News

MS Imaging

The University Medical Center Groningen (UMCG) and Faculty of Science and Engineering (FSE) have invested in a state-of-the-art mass spectrometry imaging (MSI) platform to push the boundaries of spatial biology. The platform features the Bruker timsTOF Flex MALDI-2, which integrates trapped ion mobility spectrometry (TIMS), MALDI-2 postionization, and microgrid technology to achieve 5 µm spatial resolution for imaging metabolites, drugs, lipids, and proteins in tissue sections. Complementing this, a MassTech atmospheric pressure MALDI ion source is compatible with the Orbitrap Exploris series, providing ultra-high mass resolution (up to 500,000) and 10 µm spatial resolution.

The TIMS capability of the timsTOF Flex resolves isobaric interferences, enabling precise separation of complex molecular species, including post-translational modifications and lipid isomers, while the Orbitrap ensures high-confidence molecular identification. Enhanced by MALDI-2, the platform improves sensitivity for low-abundance metabolites and resolves structural isomers, revealing deeper biological complexity.

This investment places UMCG and FSE at the forefront of spatial omics, enabling breakthroughs in biomedical research and molecular diagnostics. The platform will drive innovations in understanding tissue organization, disease pathology, and therapeutic development. On December 18, 2025, a symposium was organized to celebrate the addition of the new instrument to the MS Facility.