (2019). SLC39A8
missense variant is associated with Crohn's disease but does not
have a major impact on gut microbiome composition in healthy
subjects. PLoS ONE, 14(1),
[0211328]. https://doi.org/10.1371/journal.pone.0211328
Zeevi,
D., Korem, T., Godneva, A., Bar, N., Kurilshikov, A.,
Lotan-Pompan, M., Weinberger, A., Fu, J.,
Wijmenga, C., Zhernakova, A., & Segal, E.
(2019). Structural variation in the gut microbiome associates
with host health. Nature,
568(7750), 43-48. https://doi.org/10.1038/s41586-019-1065-y
Garmaeva,
S., Sinha, T., Kurilshikov,
A., Wijmenga, C., Fu, J.,
& Zhernakova, S. (2019). Studying the gut virome
in the metagenomic era: challenges and perspectives.
BMC Biology, 17(1), [84]. https://doi.org/10.1186/s12915-019-0704-y
Domínguez-Andrés,
J., Novakovic, B., Li, Y., Scicluna, B. P., Gresnigt,
M. S., Arts, R. J. W., Oosting, M., Moorlag, S. J. C. F. M., Groh,
L. A., Zwaag, J., Koch, R. M., Ter Horst, R., Joosten, L. A.
B., Wijmenga, C., Michelucci, A., van der Poll, T.,
Kox, M., Pickkers, P., Kumar, V., ... Netea, M. G.
(2019). The Itaconate Pathway Is a Central Regulatory Node
Linking Innate Immune Tolerance and Trained Immunity.
Cell metabolism, 29(1), 211-220.e5.
https://doi.org/10.1016/j.cmet.2018.09.003
2018
Uniken
Venema, W. T., Voskuil, M. D., Vich Vila,
A., van der Vries, G., Jansen, B. H., Jabri,
B., Faber, K. N., Dijkstra, G., Xavier,
R. J., Wijmenga, C., Graham, D. B., Weersma, R.
K., & Festen, E. A. (2019).
Single-Cell RNA Sequencing of Blood and Ileal T Cells From
Patients With Crohn's Disease Reveals Tissue-Specific
Characteristics and Drug Targets.
Gastroenterology, 156(3), 812-+. https://doi.org/10.1053/j.gastro.2018.10.046
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