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Frijlink, Prof. Erik

Erik Frijlink
Erik Frijlink

Erik Frijlink (1960, Meppel) has been professor of Pharmaceutical Technology and Biopharmacy at the University of Groningen since 1998. Prior to this, he was head of the Pharmaceutical Development department at Solvay Pharmaceuticals. His research group focuses on advanced technologies to improve the administration of medicines and is internationally prominent in this area. More than 300,000 people around the world have been treated with techniques he has developed.

Frijlink is head of an international consortium that is searching for a universal flu vaccine in a research project in which twelve international partners are participating. The European Union supports the research with a EUR 6 million grant. Frijlink is confident that a vaccine protecting people from all types of flu will be found in the near future, making the annual flu jab redundant.

Frijlink is particularly enthusiastic about drugs that can be administered via an inhaler, as these could be more effective than injections. He has already developed an innovative powder inhaler for asthma and COPD, the Novolizer, which has a number of great advantages compared to existing inhalers.

Erik Frijlink has been nominated for the Huibregtsen Prize 2016. The jury report says: ' Frijlink’s work is a textbook example of ground-breaking research that is also of great importance to society. He combines academic excellence with social relevance, while also being the inventor one of only a handful of discoveries by a Dutch university leading to a remarkable flow of patent-generated income.'

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Publications

2021

Ruigrok, M. J. R., Frijlink, H. W., Melgert, B. N., Olinga, P., & Hinrichs, W. L. J. (2021). Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directions. Molecular Therapy - Methods & Clinical Development, 20, 483-496. https://doi.org/10.1016/j.omtm.2021.01.003
Broesder, A., Berends, J. M. E., Scheepers, S. M., Nguyen, D. N., Frijlink, H. W., & Hinrichs, W. L. J. (2021). Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems. Pharmaceutics, 13(5). https://doi.org/10.3390/pharmaceutics13050731
Gareb, B., Beugeling, M., Posthumus, S., Otten, A. T., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2021). Infliximab formulation strategy for a stable ileo-colonic targeted oral dosage form intended for the topical treatment of inflammatory bowel disease. Journal of drug delivery science and technology, 64, [102552]. https://doi.org/10.1016/j.jddst.2021.102552
Heida, R., Hinrichs, W. L. J., & Frijlink, H. W. (2021). Inhaled vaccine delivery in the combat against respiratory viruses: A 2021 overview of recent developments and implications for COVID-19. Expert review of vaccines. https://doi.org/10.1080/14760584.2021.1903878
Ruigrok, M. J. R., El Amasi, K. E. M., Leeming, D. J., Sand, J. M. B., Frijlink, H. W., Hinrichs, W. L. J., & Olinga, P. (2021). Silencing Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung Slices: A Surprising Lack of Effects on Fibrogenesis? Frontiers in Medicine, 8, [607962]. https://doi.org/10.3389/fmed.2021.607962

2020

Heida, R., Bhide, Y. C., Gasbarri, M., Kocabiyik, Ö., Stellacci, F., Huckriede, A. L. W., Hinrichs, W. L. J., & Frijlink, H. W. (2021). Advances in the development of entry inhibitors for sialic-acid-targeting viruses. Drug Discovery Today, 26(1), 122-137. https://doi.org/10.1016/j.drudis.2020.10.009
Akkerman-Nijland, A. M., Akkerman, O. W., Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., Rottier, B. L., Koppelman, G. H., & Touw, D. J. (2021). The pharmacokinetics of antibiotics in cystic fibrosis. Expert Opinion on Drug Metabolism & Toxicology, 17(1), 53-68. https://doi.org/10.1080/17425255.2021.1836157
Hagedoorn, P., Bawary, W., Frijlink, H. W., & Grasmeijer, F. (2020). A comparative analysis of changes in pMDI drug dose delivery before and after detergent coating using five antistatic valved holding chambers. Journal of Allergy and Clinical Immunology: In Practice, 8(3), 1124-1125.e4. https://doi.org/10.1016/j.jaip.2019.09.021
Sibum, I., Hagedoorn, P., Botterman, C. O., Frijlink, H. W., & Grasmeijer, F. (2020). Automated Filling Equipment Allows Increase in the Maximum Dose to Be Filled in the Cyclops(R)High Dose Dry Powder Inhalation Device While Maintaining Dispersibility. Pharmaceutics, 12(7), 1-14. [645]. https://doi.org/10.3390/pharmaceutics12070645
Akkerman-Nijland, A. M., Grasmeijer, F., Kerstjens, H. A. M., Frijlink, H. W., van der Vaart, H., Vonk, J. M., Hagedoorn, P., Rottier, B. L., Koppelman, G. H., & Akkerman, O. W. (2020). Colistin dry powder inhalation with the Twincer (TM): An effective and more patient friendly alternative to nebulization. PLoS ONE, 15(9), [e0239658]. https://doi.org/10.1371/journal.pone.0239658
Hagedoorn, P., Grasmeijer, F., Bawari, W., Frijlink, H. W., & Grasmeijer, F. (2020). Comparing five antistatic valved holding chambers: How antistatic are they really? European Respiratory Journal, 56. https://doi.org/10.1183/13993003.congress-2020.3177
Gareb, B., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2020). De ontwikkeling van budesonidetabletten met nulde-orde-afgifte voor de behandeling van ileo-colonische inflammatoire darmziekten en vergelijking met huidige, commerciële preparaten. Pharmaceutisch Weekblad, 155(6), 29-36. https://www.npfo.nl/artikel/de-ontwikkeling-van-budesonidetabletten-met-nulde-orde-afgifte-voor-de-behandeling-van-ileo
Tian, Y., Bhide, Y. C., Woerdenbag, H. J., Huckriede, A. L. W., Frijlink, H. W., Hinrichs, W. L. J., & Visser, J. C. (2020). Development of an Orodispersible Film Containing Stabilized Influenza Vaccine. Pharmaceutics, 12(3), [245]. https://doi.org/10.3390/pharmaceutics12030245
Yska, J. P., Wanders, J. T. M., Odigie, B., Apers, J. A., Emous, M., Totté, E. R. E., Boerma, E. C., Ubels, F. L., Woerdenbag, H. J., Frijlink, H. W., Wilffert, B., & Van Roon, E. N. (2020). Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: A single oral dose study before and after surgery. European Journal of Hospital Pharmacy: Science and Practice, 27(E1), e19–e24. https://doi.org/10.1136/ejhpharm-2018-001804
Weerts, Z. Z. R. M., Masclee, A. A. M., Witteman, B. J. M., Clemens, C. H. M., Winkens, B., Brouwers, J. R. B. J., Frijlink, H. W., Muris, J. W. M., De Wit, N. J., Essers, B. A. B., Tack, J., Snijkers, J. T. W., Bours, A. M. H., de Ruiter-van der Ploeg, A. S., Jonkers, D. M. A. E., & Keszthelyi, D. (2020). Efficacy and Safety of Peppermint Oil in a Randomized, Double-Blind Trial of Patients With Irritable Bowel Syndrome. Gastroenterology, 158(1), 123-136. [158]. https://doi.org/10.1053/j.gastro.2019.08.026
Akkerman-Nijland, A. M., Yousofi, M., Rottier, B. L., Van der Vaart, H., Burgerhof, J. G. M., Frijlink, H. W., Touw, D. J., Koppelman, G. H., & Akkerman, O. W. (2020). Eradication of Pseudomonas aeruginosa in cystic fibrosis patients with inhalation of dry powder tobramycin. Therapeutic advances in respiratory disease, 14, [1753466620905279]. https://doi.org/10.1177/1753466620905279
Pleguezuelos, O., Dille, J., de Groen, S., Oftung, F., Niesters, H. G. M., Islam, M. A., Naess, L. M., Hungnes, O., Aldarij, N., Idema, D. L., Perez, A. F., James, E., Frijlink, H. W., Stoloff, G., Groeneveld, P., & Hak, E. (2020). Immunogenicity, Safety, and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v, in Healthy Adults. Annals of Internal Medicine, 172(7), 453-462. https://doi.org/10.7326/M19-0735
Nguyen, K. T. T., Frijlink, H. W., & Hinrichs, W. L. J. (2020). Inhomogeneous Distribution of Components in Solid Protein Pharmaceuticals: Origins, Consequences, Analysis, and Resolutions. Journal of Pharmaceutical Sciences, 109(1), 134-153. https://doi.org/10.1016/j.xphs.2019.10.010
Ruigrok, M., El-Amasi, K., Frijlink, H. W., Hinrichs, W., & Olinga, P. (2020). Knockdown of heat shock protein 47 (HSP47) and its effects on fibrogenesis. Poster session presented at Keystone Symposia on Fibrosis and Tissue Repair, Victoria, Canada.
Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2020). Optimisation of an isoniazid dry powder formulation for pulmonary administration. Journal of aerosol medicine and pulmonary drug delivery, 33(2), A2-A2.
Broesder, A., Woerdenbag, H. J., Prins, G. H., Nguyen, D. N., Frijlink, H. W., & Hinrichs, W. L. J. (2020). pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems. Drug Discovery Today, 25(8), 1362-1373. https://doi.org/10.1016/j.drudis.2020.06.011
Broesder, A., Kosta, A-M. M. A. C., Woerdenbag, H. J., Nguyen, D. N., Frijlink, H. W., & Hinrichs, W. L. J. (2020). pH-dependent ileocolonic drug delivery, part II: Preclinical evaluation of novel drugs and novel excipients. Drug Discovery Today, 25(8), 1374-1388. https://doi.org/10.1016/j.drudis.2020.06.012
Larmene-Beld, K. H. M., van Berkel, S., Wijnsma, R., Taxis, K., & Frijlink, H. W. (2020). Prefilled Cyclic Olefin Sterilized Syringes of Norepinephrine Injection Solution Do Not Need to Be Stabilized by Antioxidants. Aaps pharmscitech, 21(7), [247]. https://doi.org/10.1208/s12249-020-01784-z
Hagedoorn, P., Bawary, W., Frijlink, H. W., & Grasmeijer, F. (2020). Relative lung dose from antistatic valved holding chambers Reply. Journal of Allergy and Clinical Immunology: In Practice, 8(3), 1166-1167. https://doi.org/10.1016/j.jaip.2019.11.023
Gareb, B., Otten, A. T., Frijlink, H. W., Dijkstra, G., & Kosterink, J. G. W. (2020). Review: Local Tumor Necrosis Factor-alpha Inhibition in Inflammatory Bowel Disease. Pharmaceutics, 12(6), 1-31. [539]. https://doi.org/10.3390/pharmaceutics12060539

2019

Busscher, H. J., Woudstra, W., van Kooten, T. G., Jutte, P., Shi, L., Liu, J., Hinrichs, W. L. J., Frijlink, H. W., Shi, R., Liu, J., Parvizi, J., Kates, S., Rotello, V. M., Schaer, T. P., Williams, D., Grainger, D. W., & van der Mei, H. C. (2020). Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies. Biomaterials, 232, [119737]. https://doi.org/10.1016/j.biomaterials.2019.119737
Boudewijn, I. M., Lan, A., Faiz, A., Cox, C. A., Brouwer, S., Schokker, S., Vroegop, S. J., Nawijn, M. C., Woodruff, P. G., Christenson, S. A., Hagedoorn, P., Frijlink, H. W., Choy, D. F., Brouwer, U., Wisman, M., Postma, D. S., Fingleton, J., Beasley, R., van den Berge, M., & Guryev, V. (2020). Nasal gene expression changes with inhaled corticosteroid treatment in asthma. Allergy, 75(1), 191-194. https://doi.org/10.1111/all.13952
Yska, J. P., Punter, R. J., Woerdenbag, H. J., Emous, M., Frijlink, H. W., Wilffert, B., & Van Roon, E. N. (2019). A gastrointestinal simulation system for dissolution of oral solid dosage forms before and after Roux-en-Y gastric bypass. European Journal of Hospital Pharmacy: Science and Practice, 26(3), 152-156. https://doi.org/10.1136/ejhpharm-2017-001360
Larmené-Beld, K. H. M., Frijlink, H. W., & Taxis, K. (2019). A systematic review and meta-analysis of microbial contamination of parenteral medication prepared in a clinical versus pharmacy environment. European Journal of Clinical Pharmacology, 75(5), 609-617. https://doi.org/10.1007/s00228-019-02631-2
Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, H. W., Hagedoorn, P., Vonk, J. M., Farenhorst, M. P., ten Hacken, N. H. T., Kerstjens, H. A. M., & van den Berge, M. (2019). Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma. BMC Pulmonary Medicine, 19(1), [23]. https://doi.org/10.1186/s12890-019-0783-0
Sibum, I., Hagedoorn, P., Frijlink, H. W., & Grasmeijer, F. (2019). Characterization and Formulation of Isoniazid for High-Dose Dry Powder Inhalation. Pharmaceutics, 11(5), [233]. https://doi.org/10.3390/pharmaceutics11050233
Janssen, R., Wouters, E. F. M., Janssens, W., Daamen, W. F., Hagedoorn, P., de Wit, H. A. J. M., Serre, J., Gayan-Ramirez, G., Franssen, F. M. E., Reynaert, N. L., von der Thusen, J. H., & Frijlink, H. W. (2019). Copper-Heparin Inhalation Therapy To Repair Emphysema: A Scientific Rationale. International Journal of Chronic Obstructive Pulmonary Disease, 14, 2587-2602. https://doi.org/10.2147/COPD.S228411
Beugeling, M., Amssoms, K., Cox, F., De Clerck, B., Van Gulck, E., Verwoerd, J., Kraus, G., Roymans, D., Baert, L., Frijlink, H. W., & Hinrichs, W. (2019). Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study. Pharmaceutics, 11(10), [510]. https://doi.org/10.3390/pharmaceutics11100510
Sibum, I., Hagedoorn, P., Kluitman, M. P. G., Kloezen, M., Frijlink, H. W., & Grasmeijer, F. (2019). Dispersibility and Storage Stability Optimization of High Dose Isoniazid Dry Powder Inhalation Formulations with L-Leucine or Trileucine. Pharmaceutics, 12(1), [24]. https://doi.org/10.3390/pharmaceutics12010024
Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2019). Formulating Amikacin for dry powder inhalation. Journal of aerosol medicine and pulmonary drug delivery, 32(2), A7-A7. https://doi.org/10.1089/jamp.2019.ab01.abstracts
Luinstra, M., Isufi, V., de Jong, L., Rutgers, A. W. F., Hagedoorn, P., Puttenstein, J., van Laar, T., & Frijlink, H. W. (2019). Learning from Parkinson's patients: Usability of the Cyclops dry powder inhaler. International Journal of Pharmaceutics, 567, 118493. [118493]. https://doi.org/10.1016/j.ijpharm.2019.118493
Tian, Y., Orlu, M., Woerdenbag, H. J., Scarpa, M., Kiefer, O., Kottke, D., Sjoholm, E., Oblom, H., Sandler, N., Hinrichs, W. L. J., Frijlink, H. W., Breitkreutz, J., & Visser, J. C. (2019). Oromucosal films: from patient centricity to production by printing techniques. Expert Opinion on Drug Delivery, 16(9), 981-993. https://doi.org/10.1080/17425247.2019.1652595
Beugeling, M., Born, P., Amssoms, K., De Clerck, B., Van Gulck, E., Frijlink, H. W., Grasmeijer, N., Kraus, G., Baert, L., & Hinrichs, W. (2019). Ovalbumin-Containing Core-Shell Implants Suitable to Obtain a Delayed IgG1 Antibody Response in Mice. Poster session presented at AAPS PharmSci 360, San Antonio, United States.
Luinstra, M., Rutgers, W., van Laar, T., Grasmeijer, F., Begeman, A., Isufi, V., Steenhuis, L., Hagedoorn, P., de Boer, A., & Frijlink, H. W. (2019). Pharmacokinetics and tolerability of inhaled levodopa from a new dry-powder inhaler in patients with Parkinson's disease. Therapeutic advances in chronic disease, 10. https://doi.org/10.1177/2040622319857617
Tian, Y., Visser, C., Woerdenbag, H., Frijlink, H. W., & Hinrichs, W. (2019). Printing biopharmaceuticals onto orodispersible films. Poster session presented at AAPS PharmSci 360, San Antonio, United States.
Tomar, J., Tonnis, W. F., Patil, H. P., de Boer, A. H., Hagedoorn, P., Vanbever, R., Frijlink, H. W., & Hinrichs, W. L. J. (2019). Pulmonary immunization: deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination. Acta Pharmaceutica Sinica B, 9(6), 1231-1240. https://doi.org/10.1016/j.apsb.2019.05.003
Beugeling, M., De Zee, J., Woerdenbag, H. J., Frijlink, H. W., Wilschut, J. C., & Hinrichs, W. L. J. (2019). Respiratory syncytial virus subunit vaccines based on the viral envelope glycoproteins intended for pregnant women and the elderly. Expert review of vaccines, 18(9), 935-950. https://doi.org/10.1080/14760584.2019.1657013
van Dijk, F., Teekamp, N., Post, E., Schuppan, D., Kim, Y. O., Zuidema, J., Steendam, R., Klose, M. H. M., Meier-Menches, S. M., Casini, A., Horvatovich, P. L., Sijbrandi, N. J., Frijlink, H. W., Hinrichs, W. L. J., Poelstra, K., Beljaars, L., & Olinga, P. (2019). The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor. Journal of Controlled Release, 296, 250-257. https://doi.org/10.1016/j.jconrel.2018.12.039
Ruigrok, M., Tomar, J., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2019). The effects of oxygen concentration on cell death, anti-oxidant transcription, acute inflammation, and cell proliferation in precision-cut lung slices. Scientific Reports, 9(1), [16239]. https://doi.org/10.1038/s41598-019-52813-2
Beugeling, M., Grasmeijer, N., Born, P., van der Meulen, M., Kooij, van der, R., Schwengle, K., Baert, L., Amssoms, K., Frijlink, H. W., & Hinrichs, W. (2019). The Mechanism Behind the Biphasic Pulsatile Drug Release from Physically Mixed Poly(DL-Lactic(-Co-Glycolic) Acid)-Based Compacts. Poster session presented at AAPS PharmSci 360, San Antonio, United States.
Gareb, B., Posthumus, S., Beugeling, M., Koopmans, P., Touw, D. J., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2019). Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process. Pharmaceutics, 11(9), [428]. https://doi.org/10.3390/pharmaceutics11090428
Murti, Y. B., Hartini, Y. S., Hinrichs, W. L. J., Frijlink, H. W., & Setyaningsih, D. (2019). UV-Vis spectroscopy to enable determination of the dissolution behavior of solid dispersions containing curcumin and piperine. Journal of Young Pharmacists, 11(1), 26-30. https://doi.org/10.5530/jyp.2019.11.6
Frijlink, H. W. (2019). Wisselen van medicijnen. In Wisselen van medicijnen (pp. 1-116)

2018

Gareb, B., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2019). Development of novel zero-order release budesonide tablets for the treatment of ileo-colonic inflammatory bowel disease and comparison with formulations currently used in clinical practice. International Journal of Pharmaceutics, 554, 366-375. https://doi.org/10.1016/j.ijpharm.2018.11.019
Grasmeijer, N., Tiraboschi, V., Woerdenbag, H. J., Frijlink, H. W., & Hinrichs, W. L. J. (2019). Identifying critical process steps to protein stability during spray drying using a vibrating mesh or a two-fluid nozzle. European Journal of Pharmaceutical Sciences, 128, 152-157. https://doi.org/10.1016/j.ejps.2018.11.027
Weerts, Z. Z. R. M., Keszthelyi, D., Vork, L., Aendekerk, N. C. P., Frijlink, H. W., Brouwers, J. R. B. J., Neef, C., Jonkers, D. M. A. E., & Masclee, A. A. M. (2018). A Novel Ileocolonic Release Peppermint Oil Capsule for Treatment of Irritable Bowel Syndrome: A Phase I Study in Healthy Volunteers. Advances in therapy, 35(11), 1965-1978. https://doi.org/10.1007/s12325-018-0802-1
Tomar, J., Patil, H. P., Bracho, G., Tonnis, W. F., Frijlink, H. W., Petrovsky, N., Vanbever, R., Huckriede, A., & Hinrichs, W. L. J. (2018). Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge. Journal of Controlled Release, 288, 199-211. https://doi.org/10.1016/j.jconrel.2018.09.006
Sibum, I., Hagedoorn, P., de Boer, A. H., Frijlink, H. W., & Grasmeijer, F. (2018). Challenges for pulmonary delivery of high powder doses. International Journal of Pharmaceutics, 548(1), 325-336. https://doi.org/10.1016/j.ijpharm.2018.07.008
Akkerman, O. W., Grasmeijer, F., de Lange, W. C. M., Kerstjens, H. A. M., de Vries, G., Bolhuis, M. S., Alffenaar, J-W., Frijlink, H. W., Smith, G., Gajraj, R., de Zwaan, R., Hagedoorn, P., Dedicoat, M., van Soolingen, D., & van der Werf, T. S. (2018). Cross border, highly individualised treatment of a patient with challenging extensively drug-resistant tuberculosis. European Respiratory Journal, 51(3), [1702490]. https://doi.org/10.1183/13993003.02490-2017
Kanojia, G., Raeven, R. H. M., van der Maas, L., Bindels, T. H. E., van Riet, E., Metz, B., Soema, P. C., Ten Have, R., Frijlink, H. W., Amorij, J-P., & Kersten, G. F. A. (2018). Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization. Journal of controlled release : official journal of the Controlled Release Society, 286, 167-178. https://doi.org/10.1016/j.jconrel.2018.07.035
Tuiten, A., van Rooij, K., Bloemers, J., Eisenegger, C., van Honk, J., Kessels, R., Kingsberg, S., Derogatis, L. R., de Leede, L., Gerritsen, J., Koppeschaar, H. P. F., Olivier, B., Everaerd, W., Frijlink, H. W., Höhle, D., de Lange, R. P. J., Böcker, K. B. E., & Pfaus, J. G. (2018). Efficacy and safety of on-demand use of 2 treatments designed for different etiologies of female sexual interest/arousal disorder: 3 Randomized Clinical Trials. Journal of Sexual Medicine, 15(2), 201-216. https://doi.org/10.1016/j.jsxm.2017.11.226
Kauppinen, A., Broekhuis, J., Grasmeijer, N., Tonnis, W., Ketolainen, J., Frijlink, H. W., & Hinrichs, W. L. J. (2018). Efficient production of solid dispersions by spray drying solutions of high solid content using a 3-fluid nozzle. European Journal of Pharmaceutics and Biopharmaceutics, 123, 50-58. https://doi.org/10.1016/j.ejpb.2017.11.009
Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2018). FORMULATING ISONIAZID FOR DRY POWDER INHALATION BY SPRAY DRYING. Journal of aerosol medicine and pulmonary drug delivery, 31(2), A2-A2.
Broesder, A., Teekamp, N., van Dijk, F., Beljaars, E., Hinrichs, W., Poelstra, K., Frijlink, H. W., & Olinga, P. (2018). Formulation of biodegradable microspheres for the sustained release of PDGFβ-receptor directed HSA targeted to fibrotic tissue. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
Tuiten, A., Michiels, F., Böcker, K. B., Höhle, D., van Honk, J., de Lange, R. P., van Rooij, K., Kessels, R., Bloemers, J., Gerritsen, J., Janssen, P., de Leede, L., Meyer, J-J., Everaerd, W., Frijlink, H. W., Koppeschaar, H. P., Olivier, B., & Pfaus, J. G. (2018). Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial. Women's health (London, England), 14. https://doi.org/10.1177/1745506518788970
Frijlink, H. W. (2018). Moeiteloos inhaleren. New scientist, (Special 'Engineering in Groningen'), 28-29.
Tian, Y., Visser, J. C., Klever, J. S., Woerdenbag, H. J., Frijlink, H. W., & Hinrichs, W. L. J. (2018). Orodispersible films based on blends of trehalose and pullulan for protein delivery. European Journal of Pharmaceutics and Biopharmaceutics, 133, 104-111. https://doi.org/10.1016/j.ejpb.2018.09.016
Amssoms, K., Born, P. A., Beugeling, M., De Clerck, B., Van Gulck, E., Hinrichs, W. L. J., Frijlink, H. W., Grasmeijer, N., Kraus, G., Sutmuller, R., Simmen, K., & Baert, L. (2018). Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice. PLoS ONE, 13(8), e0202961. [0202961]. https://doi.org/10.1371/journal.pone.0202961
Tomar, J., Biel, C., de Haan, C. A. M., Rottier, P. J. M., Petrovsky, N., Frijlink, H. W., Huckriede, A., Hinrichs, W. L. J., & Peeters, B. (2018). Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge. European Journal of Pharmaceutics and Biopharmaceutics, 133, 85-95. https://doi.org/10.1016/j.ejpb.2018.10.008
Luinstra, M., Rutgers, A. W. F., Vroegop, S. J., Begeman, A., Lexmond, A. J., Grasmeijer, F., Hagedoorn, P., de Boer, A. H., & Frijlink, H. W. (2018). PHARMACOKINETIC EVALUATION AND TOLERABILITY OF INHALED DRY POWDER LEVODOPA IN PARKINSON'S DISEASE PATIENTS. Journal of aerosol medicine and pulmonary drug delivery, 31(2), A9-A9.
Gafar, F., Boudewijn, I. M., Cox, C. A., Vonk, J. M., Schokker, S., Lexmond, A. J., Frijlink, H. W., Hagedoorn, P., Postma, D. S., & van den Berge, M. (2018). Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma. Respiratory Research, 19(1), [256]. https://doi.org/10.1186/s12931-018-0961-2
Tian, Y., Visser, J. C., Frijlink, H. W., & Woerdenbag, H. (2018). Pullulan and trehalose based films for protein delivery in the oral cavity. Journal of Hepatology.
Bhide, Y., Tomar, J., Dong, W., de Vries-Idema, J., Frijlink, H. W., Huckriede, A., & Hinrichs, W. L. J. (2018). Pulmonary delivery of influenza vaccine formulations in cotton rats: Site of deposition plays a minor role in the protective efficacy against clinical isolate o H1N1pdm virus. Drug Delivery, 25(1), 533-545. https://doi.org/10.1080/10717544.2018.1435748
Lexmond, A. J., Singh, D., Frijlink, H. W., Clarke, G. W., Page, C. P., Forbes, B., & van den Berge, M. (2018). Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs. Pulmonary Pharmacology & Therapeutics, 49, 27-35. https://doi.org/10.1016/j.pupt.2018.01.004
Ruigrok, M. J. R., Xian, J-L., Frijlink, H. W., Melgert, B. N., Hinrichs, W. L. J., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. European Journal of Pharmaceutics and Biopharmaceutics, 133, 339-348. https://doi.org/10.1016/j.ejpb.2018.11.005
Ruigrok, M., Xian, J. L., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. Poster session presented at AAPS PharmSci360, Washington, United States.
Ruigrok, M., Maggan, N., Frijlink, H. W., Melgert, B., Olinga, P., & Hinrichs, W. (2018). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
Kanojia, G., Ten Have, R., Brugmans, D., Soema, P. C., Frijlink, H. W., Amorij, J-P., & Kersten, G. (2018). The effect of formulation on spray dried Sabin inactivated polio vaccine. European Journal of Pharmaceutics and Biopharmaceutics, 129, 21-29. https://doi.org/10.1016/j.ejpb.2018.05.021
Beugeling, M., Grasmeijer, N., Born, P. A., van der Meulen, M., van der Kooij, R. S., Schwengle, K., Baert, L., Amssoms, K., Frijlink, H. W., & Hinrichs, W. L. J. (2018). The mechanism behind the biphasic pulsatile drug release from physically mixed poly(DL-lactic(-co-glycolic) acid)-based compacts. International Journal of Pharmaceutics, 551(1-2), 195-202. https://doi.org/10.1016/j.ijpharm.2018.09.025
Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, H. W., Hagedoorn, P., Vonk, J. M., Farenhorst, M. P., Ten Hacken, N. H. T., Kerstjens, H. A. M., & Van den Berge, M. (2018). Unraveling adenosine and AMP induced dyspnea sensation in asthma. European Respiratory Journal, 52. https://doi.org/10.1183/13993003.congress-2018.PA3961

2017

Lexmond, A. J., Boudewijn, I. M., Hagedoorn, P., Schokker, S., Cox, C. A., Vonk, J. M., ten Hacken, N. H. T., Frijlink, H. W., Vroegop, S. J., & van den Berge, M. (2018). Bronchial Provocation Testing Can Be Improved by Using Dry Powder Adenosine Instead of Nebulized Adenosine Monophosphate. American Journal of Respiratory and Critical Care Medicine, 197(3), 391-394. https://doi.org/10.1164/rccm.201704-0715LE
van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Zuidema, J., Steendam, R., Kim, Y. O., Frijlink, H. W., Schuppand, D., Poelstra, K., Hinrichs, W. L. J., & Olinga, P. (2018). Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver. Journal of Controlled Release, 269, 258-265. https://doi.org/10.1016/j.jconrel.2017.11.029
Teekamp, N., Tian, Y., Visser, J. C., Olinga, P., Frijlink, H. W., Woerdenbag, H. J., & Hinrichs, W. L. J. (2017). Addition of Pullulan to Trehalose Glasses Improves the Stability of β-Galactosidase at High Moisture Conditions. Carbohydrate Polymers, 176, 374-380. https://doi.org/10.1016/j.carbpol.2017.08.084
Patil, H. P., Herrera Rodriguez, J., de Vries-Idema, J., Meijerhof, T., Frijlink, H. W., Hinrichs, W. L. J., & Huckriede, A. (2017). Adjuvantation of Pulmonary-Administered Influenza Vaccine with GPI-0100 Primarily Stimulates Antibody Production and Memory B Cell Proliferation. Vaccines, 5(3). https://doi.org/10.3390/vaccines5030019
Lexmond, A. J., Boudewijn, I., Hagedoorn, P., Schokker, S., Cox, C., Vonk, J., Ten Hacken, N., Frijlink, H., de Boer, A., Vroegop, S., Postma, D., & van den Berge, M. (2017). An improved bronchial provocation test with dry powder adenosine instead of nebulised adenosine monophosphate (AMP). European Respiratory Journal, 50(Suppl. 61). https://doi.org/10.1183/1393003.congress-2017.PA4756
Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2017). Characterisation of jet-milled and spray dried isoniazid for pulmonary administration. Journal of aerosol medicine and pulmonary drug delivery, 30(4), A2.
Kanojia, G., Have, R. T., Soema, P. C., Frijlink, H., Amorij, J-P., & Kersten, G. (2017). Developments in the formulation and delivery of spray dried vaccines. Human vaccines & immunotherapeutics, 13(10), 2364-2378. https://doi.org/10.1080/21645515.2017.1356952, https://doi.org/10.1080/21645515.2017.1359363
van Doorn, E., Liu, H., Ben-Yedidia, T., Hassin, S., Visontai, I., Norley, S., Frijlink, H. W., & Hak, E. (2017). Evaluating the immunogenicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine: Phase IIb study protocol. Medicine, 96(11), [e6339]. https://doi.org/10.1097/MD.0000000000006339
van Doorn, E., Pleguezuelos, O., Liu, H., Fernandez, A., Bannister, R., Stoloff, G., Oftung, F., Norley, S., Huckriede, A., Frijlink, H. W., & Hak, E. (2017). Evaluation of the immunogenicity and safety of different doses and formulations of a broad spectrum influenza vaccine (FLU-v) developed by SEEK: study protocol for a single-center, randomized, double-blind and placebo-controlled clinical phase IIb trial. BMC Infectious Diseases, 17(1), [241]. https://doi.org/10.1186/s12879-017-2341-9
Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, E. W., Hagedoorn, P., Vonk, J. M., Farenhorst, M. P., ten Hacken, N. T. H., Kerstjens, H. A. M., Postma, D. S., & van den Berge, M. (2017). Extrafine compared to non-extrafine particle ICS in smokers and ex-smokers with asthma. European Respiratory Journal, 50. https://doi.org/10.1183/1393003.congress-2017.PA521
Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, H. W., Hagedoorn, P., Vonk, J. M., Farenhorst, M. P., Ten Hacken, N. H. T., Kerstjens, H. A. M., Postma, D. S., & van den Berge, M. (2017). Extrafine compared to non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma. Respiratory Medicine, 130, 35-42. https://doi.org/10.1016/j.rmed.2017.07.005
Mensink, M. A., Frijlink, H. W., van der Voort Maarschalk, K., & Hinrichs, W. L. J. (2017). How sugars protect proteins in the solid state and during drying (review): Mechanisms of stabilization in relation to stress conditions. European Journal of Pharmaceutics and Biopharmaceutics, 114, 288-295. https://doi.org/10.1016/j.ejpb.2017.01.024
Visser, J. C., Weggemans, O. A. F., Boosman, R. J., Loos, K. U., Frijlink, H. W., & Woerdenbag, H. J. (2017). Increased drug load and polymer compatibility of bilayered orodispersible films. European Journal of Pharmaceutical Sciences, 107, 183-190. https://doi.org/10.1016/j.ejps.2017.07.010
Mensink, M., Hinrichs, W., Frijlink, H. W., & van der Voort Maarschalk, K. (2017). Kleine, flexibele suikers meest geschikt voor stabilisatie eiwit. Pharmaceutisch Weekblad, 43. http://www.pw.nl/achtergrond/2017/kleine-flexibele-suikers-meest-geschikt-voor-stabilisatie-eiwit
Teekamp, N., Van Dijk, F., Broesder, A., Evers, M., Zuidema, J., Steendam, R., Post, E., Hillebrands, J. L., Frijlink, H. W., Poelstra, K., Beljaars, L., Olinga, P., & Hinrichs, W. L. J. (2017). Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney. International Journal of Pharmaceutics, 534(1-2), 229-236. https://doi.org/10.1016/j.ijpharm.2017.09.072
Lexmond, A. J., Hagedoorn, P., Frijlink, H. W., Rottier, B. L., & de Boer, A. H. (2017). Prerequisites for a dry powder inhaler for children with cystic fibrosis. PLoS ONE, 12(8), [e0183130]. https://doi.org/10.1371/journal.pone.0183130
Jacobs, M. S., Luinstra, M., Moes, J. R., Chan, T. C. Y., Minovic, I., Frijlink, H. W., & Woerdenbag, H. J. (2017). Ready-to-use parenteral amiodarone: A feasibility study towards a long-term stable product formulation. European Journal of Hospital Pharmacy: Science and Practice, 24(2), 110-114. https://doi.org/10.1136/ejhpharm-2015-000860
Ruigrok, M. J. R., Maggan, N., Willaert, D., Frijlink, H. W., Melgert, B. N., Olinga, P., & Hinrichs, W. L. J. (2017). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung and kidney. The AAPS Journal, 19(6), 1855-1863. https://doi.org/10.1208/s12248-017-0136-y
van der Wiel, E., Lexmond, A. J., van den Berge, M., Postma, D. S., Hagedoorn, P., Frijlink, H. W., Farenhorst, M. P., de Boer, A. H., & Ten Hacken, N. H. T. (2017). Targeting the small airways with dry powder adenosine: A challenging concept. European clinical respiratory journal, 4(1), [1369328]. https://doi.org/10.1080/20018525.2017.1369328
van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Kim, Y. O., Frijlink, E., Hinrichs, W., Schuppan, D., Poelstra, K., & Olinga, P. (2017). Therapeutic proteins in the treatment of liver fibrosis: The antifibrotic potential of a sustained release formulation for a PDGF beta-receptor targeted rho-kinase inhibitor. Hepatology, 66, 217A.
Mensink, M. A., S ̌ib í k, J., Frijlink, H. W., Maarschalk, K. V. D. V., Hinrichs, W. L. J., & Zeitler, J. A. (2017). Thermal Gradient Mid- and Far-Infrared Spectroscopy as Tools for Characterization of Protein Carbohydrate Lyophilizates. Molecular pharmaceutics, 14(10), 3550-3557. https://doi.org/10.1021/acs.molpharmaceut.7b00568
Van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Schuppan, D., Kim, Y. O., Poelstra, K., Frijlink, E., Hinrichs, W., & Olinga, P. (2017). Towards clinical use of targeted therapies for liver fibrosis: development of a sustained release formulation for therapeutic proteins. Journal of Hepatology, 66(1), S44-S44.

2016

Visser, J., Eugresya, G., Hinrichs, W., Tjandrawinata, R., Avanti, C., Frijlink, H. W., & Woerdenbag, H. (2017). Development of orodispersible films with selected Indonesian medicinal plant extracts. Journal of Herbal Medicine, 7, 37-46. https://doi.org/10.1016/j.hermed.2016.10.002
de Boer, A., Hagedoorn, P., Hoppentocht, M., Buttini, F., Grasmeijer, F., & Frijlink, H. W. (2017). Dry powder inhalation: past, present and future. Expert Opinion on Drug Delivery, 14(4), 499-512. https://doi.org/10.1080/17425247.2016.1224846
Visser, J. C., Woerdenbag, H. J., Hanff, L. M., & Frijlink, H. W. (2017). Personalized Medicine in Pediatrics: The Clinical Potential of Orodispersible Films. Aaps pharmscitech, 104(5), 1292-1300. https://doi.org/10.1208/s12249-016-0515-1
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