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Wijmenga, Prof. Cisca

Cisca Wijmenga (Photo: NWO/Ivar Pel)
Cisca Wijmenga (Photo: NWO/Ivar Pel)

Prof. Cisca Wijmenga has been Professor of Human Genetics at the University of Groningen and head of the Genetics Department of the University Medical Center Groningen since 2007. The aim of her research is to understand the role that genes play in the development of chronic diseases. Her research group focuses on the genetics of inflammation-related conditions, such as coeliac disease (gluten allergy) and inflammatory intestinal disease (e.g. Crohn’s disease, ulcerative colitis). Research led by Wijmenga has discovered several genes that are involved in causing such immune-related disorders. This knowledge is leading to new insights into the disease process, and could possibly result in new treatments for patients.

Prof. Wijmenga has been elected a member of the Royal Netherlands Academy of Arts and Sciences (KNAW) in 2012. Members of KNAW are all prominent academics from all disciplines and are chosen on the basis of nominations from within and outside the Academy. In the same year she received a prestigious ERC Advanced Grant for her research project on Celiac disease. The BBMRI-NL2.0 project, a collaboration led by Wijmenga between biobanks in the Netherlands, received EUR 9.8 million from NWO in 2014. In 2015 Wijmenga has been awarded a Spinoza Prize, also referred to as the 'Dutch Nobel Prize'.

From 2019 - 2023, Wijmenga was rector magnificus of the RUG. She was the first female rector in the 405-year history of the UG.

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Article for NOS
Article for NOS

2024

Fernández-Pato, A., Sinha, T., Gacesa, R., Andreu-Sánchez, S., Gois, M. F. B., Gelderloos-Arends, J., Jansen, D. B. H., Kruk, M., Jaeger, M., Joosten, L. A. B., Netea, M. G., Weersma, R. K., Wijmenga, C., Harmsen, H. J. M., Fu, J., Zhernakova, A., & Kurilshikov, A. (2024). Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses. Scientific Reports, 14, Article 3911. https://doi.org/10.1038/s41598-024-54353-w
Lifelines Cohort Study, Zhernakova, D. V., Wang, D., Liu, L., Andreu-Sánchez, S., Zhang, Y., Ruiz-Moreno, A. J., Peng, H., Plomp, N., Del Castillo-Izquierdo, Á., Gacesa, R., Lopera-Maya, E. A., Temba, G. S., Kullaya, V. I., van Leeuwen, S. S., Xavier, R. J., de Mast, Q., Joosten, L. A. B., Riksen, N. P., ... Fu, J. (2024). Host genetic regulation of human gut microbial structural variation. Nature. Advance online publication. https://doi.org/10.1038/s41586-023-06893-w
Lifelines NEXT cohort study, Garmaeva, S., Sinha, T., Gulyaeva, A., Kuzub, N., Spreckels, J. E., Andreu-Sánchez, S., Gacesa, R., Vich Vila, A., Brushett, S., Kruk, M., Dekens, J., Sikkema, J., Kuipers, F., Shkoporov, A. N., Hill, C., Scherjon, S., Wijmenga, C., Fu, J., ... Zhernakova, A. (2024). Transmission and dynamics of mother-infant gut viruses during pregnancy and early life. Nature Communications, 15(1), Article 1945. https://doi.org/10.1038/s41467-024-45257-4

2023

BBJ, BioMe, BioVU, Canadian Partnership for Tomorrow's Health/OHS, China Kadoorie Biobank Collaborative Group, Colorado Center for Personalized Medicine, deCODE Genetics, ESTBB, FinnGen, Generation Scotland, Genes & Health, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, QIMR Berghofer Biobank, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health Initiative, UKBB, ... Hirbo, J. B. (2023). Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts. Cell Genomics, 3(1), Article 100241. https://doi.org/10.1016/j.xgen.2022.100241
Brushett, S., Gacesa, R., Vila, A. V., Gois, M. F. B., Andreu-Sánchez, S., Swarte, J. C., Klaassen, M. A. Y., Collij, V., Sinha, T., Bolte, L. A., Wu, J., Swertz, M., Kroon, M. L. A. D., Reijneveld, S. A., Wijmenga, C., Weersma, R. K., Fu, J., Loo, H. M. V., Kurilshikov, A., & Zhernakova, A. (2023). Gut feelings: the relations between depression, anxiety, psychotropic drugs and the gut microbiome. Gut Microbes, 15(2), Article 2281360. https://doi.org/10.1080/19490976.2023.2281360
Hamburg Intestinal Tissue Study Group, International Inflammatory Bowel Disease Genetics Consortium, Baumdick, M. E., Niehrs, A., Degenhardt, F., Schwerk, M., Hinrichs, O., Jordan-Paiz, A., Padoan, B., Wegner, L. H. M., Schloer, S., Zecher, B. F., Malsy, J., Joshi, V. R., Illig, C., Schröder-Schwarz, J., Möller, K. J., Martin, M. P., Yuki, Y., ... Franke, A. (2023). HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis. Gastroenterology, 165(4), 946-962.e13. https://doi.org/10.1053/j.gastro.2023.06.034
Gois, M. F. B., Fernández-Pato, A., Huss, A., Gacesa, R., Wijmenga, C., Weersma, R. K., Fu, J., Vermeulen, R. C. H., Zhernakova, A., Lenters, V. C., & Kurilshikov, A. (2023). Impact of occupational pesticide exposure on the human gut microbiome. Frontiers in Microbiology, 14, Article 1223120. https://doi.org/10.3389/fmicb.2023.1223120
TANDEM Consortium$, Eckold, C., van Doorn, C. L. R., Ruslami, R., Ronacher, K., Riza, A.-L., van Veen, S., Lee, J.-S., Kumar, V., Kerry-Barnard, S., Malherbe, S. T., Kleynhans, L., Stanley, K., Joosten, S. A., Critchley, J. A., Hill, P. C., van Crevel, R., Wijmenga, C., Haks, M. C., ... Cliff, J. M. (2023). Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity. Clinical and Translational Medicine, 13(9), Article e1375. https://doi.org/10.1002/ctm2.1375
Palasantzas, V. E. J. M., Tamargo-Rubio, I., Le, K., Slager, J., Wijmenga, C., Jonkers, I. H., Kumar, V., Fu, J., & Withoff, S. (2023). iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies. Trends in Genetics, 39(4), 268-284. https://doi.org/10.1016/j.tig.2023.01.002
eQTLGen Consortium, Dai, Q., Zhou, G., Zhao, H., Võsa, U., Franke, L., Battle, A., Teumer, A., Lehtimäki, T., Raitakari, O. T., Esko, T., Epstein, M. P., & Yang, J. (2023). OTTERS: a powerful TWAS framework leveraging summary-level reference data. Nature Communications, 14, Article 1271. https://doi.org/10.1038/s41467-023-36862-w
Bourgonje, A. R., Andreu-Sánchez, S., Vogl, T., Hu, S., Vich Vila, A., Gacesa, R., Leviatan, S., Kurilshchikov, A., Klompus, S., Kalka, I. N., van Dullemen, H. M., Weinberger, A., Visschedijk, M. C., Festen, E. A. M., Faber, K. N., Wijmenga, C., Dijkstra, G., Segal, E., Fu, J., ... Weersma, R. K. (2023). Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures. Immunity, 56(6), 1393-1409.e6. https://doi.org/10.1016/j.immuni.2023.04.017
Lifelines Cohort Study, Andreu-Sánchez, S., Bourgonje, A. R., Vogl, T., Kurilshchikov, A., Leviatan, S., Ruiz-Moreno, A. J., Hu, S., Sinha, T., Vich Vila, A., Klompus, S., Kalka, I. N., de Leeuw, K., Arends, S., Jonkers, I., Withoff, S., Brouwer, E., Weinberger, A., Wijmenga, C., ... Zhernakova, A. (2023). Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire. Immunity, 56(6), 1376-1392.e8. https://doi.org/10.1016/j.immuni.2023.04.003
The Netherlands A. C. M./P. L. N. Registry, Lifelines Cohort Study, Lopera-Maya, E. A., Li, S., de Brouwer, R., Nolte, I. M., van Breen, J., Jongbloed, J. D. H., Swertz, M. A., Snieder, H., Franke, L., Wijmenga, C., de Boer, R. A., Deelen, P., van der Zwaag, P. A., & Sanna, S. (2023). Phenotypic and Genetic Factors Associated with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA Carriers. Journal of cardiovascular translational research, 16, 1251–1266. https://doi.org/10.1007/s12265-022-10347-5
Lifelines Corona Research initiative, Goërtz, Y. M. J., Spruit, M. A., Van Herck, M., Dukers-Muijrers, N., van der Kallen, C. J. H., Burtin, C., & Janssen, D. J. A. (2023). Symptoms and quality of life before, during, and after a SARS-CoV-2 PCR positive or negative test: data from Lifelines. Scientific Reports, 13, Article 11713. https://doi.org/10.1038/s41598-023-38223-5
Lifelines Corona Research initiative, Mobach, M. P., Boezen, H. M., Mierau, J. O., Franke, H. L., Dekens, J., Deelen, P., Lanting, P., Vonk, J. M., Nolte, I., Ori, A. P. S., Claringbould, A., Boulogne, F., Dijkema, M. X. L., Wiersma, H. H., Warmerdam, R., Jankipersadsing, S. A., van Blokland, I., de Bock, G. T. H., ... Wijmenga, C. (2023). Workplace impact on employees: A Lifelines Corona Research Initiative on the return to work. PLoS ONE, 18(1), Article e0279902. https://doi.org/10.1371/journal.pone.0279902

2022

Chu, X., Janssen, A. W. M., Koenen, H., Chang, L., He, X., Joosten, I., Stienstra, R., Kuijpers, Y., Wijmenga, C., Xu, C.-J., Netea, M. G., Tack, C. J., Li, Y., & Buettner, C. (2022). A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes. eLife, 11, Article 73709. https://doi.org/10.7554/eLife.73709
Lifelines Cohort Study, Lopera-Maya, E. A., Kurilshikov, A., van der Graaf, A., Hu, S., Andreu-Sánchez, S., Chen, L., Vila, A. V., Gacesa, R., Sinha, T., Collij, V., Klaassen, M. A. Y., Bolte, L. A., Gois, M. F. B., Neerincx, P. B. T., Swertz, M. A., Harmsen, H. J. M., Wijmenga, C., Fu, J., ... Sanna, S. (2022). Author Correction: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project (Nature Genetics, (2022), 54, 2, (143-151), 10.1038/s41588-021-00992-y). Nature genetics, 54(9), 1448. https://doi.org/10.1038/s41588-022-01164-2
Gulyaeva, A., Garmaeva, S., Ruigrok, R. A. A. A., Wang, D., Riksen, N. P., Netea, M. G., Wijmenga, C., Weersma, R. K., Fu, J., Vila, A. V., Kurilshikov, A., & Zhernakova, A. (2022). Discovery, diversity, and functional associations of crAss-like phages in human gut metagenomes from four Dutch cohorts. Cell reports, 38(2), Article 110204. https://doi.org/10.1016/j.celrep.2021.110204
Lopera-Maya, E. A., Kurilshikov, A., van der Graaf, A., Hu, S., Lifelines Cohort Study, Andreu-Sánchez, S., Chen, L., Vila, A. V., Gacesa, R., Sinha, T., Collij, V., Klaassen, M. A. Y., Bolte, L. A., Brandao Gois, M. F., Neerincx, P. B. T., Swertz, M. A., Harmsen, H. J. M., Wijmenga, C., Fu, J., ... Sanna, S. (2022). Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project. Nature genetics, 54, 143-151. https://doi.org/10.1038/s41588-021-00992-y
Lifelines Cohort Study, Lopera-Maya, E. A., Kurilshikov, A., van der Graaf, A., Hu, S., Andreu-Sánchez, S., Chen, L., Vich-Vila, A., Gacesa, R., Sinha, T., Collij, V., Klassen, M. A. Y., Bolte, L. A., Brandao-Gois, M. F., Neerincx, P. B. T., Swertz, M. A., Harmsen, H. J. M., Wijmenga, C., Fu, J., ... Sanna, S. (2022). Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project. European Journal of Human Genetics, 30(SUPPL 1), 589-589.
Gacesa, R., Kurilshikov, A., Vich Vila, A., Sinha, T., Klaassen, M. A. Y., Bolte, L. A., Andreu-Sánchez, S., Chen, L., Collij, V., Hu, S., Dekens, J. A. M., Lenters, V. C., Björk, J. R., Swarte, J. C., Swertz, M. A., Jansen, B. H., Gelderloos-Arends, J., Jankipersadsing, S., Hofker, M., ... Weersma, R. K. (2022). Environmental factors shaping the gut microbiome in a Dutch population. Nature, 732–739. https://doi.org/10.1038/s41586-022-04567-7
Andreu-Sánchez, S., Aubert, G., Ripoll-Cladellas, A., Henkelman, S., Zhernakova, D. V., Sinha, T., Kurilshikov, A., Cenit, M. C., Jan Bonder, M., Franke, L., Wijmenga, C., Fu, J., van der Wijst, M. G. P., Melé, M., Lansdorp, P., & Zhernakova, A. (2022). Genetic, parental and lifestyle factors influence telomere length. Communications biology, 5(1), Article 565. https://doi.org/10.1038/s42003-022-03521-7
BIOS Consortium, Brain MEND Consortium, Hop, P. J., Zwamborn, R. A. J., Hannon, E., Shireby, G. L., Nabais, M. F., Walker, E. M., van Rheenen, W., van Vugt, J. J. F. A., Dekker, A. M., Westeneng, H. J., Tazelaar, G. H. P., van Eijk, K. R., Moisse, M., Baird, D., Al Khleifat, A., Iacoangeli, A., Ticozzi, N., ... Veldink, J. H. (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Science Translational Medicine, 14(633), Article eabj0264. https://doi.org/10.1126/scitranslmed.abj0264
deCODE Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes & Health Research Team, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, National Biobank of Korea, Penn Medicine BioBank, Qatar Biobank, The QSkin Sun and Health Study, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health Initiative, Uganda Genome Resource, UK Biobank, Biobank of the Americas, BioBank Japan Project, ... Sanna, S. (2022). Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease. Cell Genomics, 2(10), Article 100192. https://doi.org/10.1016/j.xgen.2022.100192
Swarte, J. C., Li, Y., Hu, S., Björk, J. R., Gacesa, R., Vich Vila, A., Douwes, R. M., Collij, V., Kurilshikov, A., Post, A., Klaassen, M. A. Y., Eisenga, M. F., Gomes-Neto, A. W., Kremer, D., Jansen, B. H., Knobbe, T. J., Berger, S. P., Sanders, J.-S. F., Heiner-Fokkema, M. R., ... Weersma, R. K. (2022). Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation. Science Translational Medicine, 14(660), Article eabn7566. https://doi.org/10.1126/scitranslmed.abn7566
Bourgonje, A. R., Andreu-Sánchez, S., Vogl, T., Hu, S., Vich Vila, A., Leviatan, S., Kurilshchikov, A., Klompus, S., Kalka, I. N., van Dullemen, H. M., Weinberger, A., Visschedijk, M. C., Festen, E. A. M., Faber, K. N., Wijmenga, C., Dijkstra, G., Segal, E., Fu, J., Zhernakova, A., & Weersma, R. K. (2022). In-depth characterisation of the serum antibody epitope repertoire in Inflammatory Bowel Disease by high-throughput phage-displayed immunoprecipitation sequencing. Journal of Crohn's and Colitis, 16(Suppl(1)), S100-S102. https://doi.org/10.1093/ecco-jcc/jjab232.092
Lifelines Cohort Study, Chen, L., Zhernakova, D. V., Kurilshikov, A., Andreu-Sánchez, S., Wang, D., Augustijn, H. E., Vich Vila, A., Weersma, R. K., Medema, M. H., Netea, M. G., Kuipers, F., Wijmenga, C., Zhernakova, A., & Fu, J. (2022). Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome. Nature Medicine, 28, 2333–2343. https://doi.org/10.1038/s41591-022-02014-8
Mujagic, Z., Kasapi, M., Jonkers, D. M. A. E., Garcia-Perez, I., Vork, L., Weerts, Z. Z. R. M., Serrano-Contreras, J. I., Zhernakova, A., Kurilshikov, A., Scotcher, J., Holmes, E., Wijmenga, C., Keszthelyi, D., Nicholson, J. K., Posma, J. M., & Masclee, A. A. M. (2022). Integrated fecal microbiome–metabolome signatures reflect stress and serotonin metabolism in irritable bowel syndrome. Gut Microbes, 14(1), Article 2063016. https://doi.org/10.1080/19490976.2022.2063016
Global Biobank Meta-analysis Initiative, Kanai, M., Elzur, R., Zhou, W., Daly, M. J., & Finucane, H. K. (2022). Meta-analysis fine-mapping is often miscalibrated at single-variant resolution. Cell Genomics, 2(12), Article 100210. https://doi.org/10.1016/j.xgen.2022.100210
Estonian Biobank Research Team, Lepamets, M., Auwerx, C., Nõukas, M., Claringbould, A., Porcu, E., Kals, M., Jürgenson, T., Morris, A. P., Võsa, U., Bochud, M., Stringhini, S., Wijmenga, C., Franke, L., Peterson, H., Vilo, J., Lepik, K., Mägi, R., & Kutalik, Z. (2022). Omics-informed CNV calls reduce false-positive rates and improve power for CNV-trait associations. Human Genetics and Genomics Advances, 3(4), Article 100133. https://doi.org/10.1016/j.xhgg.2022.100133
Ramírez-Sánchez, A. D., Chu, X., Modderman, R., Kooy-Winkelaar, Y., Koletzko, S., Korponay-Szabó, I. R., Troncone, R., Wijmenga, C., Mearin, L., Withoff, S., Jonkers, I. H., & Li, Y. (2022). Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers. Frontiers in Immunology, 13, Article 843086. https://doi.org/10.3389/fimmu.2022.843086
Doestzada, M., Zhernakova, D. V., C L van den Munckhof, I., Wang, D., Kurilshikov, A., Chen, L., Bloks, V. W., van Faassen, M., Rutten, J. H. W., Joosten, L. A. B., Netea, M. G., Wijmenga, C., Riksen, N. P., Zhernakova, A., Kuipers, F., & Fu, J. (2022). Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study. BMC Medicine, 20(1), Article 485. https://doi.org/10.1186/s12916-022-02688-4
TANDEM Consortium, van Doorn, C. L. R., Eckold, C., Ronacher, K., Ruslami, R., van Veen, S., Lee, J.-S., Kumar, V., Kerry-Barnard, S., Malherbe, S. T., Kleynhans, L., Stanley, K., Hill, P. C., Joosten, S. A., van Crevel, R., Wijmenga, C., Critchley, J. A., Walzl, G., Alisjahbana, B., ... Cliff, J. M. (2022). Transcriptional profiles predict treatment outcome in patients with tuberculosis and diabetes at diagnosis and at two weeks after initiation of anti-tuberculosis treatment. EBioMedicine, 82, Article 104173. https://doi.org/10.1016/j.ebiom.2022.104173

2021

Moorlag, S. J. C. F. M., Matzaraki, V., van Puffelen Heijden, J. H., van der Heijden, C., Keating, S., Groh, L., Bakker, O. B., Koeken, V. A. C. M., de Bree, L. C. J., Smeekens, S. P., Oosting, M., Gamboa, R. A., Riksen, N. P., Xavier, R. J., Wijmenga, C., Kumar, V., van Crevel, R., Novakovic, B., Joosten, L. A. B., ... Netea, M. G. (2022). An integrative genomics approach identifies KDM4 as a modulator of trained immunity. European Journal of Immunology, 52(3), 431-446. https://doi.org/10.1002/eji.202149577
Brandao Gois, M. F., Sinha, T., Spreckels, J. E., Vich Vila, A., Bolte, L. A., Weersma, R. K., Wijmenga, C., Fu, J., Zhernakova, A., & Kurilshikov, A. (2022). Role of the gut microbiome in mediating lactose intolerance symptoms. Gut, 71(1), 215-217. https://doi.org/10.1136/gutjnl-2020-323911
Gacesa, R., Vich Vila, A., Collij, V., Mujagic, Z., Kurilshikov, A., Voskuil, M. D., Festen, E. A. M., Wijmenga, C., Jonkers, D. M. A. E., Dijkstra, G., Fu, J., Zhernakova, A., Imhann, F., & Weersma, R. K. (2021). A combination of fecal calprotectin and human beta-defensin 2 facilitates diagnosis and monitoring of inflammatory bowel disease. Gut Microbes, 13(1), Article 1943288. https://doi.org/10.1080/19490976.2021.1943288
Tan, I. L., Barisani, D., Panceri, R., Modderman, R., Visschedijk, M., Weersma, R. K., Wijmenga, C., Jonkers, I., Coutinho de Almeida, R., & Withoff, S. (2021). A Combined mRNA- and miRNA-Sequencing Approach Reveals miRNAs as Potential Regulators of the Small Intestinal Transcriptome in Celiac Disease. International Journal of Molecular Sciences, 22(21), Article 11382. https://doi.org/10.3390/ijms222111382
Wang, D., Doestzada, M., Chen, L., Andreu-Sánchez, S., van den Munckhof, I. C. L., Augustijn, H. E., Koehorst, M., Ruiz-Moreno, A. J., Bloks, V. W., Riksen, N. P., Rutten, J. H. W., Joosten, L. A. B., Netea, M. G., Wijmenga, C., Zhernakova, A., Kuipers, F., & Fu, J. (2021). Characterization of gut microbial structural variations as determinants of human bile acid metabolism. Cell Host & Microbe, 29(12), 1802-1814.e5. https://doi.org/10.1016/j.chom.2021.11.003
Tan, I. L., Coutinho de Almeida, R., Modderman, R., Stachurska, A., Dekens, J., Barisani, D., Meijer, C. R., Roca, M., Martinez-Ojinaga, E., Shamir, R., Auricchio, R., Korponay-Szabó, I. R., Castillejo, G., Szajewska, H., Koletzko, S., Zhernakova, A., Kumar, V., Li, Y., Visschedijk, M. C., ... Withoff, S. (2021). Circulating miRNAs as Potential Biomarkers for Celiac Disease Development. Frontiers in Immunology, 12, Article 734763. https://doi.org/10.3389/fimmu.2021.734763
Gulyaeva, A., Garmaeva, S., Ruigrok, R. A. A. A., Wang, D., Riksen, N. P., Netea, M. G., Wijmenga, C., Weersma, R. K., Fu, J., Vila, A. V., Kurilshikov, A., & Zhernakova, A. (2021). Discovery, diversity and functional associations of crAss-like phages in human gut metagenomes from four Dutch cohorts. BioRxiv. https://doi.org/10.1101/2021.06.01.446427
Fu, J., Chen, L., Andreu-Sánchez, S., Wang, D., Augustijn, H. E., Zhernakova, D., Kurilshikov, A., Vila, A. V., Weersma, R., Medema, M., Netea, M., Kuipers, F., Wijmenga, C., & Zhernakova, A. (2021). Dominant drivers of the human plasma metabolome. BioRxiv. https://doi.org/10.21203/rs.3.rs-688716/v1
Wijmenga, C. (2021). From LD-based mapping to GWAS. Nature Reviews Genetics, 22(8). https://doi.org/10.1038/s41576-021-00366-4
Ortiz Fernández, L., Coit, P., Yilmaz, V., Yentür, S. P., Alibaz-Oner, F., Aksu, K., Erken, E., Düzgün, N., Keser, G., Cefle, A., Yazici, A., Ergen, A., Alpsoy, E., Salvarani, C., Casali, B., Kısacık, B., Kötter, I., Henes, J., Çınar, M., ... Sawalha, A. H. (2021). Genetic Association of a Gain-of-Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behcet's Disease. Arthritis & Rheumatology, 73(7), 1244-1252. https://doi.org/10.1002/art.41637
Peters, V., Tigchelaar-Feenstra, E. F., Imhann, F., Dekens, J. A. M., Swertz, M. A., Franke, L. H., Wijmenga, C., Weersma, R. K., Alizadeh, B. Z., Dijkstra, G., & Campmans-Kuijpers, M. J. E. (2021). Habitual dietary intake of IBD patients differs from population controls: A case-control study. European Journal of Nutrition, 60, 345–356. https://doi.org/10.1007/s00394-020-02250-z
Brand, E. C., Klaassen, M. A. Y., Gacesa, R., Vila, A. V., Ghosh, H., de Zoete, M. R., Boomsma, D. I., Hoentjen, F., Horjus Talabur Horje, C. S., van de Meeberg, P. C., Willemsen, G., Fu, J., Wijmenga, C., van Wijk, F., Zhernakova, A., Oldenburg, B., Weersma, R. K., & Dutch TWIN-IBD consortium and the Dutch Initiative on Crohn and Colitis (2021). Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients. Gastroenterology, 160(6), 1970-1985. https://doi.org/10.1053/j.gastro.2021.01.030
Matzaraki, V., Le, K. T. T., Jaeger, M., Aguirre-Gamboa, R., Johnson, M. D., Sanna, S., Rosati, D., Franke, L., Zhernakova, A., Fu, J., Withoff, S., Jonkers, I., Li, Y., Joosten, L. A. B., Netea, M. G., Wijmenga, C., & Kumar, V. (2021). Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability. Frontiers in Immunology, 12, Article 662171. https://doi.org/10.3389/fimmu.2021.662171
Chu, X., Jaeger, M., Beumer, J., Bakker, O. B., Aguirre-Gamboa, R., Oosting, M., Smeekens, S. P., Moorlag, S., Mourits, V. P., Koeken, V. A. C. M., de Bree, C., Jansen, T., Mathews, I. T., Dao, K., Najhawan, M., Watrous, J. D., Joosten, I., Sharma, S., Koenen, H. J. P. M., ... Li, Y. (2021). Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease. Genome Biology, 22(1), Article 198. https://doi.org/10.1186/s13059-021-02413-z
MiBioGen Consortium Initiative, Kurilshikov, A., Medina-Gomez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, C. I., Raygoza Garay, J. A., Finnicum, C. T., Liu, X., Zhernakova, D. V., Bonder, M. J., Hansen, T. H., Frost, F., Ruehlemann, M. C., Turpin, W., Moon, J.-Y., Kim, H.-N., ... Zhernakova, A. (2021). Large-scale association analyses identify host factors influencing human gut microbiome composition. Nature Genetics, 53, 156-165. https://doi.org/10.1038/s41588-020-00763-1
BIOS Consortium, i2QTL Consortium, Võsa, U., Claringbould, A., Westra, H.-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Yazar, S., Brugge, H., Oelen, R., de Vries, D. H., van der Wijst, M. G. P., Kasela, S., Pervjakova, N., Alves, I., ... Franke, L. (2021). Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nature Genetics, 53(9), 1300-1310. https://doi.org/10.1038/s41588-021-00913-z
Mc Intyre, K., Lanting, P., Deelen, P., Wiersma, H. H., Vonk, J. M., Ori, A. P. S., Jankipersadsing, S. A., Warmerdam, R., van Blokland, I., Boulogne, F., Dijkema, M. X. L., Herkert, J. C., Claringbould, A., Bakker, O., Lopera Maya, E. A., Bültmann, U., Zhernakova, A., Reijneveld, S. A., Zijlstra, E., ... Franke, L. (2021). Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort. BMJ Open, 11(3), Article e044474. https://doi.org/10.1136/bmjopen-2020-044474
Atanasovska, B., Rensen, S. S., Marsman, G., Shiri-Sverdlov, R., Withoff, S., Kuipers, F., Wijmenga, C., van de Sluis, B., & Fu, J. (2021). Long Non-Coding RNAs Involved in Progression of Non-Alcoholic Fatty Liver Disease to Steatohepatitis. Cells, 10(8), 1-15. Article 1883. https://doi.org/10.3390/cells10081883
Bolte, L. A., Vich Vila, A., Imhann, F., Collij, V., Gacesa, R., Peters, V., Wijmenga, C., Kurilshikov, A., Campmans-Kuijpers, M. J. E., Fu, J., Dijkstra, G., Zhernakova, A., & Weersma, R. K. (2021). Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome. Gut, 70(7), 1287-1298. https://doi.org/10.1136/gutjnl-2020-322670
Bolte, L. A., Klaassen, M. A. Y., Collij, V., Vich Vila, A., Fu, J., van der Meulen, T. A., de Haan, J. J., Versteegen, G. J., Dotinga, A., Zhernakova, A., Wijmenga, C., Weersma, R. K., & Imhann, F. (2021). Patient attitudes towards faecal sampling for gut microbiome studies and clinical care reveal positive engagement and room for improvement. PLoS ONE, 16(4), Article e0249405. https://doi.org/10.1371/journal.pone.0249405
Vogl, T., Klompus, S., Leviatan, S., Kalka, I. N., Weinberger, A., Wijmenga, C., Fu, J., Zhernakova, A., Weersma, R. K., & Segal, E. (2021). Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota. Nature Medicine, 27(8), 1442-1450. https://doi.org/10.1038/s41591-021-01409-3
Bakker, O. B., Ramírez-Sánchez, A. D., Borek, Z. A., de Klein, N., Li, Y., Modderman, R., Kooy-Winkelaar, Y., Johannesen, M. K., Matarese, F., Martens, J. H. A., Kumar, V., van Bergen, J., Qiao, S.-W., Lundin, K. E. A., Sollid, L. M., Koning, F., Wijmenga, C., Withoff, S., & Jonkers, I. H. (2021). Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells. Scientific Reports, 11(1), 1-15. Article 9252. https://doi.org/10.1038/s41598-021-86612-5
Garmaeva, S., Gulyaeva, A., Sinha, T., Shkoporov, A. N., Clooney, A. G., Stockdale, S. R., Spreckels, J. E., Sutton, T. D. S., Draper, L. A., Dutilh, B. E., Wijmenga, C., Kurilshikov, A., Fu, J., Hill, C., & Zhernakova, A. (2021). Stability of the human gut virome and effect of gluten-free diet. Cell reports, 35(7), 1-21. Article 109132. https://doi.org/10.1016/j.celrep.2021.109132
BIOS Consortium, van der Graaf, A., Zorro, M. M., Claringbould, A., Vosa, U., Aguirre-Gamboa, R., Li, C., Mooiweer, J., Ricano-Ponce, I., Borek, Z., Koning, F., Kooy-Winkelaar, Y., Sollid, L. M., Qiao, S.-W., Kumar, V., Li, Y., Franke, L., Withoff, S., Wijmenga, C., ... Jonkers, I. (2021). Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFN gamma Signaling in Celiac Disease. Frontiers in Genetics, 11, 562434. Article 562434. https://doi.org/10.3389/fgene.2020.562434
Ruigrok, R. A. A. A., Collij, V., Sureda, P., Klaassen, M. A. Y., Bolte, L. A., Jansen, B. H., Voskuil, M. D., Fu, J., Wijmenga, C., Zhernakova, A., Weersma, R. K., & Vich Vila, A. (2021). The composition and metabolic potential of the human small intestinal microbiota within the context of inflammatory bowel disease. Journal of Crohn's and Colitis, 15(8), 1326-1338. https://doi.org/10.1093/ecco-jcc/jjab020
Lifelines Cohort Study, Chen, L., Wang, D., Garmaeva, S., Kurilshikov, A., Vich Vila, A., Gacesa, R., Sinha, T., Segal, E., Weersma, R. K., Wijmenga, C., Zhernakova, A., & Fu, J. (2021). The long-term genetic stability and individual specificity of the human gut microbiome. Cell, 184(9), 2302-+. https://doi.org/10.1016/j.cell.2021.03.024

2020

TANDEM Consortium, Eckold, C., Kumar, V., Weiner Rd, J., Alisjahbana, B., Riza, A.-L., Ronacher, K., Coronel, J., Kerry-Barnard, S., Malherbe, S. T., Kleynhans, L., Stanley, K., Ruslami, R., Ioana, M., Ugarte-Gil, C., Walzl, G., van Crevel, R., Wijmenga, C., Critchley, J. A., ... Cliff, J. M. (2021). Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis. Clinical Infectious Diseases, 72(1), 69-78. Article ciaa751. https://doi.org/10.1093/cid/ciaa751
Tan, I. L., Withoff, S., Kolkman, J. J., Wijmenga, C., Weersma, R. K., & Visschedijk, M. C. (2021). Non-classical clinical presentation at diagnosis by male celiac disease patients of older age. European Journal of Internal Medicine, 83, 28-33. https://doi.org/10.1016/j.ejim.2020.09.020
BIOS Consortium, Xu, C.-J., Gruzieva, O., Qi, C., Esplugues, A., Gehring, U., Bergstroem, A., Mason, D., Chatzi, L., Porta, D., Carlsen, K. C. L., Baiz, N., Madore, A.-M., Alenius, H., van Rijkom, B., Jankipersadsing, S. A., van der Vlies, P., Kull, I., van Hage, M., ... Koppelman, G. H. (2021). Shared DNA methylation signatures in childhood allergy: The MeDALL study. Journal of Allergy and Clinical Immunology, 147(3), 1031-1040. https://doi.org/10.1016/j.jaci.2020.11.044
Hu, S., Vich Vila, A., Gacesa, R., Collij, V., Stevens, C., Fu, J. M., Wong, I., Talkowski, M. E., Rivas, M. A., Imhann, F., Bolte, L., van Dullemen, H., Dijkstra, G., Visschedijk, M. C., Festen, E. A., Xavier, R. J., Fu, J., Daly, M. J., Wijmenga, C., ... Weersma, R. K. (2021). Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD. Gut, 70(2), 285-296. Article 319706. https://doi.org/10.1136/gutjnl-2019-319706
BIOS Consortium, Ouwens, K. G., Jansen, R., Nivard, M. G., van Dongen, J., Frieser, M. J., Hottenga, J.-J., Arindrarto, W., Claringbould, A., van Iterson, M., Mei, H., & Franke, L. (2020). A characterization of cis- and trans-heritability of RNA-Seq-based gene expression. European Journal of Human Genetics, 28(2), 253-263. https://doi.org/10.1038/s41431-019-0511-5
BIOS Consortium, Aguirre-Gamboa, R., de Klein, N., di Tommaso, J., Claringbould, A., van der Wijst, M. G. P., de Vries, D., Brugge, H., Oelen, R., Vosa, U., Zorro, M. M., Chu, X., Bakker, O. B., Borek, Z., Ricano-Ponce, I., Deelen, P., Xu, C.-J., Swertz, M., Jonkers, I., ... Li, Y. (2020). Deconvolution of bulk blood eQTL effects into immune cell subpopulations. Bmc Bioinformatics, 21(1), Article 243. https://doi.org/10.1186/s12859-020-03576-5
Chu, X., Janssen, A. W. M., Koenen, H., Chang, L., He, X., Joosten, I., Xu, C., Wijmenga, C., Netea, M., Tack, C. J., & Li, Y. (2020). Differential genetic and environmental effects on immune parameters and functions in type 1 diabetes and health. European Journal of Human Genetics, 28(SUPPL 1), 735-736.
Chen, L., Schraa, K., van den Munckhof, I. C. L., Ter Horst, R., Koehorst, M., van Faassen, M., van der Ley, C., Doestzada, M., Zhernakova, D. V., Kurilshikov, A., Bloks, V. W., Groen, A. K., Human Functional Genomics Project, Riksen, N. P., Rutten, J. H. W., Joosten, L. A. B., Wijmenga, C., Zhernakova, A., Netea, M. G., ... Kuipers, F. (2020). Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content. Cell reports, 33(1), Article 108212. https://doi.org/10.1016/j.celrep.2020.108212
BBMRI Metabol Consortium, Pool, R., Hagenbeek, F. A., Hendriks, A. M., van Dongen, J., Willemsen, G., de Geus, E., van Dijk, K. W., Verhoeven, A., Suchiman, H. E. D., Beekman, M., Slagboom, P. E., Harms, A. C., Hankemeier, T., & Boomsma, D. (2020). Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data. Twin research and human genetics, 23(3), 145-155. https://doi.org/10.1017/thg.2020.53
Kannambath, S., Jarvis, J. N., Wake, R. M., Longley, N., Loyse, A., Matzaraki, V., Aguirre-Gamboa, R., Wijmenga, C., Doyle, R., Paximadis, M., Tiemessen, C. T., Kumar, V., Pittman, A., Meintjes, G., Harrison, T. S., Netea, M. G., & Bicanic, T. (2020). Genome-Wide Association Study Identifies Novel Colony Stimulating Factor 1 Locus Conferring Susceptibility to Cryptococcosis in Human Immunodeficiency Virus-Infected South Africans. Open Forum Infectious Diseases, 7(11), ofaa489. Article ofaa489. https://doi.org/10.1093/ofid/ofaa489
Chen, L., Collij, V., Jaeger, M., van den Munckhof, I. C. L., Vich Vila, A., Kurilshikov, A., Gacesa, R., Sinha, T., Oosting, M., Joosten, L. A. B., Rutten, J. H. W., Riksen, N. P., Xavier, R. J., Kuipers, F., Wijmenga, C., Zhernakova, A., Netea, M. G., Weersma, R. K., & Fu, J. (2020). Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity. Nature Communications, 11(1), 4018. Article 4018. https://doi.org/10.1038/s41467-020-17840-y
BBMRI Metabolomics Consortium, Hagenbeek, F. A., Pool, R., van Dongen, J., Draisma, H. H. M., Jan Hottenga, J., Willemsen, G., Abdellaoui, A., Fedko, I. O., den Braber, A., Visser, P. J., de Geus, E. J. C. N., Willems van Dijk, K., Verhoeven, A., Suchiman, H. E., Beekman, M., Slagboom, P. E., van Duijn, C. M., Harms, A. C., ... Boomsma, D. I. (2020). Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Nature Communications, 11(1), Article 39. https://doi.org/10.1038/s41467-019-13770-6
Vich Vila, A., Collij, V., Sanna, S., Sinha, T., Imhann, F., Bourgonje, A. R., Mujagic, Z., Jonkers, D. M. A. E., Masclee, A. A. M., Fu, J., Kurilshikov, A., Wijmenga, C., Zhernakova, A., & Weersma, R. K. (2020). Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. Nature Communications, 11(1), Article 362. https://doi.org/10.1038/s41467-019-14177-z
Lifelines Cohort Study, Lopera Maya, E. A., van der Graaf, A., Lanting, P., van der Geest, M., Fu, J., Swertz, M., Franke, L., Wijmenga, C., Deelen, P., Zhernakova, A., & Sanna, S. (2020). Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes. Frontiers in Genetics, 11, Article 613. https://doi.org/10.3389/fgene.2020.00613
Warmink-Perdijk, W. D. B., Peters, L. L., Tigchelaar, E. F., Dekens, J. A. M., Jankipersadsing, S. A., Zhernakova, A., Bossers, W. J. R., Sikkema, J., de Jonge, A., Reijneveld, S. A., Verkade, H. J., Koppelman, G. H., Wijmenga, C., Kuipers, F., & Scherjon, S. A. (2020). Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study. European Journal of Epidemiology, 35(2), 157-168. https://doi.org/10.1007/s10654-020-00614-7
BIOS Consortium, van der Graaf, A., Claringbould, A., Rimbert, A., Westra, H.-J., Li, Y., Wijmenga, C., Sanna, S., & Franke, L. (2020). Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids. Nature Communications, 11(1), Article 4930. https://doi.org/10.1038/s41467-020-18716-x
van den Akker, E. B., Trompet, S., Barkey Wolf, J. J. H., Beekman, M., Suchiman, H. E. D., Deelen, J., Asselbergs, F. W., Boersma, E., Cats, D., Elders, P. M., Geleijnse, J. M., Ikram, M. A., Kloppenburg, M., Mei, H., Meulenbelt, I., Mooijaart, S. P., Nelissen, R. G. H. H., Netea, M. G., Penninx, B. W. J. H., ... Slagboom, P. E. (2020). Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease. Circulation. Genomic and precision medicine, 13(5), 541-547. Article e002610. https://doi.org/10.1161/CIRCGEN.119.002610
Lanting, P., Drenth, E., Boven, L., van Hoek, A., Hijlkema, A., Poot, E., van der Vries, G., Schoevers, R., Horwitz, E., Gans, R., Kosterink, J., Plantinga, M., van Langen, I., Ranchor, A., Wijmenga, C., Franke, L., Wilffert, B., & Sijmons, R. (2020). Practical Barriers and Facilitators Experienced by Patients, Pharmacists and Physicians to the Implementation of Pharmacogenomic Screening in Dutch Outpatient Hospital Care-An Explorative Pilot Study. Journal of personalized medicine, 10(4), 1-13. Article 293. https://doi.org/10.3390/jpm10040293
Li, C. M., Zhernakova, A., Engstrand, L., Wijmenga, C., & Brusselaers, N. (2020). Systematic review with meta-analysis: the risks of proton pump inhibitors during pregnancy. Alimentary Pharmacology & Therapeutics, 51(4), 410-420. https://doi.org/10.1111/apt.15610
Zorro, M. M., Aguirre-Gamboa, R., Mayassi, T., Ciszewski, C., Barisani, D., Hu, S., Weersma, R. K., Withoff, S., Li, Y., Wijmenga, C., Jabri, B., & Jonkers, I. H. (2020). Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes. Journal of Autoimmunity, 108, Article 102422. https://doi.org/10.1016/j.jaut.2020.102422

2019

Consortium for the study of genetic associations of celiac disease in Latin-America, Ricaño-Ponce, I., Gutierrez-Achury, J., Costa, A. F., Deelen, P., Kurilshikov, A., Zorro, M. M., Platteel, M., van der Graaf, A., Sanna, S., Daffra, O., Zhernakova, A., Fu, J., Trynka, G., Smecuol, E., Niveloni, S. I., Bai, J. C., Kumar, V., & Wijmenga, C. (2020). Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease. EJHG, 28(3), 313-323. https://doi.org/10.1038/s41431-019-0520-4
Jaeger, M., Matzaraki, V., Aguirre-Gamboa, R., Gresnigt, M. S., Chu, X., Johnson, M. D., Oosting, M., Smeekens, S. P., Withoff, S., Jonkers, I., Perfect, J. R., van de Veerdonk, F. L., Kullberg, B.-J., Joosten, L. A. B., Li, Y., Wijmenga, C., Netea, M. G., & Kumar, V. (2019). A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans. The Journal of Infectious Diseases, 220(5), 862-872. https://doi.org/10.1093/infdis/jiz206
Sinha, T., Vila, A. V., Garmaeva, S., Jankipersadsing, S. A., Imhann, F., Collij, V., Bonder, M. J., Jiang, X., Gurry, T., Alm, E. J., D'Amato, M., Weersma, R. K., Scherjon, S., Wijmenga, C., Fu, J., Kurilshikov, A., & Zhernakova, A. (2019). Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles. Gut Microbes, 10(3), 358-366. https://doi.org/10.1080/19490976.2018.1528822
Klaassen, M. A. Y., Imhann, F., Collij, V., Fu, J., Wijmenga, C., Zhernakova, A., Dijkstra, G., Festen, E. A. M., Gacesa, R., Vich Vila, A., & Weersma, R. K. (2019). Anti-inflammatory Gut Microbial Pathways Are Decreased During Crohn's Disease Exacerbations. Journal of Crohn's and Colitis, 13(11), 1439-1449. https://doi.org/10.1093/ecco-jcc/jjz077
Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., ... Wilson, J. F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10(1), Article 4957. https://doi.org/10.1038/s41467-019-12283-6
Jaeger, M., Pinelli, M., Borghi, M., Constantini, C., Dindo, M., van Emst, L., Puccetti, M., Pariano, M., Ricaño-Ponce, I., Büll, C., Gresnigt, M. S., Wang, X., Gutierrez Achury, J., Jacobs, C. W. M., Xu, N., Oosting, M., Arts, P., Joosten, L. A. B., van de Veerdonk, F. L., ... Netea, M. G. (2019). A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis. Science Translational Medicine, 11(496), Article 3558. https://doi.org/10.1126/scitranslmed.aar3558
Franzosa, E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H. J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L. J., Sauk, J. S., Wilson, R. G., Stevens, B. W., Scott, J. M., Pierce, K., Deik, A. A., Bullock, K., Imhann, F., Porter, J. A., ... Xavier, R. J. (2019). Author Correction: Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nature Microbiology, 4(5), 898. https://doi.org/10.1038/s41564-019-0442-5
Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., Mujagic, Z., Masclee, A. A. M., Jonkers, D. M. A. E., Oosting, M., Joosten, L. A. B., Netea, M. G., Franke, L., Zhernakova, A., Fu, J., Wijmenga, C., & McCarthy, M. I. (2019). Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nature Genetics, 51(4), 600-605. https://doi.org/10.1038/s41588-019-0350-x
Moerkens, R., Mooiweer, J., Withoff, S., & Wijmenga, C. (2019). Celiac disease-on-chip: Modeling a multifactorial disease in vitro. United European Gastroenterology Journal, 7(4), 467-476. https://doi.org/10.1177/2050640619836057
Mayassi, T., Ladell, K., Gudjonson, H., McLaren, J. E., Shaw, D. G., Tran, M. T., Rokicka, J. J., Lawrence, I., Grenier, J.-C., van Unen, V., Ciszewski, C., Dimaano, M., Sayegh, H. E., Kumar, V., Wijmenga, C., Green, P. H. R., Gokhale, R., Jericho, H., Semrad, C. E., ... Jabri, B. (2019). Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Cell, 176(5), 967-981,e19. https://doi.org/10.1016/j.cell.2018.12.039
BIOS Consortium, van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran, D. L., Moffitt, T. E., Poulton, R., Franke, B., & Boomsma, D. (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biological Psychiatry, 86(8), 599-607. https://doi.org/10.1016/j.biopsych.2019.02.016
Le, K. T. T., Matzaraki, V., Netea, M. G., Wijmenga, C., Moser, J., & Kumar, V. (2019). Functional Annotation of Genetic Loci Associated With Sepsis Prioritizes Immune and Endothelial Cell Pathways. Frontiers in Immunology, 10, Article 1949. https://doi.org/10.3389/fimmu.2019.01949
Myositis Genetics Consortium, Scleroderma Genetics Consortium, Acosta-Herrera, M., Kerick, M., Gonzalez-Serna, D., Wijmenga, C., Franke, A., Gregersen, P. K., Padyukov, L., Worthington, J., Vyse, T. J., Eugenia Alarcon-Riquelme, M., Mayes, M. D., & Martin, J. (2019). Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. Annals of the Rheumatic Diseases, 78(3), 311-319. https://doi.org/10.1136/annrheumdis-2018-214127
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