- Groningen Research Institute of Pharmacy (GRIP), Pharmaceutical Analysis Group: assistant professor (2022- )
- MD Anderson Cancer Center, Dept. of Symptom Research, Houston, TX, USA: postdoctoral researcher (2020-2022)
- Semmelweis University, Dept. of Pharmacology and Pharmacotherapy, Budapest, Hungary: assistant research fellow (2015-2019); assistant professor (2019)
- National Institute of Pharmacy and Nutrition, Budapest, Hungary: external clinical study evaluator (2018)

Research interests: pain; neuropathic pain; cancer pain; opioids; renin-angiotensin system; glycine transporters; neuro-immune interactions.

Medication safety, anticoagulation

Multidrug-resistant tuberculosis; pediatrics

Personalized Acute Medicine

Pharmacokinetic Pharmacodynamic modelling (PKPD)
Modelling & Simulation
Clinical trial design
Pharmacokinetics
Pharmacodynamics
Clinical Pharmacology

Asthma, tuberculosis. (airway) remodelling, inflammation, extracellular matrix, integrins, signalling, therapeutic drug monitoring, toxicology

Neurodegeneration, Mitochondrial function, Inflammation, Potassium channels

Dr. Ghimire works as a postdoctoral researcher at the department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen. Her research efforts focus on establishing or revising the doses of currently used anti-TB drugs by understanding the triangular relationship between drug doses, exposure and response in individual TB patients. In addition, she has a longstanding interest in evaluating and developing alternative samples for therapeutic drug monitoring such as saliva and dried-blood spots collected utilizing limited sampling time points.

Reinoud Gosens (1977) is Professor in Translational Pharmacology at the Faculty of Science and Engineering of the University of Groningen. He obtained his PhD in pharmacology in 2004 at the University of Groningen and performed postdoctoral studies at the University of Manitoba, Canada until 2007. His research is focused on the mechanisms that regulate tissue repair and remodeling in asthma and COPD. In particular, the role and therapeutic potential of muscarinic receptors and Wnt/Frizzled receptor signaling  in tissue repair and remodeling are studied.

Global Health
Essential Medicines
Human rights (Right to Health)
Universal access to basic health care (Access to Essential Medicines)
Essential Medicines for Reproductive Health
National Pharmaceutical Policies in developing countries
WHO, UN agencies

Professor Clinical Pharmacy, in particular Oncology-Pharmacy

Hospital and Clinical Pharmacy, clinical pharmacology

Areas of Interest and expertise include diabetes, nephrology, clinical pharmacology

Clinical neuropsychopharmacologist

Targeted Drug Delivery; Microvascular Endothelial Pharmacology; Endothelial Biomedicine; Angiogenesis;  Inflammatory diseases, sepsis, cancer; In vitro-in vivo translation; Drug Development.

Behavior (affective, social, cognitive), Pharmacology, Physiology, Gene expression, microbiome, rat models for depression, rat models for sexual behavior

The translational research focuses on the molecular pharmacological aspects of the development and course of chronic inflammatory diseases. Our motivation for this research focus is very personal, we truly believe that research in the field of translational pharmacology is clustered around molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, heart failure, asthma, COPD, and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. Currently our research focus lies on chronic inflammatory disorders, and I focus nowadays on experimental models of COPD and related lung disorders, Alzheimer, Parkinson and microbial infections. We successfully undertaken the effort to link the themes to defined subcellular compartments (signalosomes). We linked  novel signaling pathways from membrane receptors towards the recently identified PLC-e isoform, the cAMP sensor Epac. I defined novel and exciting functions of the cytoskeleton driver cofilin, a signal node clearly linked to microbe invasion. I linked this novel clusters to inflammation, remodeling next to the repair of the epithelial barrier and epithelial-to-mesenchymal transition as a mechanism driving fibrosis.

Research unit: Microbes in Health and Disease (MHD)
Research unit: Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
Research Institute: GUIDE

Development of non-linear Population Approach Pharmacokinetic and Pharmacodynamic models

Pharmacokinetics

Photopharmacology, Photochemistry

Pharmacokinetics
Pharmacogenetics
Toxicology

Regenerative Pharmacology

Clinical Pharmacology, Albuminuria, Renal function, Clinical Trials