Veni, Vidi and Vici grants awarded to the University of Groningen in 2021
Grants awarded by the Netherlands Organisation for Scientific Research (NWO, Innovational Research Incentives Scheme).
Consistency in mutations
Unlike many diseases, cancer is often caused by mutations of the cell that are spontaneous instead of genetic. By examining gene networks, professor Lude Franke is aiming to find out whether there is a unifying principle behind this difference in types of mutations. As a professor of Functional Genomics at the University of Groningen and the University Medical Centre Groningen, Franke has been working on analyzing data on the genetics of complex and autoimmune diseases. By applying computational algorithms to functional genomics datasets he manages to create new insights by finding innovative and creative angles to look at existing data.
Trends in Local Graves Use
The advent of Rome meant new ways of presenting the dead in cemeteries in the Near East. This project explores the ways in which trends in epitaphs, portraits and decorative monuments were incorporated into local burial rites. This will provide new insight into cultural change.
Role Genome in Cardiometabolic Diseases
Dr Jingyuan Fu’s research focuses on decoding the human genome and metagenome in cardiometabolic diseases. She will use the Vici grant to set up a new research project in this field. As with DNA, thousands of genomes in our intestinal bacteria encode the proteins that can contribute to the development of diseases. In this project, the researchers are identifying variations in bacterial genomes and their interactions with the human genome in order to identify the role that they play in individual risk of cardiometabolic diseases.
For more information about Jingyuan Fu’s research, go to:
Use of Nanoparticles
Dr Inge Zuhorn is conducting research into ways of enabling drugs to penetrate the brain. Brain tumours are difficult to treat because drugs cannot easily penetrate the brain. She will use this Vici grant to study the use of nanoparticles. Although nanoparticles may be the solution, they must be able to change in shape and size after they have been administered to the patient. The research project involves developing nanoparticles that can change their form inside the patient.
Take your time: How cells ensure ordered cell division
To avoid errors and prevent cancer, the complicated steps of cell division have to occur in an orderly manner, one step at a time. This project will explore how proteins communicate with each other to ensure that every step only happens at the correct moment during cell division.
Language development after paediatric brain tumours
Cognitive disorders in children with brain tumours may occur due to damage caused by the tumour or due to necessary medical interventions. The researchers will study these children’s language abilities in relation to the treatment followed, consisting of surgery only or a combination of surgery, chemo, and proton radiotherapy.
Humour in Court
A. (Alberto) Godioli, PhD
Defining the legal boundaries of free speech is difficult – even more so when humour is involved. National and international courts often have an inconsistent approach to offensive humour. Building on insights from humour studies and literary theory, this project aims to improve the handling of humour in free speech regulation.
Chance and Children
When and how many children will be born is difficult to predict. Models based on medical insights on the chances of conception and machine learning can help improve prediction. Findings can inform family policies to reduce involuntary childlessness and reliance on medically assisted reproduction.
Eliminating harmful cells to promote healthy aging
Aging is the slow but steady deterioration of physiological functions. A main contributor to aging and age-related pathology is the accumulation of old or ‘senescent’ cells. Aims of this proposal are to identify markers of old cells and use these markers to develop anti-aging interventions.
|Last modified:||19 July 2021 10.56 a.m.|