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Franke, Prof. Lude

Lude Franke
Lude Franke

Lude Franke is Associate Professor at the Genetics Department of the University of Groningen/University Medical Centre Groningen and Head of Research and Education in the Dept. of Genetics, UMCG. He is a statistical geneticist, working on analyzing data on the genetics of complex and autoimmune diseases (e.g. celiac disease). He has been awarded an ERC Starting grant (2014), NWO VIDI grant (2014), NWO VENI grant (2009) and a Horizon Grant (2009) to work on identifying molecular effects due to disease-causing mutations.

In his spare time he is also a graphic designer (see his PhD thesis design ). This chance combination of skills can sometimes make life as a genetics researcher a bit easier: if you can explain your research visually, more people can understand what you are doing. Lude Franke is one of the founding members of the Young Academy Groningen and has also been appointed member of De Jonge Akademie (national Young Academy).


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Huang, Y., Ollikainen, M., Muniandy, M., Zhang, T., van Dongen, J., Hao, G., ... Wang, X. (2020). Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure. Hypertension (Dallas, Tex. : 1979), 76(1), 195-205.
BIOS Consortium (2020). Deconvolution of bulk blood eQTL effects into immune cell subpopulations. Bmc Bioinformatics, 21(1), 243.
Bangma, A., Voskuil, M. D., Uniken Venema, W. T. C., Brugge, H., Hu, S., Lanting, P., ... Weersma, R. K. (2020). Predicted efficacy of a pharmacogenetic passport for inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 51(11), 1105-1115.
Peters, V., Tigchelaar-Feenstra, E. F., Imhann, F., Dekens, J. A. M., Swertz, M. A., Franke, L. H., ... Campmans-Kuijpers, M. J. E. (2020). Habitual dietary intake of IBD patients differs from population controls: a case-control study. European journal of nutrition.
de Vries, D. H., Matzaraki, V., Bakker, O. B., Brugge, H., Westra, H-J., Netea, M. G., ... van der Wijst, M. G. P. (2020). Integrating GWAS with bulk and single-cell RNA-sequencing reveals a role for LY86 in the anti-Candida host response. PLoS Pathogens, 16(4), [1008408].
Van Der Wijst, M. G. P., De Vries, D. H., Groot, H. E., Trynka, G., Hon, C. C., Bonder, M. J., ... Franke, L. (2020). The single-cell eQTLGen consortium. eLife, 9, [52155].
BIOS Consortium, Ouwens, K. G., Jansen, R., Nivard, M. G., van Dongen, J., Frieser, M. J., ... Franke, L. (2020). A characterization of cis- and trans-heritability of RNA-Seq-based gene expression. European Journal of Human Genetics, 28(2), 253-263.
Lifelines Cohort Study (2020). Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes. Frontiers in Genetics, 11, 613.


Vojinovic, D., Radjabzadeh, D., Kurilshikov, A., Amin, N., Wijmenga, C., Franke, L., ... van Duijn, C. M. (2019). Relationship between gut microbiota and circulating metabolites in population-based cohorts. Nature Communications, 10(1), [5813].
BIOS Consortium, van Rooij, J., Mandaviya, P. R., Claringbould, A., Felix, J. F., van Dongen, J., ... van Meurs, J. B. J. (2019). Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies. Genome Biology, 20(1), [235].
Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., ... Wilson, J. F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10(1), [4957].
BIOS Consortium, van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., ... Boomsma, D. (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biological Psychiatry, 86(8), 599-607.
Porcu, E., Rueger, S., Lepik, K., eQTLgen Consortium, & BIOS Consortium (2019). Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nature Communications, 10, [3300].
BIOS Consortium (2019). Allele specific expression identifies rare variants as cause for extreme allelic imbalance. European Journal of Human Genetics, 27, 601.
Zeng, B., Lloyd-Jones, L. R., Montgomery, G. W., Metspalu, A., Esko, T., Franke, L., ... Gibson, G. (2019). Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation. Genetics, 212(3), 905-918.
van Arensbergen, J., Pagie, L., FitzPatrick, V. D., de Haas, M., Baltissen, M. P., Comoglio, F., ... van Steensel, B. (2019). High-throughput identification of human SNPs affecting regulatory element activity. Nature Genetics, 51(7), 1160-+.
Deelen, P., van Dam, S., Karjalainen, J. M., Brugge, H., Folkertsma, P., van Diemen, C. C., ... Franke, L. (2019). Improving diagnostic yield of exome-sequencing through prioritization of genes with predicted HPO assignments. European Journal of Human Genetics, 27, 537-537.
Chu, X., Jaeger, M., Bakker, O. B., Aguirre-Gamboa, R., Oosting, M., Smeekens, S. P., ... Li, Y. (2019). Integration of similar to 10,000 metabolite features with genotype data and immune phenotypes reveals genetic determinants and common regulatory modules. European Journal of Human Genetics, 27, 787-787.
Deelen, P., van Dam, S., Herkert, J. C., Karjalainen, J. M., Brugge, H., Abbott, K. M., ... Franke, L. (2019). Improving the diagnostic yield of exome-sequencing by predicting gene-phenotype associations using large-scale gene expression analysis. Nature Communications, 10(1), [2837].
GoNL Consortium, BIOS Consortium, Jadhav, B., Monajemi, R., Gagalova, K. K., Ho, D., ... Kielbasa, S. M. (2019). RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting. BMC Biology, 17(1), [50].
Peters, V., Tigchelaar, E., Imhann, F., Dekens, J., Swertz, M., Franke, L., ... Campmans-Kuijpers, M. J. (2019). Sa2029 – Habitual dietary intake of dutch IBD patients differs from population controls: A case-control study. Gastroenterology, 156(6), S477-S478. Abstract
BBMRI Metabolomics Consortium (2019). Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine. Neurology, 92(16), E1899-E1911.
Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., ... McCarthy, M. I. (2019). Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nature Genetics, 51(4), 600-605.
Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., ... McCarthy, M. I. (2019). Causal relationshipsbetween gut microbiome, short-chain fatty acids and metabolicdiseases. Nature Genetics, 51, 600-605.
CommonMind Consortium, Psychiat Genomics Consortium, iPSYCH-GEMS Schizophrenia Working, Huckins, L. M., Dobbyn, A., Ruderfer, D. M., ... Stahl, E. A. (2019). Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51(4), 659-674.
BIOS Consortium, KORA Study Grp, Schlicht, K., Nyczka, P., Caliebe, A., Freitag-Wolf, S., ... Krawczak, M. (2019). The metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus. HUMAN GENETICS, 138(4), 375-388.
BIOS Consortium, & GoNL Consortium (2019). Skewed X-inactivation is common in the general female population. European Journal of Human Genetics, 27(3), 455-465.
Aguirre-Gamboa, R., de Klein, N., di Tommaso, J., Claringbould, A., Vosa, U., Zorro, M., ... Li, Y. (2019). Deconvolution of bulk blood eQTL effects into immune cell subpopulations. bioRxiv, [548669].
23and Me Res Team, eQTLgen Consortium, Int Cannabis Consortium, & Soc Sci Genetic Association Con (2019). Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51(2), 245-257.
Kilpelainen, T. O., Nolte, I. M., van der Most, P. J., Verweij, N., Snieder, H., van der Ende, M. Y., ... Wang, Y. X. (2019). Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications, 10(1), [376].
eQTLgen Consortium, Timmers, P. R., Mounier, N., Lall, K., Fischer, K., Ning, Z., ... Clark, D. W. (2019). Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. eLife, 8, [39856].
BIOS Consortium (2019). A linear mixed-model approach to study multivariate gene-environment interactions. Nature Genetics, 51(1), 180-186.


van der Wijst, M. G. P., de Vries, D. H., Brugge, H., Westra, H-J., & Franke, L. (2018). An integrative approach for building personalized gene regulatory networks for precision medicine. Genome medicine, 10, [96].
Vich Vila, A., Imhann, F., Collij, V., Jankipersadsing, S. A., Gurry, T., Mujagic, Z., ... Weersma, R. K. (2018). Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome. Science Translational Medicine, 10(472).
BIOS Consortium, GLOBAL Meth QTL, Parmar, P., Lowry, E., Cugliari, G., Suderman, M., ... Verweij, N. (2018). Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults. EBioMedicine, 38, 206-216.
Lifelines Cohort Study, Zhernakova, D. V., Le, T. H., Kurilshikov, A., Atanasovska, B., Bonder, M. J., ... Fu, J. (2018). Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome. Nature Genetics, 50(12), [1752].
Lifelines Cohort Study, Ligthart, S., Vaez, A., Võsa, U., Stathopoulou, M. G., de Vries, P. S., ... Amini, M. (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. American Journal of Human Genetics, 103(5), 691-706.
Lifelines Cohort Study (2018). Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome. Nature Genetics, 50(11), 1524-+.
BIOS Consortium, Luijk, R., Wu, H., Ward-Caviness, C. K., Hannon, E., Carnero-Montoro, E., ... Heijmans, B. T. (2018). Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nature Communications, 9(1), 3738. [3738].
BIOS Consortium, Luijk, R., Dekkers, K. F., van Iterson, M., Arindrarto, W., Claringbould, A., ... van Zwet, E. W. (2018). Genome-wide identification of directed gene networks using large-scale population genomics data. Nature Communications, 9(1), 3097. [3097].
Bolling, M. C., Jan, S. Z., Pasmooij, A. M. G., Lemmink, H. H., Franke, L. H., Yenamandra, V. K., ... Jonkman, M. F. (2018). Generalized Ichthyotic Peeling Skin Syndrome due to FLG2 Mutations. Journal of Investigative Dermatology, 138(8), 1881-1884.
van Setten, J., Brody, J. A., Jamshidi, Y., Swenson, B. R., Butler, A. M., Campbell, H., ... Snieder, H. (2018). PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications, 9(1), [2904].
Bakker, O. B., Aguirre-Gamboa, R., Sanna, S., Oosting, M., Smeekens, S. P., Jaeger, M., ... Li, Y. (2018). Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses. Nature Immunology, 19(7), 776-786.
Pirastu, N., Joshi, P. K., de Vries, P. S., Cornelis, M. C., McKeigue, P. M., Keum, N., ... Wilson, J. F. (2018). Author Correction: GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. Nature Communications, 9(1), 2536.
Pirastu, N., Joshi, P. K., de Vries, P. S., Cornelis, M. C., Keum, N., Franceschini, N., ... Wilson, J. F. (2018). Reply to 'Misestimation of heritability and prediction accuracy of male-pattern baldness'. Nature Communications, 9(1), 2538. [2538].
MiBioGen Consortium Initiative (2018). Meta-analysis of human genome-microbiome association studies: The MiBioGen consortium initiative. Microbiome, 6(1), [101].
Scholz, R. W., Bartelsman, E. J., Diefenbach, S., Franke, L., Grunwald, A., Helbing, D., ... Pereira, G. V. (2018). Unintended Side Effects of the Digital Transition: European Scientists' Messages from a Proposition-Based Expert Round Table. Sustainability, 10(6), [2001].
Bolling, M., Jan, S., Pasmooij, A., Lemmink, H., Franke, L., Yenamandra, V., ... Jonkman, M. F. (2018). Generalized ichthyotic peeling skin syndrome due to FLG2 mutations. Journal of Investigative Dermatology, 138(5), S128.
Lifelines Cohort Study, & BIOS Consortium (2018). Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs. Nature Genetics, 50(4), 493-497.
Amini, M., Vonk, J. M., Abbasi, A., Prins, B. P., Bruinenberg, M., Franke, L., ... Alizadeh, B. Z. (2018). Blood Eosinophil Count and Metabolic, Cardiac and Pulmonary Outcomes: A Mendelian Randomization Study. Twin research and human genetics, 21(2), 89-100.
Barbieri, R., Venema, W. U., Vich Vila, A., Li, Y., Franke, L., van Dijk, F., ... Weersma, R. K. (2018). Integration of whole-exome sequencing and RNA sequencing of intestinal biopsies in inflammatory bowel disease identifies inflammation-dependent effects. Journal of Crohn's and Colitis, 12, S8-S9.
Peters, V., Tigchelaar, E., Campmans-Kuijpers, M., Sheedfar, F., Imhann, F., Dekens, J., ... Alizadeh, B. (2018). P831 - Habitual dietary intake of Dutch IBD patients differs from population controls: A case-control study. Journal of Crohn's and Colitis, 12, S536-S536. [P831].
BIOS Consortium (2018). A SNP panel for identification of DNA and RNA specimens. BMC Genomics, 19(90).
Imhann, F., Vich Vila, A., Bonder, M. J., Fu, J., Gevers, D., Visschedijk, M. C., ... Weersma, R. K. (2018). Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease. Gut, 67(1), 108-119.


van Dam, S., Võsa, U., van der Graaf, A., Franke, L., & de Magalhães, J. P. (2018). Gene co-expression analysis for functional classification and gene-disease predictions. Briefings in Bioinformatics, 19(4), 575-592.
Linner, R. K., Marioni, R. E., Rietveld, C. A., Simpkin, A. J., Davies, N. M., Watanabe, K., ... BIOS Consortium (2017). An epigenome-wide association study meta-analysis of educational attainment. Molecular Psychiatry, 22(12), 1680-1690.
Pirastu, N., Joshi, P. K., de Vries, P. S., Cornelis, M. C., McKeigue, P. M., Keum, N., ... Wilson, J. F. (2017). GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. Nature Communications, 8, [1584].
Nibbeling, E. A. R., Duarri, A., Verschuuren-Bemelmans, C. C., Fokkens, M. R., Karjalainen, J. M., Smeets, C. J. L. M., ... Verbeek, D. S. (2017). Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia. Brain, 140(11), 2860-2878.
van Dongen, J., Suderman, M., Sugden, K., Ismail, K., Mulder, R. H., Kupper, L. K., ... BIOS Consortium (2017). Epigenome-wide association study meta-analysis of aggressive behavior. Behavior Genetics, 47(6), 662-663.
Mandaviya, P. R., Joehanes, R., Aissi, D., Kuehnel, B., Marioni, R. E., Truong, V., ... Charge Consortium Epigenetics Grp (2017). Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes. PLoS ONE, 12(10), [e0182472].
Macé, A., Tuke, M. A., Deelen, P., Kristiansson, K., Mattsson, H., Nõukas, M., ... Kutalik, Z. (2017). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nature Communications, 8(1), [744].
Kreiner, E., Waage, J., Standl, M., Brix, S., Pers, T. H., Couto Alves, A., ... Bønnelykke, K. (2017). Shared genetic variants suggest common pathways in allergy and autoimmune diseases. Journal of Allergy and Clinical Immunology, 140(3), 771-781.
Matzaraki, V., Gresnigt, M. S., Jaeger, M., Ricano-Ponce, I., Johnson, M. D., Oosting, M., ... Kumar, V. (2017). An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility. PLoS ONE, 12(7), [e0180824].
Day, F. R., Thompson, D. J., Helgason, H., Chasman, D. I., Finucane, H., Sulem, P., ... PRACTICAl Consortium (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics, 49(6), 834-841.
Nolte, I. M., van der Most, P. J., Alizadeh, B. Z., de Bakker, P. I. W., Boezen, H. M., Bruinenberg, M., ... Snieder, H. (2017). Missing heritability: Is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study. European Journal of Human Genetics, 25(7), 877-885.
Tang, A. T., Hoi, J. P. C., Kotzin, J. J., Yang, Y., Hong, C. C., Hobson, N., ... Kahn, M. L. (2017). Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature, 545(7654), 305-310.
Wild, P. S., Felix, J. F., Schillert, A., Teumer, A., Chen, M-H., Leening, M. J. G., ... KNHI Investigators (2017). Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. CLIN Journal, 127(5), 1798-1812.
Nolte, I. M., van der Most, P. J., Alizadeh, B. Z., de Bakker, P. I., Boezen, H. M., Bruinenberg, M., ... Snieder, H. (2017). Missing heritability: Is the gap closing? An analysis of 32 complex traits in the LifeLines Cohort Study. Genetic epidemiology, 39(7), 572-573.
Acuna-Hidalgo, R., Deriziotis, P., Steehouwer, M., Gilissen, C., Graham, S. A., van Dam, S., ... van Bon, B. W. M. (2017). Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies. PLoS genetics, 13(3).
Kasela, S., Kisand, K., Tserel, L., Kaleviste, E., Remm, A., Fischer, K., ... Milani, L. (2017). Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4(+) versus CD8(+) T cells. PLoS genetics, 13(3).
Soderquest, K., Hertweck, A., Giambartolomei, C., Henderson, S., Mohamed, R., Goldberg, R., ... Lord, G. M. (2017). Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease. PLoS genetics, 13(2), [e1006587].
Claringbould, A., de Klein, N., & Franke, L. (2017). The genetic architecture of molecular traits. Current Opinion in Systems Biology, 1, 25-31.
van der Velde, K. J., de Boer, E. N., van Diemen, C. C., Sikkema-Raddatz, B., Abbott, K. M., Knopperts, A., ... Swertz, M. A. (2017). GAVIN: Gene-Aware Variant INterpretation for medical sequencing. Genome Biology, 18(1), [6].
Wahl, S., Drong, A. W., Lehne, B., Loh, M., Scott, W. R., Kunze, S., ... Chambers, J. C. (2017). Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 541(81), 81-86.
Marshall, C. R., Howrigan, D. P., Merico, D., Thiruvahindrapuram, B., Wu, W., Greer, D. S., ... Psychosis Endophenotypes (2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics, 49(1), 27-35.
Lepamets, M., Lepik, K., Kals, M., Carmeli, C., Claringbould, A., Bochud, M., ... Kutalik, Z. (2017). New Quality Measure for CNV: A Multi-Omics Approach. Human heredity, 83(1), 16-16.


Bonder, M. J., Luijk, R., Pital-Zhernakova, D., Moed, M., Deelen, P., Vermaat, M., ... BIOS Consortium (2017). Disease variants alter transcription factor levels and methylation of their binding sites. Nature Genetics, 49(1), 131-138.
Pital-Zhernakova, D., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., ... Franke, L. (2017). Identification of context-dependent expression quantitative trait loci in whole blood. Nature Genetics, 49(1), 139-145.
Amini, M., Bashirova, D., Prins, B. P., Corpeleijn, E., Bruinenberg, M., Franke, L., ... Lifelines Cohort Study (2016). Eosinophil Count Is a Common Factor for Complex Metabolic and Pulmonary Traits and Diseases: The LifeLines Cohort Study. PLoS ONE, 11(12), [e0168480].
Kassam, I., Qi, T., Lloyd-Jones, L., Holloway, A., Bonder, M. J., Henders, A. K., ... McRae, A. F. (2016). Evidence for mitochondrial genetic control of autosomal gene expression. Human Molecular Genetics, 25(24), 5332-5338.
Kogelman, L. J. A., Fu, J., Franke, L., Greve, J. W., Hofker, M., Rensen, S. S., & Kadarmideen, H. N. (2016). Inter-Tissue Gene Co-Expression Networks between Metabolically Healthy and Unhealthy Obese Individuals. PLoS ONE, 11(12), [e0167519].
Okbay, A., Baselmans, B. M. L., De Neve, J-E., Turley, P., Nivard, M. G., Fontana, M. A., ... Lifelines Cohort Study (2016). Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics, 48(12), 1591.
Barban, N., Jansen, R., de Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., ... BIOS Consortium (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics, 48(12), 1462-1472.
Aguirre-Gamboa, R., Joosten, I., Urbano, P. C. M., van der Molen, R. G., van Rijssen, E., van Cranenbroek, B., ... Koenen, H. J. P. M. (2016). Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits. Cell reports, 17(9), 2474-2487.
van der Zwaag, P. A., Herkert, J. C., Sarvaas, G. J. D. M., Bartelds, B., van Diemen, C. C., de Koning, T. J., ... Kerstjens-Frederikse, W. S. (2016). Rapid Whole Genome Sequencing for Critically Ill Children With Cardiomyopathy. Circulation, 134.
Li, Y., Oosting, M., Smeekens, S. P., Jaeger, M., Aguirre-Gamboa, R., Le, K. T. T., ... Netea, M. G. (2016). A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans. Cell, 167(4), 1099-1110.
Iotchkova, V., Huang, J., Morris, J. A., Jain, D., Barbieri, C., Walter, K., ... UK10K consortium (2016). Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nature Genetics, 48(11), 1303-1312.
Bonder, M. J., Kurilshchikov, A., Tigchelaar-Feenstra, E., Mujagic, Z., Imhann, F., Vich Vila, A., ... Zhernakova, A. (2016). The effect of host genetics on the gut microbiome. Nature Genetics, 48(11), 1407-1412.
Li, Y., Oosting, M., Deelen, P., Ricano-Ponce, I., Smeekens, S., Jaeger, M., ... Netea, M. G. (2016). Corrigendum: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi (vol 22, pg 1192, 2016). Nature Medicine, 22(10), 1192.
Int Headache Genetics Consortium (2016). Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine (vol 48, pg 856, 2016). Nature Genetics, 48(10), 1296.
Amin, N., Allebrandt, K. V., van der Spek, A., Mueller-Myhsok, B., Hek, K., Teder-Laving, M., ... van Duijn, C. M. (2016). Genetic variants in RBFOX3 are associated with sleep latency. European Journal of Human Genetics, 24(10), 1488-1495.
Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., ... Wellcome Trust Case-Control Consor (2016). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics, 48(10), 1171-1184.
van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., ... de Bakker, P. I. W. (2016). 52 Genetic Loci Influencing Myocardial Mass. Journal of the American College of Cardiology, 68(13), 1435-1448.
Slieker, R. C., van Iterson, M., Luijk, R., Beekman, M., Zhernakova, D. V., Moed, M. H., ... BIOS Consortium (2016). Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms. Genome Biology, 17, [191].
van Rheenen, W., Shatunov, A., Dekker, A. M., McLaughlin, R. L., Diekstra, F. P., Pulit, S. L., ... NNIPPS Study Grp (2016). Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nature Genetics, 48(9), 1043-1050.
Okbay, A., Baselmans, B. M. L., De Neve, J-E., Turley, P., Nivard, M. G., Fontana, M. A., ... Lifelines Cohort Study (2016). Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses (vol 48, pg 624, 2016). Nature Genetics, 48(8), 1587-1587.
Li, Y., Oosting, M., Deelen, P., Ricano-Ponce, I., Smeekens, S., Jaeger, M., ... Netea, M. G. (2016). Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Nature Medicine, 22(8), 952-962.
Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., ... Int Headache Genetics Consortium (2016). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48(8), 856-869.
Netea, M. G., Joosten, L. A. B., Li, Y., Kumar, V., Oosting, M., Smeekens, S., ... Wijmenga, C. (2016). Understanding human immune function using the resources from the Human Functional Genomics Project. Nature Medicine, 22(8), 831-833.
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