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Wijmenga, Prof. Cisca

Cisca Wijmenga (Photo: NWO/Ivar Pel)
Cisca Wijmenga (Photo: NWO/Ivar Pel)

Prof. Cisca Wijmenga has been Professor of Human Genetics at the University of Groningen and head of the Genetics Department of the University Medical Center Groningen since 2007. The aim of her research is to understand the role that genes play in the development of chronic diseases. Her research group focuses on the genetics of inflammation-related conditions, such as coeliac disease (gluten allergy) and inflammatory intestinal disease (e.g. Crohn’s disease, ulcerative colitis). Research led by Wijmenga has discovered several genes that are involved in causing such immune-related disorders. This knowledge is leading to new insights into the disease process, and could possibly result in new treatments for patients.

Prof. Wijmenga has been elected a member of the Royal Netherlands Academy of Arts and Sciences (KNAW) in 2012. Members of KNAW are all prominent academics from all disciplines and are chosen on the basis of nominations from within and outside the Academy. In the same year she received a prestigious ERC Advanced Grant for her research project on Celiac disease. The BBMRI-NL2.0 project, a collaboration led by Wijmenga between biobanks in the Netherlands, received EUR 9.8 million from NWO in 2014. In 2015 Wijmenga has been awarded a Spinoza Prize, also referred to as the 'Dutch Nobel Prize'.

In 2019 Wijmenga has been appointed as Rector Magnificus of the University of Groningen. She is the first female rector in the 405-year history of the UG.

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Article for NOS
Article for NOS

2021

Ortiz Fernández, L., Coit, P., Yilmaz, V., Yentür, S. P., Alibaz-Oner, F., Aksu, K., Erken, E., Düzgün, N., Keser, G., Cefle, A., Yazici, A., Ergen, A., Alpsoy, E., Salvarani, C., Casali, B., Kısacık, B., Kötter, I., Henes, J., Çınar, M., ... Sawalha, A. H. (2021). Genetic association of a gain of function interferon gamma receptor 1 (IFNGR1) polymorphism and the intergenic region LNCAROD/DKK1 with Behçet's disease. Arthritis & Rheumatology, 1-28. https://doi.org/10.1002/art.41637
Brand, E. C., Klaassen, M. A. Y., Gacesa, R., Vila, A. V., Ghosh, H., de Zoete, M. R., Boomsma, D. I., Hoentjen, F., Horjus Talabur Horje, C. S., van de Meeberg, P. C., Willemsen, G., Fu, J., Wijmenga, C., van Wijk, F., Zhernakova, A., Oldenburg, B., Weersma, R. K., & Dutch TWIN-IBD consortium and the Dutch Initiative on Crohn and Colitis (2021). Healthy cotwins share gut microbiome signatures with their inflammatory bowel disease twins and unrelated patients. Gastroenterology. https://doi.org/10.1053/j.gastro.2021.01.030
MiBioGen Consortium Initiative, Kurilshikov, A., Medina-Gomez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, C. I., Raygoza Garay, J. A., Finnicum, C. T., Liu, X., Zhernakova, D. V., Bonder, M. J., Hansen, T. H., Frost, F., Ruehlemann, M. C., Turpin, W., Moon, J-Y., Kim, H-N., ... Zhernakova, A. (2021). Large-scale association analyses identify host factors influencing human gut microbiome composition. Nature Genetics, 156-165. https://doi.org/10.1038/s41588-020-00763-1
Mc Intyre, K., Lanting, P., Deelen, P., Wiersma, H. H., Vonk, J. M., Ori, A. P. S., Jankipersadsing, S. A., Warmerdam, R., van Blokland, I., Boulogne, F., Dijkema, M. X. L., Herkert, J. C., Claringbould, A., Bakker, O., Lopera Maya, E. A., Bültmann, U., Zhernakova, A., Reijneveld, S. A., Zijlstra, E., ... Franke, L. (2021). Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort. BMJ Open, 11(3), [e044474]. https://doi.org/10.1136/bmjopen-2020-044474
Bolte, L. A., Vich Vila, A., Imhann, F., Collij, V., Gacesa, R., Peters, V., Wijmenga, C., Kurilshikov, A., Campmans-Kuijpers, M. J. E., Fu, J., Dijkstra, G., Zhernakova, A., & Weersma, R. K. (2021). Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome. Gut. https://doi.org/10.1136/gutjnl-2020-322670
Bolte, L. A., Klaassen, M. A. Y., Collij, V., Vich Vila, A., Fu, J., van der Meulen, T. A., de Haan, J. J., Versteegen, G. J., Dotinga, A., Zhernakova, A., Wijmenga, C., Weersma, R. K., & Imhann, F. (2021). Patient attitudes towards faecal sampling for gut microbiome studies and clinical care reveal positive engagement and room for improvement. PLoS ONE, 16(4), e0249405. https://doi.org/10.1371/journal.pone.0249405
BIOS Consortium, van der Graaf, A., Zorro, M. M., Claringbould, A., Vosa, U., Aguirre-Gamboa, R., Li, C., Mooiweer, J., Ricano-Ponce, I., Borek, Z., Koning, F., Kooy-Winkelaar, Y., Sollid, L. M., Qiao, S-W., Kumar, V., Li, Y., Franke, L., Withoff, S., Wijmenga, C., ... Jonkers, I. (2021). Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFN gamma Signaling in Celiac Disease. Frontiers in Genetics, 11, [562434]. https://doi.org/10.3389/fgene.2020.562434
Ruigrok, R. A. A. A., Collij, V., Sureda, P., Klaassen, M. A. Y., Bolte, L. A., Jansen, B. H., Voskuil, M. D., Fu, J., Wijmenga, C., Zhernakova, A., Weersma, R. K., & Vich Vila, A. (2021). The composition and metabolic potential of the human small intestinal microbiota within the context of inflammatory bowel disease. Journal of Crohn's and Colitis. https://doi.org/10.1093/ecco-jcc/jjab020
Lifelines Cohort Study (2021). The long-term genetic stability and individual specificity of the human gut microbiome. Cell. https://doi.org/10.1016/j.cell.2021.03.024

2020

TANDEM Consortium, Eckold, C., Kumar, V., Weiner Rd, J., Alisjahbana, B., Riza, A-L., Ronacher, K., Coronel, J., Kerry-Barnard, S., Malherbe, S. T., Kleynhans, L., Stanley, K., Ruslami, R., Ioana, M., Ugarte-Gil, C., Walzl, G., van Crevel, R., Wijmenga, C., Critchley, J. A., ... Cliff, J. M. (2021). Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis. Clinical Infectious Diseases, 72(1), 69-78. [ciaa751]. https://doi.org/10.1093/cid/ciaa751
Hu, S., Vich Vila, A., Gacesa, R., Collij, V., Stevens, C., Fu, J. M., Wong, I., Talkowski, M. E., Rivas, M. A., Imhann, F., Bolte, L., van Dullemen, H., Dijkstra, G., Visschedijk, M. C., Festen, E. A., Xavier, R. J., Fu, J., Daly, M. J., Wijmenga, C., ... Weersma, R. K. (2021). Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD. Gut, 70(2), 285-296. [319706]. https://doi.org/10.1136/gutjnl-2019-319706
BIOS Consortium, Ouwens, K. G., Jansen, R., Nivard, M. G., van Dongen, J., Frieser, M. J., Hottenga, J-J., Arindrarto, W., Claringbould, A., van Iterson, M., Mei, H., & Franke, L. (2020). A characterization of cis- and trans-heritability of RNA-Seq-based gene expression. European Journal of Human Genetics, 28(2), 253-263. https://doi.org/10.1038/s41431-019-0511-5
BIOS Consortium, Aguirre-Gamboa, R., de Klein, N., di Tommaso, J., Claringbould, A., van der Wijst, M. G. P., de Vries, D., Brugge, H., Oelen, R., Vosa, U., Zorro, M. M., Chu, X., Bakker, O. B., Borek, Z., Ricano-Ponce, I., Deelen, P., Xu, C-J., Swertz, M., Jonkers, I., ... Li, Y. (2020). Deconvolution of bulk blood eQTL effects into immune cell subpopulations. Bmc Bioinformatics, 21(1), [243]. https://doi.org/10.1101/548669, https://doi.org/10.1186/s12859-020-03576-5
Chu, X., Janssen, A. W. M., Koenen, H., Chang, L., He, X., Joosten, I., Xu, C., Wijmenga, C., Netea, M., Tack, C. J., & Li, Y. (2020). Differential genetic and environmental effects on immune parameters and functions in type 1 diabetes and health. European Journal of Human Genetics, 28(SUPPL 1), 735-736.
Chen, L., Schraa, K., van den Munckhof, I. C. L., Ter Horst, R., Koehorst, M., van Faassen, M., van der Ley, C., Doestzada, M., Zhernakova, D. V., Kurilshikov, A., Bloks, V. W., Groen, A. K., Human Functional Genomics Project, Riksen, N. P., Rutten, J. H. W., Joosten, L. A. B., Wijmenga, C., Zhernakova, A., Netea, M. G., ... Kuipers, F. (2020). Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content. Cell reports, 33(1), [108212]. https://doi.org/10.1016/j.celrep.2020.108212
BBMRI Metabol Consortium, Pool, R., Hagenbeek, F. A., Hendriks, A. M., van Dongen, J., Willemsen, G., de Geus, E., van Dijk, K. W., Verhoeven, A., Suchiman, H. E. D., Beekman, M., Slagboom, P. E., Harms, A. C., Hankemeier, T., & Boomsma, D. (2020). Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data. Twin research and human genetics, 23(3), 145-155. https://doi.org/10.1017/thg.2020.53
Kannambath, S., Jarvis, J. N., Wake, R. M., Longley, N., Loyse, A., Matzaraki, V., Aguirre-Gamboa, R., Wijmenga, C., Doyle, R., Paximadis, M., Tiemessen, C. T., Kumar, V., Pittman, A., Meintjes, G., Harrison, T. S., Netea, M. G., & Bicanic, T. (2020). Genome-Wide Association Study Identifies Novel Colony Stimulating Factor 1 Locus Conferring Susceptibility to Cryptococcosis in Human Immunodeficiency Virus-Infected South Africans. Open Forum Infectious Diseases, 7(11), ofaa489. [ofaa489]. https://doi.org/10.1093/ofid/ofaa489
Chen, L., Collij, V., Jaeger, M., van den Munckhof, I. C. L., Vich Vila, A., Kurilshikov, A., Gacesa, R., Sinha, T., Oosting, M., Joosten, L. A. B., Rutten, J. H. W., Riksen, N. P., Xavier, R. J., Kuipers, F., Wijmenga, C., Zhernakova, A., Netea, M. G., Weersma, R. K., & Fu, J. (2020). Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity. Nature Communications, 11(1), 4018. [4018]. https://doi.org/10.1038/s41467-020-17840-y
Peters, V., Tigchelaar-Feenstra, E. F., Imhann, F., Dekens, J. A. M., Swertz, M. A., Franke, L. H., Wijmenga, C., Weersma, R. K., Alizadeh, B. Z., Dijkstra, G., & Campmans-Kuijpers, M. J. E. (2020). Habitual dietary intake of IBD patients differs from population controls: a case-control study. European Journal of Nutrition. https://doi.org/10.1007/s00394-020-02250-z
BBMRI Metabolomics Consortium, Hagenbeek, F. A., Pool, R., van Dongen, J., Draisma, H. H. M., Jan Hottenga, J., Willemsen, G., Abdellaoui, A., Fedko, I. O., den Braber, A., Visser, P. J., de Geus, E. J. C. N., Willems van Dijk, K., Verhoeven, A., Suchiman, H. E., Beekman, M., Slagboom, P. E., van Duijn, C. M., Harms, A. C., ... Boomsma, D. I. (2020). Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Nature Communications, 11(1), [39]. https://doi.org/10.1038/s41467-019-13770-6
Vich Vila, A., Collij, V., Sanna, S., Sinha, T., Imhann, F., Bourgonje, A. R., Mujagic, Z., Jonkers, D. M. A. E., Masclee, A. A. M., Fu, J., Kurilshikov, A., Wijmenga, C., Zhernakova, A., & Weersma, R. K. (2020). Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. Nature Communications, 11(1), [362]. https://doi.org/10.1038/s41467-019-14177-z
Lifelines Cohort Study, Lopera Maya, E. A., van der Graaf, A., Lanting, P., van der Geest, M., Fu, J., Swertz, M., Franke, L., Wijmenga, C., Deelen, P., Zhernakova, A., & Sanna, S. (2020). Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes. Frontiers in Genetics, 11, [613]. https://doi.org/10.3389/fgene.2020.00613
Warmink-Perdijk, W. D. B., Peters, L. L., Tigchelaar, E. F., Dekens, J. A. M., Jankipersadsing, S. A., Zhernakova, A., Bossers, W. J. R., Sikkema, J., de Jonge, A., Reijneveld, S. A., Verkade, H. J., Koppelman, G. H., Wijmenga, C., Kuipers, F., & Scherjon, S. A. (2020). Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study. European Journal of Epidemiology, 35(2), 157-168. https://doi.org/10.1007/s10654-020-00614-7
BIOS Consortium, van der Graaf, A., Claringbould, A., Rimbert, A., Westra, H-J., Li, Y., Wijmenga, C., Sanna, S., & Franke, L. (2020). Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids. Nature Communications, 11(1), [4930]. https://doi.org/10.1038/s41467-020-18716-x
van den Akker, E. B., Trompet, S., Barkey Wolf, J. J. H., Beekman, M., Suchiman, H. E. D., Deelen, J., Asselbergs, F. W., Boersma, E., Cats, D., Elders, P. M., Geleijnse, J. M., Ikram, M. A., Kloppenburg, M., Mei, H., Meulenbelt, I., Mooijaart, S. P., Nelissen, R. G. H. H., Netea, M. G., Penninx, B. W. J. H., ... Slagboom, P. E. (2020). Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease. Circulation. Genomic and precision medicine, 13(5), 541-547. [e002610]. https://doi.org/10.1161/CIRCGEN.119.002610
Tan, I. L., Withoff, S., Kolkman, J. J., Wijmenga, C., Weersma, R. K., & Visschedijk, M. C. (2020). Non-classical clinical presentation at diagnosis by male celiac disease patients of older age. European Journal of Internal Medicine, 1-6. https://doi.org/10.1016/j.ejim.2020.09.020
Lanting, P., Drenth, E., Boven, L., van Hoek, A., Hijlkema, A., Poot, E., van der Vries, G., Schoevers, R., Horwitz, E., Gans, R., Kosterink, J., Plantinga, M., van Langen, I., Ranchor, A., Wijmenga, C., Franke, L., Wilffert, B., & Sijmons, R. (2020). Practical Barriers and Facilitators Experienced by Patients, Pharmacists and Physicians to the Implementation of Pharmacogenomic Screening in Dutch Outpatient Hospital Care-An Explorative Pilot Study. Journal of personalized medicine, 10(4), 1-13. [293]. https://doi.org/10.3390/jpm10040293
BIOS Consortium, Xu, C-J., Qi, C., van Rijkom, B., van der Vlies, P., Nawijn, M. C., & Wijmenga, C. (2020). Shared DNA methylation signatures in childhood allergy: the MeDALL study. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2020.11.044
Li, C. M., Zhernakova, A., Engstrand, L., Wijmenga, C., & Brusselaers, N. (2020). Systematic review with meta-analysis: the risks of proton pump inhibitors during pregnancy. Alimentary Pharmacology & Therapeutics, 51(4), 410-420. https://doi.org/10.1111/apt.15610
Zorro, M. M., Aguirre-Gamboa, R., Mayassi, T., Ciszewski, C., Barisani, D., Hu, S., Weersma, R. K., Withoff, S., Li, Y., Wijmenga, C., Jabri, B., & Jonkers, I. H. (2020). Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes. Journal of Autoimmunity, 108, [102422]. https://doi.org/10.1016/j.jaut.2020.102422

2019

Consortium for the study of genetic associations of celiac disease in Latin-America, Ricaño-Ponce, I., Gutierrez-Achury, J., Costa, A. F., Deelen, P., Kurilshikov, A., Zorro, M. M., Platteel, M., van der Graaf, A., Sanna, S., Daffra, O., Zhernakova, A., Fu, J., Trynka, G., Smecuol, E., Niveloni, S. I., Bai, J. C., Kumar, V., & Wijmenga, C. (2020). Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease. EJHG, 28(3), 313-323. https://doi.org/10.1038/s41431-019-0520-4
Jaeger, M., Matzaraki, V., Aguirre-Gamboa, R., Gresnigt, M. S., Chu, X., Johnson, M. D., Oosting, M., Smeekens, S. P., Withoff, S., Jonkers, I., Perfect, J. R., van de Veerdonk, F. L., Kullberg, B-J., Joosten, L. A. B., Li, Y., Wijmenga, C., Netea, M. G., & Kumar, V. (2019). A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans. The Journal of Infectious Diseases, 220(5), 862-872. https://doi.org/10.1093/infdis/jiz206
Jaeger, M., Pinelli, M., Borghi, M., Constantini, C., Dindo, M., van Emst, L., Puccetti, M., Pariano, M., Ricaño-Ponce, I., Büll, C., Gresnigt, M. S., Wang, X., Gutierrez Achury, J., Jacobs, C. W. M., Xu, N., Oosting, M., Arts, P., Joosten, L. A. B., van de Veerdonk, F. L., ... Netea, M. G. (2019). A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis. Science Translational Medicine, 11(496), [3558]. https://doi.org/10.1126/scitranslmed.aar3558
Sinha, T., Vila, A. V., Garmaeva, S., Jankipersadsing, S. A., Imhann, F., Collij, V., Bonder, M. J., Jiang, X., Gurry, T., Alm, E. J., D'Amato, M., Weersma, R. K., Scherjon, S., Wijmenga, C., Fu, J., Kurilshikov, A., & Zhernakova, A. (2019). Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles. Gut Microbes, 10(3), 358-366. https://doi.org/10.1080/19490976.2018.1528822
Klaassen, M. A. Y., Imhann, F., Collij, V., Fu, J., Wijmenga, C., Zhernakova, A., Dijkstra, G., Festen, E. A. M., Gacesa, R., Vich Vila, A., & Weersma, R. K. (2019). Anti-inflammatory Gut Microbial Pathways Are Decreased During Crohn's Disease Exacerbations. Journal of Crohn's and Colitis, 13(11), 1439-1449. https://doi.org/10.1093/ecco-jcc/jjz077
Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., ... Wilson, J. F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10(1), [4957]. https://doi.org/10.1038/s41467-019-12283-6
Franzosa, E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H. J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L. J., Sauk, J. S., Wilson, R. G., Stevens, B. W., Scott, J. M., Pierce, K., Deik, A. A., Bullock, K., Imhann, F., Porter, J. A., ... Xavier, R. J. (2019). Author Correction: Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nature Microbiology, 4(5), 898. https://doi.org/10.1038/s41564-019-0442-5
Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., Mujagic, Z., Masclee, A. A. M., Jonkers, D. M. A. E., Oosting, M., Joosten, L. A. B., Netea, M. G., Franke, L., Zhernakova, A., Fu, J., Wijmenga, C., & McCarthy, M. I. (2019). Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nature Genetics, 51(4), 600-605. https://doi.org/10.1038/s41588-019-0350-x
Moerkens, R., Mooiweer, J., Withoff, S., & Wijmenga, C. (2019). Celiac disease-on-chip: Modeling a multifactorial disease in vitro. United European Gastroenterology Journal, 7(4), 467-476. https://doi.org/10.1177/2050640619836057
Mayassi, T., Ladell, K., Gudjonson, H., McLaren, J. E., Shaw, D. G., Tran, M. T., Rokicka, J. J., Lawrence, I., Grenier, J-C., van Unen, V., Ciszewski, C., Dimaano, M., Sayegh, H. E., Kumar, V., Wijmenga, C., Green, P. H. R., Gokhale, R., Jericho, H., Semrad, C. E., ... Jabri, B. (2019). Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Cell, 176(5), 967-981,e19. https://doi.org/10.1016/j.cell.2018.12.039
BIOS Consortium, van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran, D. L., Moffitt, T. E., Poulton, R., Franke, B., & Boomsma, D. (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biological Psychiatry, 86(8), 599-607. https://doi.org/10.1016/j.biopsych.2019.02.016
Le, K. T. T., Matzaraki, V., Netea, M. G., Wijmenga, C., Moser, J., & Kumar, V. (2019). Functional Annotation of Genetic Loci Associated With Sepsis Prioritizes Immune and Endothelial Cell Pathways. Frontiers in Immunology, 10, [1949]. https://doi.org/10.3389/fimmu.2019.01949
Myositis Genetics Consortium, Scleroderma Genetics Consortium, Acosta-Herrera, M., Kerick, M., Gonzalez-Serna, D., Wijmenga, C., Franke, A., Gregersen, P. K., Padyukov, L., Worthington, J., Vyse, T. J., Eugenia Alarcon-Riquelme, M., Mayes, M. D., & Martin, J. (2019). Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. Annals of the Rheumatic Diseases, 78(3), 311-319. https://doi.org/10.1136/annrheumdis-2018-214127
Edwards, R. A., Vega, A. A., Norman, H. M., Ohaeri, M., Levi, K., Dinsdale, E. A., Cinek, O., Aziz, R. K., McNair, K., Barr, J. J., Bibby, K., Brouns, S. J. J., Cazares, A., de Jonge, P. A., Desnues, C., Díaz Muñoz, S. L., Fineran, P. C., Kurilshikov, A., Lavigne, R., ... Dutilh, B. E. (2019). Global phylogeography and ancient evolution of the widespread human gut virus crAssphage. Nature Microbiology, 4(10), 1727-1736. https://doi.org/10.1038/s41564-019-0494-6
Kurilshikov, A., van den Munckhof, I. C., Chen, L., Bonder, M. J., Schraa, K., Rutten, J., Riksen, N. P., de Graaf, J., Oosting, M., Sanna, S., Joosten, L. A., van der Graaf, M., Brand, T., Koonen, D. P., van Faassen, M. J., Slagboom, P. E., Xavier, R. J., Kuipers, F., Hofker, M., ... Fu, J. (2019). Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk: A Cross-Sectional Study. Circulation research, 124(12), 1808-1820. https://doi.org/10.1161/CIRCRESAHA.118.314642
Franzosa, E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H. J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L. J., Sauk, J. S., Wilson, R. G., Stevens, B. W., Scott, J. M., Pierce, K., Deik, A. A., Bullock, K., Imhann, F., Porter, J. A., ... Xavier, R. J. (2019). Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nature Microbiology, 4(2), 293-305. https://doi.org/10.1038/s41564-018-0306-4
European Scleroderma Group† (2019). GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. Nature Communications, 10(1), [4955]. https://doi.org/10.1038/s41467-019-12760-y
Hu, S., Vila, A. V., Gacesa, R., Collij, V., Xavier, R., Stevens, C., Daly, M. J., Wijmenga, C., van Dullemen, H., Dijkstra, G., Visschedijk, M. C., Festen, E. A., Fu, J., Kurilshikov, A., Zhernakova, A., & Weersma, R. K. (2019). In-depth characterization of host-genetics and gut microbiome unravels novel host-microbiome interactions in inflammatory bowel disease. Gastroenterology, 156(6), S34.
FREX Consortium, GoNL Consortium, Kim, A., Savary, C., Dubourg, C., Carre, W., Mouden, C., Guyodo, H., Le Douce, J., Pasquier, L., Flori, E., Gonzales, M., Beneteau, C., Boute, O., Attie-Bitach, T., Roume, J., Goujon, L., Akloul, L., Odent, S., ... David, V. (2019). Integrated clinical and omics approach to rare diseases: novel genes and oligogenic inheritance in holoprosencephaly. Brain, 142(1), 35-49. https://doi.org/10.1093/brain/awy290
Chu, X., Jaeger, M., Bakker, O. B., Aguirre-Gamboa, R., Oosting, M., Smeekens, S. P., Withoff, S., Netea-Maier, R. T., Koenen, H. J. P. M., Joosten, I., Xavier, R. J., Franke, L., Joosten, L. A. B., Sanna, S., Kumar, V., Wijmenga, C., Netea, M. G., & Li, Y. (2019). Integration of similar to 10,000 metabolite features with genotype data and immune phenotypes reveals genetic determinants and common regulatory modules. European Journal of Human Genetics, 27, 787-787.
BBMRI Metabolomics Consortium (2019). Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine. Neurology, 92(16), E1899-E1911. https://doi.org/10.1212/WNL.0000000000007313
Le, K. T. T., Chu, X., Jaeger, M., Plantinga, J. A., Matzaraki, V., Withoff, S., Joosten, L. A. B., Netea, M. G., Wijmenga, C., Li, Y., Moser, J., & Kumar, V. (2019). Leukocyte-Released Mediators in Response to Both Bacterial and Fungal Infections Trigger IFN Pathways, Independent of IL-1 and TNF-alpha, in Endothelial Cells. Frontiers in Immunology, 10, [2508]. https://doi.org/10.3389/fimmu.2019.02508
Porcu, E., Rueger, S., Lepik, K., eQTLgen Consortium, & BIOS Consortium (2019). Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nature Communications, 10, [3300]. https://doi.org/10.1038/s41467-019-10936-0
Marquez, A., Kerick, M., Zhernakova, A., Gutierrez-Achury, J., Chen, W-M., Onengut-Gumuscu, S., Gonzalez-Alvaro, I., Rodriguez-Rodriguez, L., Gonzalez-Gay, M. A., Mayes, M., Raychaudhuri, S., Rich, S. S., Wijmenga, C., & Martin Ibanez, J. (2019). Meta-analysis of immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations. Annals of the Rheumatic Diseases, 78, 170. https://doi.org/10.1136/annrheumdis-2019-eular.402
Kilpelainen, T. O., Nolte, I. M., van der Most, P. J., Verweij, N., Snieder, H., van der Ende, M. Y., Oldehinkel, A. J., van der Harst, P., Van Vliet-Ostaptchouk, J. V., Lifelines Cohort Study, & Wang, Y. X. (2019). Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications, 10(1), [376]. https://doi.org/10.1038/s41467-018-08008-w
Vojinovic, D., Radjabzadeh, D., Kurilshikov, A., Amin, N., Wijmenga, C., Franke, L., Ikram, M. A., Uitterlinden, A. G., Zhernakova, A., Fu, J., Kraaij, R., & van Duijn, C. M. (2019). Relationship between gut microbiota and circulating metabolites in population-based cohorts. Nature Communications, 10(1), [5813]. https://doi.org/10.1038/s41467-019-13721-1
Peters, V., Tigchelaar, E., Imhann, F., Dekens, J., Swertz, M., Franke, L., Wijmenga, C., Weersma, R. K., Alizadeh, B., Dijkstra, G., & Campmans-Kuijpers, M. J. (2019). Sa2029 – Habitual dietary intake of dutch IBD patients differs from population controls: A case-control study. Gastroenterology, 156(6), S477-S478. https://doi.org/10.1016/S0016-5085(19)38052-7 Abstract
van der Meulen, T. A., Harmsen, H. J. M., Vich Vila, A., Kurilshikov, A., Liefers, S. C., Zhernakova, A., Fu, J., Wijmenga, C., Weersma, R. K., de Leeuw, K., Bootsma, H., Spijkervet, F. K. L., Vissink, A., & Kroese, F. G. M. (2019). Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus. Journal of Autoimmunity, 97, 77-87. https://doi.org/10.1016/j.jaut.2018.10.009
BIOS Consortium, & GoNL Consortium (2019). Skewed X-inactivation is common in the general female population. European Journal of Human Genetics, 27(3), 455-465. https://doi.org/10.1038/s41431-018-0291-3
Collij, V., Imhann, F., Vich Vila, A., Fu, J., Dijkstra, G., Festen, E. A. M., Voskuil, M. D., Daly, M. J., Xavier, R. J., Wijmenga, C., Zhernakova, A., & Weersma, R. K. (2019). SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects. PLoS ONE, 14(1), [0211328]. https://doi.org/10.1371/journal.pone.0211328
Zeevi, D., Korem, T., Godneva, A., Bar, N., Kurilshikov, A., Lotan-Pompan, M., Weinberger, A., Fu, J., Wijmenga, C., Zhernakova, A., & Segal, E. (2019). Structural variation in the gut microbiome associates with host health. Nature, 568(7750), 43-48. https://doi.org/10.1038/s41586-019-1065-y
Garmaeva, S., Sinha, T., Kurilshikov, A., Wijmenga, C., Fu, J., & Zhernakova, S. (2019). Studying the gut virome in the metagenomic era: challenges and perspectives. BMC Biology, 17(1), [84]. https://doi.org/10.1186/s12915-019-0704-y
Domínguez-Andrés, J., Novakovic, B., Li, Y., Scicluna, B. P., Gresnigt, M. S., Arts, R. J. W., Oosting, M., Moorlag, S. J. C. F. M., Groh, L. A., Zwaag, J., Koch, R. M., Ter Horst, R., Joosten, L. A. B., Wijmenga, C., Michelucci, A., van der Poll, T., Kox, M., Pickkers, P., Kumar, V., ... Netea, M. G. (2019). The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity. Cell metabolism, 29(1), 211-220.e5. https://doi.org/10.1016/j.cmet.2018.09.003
Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., Claes, S., Van Oudenhove, L., Zhernakova, A., Vieira-Silva, S., & Raes, J. (2019). The neuroactive potential of the human gut microbiota in quality of life and depression. Nature Microbiology, 4(4), 623-632. https://doi.org/10.1038/s41564-018-0337-x
Genome Netherlands Consortium, Nersisyan, L., & Nikoghosyan, M. (2019). WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene. Scientific Reports, 9, [18758]. https://doi.org/10.1038/s41598-019-55109-7
Johansson, L. F., van Dijk-Bos, K. K., van der Hout, A. H., Knopperts, A. P., Leegte, B., ter Beest, J., Vos, Y. J., van Diemen, C. C., Kok, K., van Langen, I. M., Swertz, M. A., Wijmenga, C., Weersma, R. K., Sinke, R. J., Sikkema-Raddatz, B., Sijmons, R. H., & Westers, H. (2019). What if we would turn a diagnostic multi-cancer gene panel into a screening tool? European Journal of Human Genetics, 27, 1126-1126.

2018

Uniken Venema, W. T., Voskuil, M. D., Vich Vila, A., van der Vries, G., Jansen, B. H., Jabri, B., Faber, K. N., Dijkstra, G., Xavier, R. J., Wijmenga, C., Graham, D. B., Weersma, R. K., & Festen, E. A. (2019). Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets. Gastroenterology, 156(3), 812-+. https://doi.org/10.1053/j.gastro.2018.10.046
Kumar, V., Matzaraki, V., Jaeger, M., Aguirre-Gamboa, R., Johnson, M. D., Netea, M. G., & Wijmenga, C. (2018). A genetic and genomics approach identifies novel pathways of human antifungal immune responses. Medical mycology, 56, S61.
Bonfiglio, F., Henstrom, M., Nag, A., Hadizadeh, F., Zheng, T., Cenit, M. C., Tigchelaar, E., Williams, F., Reznichenko, A., Ek, W. E., Rivera, N. V., Homuth, G., Aghdassi, A. A., Kacprowski, T., Mannikko, M., Karhunen, V., Bujanda, L., Rafter, J., Wijmenga, C., ... D'Amato, M. (2018). A GWAS meta-analysis from 5 population-based cohorts implicates ion channel genes in the pathogenesis of irritable bowel syndrome. Neurogastroenterology and motility, 30(9), [13358]. https://doi.org/10.1111/nmo.13358
Hrdlickova, B., Mulder, C. J., Malamut, G., Meresse, B., Platteel, M., Kamatani, Y., Ricaño-Ponce, I., van Wanrooij, R. L. J., Zorro, M. M., Jan Bonder, M., Gutierrez-Achury, J., Cellier, C., Zhernakova, A., Nijeboer, P., Galan, P., Withoff, S., Lathrop, M., Bouma, G., Xavier, R. J., ... Kumar, V. (2018). A locus at 7p14.3 predisposes to refractory celiac disease progression from celiac disease. European journal of gastroenterology & hepatology, 30(8), 828-837. https://doi.org/10.1097/MEG.0000000000001168
Chen, L., Garmaeva, S., Zhernakova, A., Fu, J., & Wijmenga, C. (2018). A System Biology Perspective on Environment-Host-Microbe Interactions. Human Molecular Genetics, 27(R2), R187-R194. https://doi.org/10.1093/hmg/ddy137
Ghanbari, M., Peters, M. J., de Vries, P. S., Boer, C. G., van Rooij, J. G. J., Lee, Y-C., Kumar, V., Uitterlinden, A. G., Ikram, M. A., Wijmenga, C., Ordovas, J. M., Smith, C. E., van Meurs, J. B. J., Erkeland, S. J., Franco, O. H., & Dehghan, A. (2018). A systematic analysis highlights multiple long non-coding RNAs associated with cardiometabolic disorders. Journal of human genetics, 63(4), 431-446. https://doi.org/10.1038/s10038-017-0403-x
Lifelines Cohort Study, Zhernakova, D. V., Le, T. H., Kurilshikov, A., Atanasovska, B., Bonder, M. J., Sanna, S., Claringbould, A., Võsa, U., Deelen, P., Franke, L., de Boer, R. A., Kuipers, F., Netea, M. G., Hofker, M. H., Wijmenga, C., Zhernakova, A., & Fu, J. (2018). Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome. Nature Genetics, 50(12), [1752]. https://doi.org/10.1038/s41588-018-0275-9
BIOS Consortium, Luijk, R., Wu, H., Ward-Caviness, C. K., Hannon, E., Carnero-Montoro, E., Min, J. L., Mandaviya, P., Mueller-Nurasyid, M., Mei, H., van der Maarel, S. M., Relton, C., Mill, J., Waldenberger, M., Bell, J. T., Jansen, R., Zhernakova, A., Franke, L., 't Hoen, P. A. C., ... Heijmans, B. T. (2018). Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nature Communications, 9(1), 3738. [3738]. https://doi.org/10.1038/s41467-018-05714-3
Arts, R. J. W., Moorlag, S. J. C. F. M., Novakovic, B., Li, Y., Wang, S-Y., Oosting, M., Kumar, V., Xavier, R. J., Wijmenga, C., Joosten, L. A. B., Reusken, C. B. E. M., Benn, C. S., Aaby, P., Koopmans, M. P., Stunnenberg, H. G., van Crevel, R., & Netea, M. G. (2018). BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell Host & Microbe, 23(1), 89-100. https://doi.org/10.1016/j.chom.2017.12.010
Wray, N. R., Wijmenga, C., Sullivan, P. F., Yang, J., & Visscher, P. M. (2018). Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model. Cell, 173(7), 1573-1580. https://doi.org/10.1016/j.cell.2018.05.051
Jackson, M. A., Bonder, M. J., Kuncheva, Z., Zierer, J., Fu, J., Kurilshikov, A., Wijmenga, C., Zhernakova, A., Bell, J. T., Spector, T. D., & Steves, C. J. (2018). Detection of stable community structures within gut microbiota co-occurrence networks from different human populations. PeerJ, 6, [4303]. https://doi.org/10.7717/peerj.4303
Xu, C-J., Söderhäll, C., Bustamante, M., Baïz, N., Gruzieva, O., Gehring, U., Mason, D., Chatzi, L., Basterrechea, M., Llop, S., Torrent, M., Forastiere, F., Fantini, M. P., Carlsen, K. C. L., Haahtela, T., Morin, A., Kerkhof, M., Merid, S. K., van Rijkom, B., ... BIOS Consortium (2018). DNA methylation in childhood asthma: an epigenome-wide meta-analysis. The Lancet. Respiratory Medicine, 6(5), 379-388. https://doi.org/10.1016/S2213-2600(18)30052-3
van der Meulen, T. A., Harmsen, H. J. M., Bootsma, H., Liefers, S. C., Vich Vila, A., Zhernakova, A., Fu, J., Wijmenga, C., Spijkervet, F. K. L., Kroese, F. G. M., & Vissink, A. (2018). Dysbiosis of the buccal mucosa microbiome in primary Sjogren's syndrome patients. Rheumatology, 57(12), 2225-2234. https://doi.org/10.1093/rheumatology/key215
Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., Shilo, S., Lador, D., Vich Vila, A., Zmora, N., Pevsner-Fischer, M., Israeli, D., Kosower, N., Malka, G., Wolf, B. C., ... Segal, E. (2018). Environment dominates over host genetics in shaping human gut microbiota. Nature, 555(7695), 210-228. https://doi.org/10.1038/nature25973
BIOS Consortium, Luijk, R., Dekkers, K. F., van Iterson, M., Arindrarto, W., Claringbould, A., Hop, P., Boomsma, D., van Duijn, C. M., van Greevenbroek, M. M. J., Veldink, J. H., Wijmenga, C., Franke, L., 't Hoend, P. A. C., Jansen, R., van Meurs, J., Mei, H., Slagboomi, P. E., Heijmans, B. T., & van Zwet, E. W. (2018). Genome-wide identification of directed gene networks using large-scale population genomics data. Nature Communications, 9(1), 3097. [3097]. https://doi.org/10.1038/s41467-018-05452-6
Vich Vila, A., Imhann, F., Collij, V., Jankipersadsing, S. A., Gurry, T., Mujagic, Z., Kurilshikov, A., Bonder, M. J., Jiang, X., Tigchelaar, E. F., Dekens, J., Peters, V., Voskuil, M. D., Visschedijk, M. C., van Dullemen, H. M., Keszthelyi, D., Swertz, M. A., Franke, L., Alberts, R., ... Weersma, R. K. (2018). Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome. Science Translational Medicine, 10(472). https://doi.org/10.1126/scitranslmed.aap8914
Lifelines Cohort Study (2018). Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome. Nature Genetics, 50(11), 1524-+. https://doi.org/10.1038/s41588-018-0224-7
Bakker, O. B., Aguirre-Gamboa, R., Sanna, S., Oosting, M., Smeekens, S. P., Jaeger, M., Zorro, M., Vosa, U., Withoff, S., Netea-Maier, R. T., Koenen, H. J. P. M., Joosten, I., Xavier, R. J., Franke, L., Joosten, L. A. B., Kumar, V., Wijmenga, C., Netea, M. G., & Li, Y. (2018). Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses. Nature Immunology, 19(7), 776-786. https://doi.org/10.1038/s41590-018-0121-3
Imhann, F., Vich Vila, A., Bonder, M. J., Fu, J., Gevers, D., Visschedijk, M. C., Spekhorst, L. M., Alberts, R., Franke, L., van Dullemen, H. M., Ter Steege, R. W. F., Huttenhower, C., Dijkstra, G., Xavier, R. J., Festen, E. A. M., Wijmenga, C., Zhernakova, A., & Weersma, R. K. (2018). Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease. Gut, 67(1), 108-119. https://doi.org/10.1136/gutjnl-2016-312135
MiBioGen Consortium Initiative (2018). Meta-analysis of human genome-microbiome association studies: The MiBioGen consortium initiative. Microbiome, 6(1), [101]. https://doi.org/10.1186/s40168-018-0479-3
Coeliac Dis Immunochip Consortium, Rheumatoid Arthrit Consortium Int, Int Scleroderma Grp, Type 1 Diabet Genetics Consortium, Marquez, A., Kerick, M., Zhernakova, A., Gutierrez-Achury, J., Chen, W-M., Onengut-Gumuscu, S., Gonzalez-Alvaro, I., Rodriguez-Rodriguez, L., Rios-Fernandez, R., Gonzalez-Gay, M. A., Mayes, M. D., Raychaudhuri, S., Rich, S. S., Wijmenga, C., & Martin, J. (2018). Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations. Genome medicine, 10(1), [97]. https://doi.org/10.1186/s13073-018-0604-8
Lifelines-DEEP Cohort Study, & BBMRI Metabolomics Consortium (2018). Microbial impact on plasma metabolites is linked to the cardiovascular risk and phenotypes. Atherosclerosis supplements, 32, 118-119.
Vich Vila, A., Imhann, F., Collij, V., Jankipersadsing, S. A., Gurry, T., Mujagic, Z., Kurilshikov, A., Bonder, M. J., Xiaofang, J., Tigchelaar, E., Dekens, J., Peters, V., Voskuil, M. D., Visschedijk, M. C., Eleonora, F. A. M., Dijkstra, G., Masclee, A. A., Hofker, M. H., Xavier, R., ... Weersma, R. K. (2018). OP014 - Analysis of 1792 gut metagenomes reveals microbial treatment targets for inflammatory bowel disease and irritable bowel syndrome. Journal of Crohn's and Colitis, 12, S10. [OP014]. https://doi.org/10.1093/ecco-jcc/jjx180.013
Doestzada, M., Vich Vila, A., Zhernakova, A., Koonen, D. P. Y., Weersma, R. K., Touw, D. J., Kuipers, F., Wijmenga, C., & Fu, J. (2018). Pharmacomicrobiomics: A novel route towards personalized medicine? Protein & cell, 9(5). https://doi.org/10.1007/s13238-018-0547-2
Peters, V., Tigchelaar, E., Campmans-Kuijpers, M., Sheedfar, F., Imhann, F., Dekens, J., Wijmenga, C., Swertz, M., Franke, L., Weersma, R., Dijkstra, G., & Alizadeh, B. (2018). P831 - Habitual dietary intake of Dutch IBD patients differs from population controls: A case-control study. Journal of Crohn's and Colitis, 12, S536-S536. [P831]. https://doi.org/10.1093/ecco-jcc/jjx180.958
Nousiainen, K., Kanduri, K., Ricaño-Ponce, I., Wijmenga, C., Lahesmaa, R., Kumar, V., & Lähdesmäki, H. (2018). snpEnrichR: analyzing co-localization of SNPs and their proxies in genomic regions. Bioinformatics (Oxford, England), 34(23), 4112-4114. https://doi.org/10.1093/bioinformatics/bty460
Wijmenga, C., & Zhernakova, A. (2018). The importance of cohort studies in the post-GWAS era. Nature Genetics, 50(3), 322-328. https://doi.org/10.1038/s41588-018-0066-3
Tunjungputri, R. N., Li, Y., de Groot, P. G., Dinarello, C. A., Smeekens, S. P., Jaeger, M., Doppenberg-Oosting, M., Cruijsen, M., Lemmers, H., Toenhake-Dijkstra, H., Aguirre-Gamboa, R., Kumar, V., Wijmenga, C., Joosten, L. A. B., Netea, M. G., van der Ven, A., & de Mast, Q. (2018). The Inter-Relationship of Platelets with Interleukin-1 beta-Mediated Inflammation in Humans. Thrombosis and Haemostasis, 118(12), 2112-2125. https://doi.org/10.1055/s-0038-1675603
Wijmenga, C. (2018). United European Gastroenterology Research Prize Awardee 2018-Cisca Wijmenga. United European Gastroenterology Journal, 6(8), 1276-1277. https://doi.org/10.1177/2050640618802518

2017

Carmona, F. D., Vaglio, A., Mackie, S. L., Hernández-Rodríguez, J., Monach, P. A., Castañeda, S., Solans, R., Morado, I. C., Narváez, J., Ramentol-Sintas, M., Pease, C. T., Dasgupta, B., Watts, R., Khalidi, N., Langford, C. A., Ytterberg, S., Boiardi, L., Beretta, L., Govoni, M., ... Spanish CGA Group (2017). A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis. American Journal of Human Genetics, 100(1), 64-74. https://doi.org/10.1016/j.ajhg.2016.11.013
Atanasovska, B., Rensen, S. S., van der Sijde, M. R., Marsman, G., Kumar, V., Jonkers, I., Withoff, S., Shiri-Sverdlov, R., Greve, J. W. M., Faber, K. N., Moshage, H., Wijmenga, C., Sluis, van de, B., Hofker, M. H., & Fu, J. (2017). A Liver-Specific Long Noncoding RNA With a Role in Cell Viability Is Elevated in Human Nonalcoholic Steatohepatitis. Hepatology, 66(3), 794-808. https://doi.org/10.1002/hep.29034
Linner, R. K., Marioni, R. E., Rietveld, C. A., Simpkin, A. J., Davies, N. M., Watanabe, K., Armstrong, N. J., Auro, K., Baumbach, C., Bonder, M. J., Buchwald, J., Fiorito, G., Ismail, K., Iurato, S., Joensuu, A., Karell, P., Kasela, S., Lahti, J., Mcrae, A. F., ... BIOS Consortium (2017). An epigenome-wide association study meta-analysis of educational attainment. Molecular Psychiatry, 22(12), 1680-1690. https://doi.org/10.1038/mp.2017.210
Matzaraki, V., Gresnigt, M. S., Jaeger, M., Ricano-Ponce, I., Johnson, M. D., Oosting, M., Franke, L., Withoff, S., Perfect, J. R., Joosten, L. A. B., Kullberg, B. J., van de Veerdonk, F. L., Jonkers, I., Li, Y., Wijmenga, C., Netea, M. G., & Kumar, V. (2017). An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility. PLoS ONE, 12(7), [e0180824]. https://doi.org/10.1371/journal.pone.0180824

2016

Jankipersadsing, S. A., Hadizadeh, F., Bonder, M. J., Tigchelaar, E. F., Deelen, P., Fu, J., Andreasson, A., Agreus, L., Walter, S., Wijmenga, C., Hysi, P., D'Amato, M., & Zhernakova, A. (2017). A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency. Gut, 66(4), 756-758. https://doi.org/10.1136/gutjnl-2016-312398
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