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Dr. Roland Chiu

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MSc at BC Cancer Research Centre, University of British Columbia, PhD at the department of Radiation Oncology at the University of California, Los Angeles

I reserach the DNA damage response in cancer treatment

More about Dr. Roland Chiu

2024

de Ruiter, N., Wittingslow, R., & Chiu, R. (Eds.) (2024). Strange Bedfellows: An Experiment in Student-directed Interdisciplinary Research. University of Groningen Press. https://doi.org/10.21827/6399d913c9fa9

2022

de Ruiter, N., Wittingslow, R., & Chiu, R. (2024). Introduction: Making Strange. In N. de Ruiter, R. Wittingslow, & R. Chiu (Eds.), Strange Bedfellows: An Experiment in Student-directed Interdisciplinary Research (pp. 9-19). University of Groningen Press.
van der Weide, H. L., Kłos, J., Langendijk, J. A., Brouwer, C. L., Sinnige, P. F., Borra, R. J. H., Dierckx, R. A. J. O., Huitema, R. B., Rakers, S. E., Buunk, A. M., Spikman, J. M., Bosma, I. B., Enting, R. H., Blandhol, M., Chiu, R. K., van der Hoorn, A., & Kramer, M. C. A. (2022). Clinical relevance of the radiation dose bath in lower grade glioma, a cross-sectional pilot study on neurocognitive and radiological outcome. Clinical and Translational Radiation Oncology, 33, 99-105. https://doi.org/10.1016/j.ctro.2022.02.001

2019

Wang, D., Nagle, P. W., Wang, H. H., Smit, J. K., Faber, H., Baanstra, M., Karrenbeld, A., Chiu, R. K., Plukker, J. T. M., & Coppes, R. P. (2019). Hedgehog Pathway as a Potential Intervention Target in Esophageal Cancer. Cancers, 11(6), Article 821. https://doi.org/10.3390/cancers11060821

2016

Nagle, P. W., Hosper, N. A., Ploeg, E. M., van Goethem, M.-J., Brandenburg, S., Langendijk, J. A., Chiu, R. K., & Coppes, R. P. (2016). The In Vitro Response of Tissue Stem Cells to Irradiation With Different Linear Energy Transfers. International Journal of Radiation Oncology Biology Physics, 95(1), 103-111. https://doi.org/10.1016/j.ijrobp.2016.02.020
Mohiuddin, U., Kobayashi, S., Keka, I. S., Guilbaud, G., Sale, J., Narita, T., Abdel-Aziz, H. I., Wang, X., Ogawa, S., Sasanuma, H., Chiu, R., Oestergaard, V. H., Lisby, M., & Takeda, S. (2016). The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line. Dna repair, 40, 67-76. https://doi.org/10.1016/j.dnarep.2016.02.002
Wang, D., Chiu, R., Coppes, R., & Plukker, J. T. H. M. (2016). The role of mTOR inhibitors in targeting a putative cancer stem cell-like population in esophageal cancer. Journal of Clinical Oncology, 34(suppl 4), 43. https://doi.org/10.1200/jco.2016.34.4_suppl.43

2015

Wang, D., Smit, J., Chiu, R., Plukker, J., & Coppes, R. (2015). Hedgehog Pathway Regulates a Putative Cancer Stem Cell-like Population in Esophageal Cancer. Annals of Surgical Oncology, 22, S152-S152.
Kobayashi, S., Kasaishi, Y., Nakada, S., Takagi, T., Era, S., Motegi, A., Chiu, R. K., Takeda, S., & Hirota, K. (2015). Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining. Oncogene, 34(33), 4403-4411. https://doi.org/10.1038/onc.2014.371
Nagle, P., Hosper, N., Ploeg, E., van Goethem, M.-J., Langendijk, H., Chiu, R., & Coppes, R. (2015). The response of three-dimensional spheroids to particle radiotherapy. Abstract from Annual NVRB Spring Meeting , Utrecht, Netherlands.
Wang, D., Smit, J., Chiu, R., Plukker, J. T., & Coppes, R. P. (2015). Unraveling the regulation of a putative cancer stem cell-like population in esophageal cancer. Journal of Clinical Oncology, 33(3). https://doi.org/10.1200/jco.2015.33.3_suppl.77

2014

Schults, M. A., Sanen, K., Godschalk, R. W., Theys, J., van Schooten, F. J., & Chiu, R. K. (2014). Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene. Mutagenesis, 29(6), 481-487. https://doi.org/10.1093/mutage/geu034
Ramaekers, C. H. M. A., van den Beucken, T., Bristow, R. G., Chiu, R. K., Durocher, D., & Wouters, B. G. (2014). RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage. PLoS ONE, 9(2), Article e89997. https://doi.org/10.1371/journal.pone.0089997
Nagle, P., van Goethem, M.-J., van Luijk, P., Langendijk, J. A., Coppes, R., & Chiu, R. (2014). Targeting DNA repair to enhance particle radiotherapy treatment. Abstract from 40th Annual meeting of the European Radiation Research Society, Rhodes, Greece.

2013

Schults, M. A., Chiu, R. K., Nagle, P., Kleinjans, J. C., van Schooten, F. J., & Godschalk, R. W. (2013). Genetic polymorphisms in catalase and CYP1B1 determine DNA adduct formation by bento(a)pyrene ex vivo. Mutagenesis, 28(2), 181-185. https://doi.org/10.1093/mutage/ges070
Schults, M. A., Oligschlaeger, Y., Godschalk, R. W., van Schooten, F. J., & Chiu, R. (2013). Loss of VHL in RCC reduces repair and alters cellular response to bento[a]pyrene. Frontiers in Oncology, 3, Article 270. https://doi.org/10.3389/fonc.2013.00270

2012

Schults, M. A., Nagle, P. W., Rensen, S. S., Godschalk, R. W., Munnia, A., Peluso, M., Claessen, S. M., Greve, J. W., Driessen, A., Verdam, F. J., Buurman, W. A., van Schooten, F. J., & Chiu, R. K. (2012). Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity. Mutation research-Fundamental and molecular mechanisms of mutagenesis, 736(1-2), 75-81. https://doi.org/10.1016/j.mrfmmm.2011.11.001
Niemantsverdriet, M., Nagle, P., Chiu, R. K., Langendijk, J. A., Kampinga, H. H., & Coppes, R. P. (2012). Delta Np73 Enhances Promoter Activity of TGF-beta Induced Genes. PLoS ONE, 7(12), Article e50815. https://doi.org/10.1371/journal.pone.0050815

2011

Chiu, R., Schults, M. A., Godschalk, R. W., & van Schooten, F. J. (2011). Mechanisms involved in the HIF1 mediated acceleration of chemical carcinogenicity. Abstract from Annual meeting American Association for Cancer Research , Orlando, United States.

2010

Schults, M. A., Timmermans, L., Godschalk, R. W., Theys, J., WOUTERS, B., van Schooten, F. J., & Chiu, R. (2010). Diminished Carcinogen Detoxification Is a Novel Mechanism for Hypoxia-inducible Factor 1-mediated Genetic Instability. J Biol Chem, 285(19), 14558-14564. https://doi.org/10.1074/jbc.M109.076323
Güngör, N., Knaapen, A., Munnia, A., Peluso, M., Haenen, G. R. M. M., Chiu, R., Godschalk, R. W., & van Schooten, F. J. (2010). Genotoxic effects of neutrophils and hypochlorous acid. Mutagenesis, 25(2), 149-154. https://doi.org/10.1093/mutage/gep053
gungor, N., Haegens, A., Knaapen, A., Godschalk, R. W., Chiu, R., Wouters, E. F. M., & van Schooten, F. J. (2010). Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo. Mutagenesis, 25(11), 77-82. https://doi.org/10.1093/mutage/gep049
Brun, J., Chiu, R., Wouters, B. G., & Gray, D. A. (2010). Regulation of PCNA polyubiquitination in human cells. BMC Research Notes, 3, Article 85. https://doi.org/10.1186/1756-0500-3-85
Güngör, N., Pennings, J. L. A., Knaapen, A., Chiu, R., Peluso, M., Godschalk, R. W., & van Schooten, F. J. (2010). Transcriptional profiling of the acute pulmonary inflammatory response induced by LPS: role of neutrophils. Respiratory Research, 11(24), Article 24. https://doi.org/10.1186/1465-9921-11-24

2009

Chiu, R., Schults, M. A., Godschalk, R. W., Knaapen, A., Wouters, B. G., & van Schooten, F. J. (2009). Influence of hypoxia and HIF1 on carcinogen metabolism as a mechanism for genetic instability. Abstract from 13th World Conference on Lung Cancer, San Francisco, United States.
Theys, J., Jutten, B., Dubois, L., Rouschop, K. M. A., Chiu, R. K., Li, Y., Paesmans, K., Lambin, P., Lammering, G., & Wouters, B. G. (2009). The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment. Radiotherapy and Oncology, 92(3), 399-404. https://doi.org/10.1016/j.radonc.2009.06.017

2008

Brun, J., Chiu, R., Lockhart, K., Xiao, W., Wouters, B. G., & Gray, D. A. (2008). hMMS2 serves a redundant role in human PCNA polyubiquitination. BMC Molecular Biology, 9, Article 24. https://doi.org/10.1186/1471-2199-9-24

2007

Aerts, H. J. W. L., Dubois, L., Hackeng, T. M., Straathof, R., Chiu, R. K., Lieuwes, N. G., Jutten, B., Weppler, S. A., Lammering, G., Wouters, B. G., & Lambin, P. (2007). Development and evaluation of a cetuximab-based imaging probe to target EGFR and EGFRvIII. Radiotherapy and Oncology, 83(3), 326-32. https://doi.org/10.1016/j.radonc.2007.04.030
Chiu, R., & Wouters, B. G. (2007). Evaluating the importance of apoptosis and other determinants of cell death and survival. In Cancer drug discovery and development: Apoptosis, senescence and cancer Humana Press.
Langie, S. A. S., Knaapen, A. M., Ramaekers, C. H. M. A., Theys, J., Brun, J., Godschalk, R. W. L., van Schooten, F. J., Lambin, P., Gray, D. A., Wouters, B. G., & Chiu, R. K. (2007). Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity. Dna repair, 6(6), 852-62. https://doi.org/10.1016/j.dnarep.2007.02.012
Dubois, L., Douma, K., Supuran, C. T., Chiu, R. K., van Zandvoort, M. A. M. J., Pastoreková, S., Scozzafava, A., Wouters, B. G., & Lambin, P. (2007). Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors. Radiotherapy and Oncology, 83(3), 367-373. https://doi.org/10.1016/j.radonc.2007.04.018
Mengesha, A., Dubois, L., Chiu, R. K., Paesmans, K., Wouters, B. G., Lambin, P., & Theys, J. (2007). Potential and limitations of bacterial-mediated cancer therapy. Frontiers in Bioscience, 12, 3880-91.

2006

Mengesha, A., Dubois, L., Lambin, P., Landuyt, W., Chiu, R. K., Wouters, B. G., & Theys, J. (2006). Development of a flexible and potent hypoxia-inducible promoter for tumor-targeted gene expression in attenuated Salmonella. Cancer biology & therapy, 5(9), 1120-8. https://doi.org/10.4161/cbt.5.9.2951
Chiu, R. K., Brun, J., Ramaekers, C., Theys, J., Weng, L., Lambin, P., Gray, D. A., & Wouters, B. G. (2006). Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations. PLoS genetics, 2(7), 1070-1083. Article 116. https://doi.org/10.1371/journal.pgen.0020116

2003

Wouters, B. G., Koritzinsky, M., Chiu, R. K., Theys, J., Buijsen, J., & Lambin, P. (2003). Modulation of cell death in the tumor microenvironment. Seminars in radiation oncology, 13(1), 31-41. https://doi.org/10.1053/srao.2003.50004

2002

Wouters, B. G., Weppler, S. A., Koritzinsky, M., Landuyt, W., Nuyts, S., Theys, J., Chiu, R. K., & Lambin, P. (2002). Hypoxia as a target for combined modality treatments. European Journal of Cancer, 38(2), 240-57.
Hayes, G. M., Chiu, R., Carpenito, C., Dougherty, S. T., & Dougherty, G. J. (2002). Identification of sequence motifs responsible for the adhesive interaction between exon v10-containing CD44 isoforms. The Journal of Biological Chemistry, 277(52), 50529-34. https://doi.org/10.1074/jbc.M206719200

2001

Wouters, B. G., Delahoussaye, Y. M., Evans, J. W., Birrell, G. W., Dorie, M. J., Wang, J., MacDermed, D., Chiu, R. K., & Brown, J. M. (2001). Mitochondrial dysfunction after aerobic exposure to the hypoxic cytotoxin tirapazamine. Cancer Research, 61(1), 145-52.
Tsirigotis, M., Zhang, M., Chiu, R. K., Wouters, B. G., & Gray, D. A. (2001). Sensitivity of mammalian cells expressing mutant ubiquitin to protein-damaging agents. The Journal of Biological Chemistry, 276(49), 46073-46078. https://doi.org/10.1074/jbc.M109023200

1999

Chiu, R. K., Droll, A., Dougherty, S. T., Carpenito, C., Cooper, D. L., & Dougherty, G. J. (1999). Alternatively spliced CD44 isoforms containing exon v10 promote cellular adhesion through the recognition of chondroitin sulfate-modified CD44. Experimental Cell Research, 248(1), 314-321. https://doi.org/10.1006/excr.1999.4391
Chiu, R. K., Carpenito, C., Dougherty, S. T., Hayes, G. M., & Dougherty, G. J. (1999). Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44. Neoplasia, 1(5), 446-452. https://doi.org/10.1038/sj.neo.7900045

1995

Droll, A., Dougherty, S. T., Chiu, R. K., Dirks, J. F., McBride, W. H., Cooper, D. L., & Dougherty, G. J. (1995). Adhesive interactions between alternatively spliced CD44 isoforms. The Journal of Biological Chemistry, 270(19), 11567-73.
Chiu, R. K., Droll, A., Cooper, D. L., Dougherty, S. T., Dirks, J. F., & Dougherty, G. J. (1995). Molecular mechanisms regulating the hyaluronan binding activity of the adhesion protein CD44. JOURNAL OF NEURO-ONCOLOGY, 26(3), 231-9.

1994

Dougherty, G. J., Cooper, D. L., Memory, J. F., & Chiu, R. K. (1994). Ligand binding specificity of alternatively spliced CD44 isoforms. Recognition and binding of hyaluronan by CD44R1. The Journal of Biological Chemistry, 269(12), 9074-8.

1993

Miller, A. R., McBride, W. H., Dubinett, S. M., Dougherty, G. J., Thacker, J. D., Shau, H., Kohn, D. B., Moen, R. C., Walker, M. J., & Chiu, R. (1993). Transduction of human melanoma cell lines with the human interleukin-7 gene using retroviral-mediated gene transfer: comparison of immunologic properties with interleukin-2. Blood, 82(12), 3686-94.
Last modified:27 May 2024 4.55 p.m.