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About us Medical Sciences Research Department of Genetics Research Lines
University Medical Center Groningen

Research lines in the Dept of Genetics, UMCG


Complex (multifactorial) diseases

Project leaders (PIs)

Sasha Zhernakova
Sebo Withoff
Vinod Kumar
Iris Jonkers

Cisca Wijmenga

Systems Genetics/Bioinformatics

  • Big data approaches to identifying environmental risk factors for disease
  • Factor analytic modeling of expression data and EQTL mapping
  • Using systems genetics to understand complex biological systems by integrating systems biology with genetics
  • Systems genetics of celiac disease, with a focus on non-coding regions of the genome
  • Integration of high-throughput expression and sequence data into the Oncology workstation (CTMM project)

See also or the website of MOLGENIS

Morris Swertz
Lude Franke
Jingyuan Fu

Gerard te Meerman

5GPM: Five genes per minute

Whole-genome sequencing of critically ill newborns, more

Cleo van Diemen
Rolf Sijmons

Congenital diseases

Chromosome 6 research (a parent-driven project)
CHARGE syndrome
Phelan-McDermid syndrome
(22q13 deletion syndrome)

Conny van Ravenswaaij

EUROCAT - Epidemiological Surveillance of Congenital Anomalies
Eurolinkcat - establishing a linked European cohort of children with congenital anomalies

Hermien de Walle

Dystrophic epidermolysis bullosa (DEB) (more in Dutch, in English) Peter van de Akker
L1CAM Yvonne Vos


Clinical Genetics of Familial Cancer

Rolf Sijmons, Helga Westers, Klaas Kok

Renal Cell Cancer

Klaas Kok, Eva van den Berg

FaCD (Familial Cancer Database)

Rolf Sijmons


SpinoCerebellar Ataxia (SCA)

Dineke Verbeek

Genetic screening in children with epilepsy

Conny van Ravenswaaij, Patrick Rump, Yvonne Vos


ARCV (Arrhythmogenic right ventricular cardiomyopathy) Jan Jongbloed
LVOTO (Left ventricular outflow tract obstructions) Mieke Kerstjens
DIDCARE (Dutch idiopathic dilated cardiomyopathy registry) Jan Jongbloed

ELSI (Ethics, legal, and social issues in clinical genetics)

The ELSI research programme aims to provide the evidence base for offering clinical genetic services to patients using new techniques and innovations more

Irene van Langen

Last modified:19 July 2021 3.26 p.m.