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Wijmenga, Prof. Cisca

Cisca Wijmenga (Photo: NWO/Ivar Pel)
Cisca Wijmenga (Photo: NWO/Ivar Pel)

Prof. Cisca Wijmenga has been Professor of Human Genetics at the University of Groningen and head of the Genetics Department of the University Medical Center Groningen since 2007. The aim of her research is to understand the role that genes play in the development of chronic diseases. Her research group focuses on the genetics of inflammation-related conditions, such as coeliac disease (gluten allergy) and inflammatory intestinal disease (e.g. Crohn’s disease, ulcerative colitis). Research led by Wijmenga has discovered several genes that are involved in causing such immune-related disorders. This knowledge is leading to new insights into the disease process, and could possibly result in new treatments for patients.

Prof. Wijmenga has been elected a member of the Royal Netherlands Academy of Arts and Sciences (KNAW) in 2012. Members of KNAW are all prominent academics from all disciplines and are chosen on the basis of nominations from within and outside the Academy. In the same year she received a prestigious ERC Advanced Grant for her research project on Celiac disease. The BBMRI-NL2.0 project, a collaboration led by Wijmenga between biobanks in the Netherlands, received EUR 9.8 million from NWO in 2014. In 2015 Wijmenga has been awarded a Spinoza Prize, also referred to as the 'Dutch Nobel Prize'.

In 2019 Wijmenga has been appointed as Rector Magnificus of the University of Groningen. She is the first female rector in the 405-year history of the UG.

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Article for NOS
Article for NOS

2020

TANDEM Consortium, Eckold, C., Kumar, V., Weiner Rd, J., Alisjahbana, B., Riza, A-L., ... Cliff, J. M. (2020). Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis. Clinical Infectious Diseases, [ciaa751]. https://doi.org/10.1093/cid/ciaa751
Aguirre-Gamboa, R., de Klein, N., di Tommaso, J., Claringbould, A., Vosa, U., Zorro, M., ... Li, Y. (2020). Deconvolution of bulk blood eQTL effects into immune cell subpopulations. Bmc Bioinformatics, 21(1), [548669]. https://doi.org/10.1101/548669
Lifelines Cohort Study (2020). Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes. Frontiers in Genetics, 11, [613]. https://doi.org/10.3389/fgene.2020.00613
Peters, V., Tigchelaar-Feenstra, E. F., Imhann, F., Dekens, J. A. M., Swertz, M. A., Franke, L. H., ... Campmans-Kuijpers, M. J. E. (2020). Habitual dietary intake of IBD patients differs from population controls: a case-control study. European journal of nutrition. https://doi.org/10.1007/s00394-020-02250-z
Zorro, M. M., Aguirre-Gamboa, R., Mayassi, T., Ciszewski, C., Barisani, D., Hu, S., ... Jonkers, I. H. (2020). Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes. Journal of Autoimmunity, 108, [102422]. https://doi.org/10.1016/j.jaut.2020.102422
Warmink-Perdijk, W. D. B., Peters, L. L., Tigchelaar, E. F., Dekens, J. A. M., Jankipersadsing, S. A., Zhernakova, A., ... Scherjon, S. A. (2020). Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study. European Journal of Epidemiology. https://doi.org/10.1007/s10654-020-00614-7
BIOS Consortium, Ouwens, K. G., Jansen, R., Nivard, M. G., van Dongen, J., Frieser, M. J., ... Franke, L. (2020). A characterization of cis- and trans-heritability of RNA-Seq-based gene expression. European Journal of Human Genetics, 28(2), 253-263. https://doi.org/10.1038/s41431-019-0511-5
Vich Vila, A., Collij, V., Sanna, S., Sinha, T., Imhann, F., Bourgonje, A. R., ... Weersma, R. K. (2020). Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. Nature Communications, 11(1), [362]. https://doi.org/10.1038/s41467-019-14177-z
BBMRI Metabolomics Consortium, Hagenbeek, F. A., Pool, R., van Dongen, J., Draisma, H. H. M., Jan Hottenga, J., ... Boomsma, D. I. (2020). Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Nature Communications, 11(1), [39]. https://doi.org/10.1038/s41467-019-13770-6
Li, C. M., Zhernakova, A., Engstrand, L., Wijmenga, C., & Brusselaers, N. (2020). Systematic review with meta-analysis: the risks of proton pump inhibitors during pregnancy. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/apt.15610

2019

Consortium for the study of genetic associations of celiac disease in Latin-America, Ricaño-Ponce, I., Gutierrez-Achury, J., Costa, A. F., Deelen, P., Kurilshikov, A., ... Wijmenga, C. (2020). Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease. EJHG, 28(3), 313-323. https://doi.org/10.1038/s41431-019-0520-4
Vojinovic, D., Radjabzadeh, D., Kurilshikov, A., Amin, N., Wijmenga, C., Franke, L., ... van Duijn, C. M. (2019). Relationship between gut microbiota and circulating metabolites in population-based cohorts. Nature Communications, 10(1), [5813]. https://doi.org/10.1038/s41467-019-13721-1
Genome Netherlands Consortium, Nersisyan, L., & Nikoghosyan, M. (2019). WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene. Scientific Reports, 9, [18758]. https://doi.org/10.1038/s41598-019-55109-7
Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., ... Wilson, J. F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10(1), [4957]. https://doi.org/10.1038/s41467-019-12283-6
European Scleroderma Group† (2019). GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. Nature Communications, 10(1), [4955]. https://doi.org/10.1038/s41467-019-12760-y
Garmaeva, S., Sinha, T., Kurilshikov, A., Wijmenga, C., Fu, J., & Zhernakova, S. (2019). Studying the gut virome in the metagenomic era: challenges and perspectives. BMC Biology, 17(1), [84]. https://doi.org/10.1186/s12915-019-0704-y
Le, K. T. T., Chu, X., Jaeger, M., Plantinga, J. A., Matzaraki, V., Withoff, S., ... Kumar, V. (2019). Leukocyte-Released Mediators in Response to Both Bacterial and Fungal Infections Trigger IFN Pathways, Independent of IL-1 and TNF-alpha, in Endothelial Cells. Frontiers in Immunology, 10, [2508]. https://doi.org/10.3389/fimmu.2019.02508
BIOS Consortium, van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., ... Boomsma, D. (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biological Psychiatry, 86(8), 599-607. https://doi.org/10.1016/j.biopsych.2019.02.016
Edwards, R. A., Vega, A. A., Norman, H. M., Ohaeri, M., Levi, K., Dinsdale, E. A., ... Dutilh, B. E. (2019). Global phylogeography and ancient evolution of the widespread human gut virus crAssphage. Nature Microbiology, 4(10), 1727-1736. https://doi.org/10.1038/s41564-019-0494-6
Johansson, L. F., van Dijk-Bos, K. K., van der Hout, A. H., Knopperts, A. P., Leegte, B., ter Beest, J., ... Westers, H. (2019). What if we would turn a diagnostic multi-cancer gene panel into a screening tool? European Journal of Human Genetics, 27, 1126-1126.
Jaeger, M., Matzaraki, V., Aguirre-Gamboa, R., Gresnigt, M. S., Chu, X., Johnson, M. D., ... Kumar, V. (2019). A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans. The Journal of Infectious Diseases, 220(5), 862-872. https://doi.org/10.1093/infdis/jiz206
Le, K. T. T., Matzaraki, V., Netea, M. G., Wijmenga, C., Moser, J., & Kumar, V. (2019). Functional Annotation of Genetic Loci Associated With Sepsis Prioritizes Immune and Endothelial Cell Pathways. Frontiers in Immunology, 10, [1949]. https://doi.org/10.3389/fimmu.2019.01949
Porcu, E., Rueger, S., Lepik, K., eQTLgen Consortium, & BIOS Consortium (2019). Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nature Communications, 10, [3300]. https://doi.org/10.1038/s41467-019-10936-0
Chu, X., Jaeger, M., Bakker, O. B., Aguirre-Gamboa, R., Oosting, M., Smeekens, S. P., ... Li, Y. (2019). Integration of similar to 10,000 metabolite features with genotype data and immune phenotypes reveals genetic determinants and common regulatory modules. European Journal of Human Genetics, 27, 787-787.
Jaeger, M., Pinelli, M., Borghi, M., Constantini, C., Dindo, M., van Emst, L., ... Netea, M. G. (2019). A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis. Science Translational Medicine, 11(496), [3558]. https://doi.org/10.1126/scitranslmed.aar3558
Kurilshikov, A., van den Munckhof, I. C., Chen, L., Bonder, M. J., Schraa, K., Rutten, J., ... Fu, J. (2019). Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk: A Cross-Sectional Study. Circulation research, 124(12), 1808-1820. https://doi.org/10.1161/CIRCRESAHA.118.314642
Marquez, A., Kerick, M., Zhernakova, A., Gutierrez-Achury, J., Chen, W-M., Onengut-Gumuscu, S., ... Martin Ibanez, J. (2019). Meta-analysis of immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations. Annals of the Rheumatic Diseases, 78, 170. https://doi.org/10.1136/annrheumdis-2019-eular.402
Moerkens, R., Mooiweer, J., Withoff, S., & Wijmenga, C. (2019). Celiac disease-on-chip: Modeling a multifactorial disease in vitro. United European Gastroenterology Journal, 7(4), 467-476. https://doi.org/10.1177/2050640619836057
Franzosa, E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H. J., Reinker, S., ... Xavier, R. J. (2019). Author Correction: Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nature Microbiology, 4(5), 898. https://doi.org/10.1038/s41564-019-0442-5
Hu, S., Vila, A. V., Gacesa, R., Collij, V., Xavier, R., Stevens, C., ... Weersma, R. K. (2019). In-depth characterization of host-genetics and gut microbiome unravels novel host-microbiome interactions in inflammatory bowel disease. Gastroenterology, 156(6), S34.
Peters, V., Tigchelaar, E., Imhann, F., Dekens, J., Swertz, M., Franke, L., ... Campmans-Kuijpers, M. J. (2019). Sa2029 – Habitual dietary intake of dutch IBD patients differs from population controls: A case-control study. Gastroenterology, 156(6), S477-S478. https://doi.org/10.1016/S0016-5085(19)38052-7 Abstract
BBMRI Metabolomics Consortium (2019). Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine. Neurology, 92(16), E1899-E1911. https://doi.org/10.1212/WNL.0000000000007313
Klaassen, M. A. Y., Imhann, F., Collij, V., Fu, J., Wijmenga, C., Zhernakova, A., ... Weersma, R. K. (2019). Anti-inflammatory Gut Microbial Pathways Are Decreased During Crohn's Disease Exacerbations. Journal of Crohn's and Colitis, 13(11), 1439-1449. https://doi.org/10.1093/ecco-jcc/jjz077
Zeevi, D., Korem, T., Godneva, A., Bar, N., Kurilshikov, A., Lotan-Pompan, M., ... Segal, E. (2019). Structural variation in the gut microbiome associates with host health. Nature, 568(7750), 43-48. https://doi.org/10.1038/s41586-019-1065-y
Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., ... McCarthy, M. I. (2019). Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nature Genetics, 51(4), 600-605. https://doi.org/10.1038/s41588-019-0350-x
Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., ... McCarthy, M. I. (2019). Causal relationshipsbetween gut microbiome, short-chain fatty acids and metabolicdiseases. Nature Genetics, 51, 600-605.
Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., ... Raes, J. (2019). The neuroactive potential of the human gut microbiota in quality of life and depression. Nature Microbiology, 4(4), 623-632. https://doi.org/10.1038/s41564-018-0337-x
Myositis Genetics Consortium, Scleroderma Genetics Consortium, Acosta-Herrera, M., Kerick, M., Gonzalez-Serna, D., Wijmenga, C., ... Martin, J. (2019). Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. Annals of the Rheumatic Diseases, 78(3), 311-319. https://doi.org/10.1136/annrheumdis-2018-214127
BIOS Consortium, & GoNL Consortium (2019). Skewed X-inactivation is common in the general female population. European Journal of Human Genetics, 27(3), 455-465. https://doi.org/10.1038/s41431-018-0291-3
Mayassi, T., Ladell, K., Gudjonson, H., McLaren, J. E., Shaw, D. G., Tran, M. T., ... Jabri, B. (2019). Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Cell, 176(5), 967-981,e19. https://doi.org/10.1016/j.cell.2018.12.039
Franzosa, E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H. J., Reinker, S., ... Xavier, R. J. (2019). Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nature Microbiology, 4(2), 293-305. https://doi.org/10.1038/s41564-018-0306-4
van der Meulen, T. A., Harmsen, H. J. M., Vich Vila, A., Kurilshikov, A., Liefers, S. C., Zhernakova, A., ... Kroese, F. G. M. (2019). Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus. Journal of Autoimmunity, 97, 77-87. https://doi.org/10.1016/j.jaut.2018.10.009
Collij, V., Imhann, F., Vich Vila, A., Fu, J., Dijkstra, G., Festen, E. A. M., ... Weersma, R. K. (2019). SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects. PLoS ONE, 14(1), [0211328]. https://doi.org/10.1371/journal.pone.0211328
Kilpelainen, T. O., Nolte, I. M., van der Most, P. J., Verweij, N., Snieder, H., van der Ende, M. Y., ... Wang, Y. X. (2019). Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications, 10(1), [376]. https://doi.org/10.1038/s41467-018-08008-w
Domínguez-Andrés, J., Novakovic, B., Li, Y., Scicluna, B. P., Gresnigt, M. S., Arts, R. J. W., ... Netea, M. G. (2019). The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity. Cell metabolism, 29(1), 211-220.e5. https://doi.org/10.1016/j.cmet.2018.09.003
FREX Consortium, GoNL Consortium, Kim, A., Savary, C., Dubourg, C., Carre, W., ... David, V. (2019). Integrated clinical and omics approach to rare diseases: novel genes and oligogenic inheritance in holoprosencephaly. Brain, 142(1), 35-49. https://doi.org/10.1093/brain/awy290
Sinha, T., Vila, A. V., Garmaeva, S., Jankipersadsing, S. A., Imhann, F., Collij, V., ... Zhernakova, A. (2019). Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles. Gut Microbes, 10(3), 358-366. https://doi.org/10.1080/19490976.2018.1528822

2018

Uniken Venema, W. T., Voskuil, M. D., Vich Vila, A., van der Vries, G., Jansen, B. H., Jabri, B., ... Festen, E. A. (2019). Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets. Gastroenterology, 156(3), 812-+. https://doi.org/10.1053/j.gastro.2018.10.046
Coeliac Dis Immunochip Consortium, Rheumatoid Arthrit Consortium Int, Int Scleroderma Grp, Type 1 Diabet Genetics Consortium, Marquez, A., Kerick, M., ... Martin, J. (2018). Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations. Genome medicine, 10(1), [97]. https://doi.org/10.1186/s13073-018-0604-8
Vich Vila, A., Imhann, F., Collij, V., Jankipersadsing, S. A., Gurry, T., Mujagic, Z., ... Weersma, R. K. (2018). Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome. Science Translational Medicine, 10(472). https://doi.org/10.1126/scitranslmed.aap8914
Nousiainen, K., Kanduri, K., Ricaño-Ponce, I., Wijmenga, C., Lahesmaa, R., Kumar, V., & Lähdesmäki, H. (2018). snpEnrichR: analyzing co-localization of SNPs and their proxies in genomic regions. Bioinformatics (Oxford, England), 34(23), 4112-4114. https://doi.org/10.1093/bioinformatics/bty460
Lifelines Cohort Study, Zhernakova, D. V., Le, T. H., Kurilshikov, A., Atanasovska, B., Bonder, M. J., ... Fu, J. (2018). Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome. Nature Genetics, 50(12), [1752]. https://doi.org/10.1038/s41588-018-0275-9
van der Meulen, T. A., Harmsen, H. J. M., Bootsma, H., Liefers, S. C., Vich Vila, A., Zhernakova, A., ... Vissink, A. (2018). Dysbiosis of the buccal mucosa microbiome in primary Sjogren's syndrome patients. Rheumatology, 57(12), 2225-2234. https://doi.org/10.1093/rheumatology/key215
Tunjungputri, R. N., Li, Y., de Groot, P. G., Dinarello, C. A., Smeekens, S. P., Jaeger, M., ... de Mast, Q. (2018). The Inter-Relationship of Platelets with Interleukin-1 beta-Mediated Inflammation in Humans. Thrombosis and Haemostasis, 118(12), 2112-2125. https://doi.org/10.1055/s-0038-1675603
Lifelines Cohort Study (2018). Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome. Nature Genetics, 50(11), 1524-+. https://doi.org/10.1038/s41588-018-0224-7
Wijmenga, C. (2018). United European Gastroenterology Research Prize Awardee 2018-Cisca Wijmenga. United European Gastroenterology Journal, 6(8), 1276-1277. https://doi.org/10.1177/2050640618802518
BIOS Consortium, Luijk, R., Wu, H., Ward-Caviness, C. K., Hannon, E., Carnero-Montoro, E., ... Heijmans, B. T. (2018). Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nature Communications, 9(1), 3738. [3738]. https://doi.org/10.1038/s41467-018-05714-3
Bonfiglio, F., Henstrom, M., Nag, A., Hadizadeh, F., Zheng, T., Cenit, M. C., ... D'Amato, M. (2018). A GWAS meta-analysis from 5 population-based cohorts implicates ion channel genes in the pathogenesis of irritable bowel syndrome. Neurogastroenterology and motility, 30(9), [13358]. https://doi.org/10.1111/nmo.13358
BIOS Consortium, Luijk, R., Dekkers, K. F., van Iterson, M., Arindrarto, W., Claringbould, A., ... van Zwet, E. W. (2018). Genome-wide identification of directed gene networks using large-scale population genomics data. Nature Communications, 9(1), 3097. [3097]. https://doi.org/10.1038/s41467-018-05452-6
Chen, L., Garmaeva, S., Zhernakova, A., Fu, J., & Wijmenga, C. (2018). A System Biology Perspective on Environment-Host-Microbe Interactions. Human Molecular Genetics, 27(R2), R187-R194. https://doi.org/10.1093/hmg/ddy137
Hrdlickova, B., Mulder, C. J., Malamut, G., Meresse, B., Platteel, M., Kamatani, Y., ... Kumar, V. (2018). A locus at 7p14.3 predisposes to refractory celiac disease progression from celiac disease. European journal of gastroenterology & hepatology, 30(8), 828-837. https://doi.org/10.1097/MEG.0000000000001168
Bakker, O. B., Aguirre-Gamboa, R., Sanna, S., Oosting, M., Smeekens, S. P., Jaeger, M., ... Li, Y. (2018). Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses. Nature Immunology, 19(7), 776-786. https://doi.org/10.1038/s41590-018-0121-3
Wray, N. R., Wijmenga, C., Sullivan, P. F., Yang, J., & Visscher, P. M. (2018). Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model. Cell, 173(7), 1573-1580. https://doi.org/10.1016/j.cell.2018.05.051
MiBioGen Consortium Initiative (2018). Meta-analysis of human genome-microbiome association studies: The MiBioGen consortium initiative. Microbiome, 6(1), [101]. https://doi.org/10.1186/s40168-018-0479-3
Kumar, V., Matzaraki, V., Jaeger, M., Aguirre-Gamboa, R., Johnson, M. D., Netea, M. G., & Wijmenga, C. (2018). A genetic and genomics approach identifies novel pathways of human antifungal immune responses. Medical mycology, 56, S61.
Lifelines-DEEP Cohort Study, & BBMRI Metabolomics Consortium (2018). Microbial impact on plasma metabolites is linked to the cardiovascular risk and phenotypes. Atherosclerosis supplements, 32, 118-119.
Xu, C-J., Söderhäll, C., Bustamante, M., Baïz, N., Gruzieva, O., Gehring, U., ... BIOS Consortium (2018). DNA methylation in childhood asthma: an epigenome-wide meta-analysis. The Lancet. Respiratory Medicine, 6(5), 379-388. https://doi.org/10.1016/S2213-2600(18)30052-3
Doestzada, M., Vich Vila, A., Zhernakova, A., Koonen, D. P. Y., Weersma, R. K., Touw, D. J., ... Fu, J. (2018). Pharmacomicrobiomics: A novel route towards personalized medicine? Protein & cell, 9(5). https://doi.org/10.1007/s13238-018-0547-2
Ghanbari, M., Peters, M. J., de Vries, P. S., Boer, C. G., van Rooij, J. G. J., Lee, Y-C., ... Dehghan, A. (2018). A systematic analysis highlights multiple long non-coding RNAs associated with cardiometabolic disorders. Journal of human genetics, 63(4), 431-446. https://doi.org/10.1038/s10038-017-0403-x
Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., ... Segal, E. (2018). Environment dominates over host genetics in shaping human gut microbiota. Nature, 555(7695), 210-228. https://doi.org/10.1038/nature25973, https://doi.org/10.1038/nature25973
Wijmenga, C., & Zhernakova, A. (2018). The importance of cohort studies in the post-GWAS era. Nature Genetics, 50(3), 322-328. https://doi.org/10.1038/s41588-018-0066-3
Jackson, M. A., Bonder, M. J., Kuncheva, Z., Zierer, J., Fu, J., Kurilshikov, A., ... Steves, C. J. (2018). Detection of stable community structures within gut microbiota co-occurrence networks from different human populations. PeerJ, 6, [4303]. https://doi.org/10.7717/peerj.4303
Vich Vila, A., Imhann, F., Collij, V., Jankipersadsing, S. A., Gurry, T., Mujagic, Z., ... Weersma, R. K. (2018). OP014 - Analysis of 1792 gut metagenomes reveals microbial treatment targets for inflammatory bowel disease and irritable bowel syndrome. Journal of Crohn's and Colitis, 12, S10. [OP014]. https://doi.org/10.1093/ecco-jcc/jjx180.013
Peters, V., Tigchelaar, E., Campmans-Kuijpers, M., Sheedfar, F., Imhann, F., Dekens, J., ... Alizadeh, B. (2018). P831 - Habitual dietary intake of Dutch IBD patients differs from population controls: A case-control study. Journal of Crohn's and Colitis, 12, S536-S536. [P831]. https://doi.org/10.1093/ecco-jcc/jjx180.958
Arts, R. J. W., Moorlag, S. J. C. F. M., Novakovic, B., Li, Y., Wang, S-Y., Oosting, M., ... Netea, M. G. (2018). BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell Host & Microbe, 23(1), 89-100. https://doi.org/10.1016/j.chom.2017.12.010
Imhann, F., Vich Vila, A., Bonder, M. J., Fu, J., Gevers, D., Visschedijk, M. C., ... Weersma, R. K. (2018). Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease. Gut, 67(1), 108-119. https://doi.org/10.1136/gutjnl-2016-312135

2017

Linner, R. K., Marioni, R. E., Rietveld, C. A., Simpkin, A. J., Davies, N. M., Watanabe, K., ... BIOS Consortium (2017). An epigenome-wide association study meta-analysis of educational attainment. Molecular Psychiatry, 22(12), 1680-1690. https://doi.org/10.1038/mp.2017.210
Tigchelaar, E. F., Mujagic, Z., Zhernakova, A., Hesselink, M. A. M., Meijboom, S., Perenboom, C. W. M., ... Jonkers, D. M. A. E. (2017). Habitual diet and diet quality in Irritable Bowel Syndrome: A case-control study. Neurogastroenterology and motility, 29(12), [13151]. https://doi.org/10.1111/nmo.13151
Nibbeling, E. A. R., Duarri, A., Verschuuren-Bemelmans, C. C., Fokkens, M. R., Karjalainen, J. M., Smeets, C. J. L. M., ... Verbeek, D. S. (2017). Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia. Brain, 140(11), 2860-2878. https://doi.org/10.1093/brain/awx251
Tishkoff, S., Akey, J. M., Lappalainen, T., Ostrander, E. A., Lettre, G., & Wijmenga, C. (2017). Human Genetics: Questions, Challenges, and the Future. Cell, 171(2), 259-260.
Jonkers, I. H., & Wijmenga, C. (2017). Context-specific effects of genetic variants associated with autoimmune disease. Human Molecular Genetics, 26(R2), R185-R192. https://doi.org/10.1093/hmg/ddx254
van Diemen, C. C., Kerstjens-Frederikse, W. S., Bergman, K. A., de Koning, T. J., Sikkema-Raddatz, B., van der Velde, J. K., ... Wijmenga, C. (2017). Rapid Targeted Genomics in Critically Ill Newborns. Pediatrics, 140(4), [20162854]. https://doi.org/10.1542/peds.2016-2854
Atanasovska, B., Rensen, S. S., van der Sijde, M. R., Marsman, G., Kumar, V., Jonkers, I., ... Fu, J. (2017). A Liver-Specific Long Noncoding RNA With a Role in Cell Viability Is Elevated in Human Nonalcoholic Steatohepatitis. Hepatology, 66(3), 794-808. https://doi.org/10.1002/hep.29034
Kurilshikov, A., Wijmenga, C., Fu, J., & Zhernakova, A. (2017). Host Genetics and Gut Microbiome: Challenges and Perspectives. TRENDS IN IMMUNOLOGY, 38(9), 633-647. https://doi.org/10.1016/j.it.2017.06.003
Matzaraki, V., Gresnigt, M. S., Jaeger, M., Ricano-Ponce, I., Johnson, M. D., Oosting, M., ... Kumar, V. (2017). An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility. PLoS ONE, 12(7), [e0180824]. https://doi.org/10.1371/journal.pone.0180824
Nolte, I. M., van der Most, P. J., Alizadeh, B. Z., de Bakker, P. I. W., Boezen, H. M., Bruinenberg, M., ... Snieder, H. (2017). Missing heritability: Is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study. European Journal of Human Genetics, 25(7), 877-885. https://doi.org/10.1038/ejhg.2017.50
Tripathi, S. K., Chen, Z., Larjo, A., Kanduri, K., Nousiainen, K., Aijo, T., ... Lahesmaa, R. (2017). Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation. Cell reports, 19(9), 1888-1901. https://doi.org/10.1016/j.celrep.2017.05.013
Matzaraki, V., Kumar, V., Wijmenga, C., & Zhernakova, A. (2017). The MHC locus and genetic susceptibility to autoimmune and infectious diseases. Genome Biology, 18(76), [76]. https://doi.org/10.1186/s13059-017-1207-1
Nolte, I. M., van der Most, P. J., Alizadeh, B. Z., de Bakker, P. I., Boezen, H. M., Bruinenberg, M., ... Snieder, H. (2017). Missing heritability: Is the gap closing? An analysis of 32 complex traits in the LifeLines Cohort Study. Genetic epidemiology, 39(7), 572-573. https://doi.org/10.1038/ejhg.2017.50
Visser, A. E., Pazoki, R., Pulit, S. L., van Rheenen, W., Raaphorst, J., van der Kooi, A. J., ... van den Berg, L. H. (2017). No association between gluten sensitivity and amyotrophic lateral sclerosis. Journal of Neurology, 264(4), 694-700. https://doi.org/10.1007/s00415-017-8400-8
Mehta, S., Cronkite, D. A., Basavappa, M., Saunders, T. L., Adiliaghdam, F., Amatullah, H., ... Jeffrey, K. L. (2017). Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140. Journal of Reproductive Immunology, 2(9), [3160]. https://doi.org/10.1126/sciimmunol.aag3160
Blanchet, L., Smolinska, A., Baranska, A., Tigchelaar-Feenstra, E., Swertz, M., Zhernakova, A., ... van Schooten, F. J. (2017). Factors that influence the volatile organic compound content in human breath. Journal of breath research, 11(1), [016013]. https://doi.org/10.1088/1752-7163/aa5cc5
Imhann, F., Vich Vila, A., Bonder, M. J., Lopez Manosalva, A. G., Koonen, D. P. Y., Fu, J., ... Weersma, R. K. (2017). The influence of proton pump inhibitors and other commonly used medication on the gut microbiota. Gut Microbes, 8(4), 351-358. https://doi.org/10.1080/19490976.2017.1284732
Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., ... Int Consortium Blood Pressure (2017). Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci. Circulation research, 120(2), 341-353. https://doi.org/10.1161/CIRCRESAHA.116.308765
van der Velde, K. J., de Boer, E. N., van Diemen, C. C., Sikkema-Raddatz, B., Abbott, K. M., Knopperts, A., ... Swertz, M. A. (2017). GAVIN: Gene-Aware Variant INterpretation for medical sequencing. Genome Biology, 18(1), [6]. https://doi.org/10.1186/s13059-016-1141-7
Carmona, F. D., Vaglio, A., Mackie, S. L., Hernández-Rodríguez, J., Monach, P. A., Castañeda, S., ... Spanish CGA Group (2017). A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis. American Journal of Human Genetics, 100(1), 64-74. https://doi.org/10.1016/j.ajhg.2016.11.013
Wahl, S., Drong, A. W., Lehne, B., Loh, M., Scott, W. R., Kunze, S., ... Chambers, J. C. (2017). Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 541(81), 81-86. https://doi.org/10.1038/nature20784
Xu, C-J., Bonder, M. J., Soderhall, C., Bustamante, M., Baiz, N., Gehring, U., ... Koppelman, G. H. (2017). The emerging landscape of dynamic DNA methylation in early childhood. BMC Genomics, 18(25), 25. https://doi.org/10.1186/s12864-016-3452-1
BIOS Consortium (2017). MR-Link: Mendelian Randomization Under Linkage Disequilibrium and Unobserved Pleiotropy. Human heredity, 83(5), 233.
Lepamets, M., Lepik, K., Kals, M., Carmeli, C., Claringbould, A., Bochud, M., ... Kutalik, Z. (2017). New Quality Measure for CNV: A Multi-Omics Approach. Human heredity, 83(1), 16-16.

2016

Jankipersadsing, S. A., Hadizadeh, F., Bonder, M. J., Tigchelaar, E. F., Deelen, P., Fu, J., ... Zhernakova, A. (2017). A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency. Gut, 66(4), 756-758. https://doi.org/10.1136/gutjnl-2016-312398
Ji, S-G., Juran, B. D., Mucha, S., Folseraas, T., Jostins, L., Melum, E., ... Int PSC Study Grp (2017). Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nature Genetics, 49(2), 269-273. https://doi.org/10.1038/ng.3745
Bonder, M. J., Luijk, R., Pital-Zhernakova, D., Moed, M., Deelen, P., Vermaat, M., ... BIOS Consortium (2017). Disease variants alter transcription factor levels and methylation of their binding sites. Nature Genetics, 49(1), 131-138. https://doi.org/10.1038/ng.3721
Pital-Zhernakova, D., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., ... Franke, L. (2017). Identification of context-dependent expression quantitative trait loci in whole blood. Nature Genetics, 49(1), 139-145. https://doi.org/10.1038/ng.3737
Schirmer, M., Smeekens, S. P., Vlamakis, H., Jaeger, M., Oosting, M., Franzosa, E. A., ... Xavier, R. J. (2016). Corrections: Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity (vol 167, pg 1125, 2016). Cell, 167(7), 1897. https://doi.org/10.1016/j.cell.2016.11.046
Amini, M., Bashirova, D., Prins, B. P., Corpeleijn, E., Bruinenberg, M., Franke, L., ... Lifelines Cohort Study (2016). Eosinophil Count Is a Common Factor for Complex Metabolic and Pulmonary Traits and Diseases: The LifeLines Cohort Study. PLoS ONE, 11(12), [e0168480]. https://doi.org/10.1371/journal.pone.0168480
Oosting, M., Kerstholt, M., ter Horst, R., Li, Y., Deelen, P., Smeekens, S., ... Joosten, L. A. B. (2016). Functional and Genomic Architecture of Borrelia burgdorferi-Induced Cytokine Responses in Humans. Cell Host & Microbe, 20(6), 822-833. https://doi.org/10.1016/j.chom.2016.10.006
Graham, D. B., Lefkovith, A., Deelen, P., de Klein, N., Varma, M., Boroughs, A., ... Xavier, R. J. (2016). TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation. Cell reports, 17(11), 2955-2965. https://doi.org/10.1016/j.celrep.2016.11.042
Mancini, I., Ricano-Ponce, I., Pappalardo, E., Cairo, A., Gorski, M. M., Casoli, G., ... Italian Grp TTP Investigators (2016). Immunochip analysis identifies novel susceptibility loci in the human leukocyte antigen region for acquired thrombotic thrombocytopenic purpura. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 14(12), 2356-2367. https://doi.org/10.1111/jth.13548
Aguirre-Gamboa, R., Joosten, I., Urbano, P. C. M., van der Molen, R. G., van Rijssen, E., van Cranenbroek, B., ... Koenen, H. J. P. M. (2016). Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits. Cell reports, 17(9), 2474-2487. https://doi.org/10.1016/j.celrep.2016.10.053
van der Zwaag, P. A., Herkert, J. C., Sarvaas, G. J. D. M., Bartelds, B., van Diemen, C. C., de Koning, T. J., ... Kerstjens-Frederikse, W. S. (2016). Rapid Whole Genome Sequencing for Critically Ill Children With Cardiomyopathy. Circulation, 134.
Li, Y., Oosting, M., Smeekens, S. P., Jaeger, M., Aguirre-Gamboa, R., Le, K. T. T., ... Netea, M. G. (2016). A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans. Cell, 167(4), 1099-1110. https://doi.org/10.1016/j.cell.2016.10.017
ter Horst, R., Jaeger, M., Smeekens, S. P., Oosting, M., Swertz, M. A., Li, Y., ... Netea, M. G. (2016). Host and Environmental Factors Influencing Individual Human Cytokine Responses. Cell, 167(4), 1111-1124. https://doi.org/10.1016/j.cell.2016.10.018
Schirmer, M., Smeekens, S. P., Vlamakis, H., Jaeger, M., Oosting, M., Franzosa, E. A., ... Xavier, R. J. (2016). Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity. Cell, 167(4), 1125-1136. https://doi.org/10.1016/j.cell.2016.10.020
Kuja-Halkola, R., Lebwohl, B., Halfvarson, J., Wijmenga, C., Magnusson, P. K. E., & Ludvigsson, J. F. (2016). Heritability of non-HLA genetics in coeliac disease: a population-based study in 107 000 twins. Gut, 65(11), 1793-1798. https://doi.org/10.1136/gutjnl-2016-311713
Lachmandas, E., Beigier-Bompadre, M., Cheng, S-C., Kumar, V., van Laarhoven, A., Wang, X., ... Netea, M. G. (2016). Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells. European Journal of Immunology, 46(11), 2574-2586. https://doi.org/10.1002/eji.201546259
Hehir-Kwa, J. Y., Marschall, T., Kloosterman, W. P., Francioli, L. C., Baaijens, J. A., Dijkstra, L. J., ... Genome Netherlands Consortium (2016). A high-quality human reference panel reveals the complexity and distribution of genomic structural variants. Nature Communications, 7, [12989]. https://doi.org/10.1038/ncomms12989
Bonder, M. J., Kurilshchikov, A., Tigchelaar-Feenstra, E., Mujagic, Z., Imhann, F., Vich Vila, A., ... Zhernakova, A. (2016). The effect of host genetics on the gut microbiome. Nature Genetics, 48(11), 1407-1412. https://doi.org/10.1038/ng.3663
McCarthy, S., Das, S., Kretzschmar, W., Delaneau, O., Wood, A. R., Teumer, A., ... Haplotype Reference Consortium (2016). A reference panel of 64,976 haplotypes for genotype imputation. Nature Genetics, 48(10), 1279-1283. https://doi.org/10.1038/ng.3643
Li, Y., Oosting, M., Deelen, P., Ricano-Ponce, I., Smeekens, S., Jaeger, M., ... Netea, M. G. (2016). Corrigendum: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi (vol 22, pg 1192, 2016). Nature Medicine, 22(10), 1192. https://doi.org/10.1038/nm1016-1192b
Renauer, P., Coit, P., Hughes, T., Ognenovski, M., Adler, A., Ortiz-Fernandez, L., ... Sawalha, A. H. (2016). Dense Genotyping of Immune Related Loci in a Multi-Ethnic Behcet's Disease Cohort Identifies Genetic Associations in a Long Noncoding RNA Near QSOX2, RASIP1/FUT2, and IL12A-AS1. Arthritis & Rheumatology, 68.
Gensterblum, E., Hughes, T., Martinez-Bueno, M., Borghi, M. O., Pons-Estel, G. J., Espinosa, G., ... Sawalha, A. (2016). Identification of Novel Genetic Susceptibility Loci in Primary Antiphospholipid Syndrome. Arthritis & Rheumatology, 68.
Spanish GCA Grp, UKGCA Consortium, & Vasculitis Clinical Res Consortium (2016). New Insights into the Pathogenesis of Giant Cell Arteritis through a Genome-Wide Association Study. Arthritis & Rheumatology, 68.
van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., ... de Bakker, P. I. W. (2016). 52 Genetic Loci Influencing Myocardial Mass. Journal of the American College of Cardiology, 68(13), 1435-1448. https://doi.org/10.1016/j.jacc.2016.07.729
Slieker, R. C., van Iterson, M., Luijk, R., Beekman, M., Zhernakova, D. V., Moed, M. H., ... BIOS Consortium (2016). Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms. Genome Biology, 17, [191]. https://doi.org/10.1186/s13059-016-1053-6
Visschedijk, M. C., Alberts, R., Mucha, S., Deelen, P., de Jong, D. J., Pierik, M., ... Dutch Initiative on Crohn and Colitis (2016). Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2. PLoS ONE, 11(8), [e0159609]. https://doi.org/10.1371/journal.pone.0159609
Li, Y., Oosting, M., Deelen, P., Ricano-Ponce, I., Smeekens, S., Jaeger, M., ... Netea, M. G. (2016). Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Nature Medicine, 22(8), 952-962. https://doi.org/10.1038/nm.4139
Becker, J., Haas, S. L., Mokrowiecka, A., Wasielica-Berger, J., Ateeb, Z., Bister, J., ... Schumacher, J. (2016). The HLA-DQ beta 1 insertion is a strong achalasia risk factor and displays a geospatial north-south gradient among Europeans. European Journal of Human Genetics, 24(8), 1228-1231. https://doi.org/10.1038/ejhg.2015.262
Netea, M. G., Joosten, L. A. B., Li, Y., Kumar, V., Oosting, M., Smeekens, S., ... Wijmenga, C. (2016). Understanding human immune function using the resources from the Human Functional Genomics Project. Nature Medicine, 22(8), 831-833. https://doi.org/10.1038/nm.4140
Baranska, A., Mujagic, Z., Smolinska, A., Dallinga, J. W., Jonkers, D. M. A. E., Tigchelaar, E. F., ... van Schooten, F. J. (2016). Volatile organic compounds in breath as markers for irritable bowel syndrome: a metabolomic approach. Alimentary Pharmacology & Therapeutics, 44(1), 45-56. https://doi.org/10.1111/apt.13654
Dekkers, K. F., van Iterson, M., Slieker, R. C., Moed, M. H., Bonder, M. J., van Galen, M., ... BIOS Consortium (2016). Blood lipids influence DNA methylation in circulating cells. Genome Biology, 17, [138]. https://doi.org/10.1186/s13059-016-1000-6
Mujagic, Z., Tigchelaar, E. F., Zhernakova, A., Ludwig, T., Ramiro-Garcia, J., Baranska, A., ... Jonkers, D. M. A. E. (2016). A novel biomarker panel for irritable bowel syndrome and the application in the general population. Scientific Reports, 6, [26420]. https://doi.org/10.1038/srep26420
Prins, B. P., Abbasi, A., Wong, A., Vaez, A., Nolte, I., Franceschini, N., ... Inflammation Working Grp CHARGE Co (2016). Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. PLOS MEDICINE, 13(6), [e1001976]. https://doi.org/10.1371/journal.pmed.1001976
Spijkerman, M., Tan, I. L., Kolkman, J. J., Withoff, S., Wijmenga, C., Visschedijk, M. C., & Weersma, R. K. (2016). A large variety of clinical features and concomitant disorders in celiac disease: A cohort study in the Netherlands. Digestive and Liver Disease, 48(5), 499-505. https://doi.org/10.1016/j.dld.2016.01.006
Imhann, F., Bonder, M. J., Vich Vila, A., Fu, J., Mujagic, Z., Vork, L., ... Zhernakova, A. (2016). Proton pump inhibitors affect the gut microbiome. Gut, 65(5), 740-748. https://doi.org/10.1136/gutjnl-2015-310376
Withoff, S., Li, Y., Jonkers, I., & Wijmenga, C. (2016). Understanding Celiac Disease by Genomics. Trends in Genetics, 32(5), 295-308. https://doi.org/10.1016/j.tig.2016.02.003
Zhernakova, A., Kurilshchikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., ... Lifelines Cohort Study (2016). Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science, 352(6285), 565-569. https://doi.org/10.1126/science.aad3369
Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., ... Raes, J. (2016). Population-level analysis of gut microbiome variation. Science, 352(6285), 560-564. https://doi.org/10.1126/science.aad3503
Bonder, M. J., Tigchelaar, E. F., Cai, X., Trynka, G., Cenit, M. C., Hrdlickova, B., ... Zhernakova, A. (2016). The influence of a short-term gluten-free diet on the human gut microbiome. Genome medicine, 8(45), [45]. https://doi.org/10.1186/s13073-016-0295-y
Imhann, F., Vila, A. V., Bonder, M. J., Gevers, D., Fu, J., Visschedijk, M. C., ... Weersma, R. K. (2016). Gene-Microbiome Interactions Underlying the Onset and the Clinical Phenotypes of Inflammatory Bowel Disease. Gastroenterology, 150(4), S22-S22. https://doi.org/10.1016/S0016-5085(16)30198-6
Visschedijk, M. C., Alberts, R., Mucha, S., Deelen, P., de Jong, D. J., Pierik, M., ... Weersma, R. K. (2016). Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Population Suggests Population-Specific Association of Rare Variants in MUC2. Gastroenterology, 150(4), S570-S571.
Ricano-Ponce, I., Zhernakova, D., Deelen, P., Luo, O., Li, X., Isaacs, A., ... BIOS Consortium Lifelines Cohort S (2016). Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs. Journal of Autoimmunity, 68, 62-74. https://doi.org/10.1016/j.jaut.2016.01.002
Li, M., Rothwell, R., Vermaat, M., Wachsmuth, M., Schroeder, R., Laros, J. F. J., ... Genome Netherlands Consortium (2016). Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck. Genome Research, 26(4), 417-426. https://doi.org/10.1101/gr.203216.115
Tigchelaar , E. F., Bonder, M. J., Jankipersadsing, S. A., Fu, J., Wijmenga, C., & Zhernakova, A. (2016). Gut microbiota composition associated with stool consistency. Gut, 65(3), 540-542. https://doi.org/10.1136/gutjnl-2015-310328
Imhann, F., Bonder, M. J., Vich Vila, A., Fu, J., Mujagic, Z., Vork, L., ... Zhernakova, A. (2016). Proton pump inhibitors affect the gut microbiome. Journal of Crohn's and Colitis, 10, S487-S487.
Coleman, C., Quinn, E. M., Ryan, A. W., Conroy, J., Trimble, V., Mahmud, N., ... McManus, R. (2016). Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci. European Journal of Human Genetics, 24, 291-297. https://doi.org/10.1038/ejhg.2015.87
Gutierrez-Achury, J., Zorro , M. M., Ricano-Ponce, I., Zhernakova, D. V., Diogo, D., Raychaudhuri, S., ... RACI Consortium (2016). Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis. Human Molecular Genetics, 25(1), 180-190. https://doi.org/10.1093/hmg/ddv455

2015

Franke, L., El Bannoudi, H., Jansen, D. T. S. L., Kok, K., Trynka, G., Diogo, D., ... Zhernakova, A. (2016). Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes. European Journal of Human Genetics, 24(2), 263-270. https://doi.org/10.1038/ejhg.2015.95
Atanasovska, B., Kumar, V., Fu, J., Wijmenga, C., & Hofker, M. H. (2015). GWAS as a Driver of Gene Discovery in Cardiometabolic Diseases. Trends in endocrinology and metabolism, 26(12), 722-732. https://doi.org/10.1016/j.tem.2015.10.004
van Asch, C. J. J., Velthuis, B. K., Rinkel, G. J. E., Algra, A., de Kort, G. A. P., Witkamp, T. D., ... DIAGRAM Investigators (2015). Diagnostic yield and accuracy of CT angiography, MR angiography, and digital subtraction angiography for detection of macrovascular causes of intracerebral haemorrhage: prospective, multicentre cohort study. British Medical Journal, 351, [5762]. https://doi.org/10.1136/bmj.h5762
Keating, B. J., van Setten, J., Jacobson, P. A., Holmes, M. V., Verma, S. S., Chandrupatla, H. R., ... Int Genetics & Translational Res T (2015). Design and Implementation of the International Genetics and Translational Research in Transplantation Network. Transplantation, 99(11), 2401-2412. https://doi.org/10.1097/TP.0000000000000913
Scales, C. D., Bergman, J., Carter, S., Jack, G., Saigal, C. S., Litwin, M. S., & NIDDK Urologic Dis Amer Project (2015). Quality of Acute Care for Patients With Urinary Stones in the United States. Urology, 86(5), 914-921. https://doi.org/10.1016/j.urology.2015.07.040
Kato, N., Loh, M., Takeuchi, F., Verweij, N., Wang, X., Zhang, W., ... InterAct Consortium (2015). Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nature Genetics, 47(11), 1282-1293.e2. https://doi.org/10.1038/ng.3405
Cao, Z., Conway, K. L., Heath, R. J., Rush, J. S., Leshchiner, E. S., Ramirez-Ortiz, Z. G., ... Xavier, R. J. (2015). Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation. Immunity, 43(4), 715-726. https://doi.org/10.1016/j.immuni.2015.10.005
Fu, J., Bonder, M. J., Cenit, M. C., Tigchelaar-Feenstra, E., Maatman, A., Dekens, J. A. M., ... Zhernakova, A. (2015). The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids. Circulation research, 117(9), 817-824. https://doi.org/10.1161/CIRCRESAHA.115.306807
Li, Y. R., van Setten, J., Verma, S. S., Lu, Y., Holmes, M. V., Gao, H., ... Keating, B. J. (2015). Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies. Genome medicine, 7, [90]. https://doi.org/10.1186/s13073-015-0211-x
Gutierrez-Achury, J., Romanos, J., Bakker, S. F., Magadi Gopalaiah, V. K., de Haas, E. C., Trynka, G., ... Type 1 Diabet Genetics Consortium (2015). Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity. Diabetes Care, 38, S37-S44. https://doi.org/10.2337/dcs15-2007
Yang, J., Bakshi, A., Zhu, Z., Hemani, G., Vinkhuyzen, A. A. E., Lee, S. H., ... Lifelines Cohort Study (2015). Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nature Genetics, 47(10), 1114-1120. https://doi.org/10.1038/ng.3390
Lundin, K. E. A., & Wijmenga, C. (2015). Coeliac disease and autoimmune disease-genetic overlap and screening. Nature Reviews Gastroenterology & Hepatology, 12(9), 507-515. https://doi.org/10.1038/nrgastro.2015.136
van Leeuwen, E. M., Kanterakis, A., Deelen, P., Kattenberg, M. V., Slagboom, P. E., de Bakker, P. I. W., ... Genome Netherlands Consortium (2015). Population-specific genotype imputations using minimac or IMPUTE2. Nature protocols, 10(9), 1285-1296. https://doi.org/10.1038/nprot.2015.077
Cameron, A. P., Lai, J., Saigal, C. S., Clemens, J. Q., & NIDDK Urological Dis Amer Project (2015). Urological Surveillance and Medical Complications after Spinal Cord Injury in the United States. Urology, 86(3), 506-510. https://doi.org/10.1016/j.urology.2015.06.005
Lenz, T. L., Deutsch, A. J., Han, B., Hu, X., Okada, Y., Eyre, S., ... Raychaudhuri, S. (2015). Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. Nature Genetics, 47(9), 1085-1092. https://doi.org/10.1038/ng.3379
Scholtens, S., Smidt, N., Swertz, M. A., Bakker, S. J. L., Dotinga, A., Vonk, J. M., ... Stolk, R. P. (2015). Cohort Profile: LifeLines, a three-generation cohort study and biobank. International Journal of Epidemiology, 44(4), 1172-1180. https://doi.org/10.1093/ije/dyu229
Shah, S., Bonder, M. J., Marioni, R. E., Zhu, Z., McRae, A. F., Zhernakova, A., ... BIOS Consortium (2015). Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations. American Journal of Human Genetics, 97(1), 75-85. https://doi.org/10.1016/j.ajhg.2015.05.014
Emilsson, L., Wijmenga, C., Murray, J. A., & Ludvigsson, J. F. (2015). Autoimmune Disease in First-Degree Relatives and Spouses of Individuals With Celiac Disease. Clinical Gastroenterology and Hepatology, 13(7), 1271-1277.e2. https://doi.org/10.1016/j.cgh.2015.01.026
van der Velde, K. J., Kuiper, J., Thompson, B. A., Plazzer, J-P., van Valkenhoef, G., de Haan, M., ... InSiGHT Grp (2015). Evaluation of CADD Scores in Curated Mismatch Repair Gene Variants Yields a Model for Clinical Validation and Prioritization. Human Mutation, 36(7), 712-719. https://doi.org/10.1002/humu.22798
Francioli, L. C., Polak, P. P., Koren, A., Menelaou, A., Chun, S., Renkens, I., ... Genome Netherlands Consortium (2015). Genome-wide patterns and properties of de novo mutations in humans. Nature Genetics, 47(7), 822-826.e3. https://doi.org/10.1038/ng.3292
Begun, J., Lassen, K. G., Jijon, H. B., Baxt, L. A., Goel, G., Heath, R. J., ... Xavier, R. J. (2015). Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy. Cell reports, 11(12), 1905-1918. https://doi.org/10.1016/j.celrep.2015.05.045
Kloosterman, W. P., Francioli, L. C., Hormozdiari, F., Marschall, T., Hehir-Kwa, J. Y., Abdellaoui, A., ... Genome Netherlands Consortium (2015). Characteristics of de novo structural changes in the human genome. Genome Research, 25(6), 792-801. https://doi.org/10.1101/gr.185041.114
Gutierrez-Achury, J., Zhernakova, A., Pulit, S. L., Trynka, G., Hunt, K. A., Romanos, J., ... de Balcker, P. I. W. (2015). Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease. Nature Genetics, 47(6), 577-578. https://doi.org/10.1038/ng.3268
Ricano-Ponce, I., Wijmenga, C., & Gutierrez-Achury, J. (2015). Genetics of celiac disease. Best practice & research in clinical gastroenterology, 29(3), 399-412. https://doi.org/10.1016/j.bpg.2015.04.004
van Gerven, N. M. F., de Boer, Y. S., Zwiers, A., Verwer, B. J., Drenth, J. P. H., van Hoek, B., ... Dutch Autoimmune Hepatitis Study G (2015). HLA-DRB1*03: 01 and HLA-DRB1*04:01 modify the presentation and outcome in autoimmune hepatitis type-1. GENES AND IMMUNITY, 16(4), 247-252. https://doi.org/10.1038/gene.2014.82
Dijkstra, A. E., Smolonska, J., van den Berge, M., Wijmenga, C., Zanen, P., Luinge, M. A., ... Lifelines Cohort Study (2015). Correction: Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study. PLoS ONE, 10(5), [e0129524]. https://doi.org/10.1371/journal.pone.0129524
Dobon, B., Hassan, H. Y., Laayouni, H., Luisi, P., Ricano-Ponce, I., Zhernakova, A., ... Bertranpetit, J. (2015). The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape. Scientific Reports, 5, [09996]. https://doi.org/10.1038/srep09996
Westra, H-J., Arends, D., Esko, T., Peters, M. J., Schurmann, C., Schramm, K., ... Franke, L. (2015). Cell Specific eQTL Analysis without Sorting Cells. PLoS genetics, 11(5), [1005223]. https://doi.org/10.1371/journal.pgen.1005223
Jaeger, M., van der Lee, R., Cheng, S-C., Johnson, M. D., Magadi Gopalaiah, V. K., Ng, A., ... Netea, M. G. (2015). The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections. European Journal of Clinical Microbiology & Infectious Diseases, 34(5), 963-974. https://doi.org/10.1007/s10096-014-2309-2
Fu, J., Hofker, M., & Wijmenga, C. (2015). Apple or Pear: Size and Shape Matter. Cell metabolism, 21(4), 507-508. https://doi.org/10.1016/j.cmet.2015.03.016
David Carmona, F., Mackie, S. L., Martin, J-E., Taylor, J. C., Vaglio, A., Eyre, S., ... Spanish GCA Grp (2015). A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility. American Journal of Human Genetics, 96(4), 565-580. https://doi.org/10.1016/j.ajhg.2015.02.009
Senapati, S., Gutierrez-Achury, J., Sood, A., Midha, V., Szperl, A., Romanos, J., ... Trynka, G. (2015). Evaluation of European coeliac disease risk variants in a north Indian population. European Journal of Human Genetics, 23(4), 530-535. https://doi.org/10.1038/ejhg.2014.137
Segre, A. V., Wei, N., Altshuler, D., Florez, J. C., DIAGRAM Consortium, & MAGIC Investigators (2015). Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk. Diabetes, 64(4), 1470-1483. https://doi.org/10.2337/db14-0703
Deelen, P., Zhernakova, D. V., de Haan, M., van der Sijde, M., Bonder, M. J., Karjalainen, J., ... Franke, L. (2015). Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels. Genome medicine, 7(1), [30]. https://doi.org/10.1186/s13073-015-0152-4
Zhu, Z., Bakshi, A., Vinkhuyzen, A. A. E., Hemani, G., Lee, S. H., Nolte, I. M., ... Lifelines Cohort Study (2015). Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits. American Journal of Human Genetics, 96(3), 377-385. https://doi.org/10.1016/j.ajhg.2015.01.001
Dijkstra, A. E., Postma, D. S., van Ginneken, B., Wielpuetz, M. O., Schmidt, M., Becker, N., ... Groen, H. (2015). Novel Genes for Airway Wall Thickness Identified with Combined Genome-Wide Association and Expression Analyses. American Journal of Respiratory and Critical Care Medicine, 191(5), 547-556. https://doi.org/10.1164/rccm.201405-0840OC
Bossini-Castillo, L., de Kovel, C., Kallberg, H., van 't Slot, R., Italiaander, A., Coenen, M., ... Lifelines Cohort Study (2015). A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. Annals of the Rheumatic Diseases, 74(3), [15]. https://doi.org/10.1136/annrheumdis-2013-204591
van Leeuwen, E. M., Karssen, L. C., Deelen, J., Isaacs, A., Medina-Gomez, C., Mbarek, H., ... Genome Netherlands Consortium (2015). Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels. Nature Communications, 6, [6065]. https://doi.org/10.1038/ncomms7065
Wessels, M. M. S., Vriezinga, S. L., Koletzko, S., Werkstetter, K., Castillejo-De Villasante, G., Shamir, R., ... PreventCD Study Grp (2015). Impact on parents of HLA-DQ2/DQ8 genotyping in healthy children from coeliac families. European Journal of Human Genetics, 23(3), 405-408. https://doi.org/10.1038/ejhg.2014.113
Wolfs, M. G. M., Gruben, N., Rensen, S. S., Verdam, F. J., Greve, J. W., Driessen, A., ... Fu, J. (2015). Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity. Nutrition & Diabetes, 5, [146]. https://doi.org/10.1038/nutd.2014.43
Fehrmann, R. S. N., Karjalainen, J. M., Krajewska, M., Westra, H-J., Maloney, D., Simeonov, A., ... Franke, L. (2015). Gene expression analysis identifies global gene dosage sensitivity in cancer. Nature Genetics, 47(2), 115-125. https://doi.org/10.1038/ng.3173
Schaefer, A. S., Bochenek, G., Jochens, A., Ellinghaus, D., Dommisch, H., Guezeldemir-Akcakanat, E., ... Schreiber, S. (2015). Genetic Evidence for PLASMINOGEN as a Shared Genetic Risk Factor of Coronary Artery Disease and Periodontitis. Circulation-Cardiovascular Genetics, 8(1), 159-167. https://doi.org/10.1161/CIRCGENETICS.114.000554
Palles, C., Chegwidden, L., Li, X., Findlay, J. M., Farnham, G., Giner, F. C., ... Jankowski, J. (2015). Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett's Esophagus. Gastroenterology, 148(2), 367-378. https://doi.org/10.1053/j.gastro.2014.10.041
Swerdlow, D. I., Preiss, D., Kuchenbaecker, K. B., Holmes, M. V., Engmann, J. E. L., Shah, T., ... InterAct Consortium (2015). HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. The Lancet, 385(9965), 351-361. https://doi.org/10.1016/S0140-6736(14)61183-1
Kumar, V., Gutierrez-Achury, J., Kanduri, K., Almeida, R., Hrdlickova, B., Zhernakova, D. V., ... Withoff, S. (2015). Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels. Human Molecular Genetics, 24(2), 397-409. https://doi.org/10.1093/hmg/ddu453
Dijkstra, A. E., Boezen, H., van den Berge, M., Vonk, J. M., Hiemstra, P. S., Barr, R. G., ... the LifeLines Cohort Study group (2015). Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD. European Respiratory Journal, 45(1), 60-75. https://doi.org/10.1183/09031936.00093314
Tigchelaar-Feenstra, E. F., Zhernakova, A., Dekens, J. A. M., Hermes, G., Baranska, A., Mujagic, Z., ... Feskens, E. J. M. (2015). Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: Study design and baseline characteristics. BMJ Open, 5(8), [e006772]. https://doi.org/10.1136/bmjopen-2014-006772

2014

Nijmeijer, R. M., Schaap, F. G., Smits, A. J. J., Kremer, A. E., Akkermans, L. M. A., Kroese, A. B. A., ... van Erpecum, K. J. (2014). Impact of Global Fxr Deficiency on Experimental Acute Pancreatitis and Genetic Variation in the FXR Locus in Human Acute Pancreatitis. PLoS ONE, 9(12), [e114393]. https://doi.org/10.1371/journal.pone.0114393
Schaefer, A. S., Jochens, A., Dommisch, H., Graetz, C., Jockel-Schneider, Y., Harks, I., ... Loos, B. G. (2014). A large candidate-gene association study suggests genetic variants at IRF5 and PRDM1 to be associated with aggressive periodontitis. Journal of Clinical Periodontology, 41(12), 1122-1131. https://doi.org/10.1111/jcpe.12314
Kumar, V., Wijmenga, C., & Xavier, R. J. (2014). Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism. Current opinion in immunology, 31, 51-57. https://doi.org/10.1016/j.coi.2014.09.007
Deelen, P., Menelaou, A., van Leeuwen, E. M., Kanterakis, A., van Dijk, F., Medina-Gomez, C., ... Genome Netherlands Consortium (2014). Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'. European Journal of Human Genetics, 22(11), 1321-1326. https://doi.org/10.1038/ejhg.2014.19
Buffen, K., Oosting, M., Quintin, J., Ng, A., Kleinnijenhuis, J., Magadi Gopalaiah, V. K., ... Joosten, L. A. B. (2014). Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer. PLoS Pathogens, 10(10), [e1004485]. https://doi.org/10.1371/journal.ppat.1004485
Hrdlickova, B., Kumar, V., Kanduri, K., Zhernakova, D. V., Tripathi, S., Karjalainen, J., ... Withoff, S. (2014). Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity. Genome medicine, 6(10), [88]. https://doi.org/10.1186/s13073-014-0088-0
Bonder, M. J., Kasela, S., Kals, M., Tamm, R., Lokk, K., Barragan, I., ... Milani, L. (2014). Genetic and epigenetic regulation of gene expression in fetal and adult human livers. BMC Genomics, 15(860). https://doi.org/10.1186/1471-2164-15-860
Vriezinga, S. L., Auricchio, R., Bravi, E., Castillejo, G., Chmielewska, A., Crespo Escobar, P., ... Mearin, M. L. (2014). Randomized Feeding Intervention in Infants at High Risk for Celiac Disease. New England Journal of Medicine, 371(14), 1304-1315. https://doi.org/10.1056/NEJMoa1404172
Smolonska, J., Koppelman, G. H., Wijmenga, C., Vonk, J. M., Zanen, P., Bruinenberg, M., ... Postma, D. S. (2014). Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis. European Respiratory Journal, 44(4), 860-872. https://doi.org/10.1183/09031936.00001914
Hofker, M. H., Fu, J., & Wijmenga, C. (2014). The genome revolution and its role in understanding complex diseases. Biochimica et biophysica acta-Molecular basis of disease, 1842(10), 1889-1895. https://doi.org/10.1016/j.bbadis.2014.05.002
Saeed, S., Quintin, J., Kerstens, H. H. D., Rao, N. A., Aghajanirefah, A., Matarese, F., ... Stunnenberg, H. G. (2014). Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science, 345(6204), [1251086]. https://doi.org/10.1126/science.1251086
Cheng, S-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., ... Netea, M. G. (2014). mTOR- and HIF-1 alpha-mediated aerobic glycolysis as metabolic basis for trained immunity. Science, 345(6204), [1250684]. https://doi.org/10.1126/science.1250684
Kumar, V., Cheng, S-C., Johnson, M. D., Smeekens, S. P., Wojtowicz, A., Giamarellos-Bourboulis, E., ... Netea, M. G. (2014). Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia. Nature Communications, 5, [4675]. https://doi.org/10.1038/ncomms5675
Mujagic, Z., Tigchelaar, E., Smolinska, A., Zhernakova, S., Baranska, A., Swertz, M., ... Jonkers, D. (2014). Intestinal and systemic immune markers in patients with Irritable Bowel Syndrome. Neurogastroenterology and motility, 26, 34-34.
Li, N., van der Sijde, M. R., Bakker, S. J. L., Dullaart, R. P. F., van der Harst, P., Gansevoort, R. T., ... LifeLines Cohort Study Group (2014). Pleiotropic effects of lipid genes on plasma glucose, HbA1c, and HOMA-IR levels. Diabetes, 63(9), 3149-3158. https://doi.org/10.2337/db13-1800
Kilarski, L. L., Achterberg, S., Devan, W. J., Traylor, M., Malik, R., Lindgren, A., ... Int Stroke Genetics Consortium (2014). Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology, 83(8), 678-685.
Gockel, I., Becker, J., Wouters, M. M., Niebisch, S., Gockel, H. R., Hess, T., ... Schumacher, J. (2014). Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia. Nature Genetics, 46(8), 901-904. https://doi.org/10.1038/ng.3029
Cleynen, I., Vazeille, E., Artieda, M., Verspaget, H. W., Szczypiorska, M., Bringer, M-A., ... Darfeuille-Michaud, A. (2014). Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease. Gut, 63(8), 1265-1274. https://doi.org/10.1136/gutjnl-2012-303205
de Boer, Y. S., van Gerven, N. M. F., Zwiers, A., Verwer, B. J., van Hoek, B., van Erpecum, K. J., ... Dutch Autoimmune Hepatitis Study Group (2014). Genome-wide association study identifies variants associated with autoimmune hepatitis type 1. Gastroenterology, 147(2), 443-452.e5. https://doi.org/10.1053/j.gastro.2014.04.022
Steck, A. K., Dong, F., Wong, R., Fouts, A., Liu, E., Romanos, J., ... Rewers, M. J. (2014). Improving prediction of type 1 diabetes by testing non-HLA genetic variants in addition to HLA markers. Pediatric Diabetes, 15(5), 355-362. https://doi.org/10.1111/pedi.12092
Francioli, L. C., Menelaou, A., Pulit, S. L., Van Dijk, F., Palamara, P. F., Elbers, C. C., ... Lifelines Cohort Study (2014). Whole-genome sequence variation, population structure and demographic history of the Dutch population. Nature Genetics, 46(8), 818-825. https://doi.org/10.1038/ng.3021
Simino, J., Shi, G., Bis, J. C., Chasman, D. I., Ehret, G. B., Gu, X., ... Lifelines Cohort Study (2014). Gene-Age Interactions in Blood Pressure Regulation: A Large-Scale Investigation with the CHARGE, Global BPgen, and ICBP Consortia. American Journal of Human Genetics, 95(1), 24-38. https://doi.org/10.1016/j.ajhg.2014.05.010
Shamir, R., Heyman, M. B., Koning, F., Wijmenga, C., Gutierrez Achury, J., Catassi, C., ... Troncone, R. (2014). Celiac Disease: Past, Present, and Future Challenges Dedicated to the Memory of Our Friend and Colleague, Prof David Branski (1944-2013). Journal of Pediatric Gastroenterology and Nutrition, 59(Suppl. 1), S1-S1.
Wijmenga, C., & Gutierrez Achury, J. (2014). Celiac Disease Genetics: Past, Present and Future Challenges. Journal of Pediatric Gastroenterology and Nutrition, 59, S4-S7. https://doi.org/10.1097/01.mpg.0000450392.23156.10
Li, H., Chan, L., Bartuzi, P., Melton, S. D., Weber, A., Ben-Shlomo, S., ... Burstein, E. (2014). Copper Metabolism Domain-Containing 1 Represses Genes That Promote Inflammation and Protects Mice From Colitis and Colitis-Associated Cancer. Gastroenterology, 147(1), 184-195.e3. https://doi.org/10.1053/j.gastro.2014.04.007
Loth, D. W., Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., ... London, S. J. (2014). Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nature Genetics, 46(7), 669-677. https://doi.org/10.1038/ng.3011
Kallionpaa, H., Elo, L. L., Laajala, E., Mykkanen, J., Ricano-Ponce, I., Vaarma, M., ... Lahesmaa, R. (2014). Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility. Diabetes, 63(7), 2402-2414. https://doi.org/10.2337/db13-1775
Rostami-Nejad, M., Romanos, J., Rostami, K., Ganji, A., Ehsani-Ardakani, M. J., Bakhshipour, A-R., ... Wijmenga, C. (2014). Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients. World Journal of Gastroenterology, 20(20), 6302-6308. https://doi.org/10.3748/wjg.v20.i20.6302
de Almeida, R., Ricaño Ponce, I., Kumar, V., Deelen, P., Szperl, A., Trynka, G., ... Wijmenga, C. (2014). Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant. Human Molecular Genetics, 23(9), 2481-2489. https://doi.org/10.1093/hmg/ddt619
Yoneyama, S., Guo, Y., Lanktree, M. B., Barnes, M. R., Elbers, C. C., Karczewski, K. J., ... CARe IBC Consortium (2014). Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Human Molecular Genetics, 23(9), 2498-2510. https://doi.org/10.1093/hmg/ddt626
Fransen, K., van Sommeren, S., Westra, H. J., Veenstra, M., Lamberts, L. E., Modderman, R., ... van Diemen, C. C. (2014). Correlation of Genetic Risk and Messenger RNA Expression in a Th17/IL23 Pathway Analysis in Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 20(5), 777-782. https://doi.org/10.1097/MIB.0000000000000013
Dijkstra, A. E., Smolonska, J., van den Berge, M., Wijmenga, C., Zanen, P., Luinge, M. A., ... Lifelines Cohort Study (2014). Susceptibility to chronic mucus hypersecretion, a genome wide association study. PLoS ONE, 9(4), [e91621]. https://doi.org/10.1371/journal.pone.0091621
Vonk, W. I. M., Kakkar, V., Bartuzi, P., Jaarsma, D., Berger, R., Hofker, M. H., ... van de Sluis, B. (2014). The Copper Metabolism MURR1 Domain Protein 1 (COMMD1) Modulates the Aggregation of Misfolded Protein Species in a Client-Specific Manner. PLoS ONE, 9(4), [e92408]. https://doi.org/10.1371/journal.pone.0092408
Tragante, V., Barnes, M. R., Ganesh, S. K., Lanktree, M. B., Guo, W., Franceschini, N., ... Keating, B. J. (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics, 94(3), 349-360. https://doi.org/10.1016/j.ajhg.2013.12.016
Romanos, J., Rosen, A., Magadi Gopalaiah, V. K., Trynka, G., Franke, L., Szperl, A., ... PreventCD Grp (2014). Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants. Gut, 63(3), 415-422. https://doi.org/10.1136/gutjnl-2012-304110
Scholtens, S., Postma, D. S., Moffatt, M. F., Panasevich, S., Granell, R., Henderson, A. J., ... GABRIELA Study Grp (2014). Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure. Journal of Allergy and Clinical Immunology, 133(3), 885-888. https://doi.org/10.1016/j.jaci.2013.08.049
Bondar, C., Plaza-Izurieta, L., Fernandez-Jimenez, N., Irastorza, I., Withoff, S., Wijmenga, C., ... CEGEC (2014). THEMIS and PTPRK in celiac intestinal mucosa: Coexpression in disease and after in vitro gliadin challenge. European Journal of Human Genetics, 22(3), 358-362. https://doi.org/10.1038/ejhg.2013.136
Laayouni, H., Oosting, M., Luisi, P., Ioana, M., Alonso, S., Ricaño Ponce, I., ... Netea, M. G. (2014). Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-like receptors. Proceedings of the National Academy of Science of the United States of America, 111(7), 2668-2673. https://doi.org/10.1073/pnas.1317723111
Manichaikul, A., Hoffman, E. A., Smolonska, J., Gao, W., Cho, M. H., Baumhauer, H., ... Barr, R. G. (2014). Genome-wide study of percent emphysema on computed tomography in the general population: The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. American Journal of Respiratory and Critical Care Medicine, 189(4), 408-418. https://doi.org/10.1164/rccm.201306-1061OC
Geremek, M., Zietkiewicz, E., Bruinenberg, M., Franke, L., Pogorzelski, A., Wijmenga, C., & Witt, M. (2014). Ciliary Genes Are Down-Regulated in Bronchial Tissue of Primary Ciliary Dyskinesia Patients. PLoS ONE, 9(2), [e88216]. https://doi.org/10.1371/journal.pone.0088216
Stoffels, M., Szperl, A., Simon, A., Netea, M. G., Plantinga, T. S., van Deuren, M., ... van der Meer, J. W. M. (2014). MEFV mutations affecting pyrin amino acid 577 cause autosomal dominant autoinflammatory disease. Annals of the Rheumatic Diseases, 73(2), 455-461. https://doi.org/10.1136/annrheumdis-2012-202580
Boomsma, D. I., Wijmenga, C., Slagboom, E. P., Swertz, M. A., Karssen, L. C., Abdellaoui, A., ... van Duijn, C. M. (2014). The Genome of the Netherlands: design, and project goals. European Journal of Human Genetics, 22(2), 221-227. https://doi.org/10.1038/ejhg.2013.118
Claussnitzer, M., Dankel, S. N., Klocke, B., Grallert, H., Glunk, V., Berulava, T., ... DIAGRAM Consortium (2014). Leveraging Cross- Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms. Cell, 156(1-2), 343-358. https://doi.org/10.1016/j.cell.2013.10.058
Mayes, M. D., Bossini-Castillo, L., Gorlova, O., Martin, J. E., Zhou, X., Chen, W. V., ... Spanish Scleroderma Grp (2014). Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis. American Journal of Human Genetics, 94(1), 47-61. https://doi.org/10.1016/j.ajhg.2013.12.002

2013

Nijmeijer, R. M., van Santvoort, H. C., Zhernakova, A., Teller, S., Scheiber, J. A., de Kovel, C. G., ... Dutch Pancreatitis Study Grp (2013). Association Analysis of Genetic Variants in the Myosin IXB Gene in Acute Pancreatitis. PLoS ONE, 8(12), [e85870]. https://doi.org/10.1371/journal.pone.0085870
Yuan, J., Gao, J., Li, X., Liu, F., Wijmenga, C., Chen, H., & Gilissen, L. J. W. J. (2013). The Tip of the "Celiac Iceberg" in China: A Systematic Review and Meta-Analysis. PLoS ONE, 8(12), [e81151]. https://doi.org/10.1371/journal.pone.0081151
Zhernakova, A., Withoff, S., & Wijmenga, C. (2013). Clinical implications of shared genetics and pathogenesis in autoimmune diseases. Nature reviews endocrinology, 9(11), 646-659. https://doi.org/10.1038/nrendo.2013.161
Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., ... Kathiresan, S. (2013). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature Genetics, 45(11), 1345-52. https://doi.org/10.1038/ng.2795
Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., ... Global Lipids Genetics Consortium (2013). Discovery and refinement of loci associated with lipid levels. Nature Genetics, 45(11), 1274-1283. https://doi.org/10.1038/ng.2797
Bradley, D. T., Hughes, A. E., Badger, S. A., Jones, G. T., Harrison, S. C., Wright, B. J., ... Bown, M. J. (2013). A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm. Circulation-Cardiovascular Genetics, 6(5), 498-504. https://doi.org/10.1161/CIRCGENETICS.113.000165
Sokol, H., Conway, K. L., Zhang, M., Choi, M., Morin, B., Cao, Z., ... Xavier, R. J. (2013). Card9 Mediates Intestinal Epithelial Cell Restitution, T-Helper 17 Responses, and Control of Bacterial Infection in Mice. Gastroenterology, 145(3), 591-+. https://doi.org/10.1053/j.gastro.2013.05.047
Ellinghaus, D., Folseraas, T., Holm, K., Ellinghaus, E., Melum, E., Balschun, T., ... Karlsen, T. H. (2013). Genome-Wide Association Analysis in Primary Sclerosing Cholangitis and Ulcerative Colitis Identifies Risk Loci at GPR35 and TCF4. Hepatology, 58(3), 1074-1083. https://doi.org/10.1002/hep.25977
Baranska, A., Tigchelaar, E., Smolinska, A., Dallinga, J. W., Moonen, E. J. C., Dekens, J. A. M., ... van Schooten, F. J. (2013). Profile of volatile organic compounds in exhaled breath changes as a result of gluten-free diet. Journal of breath research, 7(3), [037104]. https://doi.org/10.1088/1752-7155/7/3/037104
Ganesh, S. K., Tragante, V., Guo, W., Guo, Y., Lanktree, M. B., Smith, E. N., ... Lifelines Cohort Study (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array (Correction to Ganesh et al. 22 (8): 1663). Human Molecular Genetics, 22(16), 3394-3395. https://doi.org/10.1093/hmg/ddt177
Ellinghaus, D., Zhang, H., Zeissig, S., Lipinski, S., Till, A., Jiang, T., ... Franke, A. (2013). Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies. Gastroenterology, 145(2), 339-347. https://doi.org/10.1053/j.gastro.2013.04.040
Knevel, R., de Rooy, D. P. C., Zhernakova, A., Grondal, G., Krabben, A., Steinsson, K., ... van der Helm-van Mil, A. H. M. (2013). Association of Variants in IL2RA With Progression of Joint Destruction in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 65(7), 1684-1693. https://doi.org/10.1002/art.37938
Zhernakova, D. V., de Klerk, E., Westra, H-J., Mastrokolias, A., Amini, S., Ariyurek, Y., ... Franke, L. (2013). DeepSAGE Reveals Genetic Variants Associated with Alternative Polyadenylation and Expression of Coding and Non-coding Transcripts. PLoS genetics, 9(6), [e1003594]. https://doi.org/10.1371/journal.pgen.1003594
Lam, V. K. L., Ma, R. C. W., Lee, H. M., Hu, C., Park, K. S., Furuta, H., ... DIAGRAM Consortium (2013). Genetic Associations of Type 2 Diabetes with Islet Amyloid Polypeptide Processing and Degrading Pathways in Asian Populations. PLoS ONE, 8(6), [e62378]. https://doi.org/10.1371/journal.pone.0062378
Liu, J. Z., Hov, J. R., Folseraas, T., Ellinghaus, E., Rushbrook, S. M., Doncheva, N. T., ... Int PSCSC Study Grp (2013). Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nature Genetics, 45(6), 670-675. https://doi.org/10.1038/ng.2616
van Setten, J., Isgum, I., Smolonska, J., Ripke, S., de Jong, P. A., Oudkerk, M., ... de Bakker, P. I. W. (2013). Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. ATHEROSCLEROSIS, 228(2), 400-405. https://doi.org/10.1016/j.atherosclerosis.2013.02.039
den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. J. J. M., Peal, D. S., Evans, D. M., ... CHARGE-AF Consortium (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45(6), 621-31. https://doi.org/10.1038/ng.2610
Schaefer, A. S., Bochenek, G., Manke, T., Nothnagel, M., Graetz, C., Thien, A., ... Schreiber, S. (2013). Validation of reported genetic risk factors for periodontitis in a large-scale replication study. Journal of Clinical Periodontology, 40(6), 563-572. https://doi.org/10.1111/jcpe.12092
Gockel, I., Becker, J., Wouters, M. M., Brun, P., Vigo, A. G., Trynka, G., ... Schumacher, J. (2013). An Insertion of Eight Amino Acids in HLA-DQA1 and Three Amino Acid Substitutions in HLA-DQA1 and HLA-DQB1 Confer Risk to Idiopathic Achalasia. Gastroenterology, 144(5), S142-S142.
Ganesh, S. K., Tragante, V., Guo, W., Guo, Y., Lanktree, M. B., Smith, E. N., ... Lifelines Cohort Study (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics, 22(8), 1663-1678. https://doi.org/10.1093/hmg/dds555
Bauer, F., Beulens, J. W. J., van der A, D. L., Wijmenga, C., Grobbee, D. E., Spijkerman, A. M. W., ... Onland-Moret, N. C. (2013). Dietary patterns and the risk of type 2 diabetes in overweight and obese individuals. European journal of nutrition, 52(3), 1127-1134. https://doi.org/10.1007/s00394-012-0423-4
Gonzaludo, N., Zheng, H-X., Wang, J., Chanock, S. J., Jin, L., Scherer, S., ... Brookes, A. J. (2013). HGV2012: Leveraging Next-Generation Technology and Large Datasets to Advance Disease Research. Human Mutation, 34(4), 657-660. https://doi.org/10.1002/humu.22270
Hughes, T., Coit, P., Adler, A., Yilmaz, V., Aksu, K., Duzgun, N., ... Sawalha, A. H. (2013). Identification of multiple independent susceptibility loci in the HLA region in Behcet's disease. Nature Genetics, 45(3), 319-324. https://doi.org/10.1038/ng.2551
Faraco, J., Lin, L., Kornum, B. R., Kenny, E. E., Trynka, G., Einen, M., ... Mignot, E. (2013). ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy. PLoS genetics, 9(2), [e1003270]. https://doi.org/10.1371/journal.pgen.1003270
Kiezun, A., Pulit, S. L., Francioli, L. C., van Dijk, F., Swertz, M., Boomsma, D. I., ... Genome Netherlands Consortium (2013). Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency. PLoS genetics, 9(2), [1003301]. https://doi.org/10.1371/journal.pgen.1003301
Hoesein, F. A. A. M., Wauters, E., Janssens, W., Groen, H., Smolonska, J., Wijmenga, C., ... Zanen, P. (2013). Variants in the 15q24/25 locus associate with lung function decline in active smokers. PLoS ONE, 8(1), [e53219]. https://doi.org/10.1371/journal.pone.0053219
Smeekens, S. P., Ng, A., Kumar, V., Johnson, M. D., Plantinga, T. S., van Diemen, C., ... Xavier, R. J. (2013). Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. Nature Communications, 4, [1342]. https://doi.org/10.1038/ncomms2343
Kumar, V., Westra, H-J., Karjalainen, J., Zhernakova, D. V., Esko, T., Hrdlickova, B., ... Vosa, U. (2013). Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression. PLoS genetics, 9(1), [e1003201]. https://doi.org/10.1371/journal.pgen.1003201
Ricaño-Ponce, I., & Wijmenga, C. (2013). Mapping of Immune-Mediated Disease Genes. Annual Review of Genomics and Human Genetics, 14, 325-353. https://doi.org/10.1146/annurev-genom-091212-153450
Zhernakova, D., Deelen, P., van der Sijde, M., van der Velde, J., de Haan, M., Abbott, K., ... Franke, L. (2013). Resolving Variants of Unknown Significance Through Large-Scale RNA-seq. Human heredity, 76(2), 106-107.

2012

Hancock, D. B., Artigas, M. S., Gharib, S. A., Henry, A., Manichaikul, A., Ramasamy, A., ... London, S. J. (2012). Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS genetics, 8(12), [e1003098]. https://doi.org/10.1371/journal.pgen.1003098
Eyre, S., Bowes, J., Diogo, D., Lee, A., Barton, A., Martin, P., ... Wellcome Trust Case-Control Consor (2012). High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nature Genetics, 44(12), 1336-1340. https://doi.org/10.1038/ng.2462
Tsoi, L. C., Spain, S. L., Knight, J., Ellinghaus, E., Stuart, P. E., Capon, F., ... Wellcome Trust Case-Control Consor (2012). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genetics, 44(12), 1341-1348. https://doi.org/10.1038/ng.2467
Duarri, A., Jezierska, J., Fokkens, M., Meijer, M., Schelhaas, H. J., den Dunnen, W. F. A., ... Verbeek, D. S. (2012). Mutations in Potassium Channel KCND3 Cause Spinocerebellar Ataxia Type 19. Annals of Neurology, 72(6), 870-880. https://doi.org/10.1002/ana.23700
Ruigrok, Y. M., Baas, A. F., Medic, J., Wijmenga, C., & Rinkel, G. J. E. (2012). The transforming growth factor-beta receptor genes and the risk of intracranial aneurysms. International Journal of Stroke, 7(8), 645-648. https://doi.org/10.1111/j.1747-4949.2011.00615.x
Asselbergs, F. W., Guo, Y., van Iperen, E. P. A., Sivapalaratnam, S., Tragante, V., Lanktree, M. B., ... Lifelines Cohort Study (2012). Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. American Journal of Human Genetics, 91(5), 823-838. https://doi.org/10.1016/j.ajhg.2012.08.032
Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., ... Int IBD Genetics Consortium IIBDGC (2012). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature, 491(7422), 119-124. https://doi.org/10.1038/nature11582
Wilk, J. B., Shrine, N. R. G., Loehr, L. R., Zhao, J. H., Manichaikul, A., Lopez, L. M., ... Stricker, B. H. (2012). Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. American Journal of Respiratory and Critical Care Medicine, 186(7), 622-632. https://doi.org/10.1164/rccm.201202-0366OC
Su, Z., Gay, L. J., Strange, A., Palles, C., Band, G., Whiteman, D. C., ... Wellcome Trust Case-Control Consor (2012). Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nature Genetics, 44(10), 1131-+. https://doi.org/10.1038/ng.2408
Helgadottir, A., Gretarsdottir, S., Thorleifsson, G., Holm, H., Patel, R. S., Gudnason, T., ... Stefansson, K. (2012). Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism. Journal of the American College of Cardiology, 60(8), 722-729. https://doi.org/10.1016/j.jacc.2012.01.078
Quintin, J., Saeed, S., Martens, J. H. A., Giamarellos-Bourboulis, E. J., Ifrim, D. C., Logie, C., ... Netea, M. G. (2012). Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes. Cell Host & Microbe, 12(2), 223-232. https://doi.org/10.1016/j.chom.2012.06.006
Voight, B. F., Peloso, G. M., Orho-Melander, M., Frikke-Schmidt, R., Barbalic, M., Jensen, M. K., ... Kathiresan, S. (2012). Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study. LANCET, 380(9841), 572-580. https://doi.org/10.1016/S0140-6736(12)60312-2
Folseraas, T., Melum, E., Rausch, P., Juran, B. D., Ellinghaus, E., Shiryaev, A., ... Karlsen, T. H. (2012). Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci. Journal of Hepatology, 57(2), 366-375. https://doi.org/10.1016/j.jhep.2012.03.031
Kumar, V., Wijmenga, C., & Withoff, S. (2012). From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases. Seminars in immunopathology, 34(4), 567-580. https://doi.org/10.1007/s00281-012-0312-1
Lanktree, M. B., Guo, Y., Murtaza, M., Glessner, J. T., Bailey, S. D., Onland-Moret, N. C., ... Whitehall II Study WHII 50K Grp (2012). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height (vol 88, pg 6, 2010). American Journal of Human Genetics, 90(6), 1116-1117. https://doi.org/10.1016/j.ajhg.2012.05.017
Netea, M. G., Wijmenga, C., & O'Neill, L. A. J. (2012). Genetic variation in Toll-like receptors and disease susceptibility. Nature Immunology, 13(6), 535-542. https://doi.org/10.1038/ni.2284
Stahl, E. A., Wegmann, D., Trynka, G., Gutierrez Achury, J., Do, R., Voight, B. F., ... Myocardial Infarction Genetics Con (2012). Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nature Genetics, 44(5), 483-+. https://doi.org/10.1038/ng.2232
Dolmans, G. H., Werker, P. M., de Jong, I. J., Nijman, R. J., Wijmenga, C., Ophoff, R. A., & Lifelines Cohort Study (2012). WNT2 Locus Is Involved in Genetic Susceptibility of Peyronie's Disease. Journal of Sexual Medicine, 9(5), 1430-1434. https://doi.org/10.1111/j.1743-6109.2012.02704.x
van Eerde, A. M., Duran, K., van Riel, E., de Kovel, C. G. F., Koeleman, B. P. C., Knoers, N. V. A. M., ... Wijmenga, C. (2012). Genes in the Ureteric Budding Pathway: Association Study on Vesico-Ureteral Reflux Patients. PLoS ONE, 7(4), [e31327]. https://doi.org/10.1371/journal.pone.0031327
Saxena, R., Elbers, C. C., Guo, Y., Peter, I., Gaunt, T. R., Mega, J. L., ... DIAGRAM Consortium (2012). Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci (vol 90, pg 410, 2012). American Journal of Human Genetics, 90(4), 753-753. https://doi.org/10.1016/j.ajhg.2012.03.001
Yang, J., Ferreira, T., Morris, A. P., Medland, S. E., Madden, P. A. F., Heath, A. C., ... DIAbet Genetics Replication Meta-A (2012). Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nature Genetics, 44(4), 369-U170. https://doi.org/10.1038/ng.2213
Anto, J. M., Pinart, M., Akdis, M., Auffray, C., Bachert, C., Basagana, X., ... WHO Collaborating Ctr Asthma (2012). Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar. Journal of Allergy and Clinical Immunology, 129(4), 943-U421. https://doi.org/10.1016/j.jaci.2012.01.047
Saxena, R., Elbers, C. C., Guo, Y., Peter, I., Gaunt, T. R., Mega, J. L., ... PROCARDIS (2012). Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci. American Journal of Human Genetics, 90(3), 410-425. https://doi.org/10.1016/j.ajhg.2011.12.022
van Vliet-Ostaptchouk, J. V., van Haeften, T. W., Landman, G. W. D., Reiling, E., Kleefstra, N., Bilo, H. J. G., ... 't Hart, L. M. (2012). Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp. PLoS ONE, 7(3), [e32148]. https://doi.org/10.1371/journal.pone.0032148
Steck, A. K., Wong, R., Wagner, B., Johnson, K., Liu, E., Romanos, J., ... Rewers, M. J. (2012). Effects of Non-HLA Gene Polymorphisms on Development of Islet Autoimmunity and Type 1 Diabetes in a Population With High-Risk HLA-DR,DQ Genotypes. Diabetes, 61(3), 753-758. https://doi.org/10.2337/db11-1228
Fu, J., Wolfs, M. G. M., Deelen, P., Westra, H. J., Fehrmann, R. S. N., te Meerman, G., ... Franke, L. (2012). Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS genetics, 8(1), [e1002431]. https://doi.org/10.1371/journal.pgen.1002431
Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., ... MAGIC Investigators (2012). A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans. PLoS ONE, 7(1), [e29202]. https://doi.org/10.1371/journal.pone.0029202
Hunt, K. A., Smyth, D. J., Balschun, T., Ban, M., Mistry, V., Ahmad, T., ... Wellcome Trust Case (2012). Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics, 44(1), 3-5. https://doi.org/10.1038/ng.1037
Vonk, W. I. M., de Bie, P., Wichers, C. G. K., van den Berghe, P. V. E., van der Plaats, R., Berger, R., ... van de Sluis, B. (2012). The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression. Cellular and molecular life sciences, 69(1), 149-163. https://doi.org/10.1007/s00018-011-0743-1

2011

Vonk, W. I. M., Bartuzi, P., de Bie, P., Kloosterhuis, N., Wichers, C. G. K., Berger, R., ... van de Sluis, B. (2011). Liver-Specific Commd1 Knockout Mice Are Susceptible to Hepatic Copper Accumulation. PLoS ONE, 6(12), [29183]. https://doi.org/10.1371/journal.pone.0029183
Trynka, G., Hunt, K. A., Bockett, N. A., Romanos, J., Mistry, V., Szperl, A., ... WTCCC (2011). Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nature Genetics, 43(12), 1193-U45. https://doi.org/10.1038/ng.998
Shi, J., Zhou, L., Zhernakova, A., Qian, J., Zhu, F., Sun, G., ... Weersma, R. K. (2011). Haplotype-based Analysis of Ulcerative Colitis Risk Loci Identifies Both IL2 and IL21 as Susceptibility Genes in Han Chinese. Inflammatory Bowel Diseases, 17(12), 2472-2479. https://doi.org/10.1002/ibd.21652
Elbers, C. C., Onland-Moret, N. C., Eijkemans, M. J. C., Wijmenga, C., Grobbee, D. E., & van der Schouw, Y. T. (2011). Low fertility and the risk of type 2 diabetes in women. Human Reproduction, 26(12), 3472-3478. https://doi.org/10.1093/humrep/der332
Bown, M. J., Jones, G. T., Harrison, S. C., Wright, B. J., Bumpstead, S., Baas, A. F., ... VRCNZ Consortium (2011). Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1. American Journal of Human Genetics, 89(5), 619-627. https://doi.org/10.1016/j.ajhg.2011.10.002
Ophoff, R. A., Dolmans, G. H., & Wijmenga, C. (2011). Wnt Signaling and Dupuytren's Disease REPLY. New England Journal of Medicine, 365(18), 1740-1740.
Diaz-Gallo, L-M., Espino-Paisan, L., Fransen, K., Gomez-Garcia, M., van Sommeren, S., Cardena, C., ... Martin, J. (2011). Differential Association of Two PTPN22 Coding Variants with Crohn's Disease and Ulcerative Colitis. Inflammatory Bowel Diseases, 17(11), 2287-2294. https://doi.org/10.1002/ibd.21630
Soler Artigas, M., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, M., Tang, W., ... International Lung Cancer Consortium (2011). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43(11), 1082-1090. https://doi.org/10.1038/ng.941
Surakka, I., Isaacs, A., Karssen, L. C., Laurila, P-P. P., Middelberg, R. P. S., Tikkanen, E., ... ENGAGE Consortium (2011). A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol. PLoS genetics, 7(10), [1002333]. https://doi.org/10.1371/journal.pgen.1002333
Fu, J., Festen, E. A. M., & Wijmenga, C. (2011). Multi-ethnic studies in complex traits. Human Molecular Genetics, 20, R206-R213. https://doi.org/10.1093/hmg/ddr386
Hrdlickova, B., Westra, H-J., Franke, L., & Wijmenga, C. (2011). Celiac disease: moving from genetic associations to causal variants. Clinical Genetics, 80(3), 203-213. https://doi.org/10.1111/j.1399-0004.2011.01707.x
Nijmeijer, R. M., Gadaleta, R. M., van Mil, S. W. C., van Bodegraven, A. A., Crusius, J. B. A., Dijkstra, G., ... Dutch Initiative Crohn (2011). Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease. PLoS ONE, 6(8), [23745]. https://doi.org/10.1371/journal.pone.0023745
Cotsapas, C., Voight, B. F., Rossin, E., Lage, K., Neale, B. M., Wallace, C., ... FOCiS Network Consortia (2011). Pervasive Sharing of Genetic Effects in Autoimmune Disease. PLoS genetics, 7(8), [1002254]. https://doi.org/10.1371/journal.pgen.1002254
Fehrmann, R. S. N., Jansen, R. C., Veldink, J. H., Westra, H. J., Arends, D., Bonder, M. J., ... Franke, L. (2011). Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS genetics, 7(8), [1002197]. https://doi.org/10.1371/journal.pgen.1002197
Westra, H-J., Jansen, R. C., Fehrmann, R. S. N., te Meerman, G. J., van Heel, D., Wijmenga, C., ... te Meerman, G. (2011). MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects. Bioinformatics, 27(15), 2104-2111. https://doi.org/10.1093/bioinformatics/btr323
Szperl, A. M., Ricaño-Ponce, I., Li, J. K., Deelen, P., Kanterakis, A., Plagnol, V., ... Zheng, H. C. H. (2011). Exome sequencing in a family segregating for celiac disease. Clinical Genetics, 80(2), 138-147. https://doi.org/10.1111/j.1399-0004.2011.01714.x
van Sommeren, S., Visschedijk, M. C., Festen, E. A. M., de Jong, D. J., Ponsioen, C. Y., Wijmenga, C., & Weersma, R. K. (2011). HNF4 alpha and CDH1 Are Associated with Ulcerative Colitis in a Dutch Cohort. Inflammatory Bowel Diseases, 17(8), 1714-1718. https://doi.org/10.1002/ibd.21541
Dolmans, G. H., Werker, P. M., Hennies, H. C., Furniss, D., Festen, E. A., Franke, L., ... BSSH-GODD Consortium, N. V. (2011). Wnt Signaling and Dupuytren's Disease. New England Journal of Medicine, 365(4), 307-317. https://doi.org/10.1056/NEJMoa1101029
de Greef, J. C., Wang, J., Balog, J., den Dunnen, J. T., Frants, R. R., Straasheijm, K. R., ... van der Maarel, S. M. (2011). Mutations in Z8T824 Are Associated with Immunodeficiency, Centromeric Instability, and Facial Anomalies Syndrome Type 2. American Journal of Human Genetics, 88(6), 796-804. https://doi.org/10.1016/j.ajhg.2011.04.018
Janse, M., Weersma, R. K., Sudan, D. L., Festen, E. A. M., Wijmenga, C., Dijkstra, G., & Mercer, D. (2011). Association of Crohn's disease-associated NOD2 variants with intestinal failure requiring small bowel transplantation and clinical outcomes. Gut, 60(6), 877-878. https://doi.org/10.1136/gut.2009.196238
Niedoszytko, M., Bruinenberg, M., de Monchy, J., Weersma, R. K., Wijmenga, C., Jassem, E., & Oude Elberink, J. N. G. (2011). Changes in gene expression caused by insect venom immunotherapy responsible for the long-term protection of insect venom-allergic patients. Annals of allergy asthma & immunology, 106(6), 502-510. https://doi.org/10.1016/j.anai.2011.01.007
Szperl, A., Saavalainen, P., Weersma, R. K., Lappalainen, M., Paavola-Sakki, P., Halme, L., ... van Diemen, C. C. (2011). Functional Polymorphism in IL12B Promoter Site Is Associated with Ulcerative Colitis. Inflammatory Bowel Diseases, 17(6), E38-E40. https://doi.org/10.1002/ibd.21670
Einarsdottir, E., Bevova, M. R., Zhernakova, A., Monsuur, A., Koskinen, L. L. E., van't Slot, R., ... Saavalainen, P. (2011). Multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations. European Journal of Human Genetics, 19(6), 682-686. https://doi.org/10.1038/ejhg.2011.2
Gutierrez-Achury, J., Coutinho de Almeida, R., & Wijmenga, C. (2011). Shared genetics in coeliac disease and other immune-mediated diseases. Journal of Internal Medicine, 269(6), 591-603. https://doi.org/10.1111/j.1365-2796.2011.02375.x
Janse, M., Lamberts, L. E., Franke, L., Raychaudhuri, S., Ellinghaus, E., Boberg, K. M., ... Weersma, R. K. (2011). Three Ulcerative Colitis Susceptibility Loci Are Associated with Primary Sclerosing Cholangitis and Indicate a Role for IL2, REL, and CARD9. Hepatology, 53(6), 1977-1985. https://doi.org/10.1002/hep.24307
Niedoszytko, M., Bruinenberg, M., van Doormaal, J. J., de Monchy, J. G. R., Nedoszytko, B., Koppelman, G. H., ... Oude Elberink, J. N. G. (2011). Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis. Allergy, 66(5), 648-657. https://doi.org/10.1111/j.1398-9995.2010.02521.x
Bousquet, J., Anto, J., Auffray, C., Akdis, M., Cambon-Thomsen, A., Keil, T., ... Zuberbier, T. (2011). MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy, 66(5), 596-604. https://doi.org/10.1111/j.1398-9995.2010.02534.x
Knauff, E. A. H., Blauw, H. M., Pearson, P. L., Kok, K., Wijmenga, C., Veldink, J. H., ... Dutch Primary Ovarian Insufficienc (2011). Copy number variants on the X chromosome in women with primary ovarian insufficiency. Fertility and sterility, 95(5), 1584-1588. https://doi.org/10.1016/j.fertnstert.2011.01.018
van Disseldorp, J., Franke, L., Eijkemans, R., Broekmans, F., Macklon, N., Wijmenga, C., & Fauser, B. (2011). Genome-wide analysis shows no genomic predictors of ovarian response to stimulation by exogenous FSH for IVF. Reproductive Biomedicine Online, 22(4), 382-388. https://doi.org/10.1016/j.rbmo.2010.12.006
Szperl, A. M., Golachowska, M. R., Bruinenberg, M., Prekeris, R., Thunnissen, A-M. W. H., Karrenbeld, A., ... van IJzendoorn, S. C. D. (2011). Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease. Journal of Pediatric Gastroenterology and Nutrition, 52(3), 307-313. https://doi.org/10.1097/MPG.0b013e3181eea177
Geremek, M., Bruinenberg, M., Zietkiewicz, E., Pogorzelski, A., Wijmenga, C., & Witt, M. (2011). Gene expression studies in cells from primary ciliary dyskinesia patients identify 208 potential ciliary genes. HUMAN GENETICS, 129(3), 283-293. https://doi.org/10.1007/s00439-010-0922-4
Brown, S. J., Asai, Y., Cordell, H. J., Campbell, L. E., Zhao, Y., Liao, H., ... McLean, W. H. I. (2011). Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. Journal of Allergy and Clinical Immunology, 127(3), 661-667. https://doi.org/10.1016/j.jaci.2011.01.031
Anderson, C. A., Boucher, G., Lees, C. W., Franke, A., D'Amato, M., Taylor, K. D., ... Rioux, J. D. (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nature Genetics, 43(3), 246-U94. https://doi.org/10.1038/ng.764
Zhernakova, A., Stahl, E. A., Trynka, G., Raychaudhuri, S., Festen, E. A., Franke, L., ... Plenge, R. M. (2011). Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci. PLoS genetics, 7(2), [1002004]. https://doi.org/10.1371/journal.pgen.1002004
Wensley, F., Gao, P., Burgess, S., Kaptoge, S., Di Angelantonio, E., Shah, T., ... WOSCOPS (2011). Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. British Medical Journal, 342, [548]. https://doi.org/10.1136/bmj.d548
Roberts, R. L., Hollis-Moffatt, J. E., Gómez-García, M., Fransen, K., Ponsioen, C. Y., Crusius, B. A., ... Alizadeh, B. Z. (2011). Association of the protein-tyrosine phosphatase nonreceptor type substrate 1 (PTPNS1) gene with inflammatory bowel disease. Inflammatory Bowel Diseases, 17(2), E19-21. https://doi.org/10.1002/ibd.21470
Windelinckx, A., De Mars, G., Huygens, W., Peeters, M. W., Vincent, B., Wijmenga, C., ... Thomis, M. A. (2011). Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene. European Journal of Human Genetics, 19(2), 208-215. https://doi.org/10.1038/ejhg.2010.173
Festen, E. A. M., Goyette, P., Green, T., Boucher, G., Beauchamp, C., Trynka, G., ... Rioux, J. D. (2011). A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease. PLoS genetics, 7(1), [1001283]. https://doi.org/10.1371/journal.pgen.1001283
Lanktree, M. B., Guo, Y., Murtaza, M., Glessner, J. T., Bailey, S. D., Onland-Moret, N. C., ... WHII 50K Grp (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88(1), 6-18. https://doi.org/10.1016/j.ajhg.2010.11.007
Melum, E., Franke, A., Schramm, C., Weismueller, T. J., Gotthardt, D. N., Offner, F. A., ... Karlsen, T. H. (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nature Genetics, 43(1), 17-19. https://doi.org/10.1038/ng.728
Smolonska, J., Koppelman, G. H., Wijmenga, C., Vonk, J., Zanen, P., Bruinenberg, M., ... Postma, D. S. (2011). Identification Of Novel Genes That Contribute To Both Asthma And COPD, With Replication In A Large Population-Based Cohort. American Journal of Respiratory and Critical Care Medicine, 183.

2010

Weersma, R. K., Crusius, J. B. A., Roberts, R. L., Koeleman, B. P. C., Palomino-Morales, R., Wolfkamp, S., ... Alizadeh, B. Z. (2010). Association of FcgR2a, but Not FcgR3a, with Inflammatory Bowel Diseases Across Three Caucasian Populations. Inflammatory Bowel Diseases, 16(12), 2080-2089. https://doi.org/10.1002/ibd.21342
Sotoodehnia, N., Isaacs, A., de Bakker, P. I. W., Doerr, M., Newton-Cheh, C., Nolte, I. M., ... Arking, D. E. (2010). Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature Genetics, 42(12), 1068-U62. https://doi.org/10.1038/ng.716
Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., ... Parkes, M. (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nature Genetics, 42(12), 1118-+. https://doi.org/10.1038/ng.717
Esch, C. E. H., Rosen, A., Auricchio, R., Romanos, J., Chmielewska, A., Putter, H., ... PreventCD Study Grp (2010). The PreventCD Study design: towards new strategies for the prevention of coeliac disease. European journal of gastroenterology & hepatology, 22(12), 1424-1430. https://doi.org/10.1097/MEG.0b013e32833fe9ae
Bakalkin, G., Watanabe, H., Jezierska, J., Depoorter, C., Verschuuren - Bemelmans, C., Bazov, I., ... Verbeek, D. S. (2010). Prodynorphin Mutations Cause the Neurodegenerative Disorder Spinocerebellar Ataxia Type 23. American Journal of Human Genetics, 87(5), 593-603. https://doi.org/10.1016/j.ajhg.2010.10.001
Trynka, G., Wijmenga, C., & van Heel, D. A. (2010). A genetic perspective on coeliac disease. TRENDS IN MOLECULAR MEDICINE, 16(11), 537-550. https://doi.org/10.1016/j.molmed.2010.09.003
Lu, Y., Feskens, E. J. M., Boer, J. M. A., Imholz, S., Verschuren, W. M. M., Wijmenga, C., ... Dolle, M. E. T. (2010). Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study. ATHEROSCLEROSIS, 213(1), 200-205. https://doi.org/10.1016/j.atherosclerosis.2010.08.053
Vonk, W. I. M., Wijmenga, C., Berger, R., van de Sluis, B., & Klomp, L. W. J. (2010). Cu,Zn Superoxide Dismutase Maturation and Activity Are Regulated by COMMD1. The Journal of Biological Chemistry, 285(37), 28991-29000. https://doi.org/10.1074/jbc.M110.101477
Fransen, K., Visschedijk, M. C., van Sommeren, S., Fu, J. Y., Franke, L., Festen, E. A. M., ... Weersma, R. K. (2010). Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. Human Molecular Genetics, 19(17), 3482-3488. https://doi.org/10.1093/hmg/ddq264
Hov, J. R., Keitel, V., Laerdahl, J. K., Spomer, L., Ellinghaus, E., ElSharawy, A., ... IBSEN Study Grp (2010). Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis. PLoS ONE, 5(8), [12403]. https://doi.org/10.1371/journal.pone.0012403
Krischek, B., Tajima, A., Akagawa, H., Narita, A., Ruigrok, Y., Rinkel, G., ... Inoue, I. (2010). ASSOCIATION OF THE JUN DIMERIZATION PROTEIN 2 GENE WITH INTRACRANIAL ANEURYSMS IN JAPANESE AND KOREAN COHORTS AS COMPARED TO A DUTCH COHORT. Neuroscience, 169(1), 339-343. https://doi.org/10.1016/j.neuroscience.2010.05.002
Wolfs, M. G. M., Rensen, S. S., Dijk, E. J. B-V., Verdam, F. J., Greve, J-W., Sanjabi, B., ... Hofker, M. H. (2010). Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study. BMC Medical Genomics, 3, [34]. https://doi.org/10.1186/1755-8794-3-34
Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J-P. P. M., ... Stefansson, K. (2010). Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics, 42(8), 692-U71. https://doi.org/10.1038/ng.622
Voight, B. F., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., ... GIANT Consortium (2010). Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature Genetics, 42(7), 579-U155. https://doi.org/10.1038/ng.609
Zhernakova, A., Elbers, C. C., Ferwerda, B., Romanos, J., Trynka, G., Dubois, P. C., ... Finnish Celiac Dis Study Grp (2010). Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection. American Journal of Human Genetics, 86(6), 970-977. https://doi.org/10.1016/j.ajhg.2010.05.004
Persengiev, S., Koeleman, B. P. C., Downes, K., Valdigem, G., van der Slik, A. R., Eerligh, P., ... Alizadeh, B. Z. (2010). Association analysis of myosin IXB and type 1 diabetes. Human Immunology, 71(6), 598-601. https://doi.org/10.1016/j.humimm.2010.03.002
van de Sluis, B., Mao, X., Zhai, Y., Groot, A. J., Vermeulen, J. F., van der Wall, E., ... Burstein, E. (2010). COMMD1 disrupts HIF-1 alpha/beta dimerization and inhibits human tumor cell invasion. The Journal of Clinical Investigation, 120(6), 2119-2130. https://doi.org/10.1172/JCI40583
Stahl, E. A., Raychaudhuri, S., Remmers, E. F., Xie, G., Eyre, S., Thomson, B. P., ... YEAR Consortium (2010). Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nature Genetics, 42(6), 508-U56. https://doi.org/10.1038/ng.582
Buizer-Voskamp, J. E., Franke, L., Staal, W. G., van Daalen, E., Kemner, C., Ophoff, R. A., ... Wijmenga, C. (2010). Systematic genotype-phenotype analysis of autism susceptibility loci implicates additional symptoms to co-occur with autism. European Journal of Human Genetics, 18(5), 588-595. https://doi.org/10.1038/ejhg.2009.206
van der Heide, F., Nolte, I. M., Kleibeuker, J. H., Wijmenga, C., Dijkstra, G., & Weersma, R. K. (2010). Differences in Genetic Background Between Active Smokers, Passive Smokers, and Non-Smokers With Crohn's Disease. AMERICAN JOURNAL OF GASTROENTEROLOGY, 105(5), 1165-1172. https://doi.org/10.1038/ajg.2009.659
Niedoszytko, M., Bruinenberg, M., de Monchy, J., Wijmenga, C., Platteel, M., Jassem, E., & Oude Elberink, J. N. G. (2010). Gene expression analysis in predicting the effectiveness of insect venom immunotherapy. Journal of Allergy and Clinical Immunology, 125(5), AB120-AB120. https://doi.org/10.1016/j.jaci.2010.01.021
Yasuno, K., Bilguvar, K., Bijlenga, P., Low, S-K., Krischek, B., Auburger, G., ... Guenel, M. (2010). Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nature Genetics, 42(5), 420-U69. https://doi.org/10.1038/ng.563
Smolonska, J., Wijmenga, C., Postma, D. S., & Boezen, H. M. (2010). Erratum: Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research. American Journal of Respiratory and Critical Care Medicine, 181(7), 765. https://doi.org/10.1164/ajrccm.181.7.765
Baas, A. F., Medic, J., van't Slot, R., de Vries, J-P. P. M., van Sambeek, M. R. H. M., Geelkerken, B. H., ... Blankensteijn, J. D. (2010). Association Study of Single Nucleotide Polymorphisms on Chromosome 19q13 With Abdominal Aortic Aneurysm. Angiology, 61(3), 243-247. https://doi.org/10.1177/0003319709354752
McGovern, D. P. B., Gardet, A., Torkvist, L., Goyette, P., Essers, J., Taylor, K. D., ... NIDDK IBD Genetics Consortium (2010). Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nature Genetics, 42(4), 332-U88. https://doi.org/10.1038/ng.549
Wolters, V. M., Alizadeh, B. Z., Weijerman, M. E., Zhernakova, A., van Hoogstraten, I. M. W., Mearin, M. L., ... Schreurs, M. W. J. (2010). Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. Human Immunology, 71(4), 392-396. https://doi.org/10.1016/j.humimm.2010.01.016
Dubois, P. C. A., Trynka, G., Franke, L., Hunt, K. A., Romanos, J., Curtotti, A., ... van Heel, D. A. (2010). Multiple common variants for celiac disease influencing immune gene expression. Nature Genetics, 42(4), 295-U42. https://doi.org/10.1038/ng.543
Baas, A. F., Medic, J., van 't Slot, R., de Vries, J-P. P. M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., ... Ruigrok, Y. M. (2010). The Intracranial Aneurysm Susceptibility Genes HSPG2 and CSPG2 Are Not Associated With Abdominal Aortic Aneurysm. Angiology, 61(3), 238-242. https://doi.org/10.1177/0003319709354751
Kurreeman, F. A. S., Goulielmos, G. N., Alizadeh, B. Z., Rueda, B., Houwing-Duistermaat, J., Sanchez, E., ... SLEGEN Consortium (2010). The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases. Annals of the Rheumatic Diseases, 69(4), 696-699. https://doi.org/10.1136/ard.2008.106567
Lambrechts, D., Buysschaert, I., Zanen, P., Coolen, J., Lays, N., Cuppens, H., ... Janssens, W. (2010). The 15q24/25 Susceptibility Variant for Lung Cancer and Chronic Obstructive Pulmonary Disease Is Associated with Emphysema. American Journal of Respiratory and Critical Care Medicine, 181(5), 486-493. https://doi.org/10.1164/rccm.200909-1364OC
Karlsen, T. H., Franke, A., Melum, E., Kaser, A., Hov, J. R., Balschun, T., ... Schreiber, S. (2010). Genome-Wide Association Analysis in Primary Sclerosing Cholangitis. Gastroenterology, 138(3), 1102-1111. https://doi.org/10.1053/j.gastro.2009.11.046
Baas, A. F., Medic, J., van't Slot, R., de Kovel, C. G., Zhernakova, A., Geelkerken, R. H., ... Ruigrok, Y. M. (2010). Association of the TGF-beta receptor genes with abdominal aortic aneurysm. European Journal of Human Genetics, 18(2), 240-244. https://doi.org/10.1038/ejhg.2009.141
Festen, E. A. M., Stokkers, P. C. F., van Diemen, C. C., van Bodegraven, A. A., Boezen, H. M., Crusius, B. J. A., ... Weersma, R. K. (2010). Correction: Genetic Analysis in A Dutch Study Sample Identifies More Ulcerative Colitis Susceptibility Loci and Shows Their Additive Role in Disease Risk (vol 105, pg 395, 2010). AMERICAN JOURNAL OF GASTROENTEROLOGY, 105(2), 479. https://doi.org/10.1038/ajg.2009.576
Ruigrok, Y. M., Slooter, A. J. C., Rinkel, G. J. E., Wijmenga, C., & Rosendaal, F. R. (2010). Genes influencing coagulation and the risk of aneurysmal subarachnoid hemorrhage, and subsequent complications of secondary cerebral ischemia and rebleeding. Acta Neurochirurgica, 152(2), 257-262. https://doi.org/10.1007/s00701-009-0505-0
Festen, E. A. M., Stokkers, P. C. F., van Diemen, C. C., van Bodegraven, A. A., Boezen, H., Crusius, B. J. A., ... Weersma, R. K. (2010). Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. AMERICAN JOURNAL OF GASTROENTEROLOGY, 105(2), 395-402. https://doi.org/10.1038/ajg.2009.576
Bauer, F., Charlotte, O-M. N., Niehoff, A. G., Elbers, C. C., Grobbee, D. E., Wijmenga, C., & van der Schouw, Y. T. (2010). PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterol. European journal of cardiovascular prevention & rehabilitation, 17(1), 28-34. https://doi.org/10.1097/HJR.0b013e32832d30c4
Dijkstra, A. E., Smolonska, J., Boezen, H. M., Groen, H. J. M., Wijmenga, C., Zanen, P., ... Postma, D. S. (2010). Genetic susceptibility for Chronic Bronchitis: A Genome-Wide Association Study. American Journal of Respiratory and Critical Care Medicine, 181.

2009

Coenen, M. J. H., Trynka, G., Heskamp, S., Franke, B., van Diemen, C. C., Smolonska, J., ... Zhernakova, A. (2009). Common and different genetic background for rheumatoid arthritis and coeliac disease. Human Molecular Genetics, 18(21), 4195-4203. https://doi.org/10.1093/hmg/ddp365
van Vliet-Ostaptchouk, J. V., Hofker, M. H., van der Schouw, Y. T., Wijmenga, C., & Onland-Moret, N. C. (2009). Genetic variation in the hypothalamic pathways and its role on obesity. Obesity Reviews, 10(6), 593-609. https://doi.org/10.1111/j.1467-789X.2009.00597.x
Ferwerda, B., Ferwerda, G., Plantinga, T. S., Willment, J. A., van Spriel, A. B., Venselaar, H., ... Netea, M. G. (2009). Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections. New England Journal of Medicine, 361(18), 1760-1767. https://doi.org/10.1056/NEJMoa0901053
van de Sluis, B., Groot, A. J., Vermeulen, J., van der Wall, E., van Diest, P. J., Wijmenga, C., ... Vooijs, M. (2009). COMMD1 Promotes pVHL and O-2-Independent Proteolysis of HIF-1 alpha via HSP90/70. PLoS ONE, 4(10), [e7332]. https://doi.org/10.1371/journal.pone.0007332
Smolonska, J., Wijmenga, C., Postma, D. S., & Boezen, H. M. (2009). Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research. American Journal of Respiratory and Critical Care Medicine, 180(7), 618-631. https://doi.org/10.1164/rccm.200905-0722OC
Bauer, F., Elbers, C. C., Adan, R. A. H., Loos, R. J. F., Onland-Moret, N. C., Grobbee, D. E., ... van der Schouw, Y. T. (2009). Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. American Journal of Clinical Nutrition, 90(4), 951-959. https://doi.org/10.3945/ajcn.2009.27781
van den Berg, S. W., Dolle, M. E. T., Imholz, S., van der A, D. L., van 't Slot, R., Wijmenga, C., ... Boer, J. M. A. (2009). Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study. International Journal of Obesity, 33(10), 1143-1152. https://doi.org/10.1038/ijo.2009.152
Romanos, J., Van Diemen, C. C., Nolte, I. M., Trynka, G., Zhernakova, A., Fu, J., ... Wijmenga, C. (2009). Analysis of HLA and Non-HLA Alleles Can Identify Individuals at High Risk for Celiac Disease. Gastroenterology, 137(3), 834-840. https://doi.org/10.1053/j.gastro.2009.05.040
Knauff, E. A. H., Franke, L., van Es, M. A., van den Berg, L. H., van der Schouw, Y. T., Laven, J. S. E., ... Dutch POF Consortium (2009). Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. Human Reproduction, 24(9), 2372-2378. https://doi.org/10.1093/humrep/dep197
Trynka, G., Zhernakova, A., Romanos, J., Franke, L., Hunt, K. A., Turner, G., ... Wijmenga, C. (2009). Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappa B signalling. Gut, 58(8), 1078-1083. https://doi.org/10.1136/gut.2008.169052
Elbers, C. C., van Eijk, K. R., Franke, L., Mulder, F., van der Schouw, Y. T., Wijmenga, C., & Onland-Moret, N. C. (2009). Using Genome-Wide Pathway Analysis to Unravel the Etiology of Complex Diseases. Genetic epidemiology, 33(5), 419-431. https://doi.org/10.1002/gepi.20395
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Wolters, V. M., Alizadeh, B. Z., Weijerman, M., Zhernakova, A., Hoogstraten, I. M., Mearin, L., ... Shreurs, M. W. (2009). Evaluating the Relation Between Serologic Coeliac Disease Markers and Variants in Intestinal Barrier Genes. Gastroenterology, 136(5), A469-A469.
Weersma, R. K., Crusius, B., Koeleman, B. P., Roberts, R. L., Palomino-Morales, R. J., Woltkamp, S. C., ... Alizadeh, B. Z. (2009). The Differential Association of the FcgR2a and FcgR3a Genes in Inflammatory Bowel Diseases Across Three Caucasian Populations. Gastroenterology, 136(5), A206-A206.
Golachowska, M. R., Szperl, A., Bruineberg, M., Prekeris, R., Thunnissen, A-M. W. H., Hoekstra, D., ... van Ijzendoorn, S. (2009). Apical Recycling Endosome-Associated Myosin Vb Is Mutated in Microvillus Inclusion Disease and Is Involved in Intestinal Brush Border Development. Gastroenterology, 136(5), A66-A66.
Festen, E. A., Stokkers, P., Wapenaar, M. C., van Diemen, C. C., van Bodegraven, A. A., Bruinenberg, M., ... Weersma, R. K. (2009). Genetic and Mucosal Expression Analysis Shows Important Roles for JAK2 and MST1 in the Pathogenesis of Ulcerative Colitis and Identifies More Susceptibility Loci. Gastroenterology, 136(5), A38.
Muller, P. A. J., van de Sluis, B., Groot, A. J., Verbeek, D., Vonk, W. I. M., Maine, G. N., ... Klomp, L. W. J. (2009). Nuclear-Cytosolic Transport of COMMD1 Regulates NF-kappa B and HIF-1 Activity. Traffic, 10(5), 514-527. https://doi.org/10.1111/j.1600-0854.2009.00892.x
Koskinen, L., Romanos, J., Kaukinen, K., Mustalahti, K., Korponay-Szabo, I., Barisani, D., ... Saavalainen, P. (2009). Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations. Immunogenetics, 61(4), 247-256. https://doi.org/10.1007/s00251-009-0361-3
Siezen, C. L. E., Bont, L., Hodemaekers, H. M., Ermers, M. J., Doornbos, G., van't Slot, R., ... Janssen, R. (2009). GENETIC SUSCEPTIBILITY TO RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN PRETERM CHILDREN IS ASSOCIATED WITH AIRWAY REMODELING GENES AND INNATE IMMUNE GENES. Pediatric infectious disease journal, 28(4), 333-335. https://doi.org/10.1097/INF.0b013e31818e2aa9
Wolfs, M. G. M., Hofker, M. H., Wijmenga, C., & van Haeften, T. W. (2009). Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics. Current Genomics, 10(2), 110-118.
Koskinen, L. L. E., Einarsdottir, E., Dukes, E., Heap, G. A. R., Dubois, P., Korponay-Szabo, I. R., ... Saavalainen, P. (2009). Association study of the IL18RAP locus in three European populations with coeliac disease. Human Molecular Genetics, 18(6), 1148-1155. https://doi.org/10.1093/hmg/ddn438
Weersma, R. K., Stokkers, P. C. F., Cleynen, I., Wolfkamp, S. C. S., Henckaerts, L., Schreiber, S., ... Vermeire, S. (2009). Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large Dutch-Belgian Cohort. AMERICAN JOURNAL OF GASTROENTEROLOGY, 104(3), 630-638.
Weersma, R. K., Stokkers, P. C. F., van Bodegraven, A. A., van Hogezand, R. A., Verspaget, H. W., de Jong, D. J., ... Dutch Initiative on Crohn and Colitis (2009). Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. Gut, 58(3), 388-395. https://doi.org/10.1136/gut.2007.144865
Heinz-Erian, P., Mueller, T., Krabichler, B., Schranz, M., Becker, C., Rueschendorf, F., ... Janecke, A. R. (2009). Mutations in SPINT2 Cause a Syndromic Form of Congenital Sodium Diarrhea. American Journal of Human Genetics, 84(2), 188-196. https://doi.org/10.1016/j.ajhg.2009.01.004
Hofker, M., & Wijmenga, C. (2009). A supersized list of obesity genes. Nature Genetics, 41(2), 139-140. https://doi.org/10.1038/ng0209-139
Heap, G. A., Trynka, G., Jansen, R. C., Bruinenberg, M., Swertz, M. A., Dinesen, L. C., ... Heel, D. A. V. (2009). Complex nature of SNP genotype effects on gene expression in primary human leucocytes. BMC Medical Genomics, 2(1), [1]. https://doi.org/10.1186/1755-8794-2-1
Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009). Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nature Reviews Genetics, 10(1), 43-55. https://doi.org/10.1038/nrg2489
Romanos, J., Barisani, D., Trynka, G., Zhernakova, A., Bardella, M. T., & Wijmenga, C. (2009). Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease. JOURNAL OF MEDICAL GENETICS, 46(1), 60-63. https://doi.org/10.1136/jmg.2008.061457
Golachowska, M. R., Szperl, A., Bruineberg, M., Prekeris, R., Thunnissen, A-M. W. H., Hoekstra, D., ... IJzendoorn, S. C. (2009). Apical Recycling Endosome-Associated Myosin Vb Is Mutated in Microvillus Inclusion Disease and Is Involved in Intestinal Brush Border Development.
Ruigrok, Y. M., Rinkel, G. J. E., Wijmenga, C., Kasuya, H., Tajima, A., Takahashi, T., ... Krischek, B. (2009). Association Analysis of Genes Involved in the Maintenance of the Integrity of the Extracellular Matrix with Intracranial Aneurysms in a Japanese Cohort. Cerebrovascular Diseases, 28(2), 131-134. https://doi.org/10.1159/000223438
Visschedijk, M., Festen, E., Weersma, R., & Wijmenga, T. (2009). De genetische achtergrond van inflammatoire darmziekten ontrafeld door genoomwijde associatiestudies. Nederlands Tijdschrift voor Geneeskunde, 153(A402), 1-6. [19900309].
Forabosco, P., Neuhausen, S. L., Greco, L., Naluai, A. T., Wijmenga, C., Saavalainen, P., ... Lewis, C. M. (2009). Meta-Analysis of Genome-Wide Linkage Studies in Celiac Disease. Human heredity, 68(4), 223-230. https://doi.org/10.1159/000228920

2008

Smyth, D. J., Plagnol, V., Walker, N. M., Cooper, J. D., Downes, K., Yang, J. H. M., ... Todd, J. A. (2008). Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease. New England Journal of Medicine, 359(26), 2767-2777.
Bauer, F., Onland-Moret, N. C., Niehoff, A. G., Elbers, C. C., Grobbee, D. E., Wijmenga, C., & van der Schouw, Y. T. (2008). No Association of PTPN1 Polymorphisms With Macronutrient Intake and Measures of Adiposity. Obesity, 16(12), 2767-2771. https://doi.org/10.1038/oby.2008.426
Bilguvar, K., Yasuno, K., Niemela, M., Ruigrok, Y. M., Fraunberg, M. V. U. Z., van Duijn, C. M., ... Guenel, M. (2008). Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nature Genetics, 40(12), 1472-1477. https://doi.org/10.1038/ng.240
van Loo, K. M. J., Dejaegere, T., van Zweeden, M., van Schijndel, J. E., Wijmenga, C., Trip, M. D., & Martens, G. J. M. (2008). Male-Specific Association between a gamma-Secretase Polymorphism and Premature Coronary Atherosclerosis. PLoS ONE, 3(11), [3662]. https://doi.org/10.1371/journal.pone.0003662
Jungerius, B. J., Hoogendoorn, M. L. C., Bakker, S. C., van't Slot, R., Bardoel, A. F., Ophoff, R. A., ... Sinke, R. J. (2008). An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. Molecular Psychiatry, 13(11), 1060-1068. https://doi.org/10.1038/sj.mp.4002080
Franke, A., Balschun, T., Karlsen, T. H., Sventoraityte, J., Nikolaus, S., Mayr, G., ... IBSEN Study Grp (2008). Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nature Genetics, 40(11), 1319-1323. https://doi.org/10.1038/ng.221
Vonk, W. I. M., Wijmenga, C., & van de Sluis, B. (2008). Relevance of animal models for understanding mammalian copper homeostasis. American Journal of Clinical Nutrition, 88(3), 840S-845S.
Festen, E. A., Zhernakova, A., Wijmenga, C., & Weersma, R. K. (2008). Association of DLG5 variants with gluten-sensitive enteropathy. Gut, 57(7), 1027-1028. https://doi.org/10.1136/gut.2007.144857
Orozco, G., Alizadeh, B. Z., Delgado-Vega, A. M., Gonzalez-Gay, M. A., Balsa, A., Pascual-Salcedo, D., ... Martin, J. (2008). Association of STAT4 with rheumatoid arthritis - A replication study in three European populations: a replication study in three European populations. ARTHRITIS AND RHEUMATISM, 58(7), 1974-1980. https://doi.org/10.1002/art.23549
Meex, S. J. R., van Vliet-Ostaptchouk, J. V., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Schalkwijk, C. G., Feskens, E. J. M., ... de Bruin, T. W. A. (2008). Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: Association study in 2000 Dutch Caucasians. Molecular Genetics and Metabolism, 94(3), 352-355. https://doi.org/10.1016/j.ymgme.2008.03.011
Franke, L., de Kovel, C. G. E., Aulchenko, Y. S., Trynka, G., Zhernakova, A., Hunt, K. A., ... Wijmenga, C. (2008). Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays. American Journal of Human Genetics, 82(6), 1316-1333. https://doi.org/10.1016/j.ajhg.2008.05.008
Ruigrok, Y. M., Tan, S., Medic, J., Rinkel, G. J. E., & Wijmenga, C. (2008). Genes involved in the transforming growth factor beta signalling pathway and the risk of intracranial aneurysms. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 79(6), 722-724. https://doi.org/10.1136/jnnp.2007.128041
Geremek, M., Schoenmaker, F., Zietkiewicz, E., Pogorzelski, A., Diehl, S., Wijmenga, C., & Witt, M. (2008). Sequence analysis of 21 genes located in the Kartagener syndrome linkage region on chromosome 15q. European Journal of Human Genetics, 16(6), 688-695. https://doi.org/10.1038/ejhg.2008.5
Monsuur, A. J., de Bakker, P. I. W., Zhernakova, A., Pinto, D., Verduijn, W., Romanos, J., ... Wijmenga, C. (2008). Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms. PLoS ONE, 3(5), [e2270]. https://doi.org/10.1371/journal.pone.0002270
Zhernakova, A., Festen, E. M., Franke, L., Trynka, G., van Diemen, C. C., Monsuur, A. J., ... Weersma, R. K. (2008). Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. American Journal of Human Genetics, 82(5), 1202-1210. https://doi.org/10.1016/j.ajhg.2008.03.016
van Vliet-Ostaptchouk, J. V., Onland-Moret, N. C., van Haeften, T. W., Franke, L., Elbers, C. C., Shiri-Sverdlov, R., ... Wijmenga, C. (2008). HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. European Journal of Human Genetics, 16(5), 652-656. https://doi.org/10.1038/sj.ejhg.5202008
Jungerius, B. J., Bakker, S. C., Monsuur, A. J., Sinke, R. J., Kahn, R. S., & Wijmenga, C. (2008). Is MYO9B the missing link between schizophrenia and celiac disease? American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B(3), 351-355. https://doi.org/10.1002/ajmg.b.30605
Wapenaar, M. C., Monsuur, A. J., van Bodegraven, A. A., Weersma, R. K., Bevova, M. R., Linskens, R. K., ... Wijmenga, C. (2008). Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis. Gut, 57(4), 463-467. https://doi.org/10.1136/gut.2007.133132
Ruigrok, Y. M., Wijmenga, C., Rinkel, G. J. E., Van't Slot, R., Baas, F., Wolfs, M., ... Roos, Y. B. W. E. M. (2008). Genomewide linkage in a large Dutch family with intracranial aneurysms - Replication of 2 loci for intracranial aneurysms to chromosome 1p36.11-p36.13 and Xp22.2-p22.32. Stroke, 39(4), 1096-1102. https://doi.org/10.1161/STROKEAHA.107.495168
Koskinen, L. L. E., Korponay-Szabo, I. R., Viiri, K., Juuti-Uusitalo, K., Kaukinen, K., Lindfors, K., ... Saavalainen, P. (2008). Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association. JOURNAL OF MEDICAL GENETICS, 45(4), 222-227. https://doi.org/10.1136/jmg.2007.053991
Hunt, K. A., Zhernakova, A., Turner, G., Heap, G. A. R., Franke, L., Bruinenberg, M., ... van Heel, D. A. (2008). Newly identified genetic risk variants for celiac disease related to the immune response. Nature Genetics, 40(4), 395-402. https://doi.org/10.1038/ng.102
Weersma, R. K., Zhernakova, A., Nolte, I. M., Lefebvre, C., Rioux, J. D., Mulder, F., ... Dijkstra, G. (2008). ATG16L1 and IL23R Are Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands. AMERICAN JOURNAL OF GASTROENTEROLOGY, 103(3), 621-627.
Friedman, J. I., Vrijenhoek, T., Markx, S., Janssen, I. M., Van der Vliet, W. A., Faas, B. H. W., ... Veltman, J. A. (2008). CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy. Molecular Psychiatry, 13(3), 261-266. https://doi.org/10.1038/sj.mp.4002049
Helgadottir, A., Thorleifsson, G., Magnusson, K. P., Gretarsdottir, S., Steinthorsdottir, V., Manolescu, A., ... Stefansson, K. (2008). The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nature Genetics, 40(2), 217-224. https://doi.org/10.1038/ng.72
van Vliet-Ostaptchouk, J. V., Onland-Moret, N. C., Shiri-Sverdlov, R., van Gorp, P. J. J., Custers, A., Peeters, P. H. M., ... van der Schouw, Y. T. (2008). Polymorphisms of the TUB Gene Are Associated with Body Composition and Eating Behavior in Middle-Aged Women. PLoS ONE, 3(1), [1405]. https://doi.org/10.1371/journal.pone.0001405
Wolters, V. M., & Wijmenga, C. (2008). Genetic background of celiac disease and its clinical implications. AMERICAN JOURNAL OF GASTROENTEROLOGY, 103(1), 190-195.
van Es, M. A., van Vught, P. W., Blauw, H. M., Franke, L., Saris, C. G. J., Van Den Bosch, L., ... van den Berg, L. H. (2008). Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nature Genetics, 40(1), 29-31. https://doi.org/10.1038/ng.2007.52

2007

Zhernakova, A., Alizadeh, B. Z., Bevova, M., van Leeuwen, M. A., Coenen, M. J. H., Franke, B., ... Wijmenga, C. (2007). Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases. American Journal of Human Genetics, 81(6), 1284-1288. https://doi.org/10.1086/522037
Wolters, V. M., Verbeek, W. H. M., Zhernakova, A., Onland-Moret, C., Schreurs, M. W. J., Monsuur, A. J., ... Mulder, C. J. J. (2007). The MY09B gene is a strong risk factor for developing refractory Celiac disease. Clinical Gastroenterology and Hepatology, 5(12), 1399-1405. https://doi.org/10.1016/j.cgh.2007.08.018
Alizadeh, B. Z., Valdigem, G., Coenen, M. J. H., Zhernakova, A., Franke, B., Monsuur, A., ... Koeleman, B. P. C. (2007). Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis. Human Molecular Genetics, 16(21), 2552-2559. https://doi.org/10.1093/hmg/ddm194
de Bie, P., Muller, P., Wijmenga, C., & Klomp, L. W. J. (2007). Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes. JOURNAL OF MEDICAL GENETICS, 44(11), 673-688. https://doi.org/10.1136/jmg.2007.052746
de Bie, P., van de Sluis, B., Burstein, E., van den Berghe, P. V. E., Muller, P., Berger, R., ... Klomp, L. W. J. (2007). Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B. Gastroenterology, 133(4), 1316-1326. https://doi.org/10.1053/j.gastro.2007.07.020
van Es, M. A., Van Vught, P. W., Blauw, H. M., Franke, L., Saris, C. G., Andersen, P. M., ... van den Berg, L. H. (2007). ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. Lancet Neurology, 6(10), 869-877. https://doi.org/10.1016/S1474-4422(07)70222-3
Janssen, R., Bont, L., Siezen, C. L. E., Hodemaekers, H. M., Ermers, M. J., Doornbos, G., ... Hoebee, B. (2007). Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. Journal of infectious diseases, 196(6), 826-834. https://doi.org/10.1086/520886
van de Sluis, B., Groot, A. J., Wijmenga, C., Vooijs, M., & Klomp, L. W. (2007). COMMD1 - A novel protein involved in the proteolysis of proteins. Cell Cycle, 6(17), 2091-2098.
Saunders, C. L., Chiodini, B. D., Sham, P., Lewis, C. M., Abkevich, V., Adeyemo, A. A., ... Collier, D. A. (2007). Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity, 15(9), 2263-2275. https://doi.org/10.1038/oby.2007.269
Gudmundsson, J., Sulem, P., Steinthorsdottir, V., Bergthorsson, J. T., Thorleifsson, G., Manolescu, A., ... Stefansson, K. (2007). Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nature Genetics, 39(8), 977-983. https://doi.org/10.1038/ng2062
Sanchez, E., Alizadeh, B. Z., Valdigem, G., Ortego-Centeno, N., Jimenez-Alonso, J., de Ramon, E., ... Koeleman, B. P. C. (2007). MY09B gene polymorphisms are associated with autoimmune diseases in Spanish population. Human Immunology, 68(7), 610-615. https://doi.org/10.1016/j.humimm.2007.03.006
van Heel, D. A., Franke, L., Hunt, K. A., Gwilliam, R., Zhernakova, A., Inouye, M., ... Wijmenga, C. (2007). A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nature Genetics, 39(7), 827-829. https://doi.org/10.1038/ng2058
Steinthorsdottir, V., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Jonsdottir, T., Walters, G. B., ... Stefansson, K. (2007). A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nature Genetics, 39(6), 770-775. https://doi.org/10.1038/ng2043
van de Sluis, B., Muller, P., Duran, K., Chen, A., Groot, A. J., Klomp, L. W., ... Wijmenga, C. (2007). Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice. Molecular and Cellular Biology, 27(11), 4142-4156. https://doi.org/10.1128/MCB.01932-06
Muller, P., van Bakel, H., van de Sluis, B., Holstege, F., Wijmenga, C., & Klomp, L. W. J. (2007). Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genes. Journal of biological inorganic chemistry, 12(4), 495-507. https://doi.org/10.1007/s00775-006-0201-y
Diosdado, B., Van Bakel, H., Strengman, E., Franke, L., Van Oort, E., Mulder, C. J., ... Wapenaar, M. C. (2007). Neutrophil recruitment and barrier impairment in celiac disease: A genomic study. Clinical Gastroenterology and Hepatology, 5(5), 574-581. https://doi.org/10.1016/j.cgh.2006.11.014
Wapenaar, M. C., Monsuur, A. J., Poell, J., Slot, R. V. ., Meijer, J. W. R., Meijer, G. A., ... Wijmenga, C. (2007). The SPINK gene family and celiac disease susceptibility. Immunogenetics, 59(5), 349-357. https://doi.org/10.1007/s00251-007-0199-5
Alizadeh, B. Z., Eerligh, P., van der Slik, A. R., Shastry, A., Zhernakova, A., Valdigem, G., ... Koeleman, B. P. C. (2007). MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: An association and meta-analysis. Molecular Immunology, 44(11), 2806-2812. https://doi.org/10.1016/j.molimm.2007.01.032
van Vliet-Ostaptchouk, J. V., Shiri-Sverdlov, R., Zhernakova, A., Strengman, E., van Haeften, T. W., Hofker, M. H., & Wijmenga, C. (2007). Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort. Diabetologia, 50(1), 59-62. https://doi.org/10.1007/s00125-006-0477-z
Rustici, G., van Bakel, H., Lackner, D. H., Holstege, F., Wijmenga, C., Baehler, J., & Brazma, A. (2007). Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study. Genome Biology, 8(5), [73]. https://doi.org/10.1186/gb-2007-8-5-r73

2006

de Bie, P., van de Sluis, B., Burstein, E., Duran, K. J., Berger, R., Duckett, C. S., ... Klomp, L. W. J. (2006). Characterization of COMMD protein-protein interactions in NF-kappaB signalling. Biochemical Journal, 398(1), 63-71. https://doi.org/10.1042/BJ20051664
Zhernakova, A., Alizadeh, B. Z., Eerligh, P., Hanifi-Moghaddam, P., Schloot, N. C., Diosdado, B., ... Koeleman, B. P. C. (2006). Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes. GENES AND IMMUNITY, 7(7), 544-549. https://doi.org/10.1038/sj.gene.6364326
Shiri-Sverdlov, R., Custers, A., van Vliet-Ostaptchouk, J. V., van Gorp, P. J., Lindsey, P. J., van Tilburg, J. H., ... Wijmenga, C. (2006). Identification of TUB as a novel candidate gene influencing body weight in humans. Diabetes, 55(2), 385-389.
Geremek, M., Zietkiewicz, E., Diehl, S. R., Alizadeh, B. Z., Wijmenga, C., & Witt, M. (2006). Linkage analysis localises a Kartagener syndrome gene to a 3.5 cM region on chromosome 15q24-25. JOURNAL OF MEDICAL GENETICS, 43(1), [1]. https://doi.org/10.1136/jmg.2005.031526

2005

Monsuur, AJ., de Bakker, PIW., Alizadeh, BZ., Zhernakova, A., Bevova, MR., Strengman, E., ... Wijmenga, C. (2005). Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nature Genetics, 37(12), 1341-1344. https://doi.org/10.1038/ng1680
Ruigrok, YM., Slooter, AJC., Bardoel, A., Frijns, CJM., Rinkel, GJE., & Wijmenga, C. (2005). Genes and outcome after aneurysmal subarachnoid haemorrhage. Journal of Neurology, 252(4), 417-422. https://doi.org/10.1007/s00415-005-0661-y
de Bie, P., van de Sluis, B., Klomp, L., & Wijmenga, C. (2005). The many faces of the copper metabolism protein MURR1/COMMD1. Journal of Heredity, 96(7), 803-11. https://doi.org/10.1093/jhered/esi110

2004

Diosdado, B., Wapenaar, MC., Franke, L., Duran, KJ., Goerres, MJ., Hadithi, M., ... Wijmenga, C. (2004). A microarray screen for novel candidate genes in coeliac disease pathogenesis. Gut, 53(7), 944-951. https://doi.org/10.1136/gut.2003.018374
Giltay, JC., Deege, M., Blankenstein, RA., Kastrop, PMM., Wijmenga, C., & Lock, TTWT. (2004). Apparent primary follicle-stimulating hormone deficiency is a rare cause of treatable male infertility. Fertility and sterility, 81(3), 693-696. https://doi.org/10.1016/j.fertnstert.2003.07.030
Ruigrok, YM., Rinkel, GJE., & Wijmenga, C. (2004). Familial intracranial aneurysms. Stroke, 35(3). https://doi.org/10.1161/01.STR.0000117966.47696.3A
Wijmenga, C., & Klomp, LWJ. (2004). Molecular regulation of copper excretion in the liver. Proceedings of the nutrition society, 63(1), 31-39. https://doi.org/10.1079/PNS2003316
Burstein, E., Ganesh, L., Dick, R. D., van De Sluis, B., Wilkinson, J. C., Klomp, L. W. J., ... Duckett, C. S. (2004). A novel role for XIAP in copper homeostasis through regulation of MURR1. The EMBO Journal, 23(1), 244-254. https://doi.org/10.1038/sj.emboj.7600031

2003

Klomp, A. E. M., van de Sluis, B., Klomp, L. W. J., & Wijmenga, C. (2003). The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis. Journal of Hepatology, 39(5), 703-709. https://doi.org/10.1016/S0168-8278(03)00380-5
van Tilburg, JHO., Wijmenga, C., & van Haeften, TW. (2003). -to: Shafrir E, Raz I (2003) - For debate. Diabetes: mellitus or lipidus? Diabetologia 46: 433-440. Diabetologia, 46(11), 1588-1588. https://doi.org/10.1007/s00125-003-1217-2
van de Sluis, B., Peter, A. T., & Wijmenga, C. (2003). Indirect Molecular Diagnosis of Copper Toxicosis in Bedlington Terriers Is Complicated by Haplotype Diversity. Journal of Heredity, 94(3), 256-259. https://doi.org/10.1093/jhered/esg030
Müller, T., van de Sluis, B., Zhernakova, A., van Binsbergen, E., Janecke, A. R., Bavdekar, A., ... Wijmenga, C. (2003). The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. Journal of Hepatology, 38(2), 164-168. https://doi.org/10.1016/S0168-8278(02)00356-2
van Tilburg, JH., Wijmenga, C., van Bakel, H., Rozeman, L., Pearson, PL., & van Haeften, T. W. (2003). Relationship of beta 2-adrenergic receptor polymorphism with obesity in type 2 diabetes. Diabetes Care, 26(1), 251-252.

2002

van de Sluis, B., Rothuizen, J., Pearson, PL., van Oost, BA., & Wijmenga, C. (2002). Identification of a new copper metabolism gene by positional cloning in a purebred dog population. Human Molecular Genetics, 11(2), 165-173. https://doi.org/10.1093/hmg/11.2.165

2001

Ausems, M. G. E. M., ten Berg, K., Sandkuijl, L. A., Kroos, M. A., Bardoel, A. F., Roumelioti, K. N., ... Wijmenga, C. (2001). Dutch patients with glycogen storage disease type II show common ancestry for the 525delT and del exon 18 mutations. JOURNAL OF MEDICAL GENETICS, 38(8), 527-9.
van de Sluis, B., Nanji, M. S., Breen, M., Pearson, P. L., Oost, B. A., Cox, D. W., & Wijmenga, C. (2001). Characterization and chromosomal localization of five canine ATOX1 pseudogenes. Cytogenetics and cell genetics, 93(1-2), 105-108. https://doi.org/10.1159/000056959

2000

van de Sluis, B., Kole, S., van Wolferen, M., Holmes, N. G., Pearson, P. L., Rothuizen, J., ... Wijmenga, C. (2000). Refined genetic and comparative physical mapping of the canine copper toxicosis locus. Mammalian Genome, 11(6), 455-460. https://doi.org/10.1007/s003350010086

1999

Müller, T., van de Sluis, B., Müller, W., Pearson, P., & Wijmenga, C. (1999). Non-Indian childhood cirrhosis. European journal of medical research, 4(7), 293-297.
van de Sluis, B. J., Breen, M., Nanji, M., van Wolferen, M., de Jong, P., Binns, M. M., ... van Oost, B. A. (1999). Genetic mapping of the copper toxicosis locus in Bedlington terriers to dog chromosome 10, in a region syntenic to human chromosome region 2p13-p16. Human Molecular Genetics, 8(3), 501-507. https://doi.org/10.1093/hmg/8.3.501

1991

VANDERHOUT, AH., VANDERVLIES, P., WIJMENGA, C., LI, FP., OOSTERHUIS, JW., & BUYS, CHCM. (1991). THE REGION OF COMMON ALLELIC LOSSES IN SPORADIC RENAL-CELL CARCINOMA IS BORDERED BY THE LOCI-D3S2 AND THRB. GENOMICS, 11(3), 537-542.
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