|PhD ceremony:||Ms P.M. (Pauline) Snijder|
|When:||December 01, 2014|
|Supervisors:||prof. dr. H. (Harry) van Goor, prof. dr. H.G.D. (Henri) Leuvenink|
|Where:||Academy building RUG|
|Faculty:||Medical Sciences / UMCG|
Hydrogen Sulfide (H2S) is a gas with the characteristic smell of rotten eggs. H2S can induce a hypometabolic, hibernation-like state that is characterized by reduced oxygen consumption and carbon dioxide production. In this thesis we used this feature to protect the heart during episodes of oxygen depletion. Recently, this pungent gas was discovered to be synthesized enzymatically in mammalian and human tissues in low concentrations, which positively transformed the apparent image of H2S into a promising therapeutic compound. H2S is important in the regulation of blood pressure, inflammatory processes and the activity of several proteins. This thesis addresses the protective effects of H2S in several models of disease where similar damaging processes are important. We show that H2S protects heart and kidneys from high blood pressure related damage. Also, we found that H2Sdecreases neurodegeneration in a fruit fly model. Furthermore, we investigated different dosages and modes of administration to pave the way for clinical use of H2S-based therapy.