Automated NIPT diagnostics pipeline. The development of an automated Non Invasive Prenatal Test analysis pipeline using MOLGENIS compute framework
by H.A. de Weerd, F. van Dijk, E.N. de Boer, M. Dijkstra, B. Sikkema-Raddatz, G.J. te Meerman, M.A. Swertz, and L.F. JohanssonDepartment of Genetics, and Genomics Coordination Center, Department of Genetics, University Medical Center Groningen, the Netherlands
Dirk de Weerd's poster on NIPT has won a prize in the Hanze University's Institute of Life Science and Technology poster competition, which had some 100 submissions from students taking courses at HBO/undergraduate/Bachelor of Applied Science level, for example, in bioinformatics, chemistry, and biomedical laboratory studies.
Dirk de Weerd is a student of bioinformatics at the Hanze University of Applied Sciences. He was an intern in the Genomics Coordination Centre from January - September 2014. His internship project was to develop the Non-Invasive Prenatal Test (NIPT) pipeline in compute 5.
More about the GCC
PosterIntroduction. Detecting chromosomal aneuploidies is a major goal of prenatal screening tests. Prenatal testing methods are invasive and associated with miscarriage. Here a non-invasive screening test is presented: an automated non-invasive prenatal testing pipeline implemented in the Molgenis/Compute 5 framework. Up to 30% of cell free DNA in the maternal bloodstream (figure 1) originates from the fetus. If an expecting mother carries a fetus with a trisomy, a small increase of fragments mapping to the duplicated chromosome can be observed. In relation to a healthy control group a Z-score is calculated. Aligning and quality control is done with the inhouse method. Statistical analysis steps are tailored for NIPT. more
As a part of the Jantina Tammes School, the 'Language and AI' theme is an interdisciplinary initiative that aims to encourage collaboration among academics, PhD candidates, students, and industry representatives who share a keen interest in the...
Prof. Moniek Tromp has been appointed Captain of Science of the Chemistry Top Sector by the Minister of Economic Affairs and Climate Policy. As from 1 July 2023, she succeeded Prof. Bert Weckhuysen from Utrecht University.
Leonardo Arriagada Beltran conducted his PhD research on the interface of computer-generated art and the constantly evolving field of Artificial Intelligence (AI). He will defend his Phd thesis on 21 September. His research offers valuable insights...
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether you want to accept
or reject other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information