Frijlink, prof. dr. Erik
Erik Frijlink (1960, Meppel) is sinds 1998 hoogleraar Farmaceutische Technologie en Biofarmacie aan de Rijksuniversiteit Groningen. Daarvoor was hij hoofd van de afdeling Farmaceutische Ontwikkeling van Solvay Pharmaceuticals. Zijn onderzoeksgroep richt zich op geavanceerde technologie voor verbeterde toediening van medicijnen en heeft internationaal een prominente plaats verworven op dit terrein.
Zeker 600.000 patiënten gebruiken een inhalator die is bedacht door het team rondom Frijlink. ‘En het gaat richting de één miljoen. Het is mooi als je een product ontwikkelt dat patiënten kan helpen’, zegt Frijlink. De Novolizer is een poederinhalator, waarmee bijvoorbeeld astmapatiënten medicijnen in hun longen krijgen. Het geheim van de inhalator is de cycloon, een kamer waarin het geneesmiddel snel ronddraait, aangedreven door de inhalatiekracht van de patiënt.
Huibregtsenprijs nominatie prof.dr. Erik Frijlink
Frijlink leidt een internationaal consortium dat zoekt naar een universeel griepvaccin. Het onderzoek wordt uitgevoerd door twaalf internationale partners. De Europese Unie steunt het onderzoek met een subsidie van zes miljoen euro. Frijlink denkt dat het niet lang meer duurt voor er een vaccin is dat mensen beschermt tegen alle vormen van griep. Zo'n vaccin zou de jaarlijkse seizoensprik overbodig maken. Frijlink verwacht vooral veel van middelen die via een inhalator kunnen worden toegediend. Dat zou effectiever kunnen zijn dan een injectie.
Frijlink was genomineerd voor de Huibregtsenprijs 2016. Uit het juryrapport: "Het werk van Frijlink is exemplarisch voor baanbrekend onderzoek dat tegelijkertijd van groot belang is voor onze maatschappij. Het koppelt wetenschappelijke excellentie aan maatschappelijke relevantie en is tevens een van de weinige voorbeelden van hoe een vinding op een Nederlandse universiteit leidt tot een aanmerkelijke licentiestroom."
Eerder in het nieuws
2025
Dekkers,
B. G. J., Kerstjens, H. A. M., Breisnes, H. W.,
Leeming, D. J., Anthony, R. M., Frijlink, H. W.,
van der Werf, T. S., Kosterink, J. G. W.,
Alffenaar, J.-W. C., & Akkerman, O. W.
(2025). Azithromycin as host-directed therapy for pulmonary
tuberculosis - a randomized pilot trial. The
Journal of Infectious Diseases. Advance online
publication. https://doi.org/10.1093/infdis/jiaf069
van
der Koog, L., Woest, M., Gorter, I., Verschut,
V., Elferink, R., Zuidhof, A., Koloko Ngassie,
M. L., Bos, I. S. T., Dhakad, D.,
Wolters, J. C., Horvatovich, P., Prakash, Y.
S., Timens, W., Yildirim, A. O., Brandsma,
C.-A., Frijlink, H. W., Nagelkerke,
A., & Gosens, R. (Accepted/In press).
Fibroblast-derived osteoglycin promotes epithelial cell
repair. npj Regenerative Medicine,
10(16).
Jansen,
E. M., van der Koog, L., Elferink, R.,
Rafie, K., Nagelkerke, A., Gosens,
R., Frijlink, H. W., & Hinrichs,
W. (2025). Stabilized Extracellular Vesicle
Formulations for Inhalable Dry Powder Development.
Small. Advance online publication. https://doi.org/10.1002/smll.202411096
Akkerman-Nijland,
A. M., Hagedoorn, P., Rottier, B.
L., Grasmeijer, F., Frijlink, H. E.
W., van Luin, M., Ter Weijden, E., Merkus, P. J.,
Touw, D. J., Akkerman, O. W., &
Koppelman, G. H. (2025). Tolerability and
Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin in
Children with Cystic Fibrosis.
Pharmaceutics, 17(3), Article 347.
https://doi.org/10.3390/pharmaceutics17030347
Visscher,
M., Frijlink, H. W., & Hinrichs, W.
L. J. (2025). What Is the Optimal Geometry of
Dissolving Microneedle Arrays? A Literature Review.
Pharmaceutics, 17(1), Article 124.
https://doi.org/10.3390/pharmaceutics17010124
2024
Nguyen,
K. T. T., Zillen, D., Lasorsa,
A., van der Wel, P. C. A., Frijlink, H.
W., & Hinrichs, W. L. J. (2024).
Combinations of arginine and pullulan reveal the selective
effect of stabilization mechanisms on different lyophilized
proteins. International Journal of
Pharmaceutics, 654, Article 123938. https://doi.org/10.1016/j.ijpharm.2024.123938
Janssen,
P. H. M., Fathollahi, S., Dickhoff, B. H. J., &
Frijlink, H. W. (2024). Critical review on the role of
excipient properties in pharmaceutical powder-to-tablet continuous
manufacturing. Expert Opinion on Drug
Delivery, 21(7), 1069-1079. https://doi.org/10.1080/17425247.2024.2384698
Heida,
R., Jacob Silva, P. H., Akkerman, R.,
Moser, J., de Vries-Idema, J., Bornet, A.,
Pawar, S., Stellacci, F., Frijlink, H. W.,
Huckriede, A. L. W., & Hinrichs, W. L. J.
(2024). Inhibition of influenza virus infection in mice by
pulmonary administration of a spray dried antiviral.
European journal of pharmaceutics and biopharmaceutics :
official journal of Arbeitsgemeinschaft fur Pharmazeutische
Verfahrenstechnik e.V, 204, Article 114507. https://doi.org/10.1016/j.ejpb.2024.114507
Gosens,
R., van der Koog, L., Nagelkerke, A.
P., & Frijlink, H. W. (2024). Osteoglycin as regenerative agent for lung
tissue. (Patent No. WO2024258278).
de
Jong, L., Luinstra, M., Aalbers, A. F.,
Wijma-Vos, A. J., D’Angremont, E., van der Meulen, A. A. E.,
Rutgers, A. W. F., Steenhuis, L., Hagedoorn, P.,
van Laar, T., & Frijlink, H. W. (2024).
Therapeutic effect of an inhaled levodopa dry powder
formulation on off episodes in patients with Parkinson's
disease. Therapeutic advances in neurological
disorders, 17. https://doi.org/10.1177/17562864241289207
2023
Otten,
A. T., van der Meulen, H. H., Steenhuis, M., Loeff, F.
C., Touw, D. J., Kosterink, J. G.
W., Frijlink, H. W., Rispens, T.,
Dijkstra, G., Visschedijk, M. C., &
Bourgonje, A. R. (2024). Clinical Validation of a
Capillary Blood Home-Based Self-Sampling Technique for Monitoring
of Infliximab, Vedolizumab, and C-Reactive Protein Concentrations
in Patients With Inflammatory Bowel Disease.
Inflammatory Bowel Diseases, 30(3),
325–335. https://doi.org/10.1093/ibd/izad103
van
der Kooij, R. S., Beukema, M., Huckriede,
A. L. W., Zuidema, J., Steendam, R., Frijlink, H.
W., & Hinrichs, W. L. J. (2023). A
Single Injection with Sustained-Release Microspheres and a
Prime-Boost Injection of Bovine Serum Albumin Elicit the Same IgG
Antibody Response in Mice.
Pharmaceutics, 15(2), Article 676.
https://doi.org/10.3390/pharmaceutics15020676
Frijlink,
H., Lagarce, F., Touw, D., &
Woerdenbag, H. (2023). Biopharmaceutics. In P.
Le Brun, S. Crauste-Manciet, I. Krämer, J. Smith, & H.
Woerdenbag (Eds.), Practical Pharmaceutics: An International
Guideline for the Preparation, Care and Use of Medicinal Products,
Second Edition (pp. 67-91). Springer International Publishing
AG. https://doi.org/10.1007/978-3-031-20298-8_5
Ahmed,
A. A., Otten, A. T., Gareb, B., Huijmans,
J. E., Eissens, A. C., Rehman, A., Dijkstra,
G., Kosterink, J. G. W., Frijlink, H.
W., & Schellekens, R. C. A. (2023). Capsules with
Ileocolonic-Targeted Release of Vitamin B2, B3, and C (ColoVit)
Intended for Optimization of Gut Health: Development and Validation
of the Production Process.
Pharmaceutics, 15(5), Article 1354.
https://doi.org/10.3390/pharmaceutics15051354
Nugrahadi,
P. P., Hinrichs, W. L. J., Frijlink, H.
W., Schöneich, C., & Avanti, C. (2023).
Designing Formulation Strategies for Enhanced Stability of
Therapeutic Peptides in Aqueous Solutions: A Review.
Pharmaceutics, 15(3), Article
15030935. https://doi.org/10.3390/pharmaceutics15030935
Heida,
R., Akkerman, R., Silva, P. H. J., Lakerveld,
A., Ortiz, D., Bigogno, C., Gasbarri, M., Van Kasteren, P. B.,
Stellacci, F., Frijlink, H. W., Huckriede,
A., & Hinrichs, W. (2023).
Development of an inhalable antiviral powder formulation
against respiratory syncytial virus. Journal of
Controlled Release, 357(5), 264-273. https://doi.org/10.1016/j.jconrel.2023.03.059
Otten,
A. T., Peters, V., Barth,
I., Stevens, C. L., Bourgonje, A.
R., Frijlink, H. W., Harmsen, H. J.
M., Rehman, A., Campmans-Kuijpers, M. J.
E., & Dijkstra, G. (2023). Effects of
ileocolonic delivered vitamin B2, B3 and C
(ColoVit) or the Groningen anti-inflammatory diet on disease course
and microbiome of patients with Crohn's disease (VITA-GrAID study):
a protocol for a randomised and partially blinded trial.
BMJ Open, 13(3), Article e069654. https://doi.org/10.1136/bmjopen-2022-069654
Heida,
R., Frijlink, H. W., & Hinrichs, W.
L. J. (2023). Inhalation of vaccines and antiviral
drugs to fight respiratory virus infections: Reasons to prioritize
the pulmonary route of administration.
mBio, 14(5), Article e0129523. https://doi.org/10.1128/mbio.01295-23
Mahri,
S., Wilms, T., Hagedorm, P., Guichard, M. J., Vanvarenberg, K.,
Dumoulin, M., Frijlink, H., & Vanbever, R. (2023).
Nebulization of PEGylated recombinant human deoxyribonuclease
I using vibrating membrane nebulizers: A technical feasibility
study. European Journal of Pharmaceutical
Sciences, 189, Article 106522. https://doi.org/10.1016/j.ejps.2023.106522
Frijlink,
H. W., Eissens, A. C., van Goor,
H., Mulder, D. J., & Joles, J. A. (2023).
Oral dosage forms of a therapeutically active
acid-labile salt and methods and uses related thereto.
(Patent No. WO2023140729).
Heida,
R., Hagedoorn, P., Van Meel, M. C., Prins, R.,
Simonis, F., Akkerman, R., Frijlink, H.
W., Huckriede, A., de Boer,
A., & Hinrichs, W. (2023).
Performance Testing of a Homemade Aerosol Generator for
Pulmonary Administration of Dry Powder Formulations to Mice.
Pharmaceutics, 15(7), Article 1847.
https://doi.org/10.3390/pharmaceutics15071847
Nguyen,
K. T. T., Zillen, D., van Heijningen, F. F. M.,
van Bommel, K. J. C., van Ee, R. J., Frijlink, H.
W., & Hinrichs, W. L. J. (2023).
Surface Engineering Methods for Powder Bed Printed Tablets to
Optimize External Smoothness and Facilitate the Application of
Different Coatings. Pharmaceutics,
15(9), Article 2193. https://doi.org/10.3390/pharmaceutics15092193
2022
van
der Kooij, R. S., Steendam, R., Frijlink, H.
W., & Hinrichs, W. L. J. (2022). An
overview of the production methods for core-shell microspheres for
parenteral controlled drug delivery. European
journal of pharmaceutics and biopharmaceutics : official journal of
Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik
e.V, 170, 24-42. https://doi.org/10.1016/j.ejpb.2021.11.007
Jansen,
E. M., Frijlink, H. W., Hinrichs, W. L.
J., & Ruigrok, M. J. R. (2022). Are
inhaled mRNA vaccines safe and effective? A review of preclinical
studies. Expert Opinion on Drug
Delivery, 19(11), 1471-1485. https://doi.org/10.1080/17425247.2022.2131767
Heida,
R., Born, P. A., Tapia-Calle,
G., Frijlink, H. W., Salvati,
A., Huckriede, A. L. W., & Hinrichs,
W. L. J. (2022). Assessing the Immunomodulatory Effect
of Size on the Uptake and Immunogenicity of Influenza- and
Hepatitis B Subunit Vaccines In Vitro.
Pharmaceuticals, 15(7), Article 887.
https://doi.org/10.3390/ph15070887
Nguyen,
K. T. T., Heijningen, F. F. M., Zillen, D., van
Bommel, K. J. C., van Ee, R. J., Frijlink, H.
W., & Hinrichs, W. L. J. (2022).
Formulation of a 3D Printed Biopharmaceutical: The
Development of an Alkaline Phosphatase Containing Tablet with
Ileo-Colonic Release Profile to Treat Ulcerative Colitis.
Pharmaceutics, 14(10), Article 2179.
https://doi.org/10.3390/pharmaceutics14102179
Tian,
Y., Lee, J., van der Maaden, K., Bhide,
Y., de Vries-Idema, J. J., Akkerman,
R., O'Mahony, C., Jiskoot, W., Frijlink, H.
W., Huckriede, A. L. W., Hinrichs, W. L.
J., Bouwstra, J. A., & Beukema, M. (2022).
Intradermal Administration of Influenza Vaccine with
Trehalose and Pullulan-Based Dissolving Microneedle Arrays.
Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.xphs.2022.01.033
Woerdenbag,
H. J., Visser, J. C., Leferink Op Reinink, M.
P. A. M., van Orsoy, R. R., Eissens, A. C.,
Hagedoorn, P., Dijkstra, H., Allersma, D. P., Ng, S. W.,
Smeets, O. S. N. M., & Frijlink, H. W. (2022).
Performance of Tablet Splitters, Crushers, and Grinders in
Relation to Personalised Medication with Tablets.
Pharmaceutics, 14(2), Article 320.
https://doi.org/10.3390/pharmaceutics14020320
Ruigrok,
M. J. R., Roest, M. A. P., Frijlink, H.
W., Olinga, P., Hinrichs, W. L.
J., & Melgert, B. N. (2022). RANKL
confers protection against cell death in precision-cut lung
slices. Frontiers in Physiology,
13, Article 1029697. https://doi.org/10.3389/fphys.2022.1029697
de
Reus, Y. A., Hagedoorn, P., Sturkenboom,
M. G. G., Grasmeijer, F., Bolhuis, M.
S., Sibum, I., Kerstjens, H. A. M.,
Frijlink, H. W., & Akkerman, O. W. (2022).
Tolerability and pharmacokinetic evaluation of inhaled dry
powder hydroxychloroquine in healthy volunteers.
PLoS ONE, 17(8), Article e0272034.
https://doi.org/10.1371/journal.pone.0272034
2021
Heida,
R., Hinrichs, W. L. J., & Frijlink,
H. W. (2022). Inhaled vaccine delivery in the combat
against respiratory viruses: A 2021 overview of recent developments
and implications for COVID-19. Expert review of
vaccines, 21(7), 957-974. https://doi.org/10.1080/14760584.2021.1903878
Larmené-Beld,
K., Wijnsma, R., Kuiper, A., van Berkel, S., Robben, H.,
Taxis, K., & Frijlink, H. (2022).
Science- and risk-based strategy to qualify prefillable
autoclavable syringes as primary packaging material.
European Journal of Hospital Pharmacy: Science and
Practice, 29(5), 248-254. https://doi.org/10.1136/ejhpharm-2020-002333
Broesder,
A., Bircan, S. Y., De Waard, A. B., Eissens, A.
C., Frijlink, H. W., & Hinrichs, W.
L. J. (2021). Formulation and in vitro evaluation of
pellets containing sulfasalazine and caffeine to verify
ileo-colonic drug delivery.
Pharmaceutics, 13(12), Article 1985.
https://doi.org/10.3390/pharmaceutics13121985
Ruigrok,
M. J. R., Frijlink, H. W., Melgert, B.
N., Olinga, P., & Hinrichs, W. L.
J. (2021). Gene therapy strategies for idiopathic
pulmonary fibrosis: recent advances, current challenges, and future
directions. Molecular Therapy - Methods &
Clinical Development, 20, 483-496. https://doi.org/10.1016/j.omtm.2021.01.003
Broesder,
A., Berends, J. M. E., Scheepers, S. M.,
Nguyen, D. N., Frijlink, H. W., & Hinrichs,
W. L. J. (2021). Ileo-Colon Targeting of the Poorly
Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in
Combination with Self-Emulsifying Drug Delivery or Solid Dispersion
Systems. Pharmaceutics,
13(5). https://doi.org/10.3390/pharmaceutics13050731
Gareb,
B., Beugeling, M., Posthumus, S., Otten,
A. T., Dijkstra, G., Kosterink, J. G.
W., & Frijlink, H. W. (2021).
Infliximab formulation strategy for a stable ileo-colonic
targeted oral dosage form intended for the topical treatment of
inflammatory bowel disease. Journal of drug
delivery science and technology, 64, Article
102552. https://doi.org/10.1016/j.jddst.2021.102552
van
der Kooij, R. S., Steendam, R., Zuidema, J., Frijlink,
H. W., & Hinrichs, W. L. J. (2021).
Microfluidic Production of Polymeric Core-Shell Microspheres
for the Delayed Pulsatile Release of Bovine Serum Albumin as a
Model Antigen. Pharmaceutics,
13(11), Article 1854. https://doi.org/10.3390/pharmaceutics13111854
Zillen,
D., Beugeling, M., Hinrichs, W. L.
J., Frijlink, H. W., & Grasmeijer,
F. (2021). Natural and bioinspired excipients for dry
powder inhalation formulations. Current Opinion in
Colloid and Interface Science, 56, Article
101497. https://doi.org/10.1016/j.cocis.2021.101497
Ruigrok,
M. J. R., El Amasi, K. E. M., Leeming, D. J., Sand, J. M.
B., Frijlink, H. W., Hinrichs, W. L.
J., & Olinga, P. (2021). Silencing
Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung
Slices: A Surprising Lack of Effects on Fibrogenesis?
Frontiers in Medicine, 8, Article
607962. https://doi.org/10.3389/fmed.2021.607962
2020
Heida,
R., Bhide, Y. C., Gasbarri, M., Kocabiyik,
Ö., Stellacci, F., Huckriede, A. L. W.,
Hinrichs, W. L. J., & Frijlink, H. W.
(2021). Advances in the development of entry inhibitors for
sialic-acid-targeting viruses. Drug Discovery
Today, 26(1), 122-137. https://doi.org/10.1016/j.drudis.2020.10.009
Akkerman-Nijland,
A. M., Akkerman, O. W., Grasmeijer,
F., Hagedoorn, P., Frijlink, H.
W., Rottier, B. L., Koppelman, G.
H., & Touw, D. J. (2021). The
pharmacokinetics of antibiotics in cystic fibrosis.
Expert Opinion on Drug Metabolism &
Toxicology, 17(1), 53-68. https://doi.org/10.1080/17425255.2021.1836157
Hagedoorn,
P., Bawary, W., Frijlink, H. W., &
Grasmeijer, F. (2020). A comparative analysis of
changes in pMDI drug dose delivery before and after detergent
coating using five antistatic valved holding chambers.
The Journal of Allergy and Clinical Immunology: In
Practice, 8(3), 1124-1125.e4. https://doi.org/10.1016/j.jaip.2019.09.021
Sibum,
I., Hagedoorn, P., Botterman, C. O.,
Frijlink, H. W., & Grasmeijer, F. (2020).
Automated Filling Equipment Allows Increase in the Maximum
Dose to Be Filled in the Cyclops(R)High Dose Dry Powder Inhalation
Device While Maintaining Dispersibility.
Pharmaceutics, 12(7), 1-14. Article
645. https://doi.org/10.3390/pharmaceutics12070645
Akkerman-Nijland,
A. M., Grasmeijer, F., Kerstjens, H. A.
M., Frijlink, H. W., van der Vaart,
H., Vonk, J. M., Hagedoorn,
P., Rottier, B. L., Koppelman, G.
H., & Akkerman, O. W. (2020).
Colistin dry powder inhalation with the Twincer (TM): An
effective and more patient friendly alternative to
nebulization. PLoS ONE,
15(9), Article e0239658. https://doi.org/10.1371/journal.pone.0239658
Hagedoorn,
P., Grasmeijer, F., Bawari, W., Frijlink,
H. W., & Grasmeijer, F. (2020).
Comparing five antistatic valved holding chambers: How
antistatic are they really? European Respiratory
Journal, 56. https://doi.org/10.1183/13993003.congress-2020.3177
Gareb,
B., Dijkstra, G., Kosterink, J. G.
W., & Frijlink, H. W. (2020). De
ontwikkeling van budesonidetabletten met nulde-orde-afgifte voor de
behandeling van ileo-colonische inflammatoire darmziekten en
vergelijking met huidige, commerciële preparaten.
Pharmaceutisch Weekblad, 155(6),
29-36. https://www.npfo.nl/artikel/de-ontwikkeling-van-budesonidetabletten-met-nulde-orde-afgifte-voor-de-behandeling-van-ileo
Tian,
Y., Bhide, Y. C., Woerdenbag, H.
J., Huckriede, A. L. W., Frijlink, H.
W., Hinrichs, W. L. J., & Visser, J.
C. (2020). Development of an Orodispersible Film
Containing Stabilized Influenza Vaccine.
Pharmaceutics, 12(3), Article 245.
https://doi.org/10.3390/pharmaceutics12030245
Weerts,
Z. Z. R. M., Masclee, A. A. M., Witteman, B. J. M., Clemens, C. H.
M., Winkens, B., Brouwers, J. R. B. J., Frijlink, H.
W., Muris, J. W. M., De Wit, N. J., Essers, B. A. B., Tack,
J., Snijkers, J. T. W., Bours, A. M. H., de Ruiter-van der Ploeg,
A. S., Jonkers, D. M. A. E., & Keszthelyi, D. (2020).
Efficacy and Safety of Peppermint Oil in a Randomized,
Double-Blind Trial of Patients With Irritable Bowel
Syndrome. Gastroenterology,
158(1), 123-136. Article 158. https://doi.org/10.1053/j.gastro.2019.08.026
Akkerman-Nijland,
A. M., Yousofi, M., Rottier, B. L., Van
der Vaart, H., Burgerhof, J. G. M.,
Frijlink, H. W., Touw, D. J., Koppelman,
G. H., & Akkerman, O. W. (2020).
Eradication of Pseudomonas aeruginosa in cystic fibrosis
patients with inhalation of dry powder tobramycin.
Therapeutic advances in respiratory disease,
14, Article 1753466620905279. https://doi.org/10.1177/1753466620905279
Pleguezuelos,
O., Dille, J., de Groen, S., Oftung, F.,
Niesters, H. G. M., Islam, M. A., Naess, L. M., Hungnes, O.,
Aldarij, N., Idema, D. L., Perez, A. F., James, E., Frijlink,
H. W., Stoloff, G., Groeneveld, P., & Hak,
E. (2020). Immunogenicity, Safety, and Efficacy of a
Standalone Universal Influenza Vaccine, FLU-v, in Healthy
Adults. Annals of Internal Medicine,
172(7), 453-462. https://doi.org/10.7326/M19-0735
Nguyen,
K. T. T., Frijlink, H. W., &
Hinrichs, W. L. J. (2020). Inhomogeneous Distribution
of Components in Solid Protein Pharmaceuticals: Origins,
Consequences, Analysis, and Resolutions. Journal
of Pharmaceutical Sciences, 109(1), 134-153.
https://doi.org/10.1016/j.xphs.2019.10.010
Ruigrok,
M., El-Amasi, K., Frijlink, H. W.,
Hinrichs, W., & Olinga, P. (2020).
Knockdown of heat shock protein 47 (HSP47) and its
effects on fibrogenesis. Poster session presented at
Keystone Symposia on Fibrosis and Tissue Repair, Victoria,
Canada.
Sibum,
I., Grasmeijer, F., Hagedoorn, P.,
& Frijlink, H. W. (2020). Optimisation of an
isoniazid dry powder formulation for pulmonary
administration. Journal of aerosol medicine and
pulmonary drug delivery, 33(2), A2-A2.
Broesder,
A., Woerdenbag, H. J., Prins, G.
H., Nguyen, D. N., Frijlink, H. W., &
Hinrichs, W. L. J. (2020). pH-dependent ileocolonic
drug delivery, part I: in vitro and clinical evaluation of novel
systems. Drug Discovery Today,
25(8), 1362-1373. https://doi.org/10.1016/j.drudis.2020.06.011
Broesder,
A., Kosta, A.-M. M. A. C., Woerdenbag, H.
J., Nguyen, D. N., Frijlink, H. W., &
Hinrichs, W. L. J. (2020). pH-dependent ileocolonic
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