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Franke, Prof. Lude

Lude Franke
Lude Franke

Lude Franke is Associate Professor at the Genetics Department of the University of Groningen/University Medical Centre Groningen and Head of Research and Education in the Dept. of Genetics, UMCG. He is a statistical geneticist, working on analyzing data on the genetics of complex and autoimmune diseases (e.g. celiac disease). He has been awarded an ERC Starting grant (2014), NWO VIDI grant (2014), NWO VENI grant (2009) and a Horizon Grant (2009) to work on identifying molecular effects due to disease-causing mutations.

In his spare time he is also a graphic designer. This chance combination of skills can sometimes make life as a genetics researcher a bit easier: if you can explain your research visually, more people can understand what you are doing. Lude Franke is one of the founding members of the Young Academy Groningen and has also been appointed member of De Jonge Akademie (National Young Academy).

In 2021 Franke was awarded a Vici grant. Many diseases have a genetic basis, but cancer is often caused by mutations that arise during life, whereas other diseases are caused by genetic differences that are inherited from parents. Frankes project uses gene networks to test whether a unifying principle exists that links these different types of mutations.

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COVID-19 Host Genetics Initiative (2022). A first update on mapping the human genetic architecture of COVID-19. Nature, 608, E1–E10.
SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium, van Rheenen, W., van der Spek, R. A. A., Bakker, M. K., van Vugt, J. J. F. A., Hop, P. J., Zwamborn, R. A. J., de Klein, N., Westra, H-J., Bakker, O. B., Deelen, P., Shireby, G., Hannon, E., Moisse, M., Baird, D., Restuadi, R., ... Veldink, J. H. (2022). Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology (vol 53, pg 1636, 2021). Nature genetics, 54(3), 361-361.
BIOS Consortium (2022). Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression. Genome Biology, 23(1), 24.
Andreu-Sánchez, S., Aubert, G., Ripoll-Cladellas, A., Henkelman, S., Zhernakova, D. V., Sinha, T., Kurilshikov, A., Cenit, M. C., Jan Bonder, M., Franke, L., Wijmenga, C., Fu, J., van der Wijst, M. G. P., Melé, M., Lansdorp, P., & Zhernakova, A. (2022). Genetic, parental and lifestyle factors influence telomere length. Communications biology, 5(1), [565].
BIOS Consortium, Brain MEND Consortium, Hop, P. J., Zwamborn, R. A. J., Hannon, E., Shireby, G. L., Nabais, M. F., Walker, E. M., van Rheenen, W., van Vugt, J. J. F. A., Dekker, A. M., Westeneng, H. J., Tazelaar, G. H. P., van Eijk, K. R., Moisse, M., Baird, D., Al Khleifat, A., Iacoangeli, A., Ticozzi, N., ... Veldink, J. H. (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Science Translational Medicine, 14(633), [eabj0264].
Uniken Venema, W. T. C., Ramírez-Sánchez, A. D., Bigaeva, E., Withoff, S., Jonkers, I., McIntyre, R. E., Ghouraba, M., Raine, T., Weersma, R. K., Franke, L., Festen, E. A. M., & van der Wijst, M. G. P. (2022). Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels. Scientific Reports, 12, [9897].
Lifelines Corona Research initiative, Warmerdam, C. A. R., Wiersma, H. H., Lanting, P., Ani, A., Dijkema, M. X. L., Snieder, H., Vonk, J. M., Boezen, H. M., Deelen, P., & Franke, L. H. (2022). Increased genetic contribution to wellbeing during the COVID-19 pandemic. PLoS genetics, 18(5), [e1010135].
Bios Consortium , Porcu, E., Claringbould, A., Weihs, A., Lepik, K., Richardson, T. G., Voelker, U., Santoni, F. A., Teumer, A., Franke, L., Reymond, A., & Kutalik, Z. (2022). Limited evidence for blood eQTLs in human sexual dimorphism. Genome medicine, 14(1), [89].
Estonian Biobank Research Team, Lepamets, M., Auwerx, C., Nõukas, M., Claringbould, A., Porcu, E., Kals, M., Jürgenson, T., Morris, A. P., Võsa, U., Bochud, M., Stringhini, S., Wijmenga, C., Franke, L., Peterson, H., Vilo, J., Lepik, K., Mägi, R., & Kutalik, Z. (2022). Omics-informed CNV calls reduce false-positive rates and improve power for CNV-trait associations. Human Genetics and Genomics Advances, 3(4), [100133].
23andMe Research Team, Social Science Genetic Association Consortium, Okbay, A., Wu, Y., Wang, N., Jayashankar, H., Bennett, M., Nehzati, S. M., Sidorenko, J., Kweon, H., Goldman, G., Gjorgjieva, T., Jiang, Y., Hicks, B., Tian, C., Hinds, D. A., Ahlskog, R., Magnusson, P. K. E., Oskarsson, S., ... Young, A. I. (2022). Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals. Nature genetics, 54(4), 437-449.
Single-Cell EQTLGen Consortium, Bios Consortium , Oelen, R., de Vries, D. H., Brugge, H., Gordon, M. G., Vochteloo, M., Ye, C. J., Westra, H-J., Franke, L., & van der Wijst, M. G. P. (2022). Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure. Nature Communications, 13(1), [3267].
Lifelines Corona Research initiative, Dite, G. S., Murphy, N. M., Spaeth, E., & Allman, R. (2022). Validation of a clinical and genetic model for predicting severe COVID-19. Epidemiology And Infection, 150, [e91].


Lifelines Cohort Study, Warmerdam, R., Lanting, P., Deelen, P., & Franke, L. (2022). Idéfix: identifying accidental sample mix-ups in biobanks using polygenic scores. Bioinformatics (Oxford, England), 38(4), 1059–1066.
Lifelines Corona Research initiative, Zhang, J., Loman, L., Kamphuis, E., Schuttelaar, M. L. A., Boezen, H. M., Mierau, J., Franke, H. L., Dekens, J., Deelen, P., Lanting, P., Vonk, J. M., Nolte, I. M., Ori, A. P. S., Claringbould, A., Boulogne, F., Dijkema, M. X. L., Wiersma, H. H., Warmerdam, R., ... van Blokland, I. (2022). Impact of the COVID-19 pandemic on adults with moderate-to-severe atopic dermatitis in the Dutch general population. JAAD international, 6, 86-93.
van Blokland, I. V., Groot, H. E., Franke, L. H., van der Wijst, M. G. P., & van der Harst, P. (2022). Translational insights from single-cell technologies across the cardiovascular disease continuum. TRENDS IN CARDIOVASCULAR MEDICINE, 32(3), 127-135.
The International Headache Genetics Consortium (IHGC), Tanha, H. M., Martin, N. G., Whitfield, J. B., & Nyholt, D. R. (2021). Association and genetic overlap between clinical chemistry tests and migraine. Cephalalgia, 41(11-12), 1208-1221.
SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium, van Rheenen, W., van der Spek, R. A. A., Bakker, M. K., van Vugt, J. J. F. A., Hop, P. J., Zwamborn, R. A. J., de Klein, N., Westra, H. J., Bakker, O. B., Deelen, P., Shireby, G., Hannon, E., Moisse, M., Baird, D., Restuadi, R., ... Veldink, J. H. (2021). Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nature genetics, 53(12), 1636-1648.
BIOS Consortium, Pellegrino-Coppola, D., Claringbould, A., Stutvoet, M., Boomsma, D. I., Ikram, M. A., Slagboom, P. E., Westra, H-J., & Franke, L. (2021). Correction for both common and rare cell types in blood is important to identify genes that correlate with age. BMC Genomics, 22(1), [184].
BIOS Consortium, van Dongen, J., Hagenbeek, F. A., Suderman, M., Roetman, P. J., Sugden, K., Chiocchetti, A. G., Ismail, K., Mulder, R. H., Hafferty, J. D., Adams, M. J., Walker, R. M., Morris, S. W., Lahti, J., Küpers, L. K., Escaramis, G., Alemany, S., Jan Bonder, M., Meijer, M., ... Franke, L. (2021). DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan. Molecular Psychiatry, 26, 2148-2162.
Karabegovic, I., Portilla-Fernandez, E., Li, Y., Ma, J., Maas, S. C. E., Sun, D., Hu, E. A., Kuhnel, B., Zhang, Y., Ambatipudi, S., Fiorito, G., Huang, J., Castillo-Fernandez, J. E., Wiggins, K. L., de Klein, N., Grioni, S., Swenson, B. R., Polidoro, S., Treur, J. L., ... Ghanbari, M. (2021). Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. Nature Communications, 12(1), [2830].
Zhang, Z., van Dijk, F., de Klein, N., van Gijn, M. E., Franke, L. H., Sinke, R. J., Swertz, M. A., & van der Velde, K. J. (2021). Feasibility of predicting allele specific expression from DNA sequencing using machine learning. Scientific Reports, 11(1), [10606].
Lifelines Corona Research initiative, Vloo, A., Alessie, R. J. M., Mierau, J. O., & Mierau, J. O. (2021). Gender differences in the mental health impact of the COVID-19 lockdown: Longitudinal evidence from the Netherlands. SSM - Population Health, 15, [100878].
Biobank-based Integrative Omics St, eQTLgen Consortium, BioBank Japan Project, China Kadoorie Biobank Collaborati, kConFab Investigators, Lifelines Cohort Study, InterAct Consortium, 23 Me Res Team, Ruth, K. S., Day, F. R., Hussain, J., Martinez-Marchal, A., Aiken, C. E., Azad, A., Thompson, D. J., Knoblochova, L., Abe, H., Tarry-Adkins, J. L., Gonzalez, J. M., ... Andersen, C. Y. (2021). Genetic insights into biological mechanisms governing human ovarian ageing. Nature, 596(7872), 393-397.
Peters, V., Tigchelaar-Feenstra, E. F., Imhann, F., Dekens, J. A. M., Swertz, M. A., Franke, L. H., Wijmenga, C., Weersma, R. K., Alizadeh, B. Z., Dijkstra, G., & Campmans-Kuijpers, M. J. E. (2021). Habitual dietary intake of IBD patients differs from population controls: a case-control study. European Journal of Nutrition.
Warmerdam, R., Lanting, P., Deelen, P., & Franke, L. (2021). Idéfix: identifying accidental sample mix-ups in biobanks using polygenic scores. (bioRxiv). BioRxiv.
Matzaraki, V., Le, K. T. T., Jaeger, M., Aguirre-Gamboa, R., Johnson, M. D., Sanna, S., Rosati, D., Franke, L., Zhernakova, A., Fu, J., Withoff, S., Jonkers, I., Li, Y., Joosten, L. A. B., Netea, M. G., Wijmenga, C., & Kumar, V. (2021). Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability. Frontiers in Immunology, 12, [662171].
Chu, X., Jaeger, M., Beumer, J., Bakker, O. B., Aguirre-Gamboa, R., Oosting, M., Smeekens, S. P., Moorlag, S., Mourits, V. P., Koeken, V. A. C. M., de Bree, C., Jansen, T., Mathews, I. T., Dao, K., Najhawan, M., Watrous, J. D., Joosten, I., Sharma, S., Koenen, H. J. P. M., ... Li, Y. (2021). Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease. Genome Biology, 22(1), [198].
MiBioGen Consortium Initiative, Kurilshikov, A., Medina-Gomez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, C. I., Raygoza Garay, J. A., Finnicum, C. T., Liu, X., Zhernakova, D. V., Bonder, M. J., Hansen, T. H., Frost, F., Ruehlemann, M. C., Turpin, W., Moon, J-Y., Kim, H-N., ... Zhernakova, A. (2021). Large-scale association analyses identify host factors influencing human gut microbiome composition. Nature Genetics, 53, 156-165.
BIOS Consortium, i2QTL Consortium, Võsa, U., Claringbould, A., Westra, H-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Yazar, S., Brugge, H., Oelen, R., de Vries, D. H., van der Wijst, M. G. P., Kasela, S., Pervjakova, N., Alves, I., ... Franke, L. (2021). Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nature Genetics, 53(9), 1300-1310.
Mc Intyre, K., Lanting, P., Deelen, P., Wiersma, H. H., Vonk, J. M., Ori, A. P. S., Jankipersadsing, S. A., Warmerdam, R., van Blokland, I., Boulogne, F., Dijkema, M. X. L., Herkert, J. C., Claringbould, A., Bakker, O., Lopera Maya, E. A., Bültmann, U., Zhernakova, A., Reijneveld, S. A., Zijlstra, E., ... Franke, L. (2021). Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort. BMJ Open, 11(3), [e044474].
COVID-19 Host Genetics Initiative, 23andMe COVID-19 Team, Norwegian SARS-CoV-2 Study Grp, Humanitas COVID-19 Task Force, Humanitas Gavazzeni COVID-19 Task, FHoGID, RegCOVID, P-PredictUs, SeroCOVID, CRiPSI, Genes & Hlth Res Team, & UCLA Hlth ATLAS Data Mart Working (2021). Mapping the human genetic architecture of COVID-19. Nature, 600, 472–477.
Estonian Biobank Research Team, Genetics of DNA Methylation Consortium, Schlosser, P., Tin, A., Matias-Garcia, P. R., Thio, C. H. L., Joehanes, R., Liu, H., Weihs, A., Yu, Z., Hoppmann, A., Grundner-Culemann, F., Min, J. L., Adeyemo, A. A., Agyemang, C., Ärnlöv, J., Aziz, N. A., Baccarelli, A., Bochud, M., ... Snieder, H. (2021). Meta-analyses identify DNA methylation associated with kidney function and damage. Nature Communications, 12, [7174].
Hemani, G., Powell, J. E., Wang, H., Shakhbazov, K., Westra, H-J., Esko, T., Henders, A. K., McRae, A. F., Martin, N. G., Metspalu, A., Franke, L., Montgomery, G. W., Goddard, M. E., Gibson, G., Yang, J., & Visscher, P. M. (2021). Phantom epistasis between unlinked loci. Nature, 596(7871), E1-E3.
Hemani, G., Shakhbazov, K., Westra, H-J., Esko, T., Henders, A. K., McRae, A. F., Yang, J., Gibson, G., Martin, N. G., Metspalu, A., Franke, L., Montgomery, G. W., Visscher, P. M., & Powell, J. E. (2021). Retraction Note: Detection and replication of epistasis influencing transcription in humans. Nature, 596(7871), 306.
Ballering, A. V., Oertelt-Prigione, S., Olde Hartman, T. C., Rosmalen, J. G. M., Boezen, M., Mierau, J. O., Franke, L. H., Dekens, J., Deelen, P., Lanting, P., Vonk, J. M., Nolte, I., Ori, A. P. S., Claringbould, A., Boulogne, F., Dijkema, M. X. L., Wiersma, H. H., Warmerdam, R., & Jankipersadsing, S. A. (2021). Sex and Gender-Related Differences in COVID-19 Diagnoses and SARS-CoV-2 Testing Practices During the First Wave of the Pandemic: The Dutch Lifelines COVID-19 Cohort Study. Journal of womens health, 30(12), 1686-1692.
BIOS Consortium, van der Graaf, A., Zorro, M. M., Claringbould, A., Vosa, U., Aguirre-Gamboa, R., Li, C., Mooiweer, J., Ricano-Ponce, I., Borek, Z., Koning, F., Kooy-Winkelaar, Y., Sollid, L. M., Qiao, S-W., Kumar, V., Li, Y., Franke, L., Withoff, S., Wijmenga, C., ... Jonkers, I. (2021). Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFN gamma Signaling in Celiac Disease. Frontiers in Genetics, 11, 562434. [562434].
Lifelines COVID-19 cohort study, van Blokland, I. V., Lanting, P., Ori, A. P. S., Vonk, J. M., Warmerdam, R. C. A., Herkert, J. C., Boulogne, F., Claringbould, A., Lopera-Maya, E. A., Bartels, M., Hottenga, J-J., Ganna, A., & Karjalainen, J. (2021). Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility. PLoS ONE, 16(8), [e0255402].


BIOS Consortium, Ouwens, K. G., Jansen, R., Nivard, M. G., van Dongen, J., Frieser, M. J., Hottenga, J-J., Arindrarto, W., Claringbould, A., van Iterson, M., Mei, H., & Franke, L. (2020). A characterization of cis- and trans-heritability of RNA-Seq-based gene expression. European Journal of Human Genetics, 28(2), 253-263.
BIOS Consortium, Lu, X., Fraszczyk, E., van der Meer, T. P., van Faassen, M., Bloks, V. W., Kema, I. P., van Beek, A. P., Li, S., Franke, L., Westra, H-J., Xu, X., Huo, X., Snieder, H., Wolffenbuttel, B. H. R., & van Vliet-Ostaptchouk, J. V. (2020). An epigenome-wide association study identifies multiple DNA methylation markers of exposure to endocrine disruptors. Environment international, 144, [106016].
BIOS Consortium, Aguirre-Gamboa, R., de Klein, N., di Tommaso, J., Claringbould, A., van der Wijst, M. G. P., de Vries, D., Brugge, H., Oelen, R., Vosa, U., Zorro, M. M., Chu, X., Bakker, O. B., Borek, Z., Ricano-Ponce, I., Deelen, P., Xu, C-J., Swertz, M., Jonkers, I., ... Li, Y. (2020). Deconvolution of bulk blood eQTL effects into immune cell subpopulations. Bmc Bioinformatics, 21(1), [243].
Claus, L. R., Boulogne, F., Lilien, M. R., Rookmaaker, M. B., van der Zwaag, A., Nguyen, T. Q., Verhaar, M. C., Knoers, N. V. A. M., Deelen, P., Franke, L., de Borst, M. H., & van Eerde, A. M. (2020). GeNepher: building a data- and biobank for (suspected) hereditary renal disease. European Journal of Human Genetics, 28(SUPPL 1), 821-822.
Folkersen, L., Gustafsson, S., Wang, Q., Hansen, D. H., Hedman, Å. K., Schork, A., Page, K., Zhernakova, D. V., Wu, Y., Peters, J., Eriksson, N., Bergen, S. E., Boutin, T. S., Bretherick, A. D., Enroth, S., Kalnapenkis, A., Gådin, J. R., Suur, B. E., Chen, Y., ... Mälarstig, A. (2020). Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals. Nature Metabolism, 2(10), 1135-1148.
Huang, Y., Ollikainen, M., Muniandy, M., Zhang, T., van Dongen, J., Hao, G., van Der Most, P. J., Pan, Y., Pervjakova, N., Sun, Y., Hui, Q., Lahti, J., Fraszczyk, E., Lu, X., Sun, D., Richard, M. A., Willemsen, G., Heikkila, K., Leach, I. M., ... Snieder, H. (2020). Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure. Hypertension, 76(1), 195-205.
de Vries, D. H., Matzaraki, V., Bakker, O. B., Brugge, H., Westra, H-J., Netea, M. G., Franke, L., Kumar, V., & van der Wijst, M. G. P. (2020). Integrating GWAS with bulk and single-cell RNA-sequencing reveals a role for LY86 in the anti-Candida host response. PLoS Pathogens, 16(4), [1008408].
Lifelines Cohort Study, Lopera Maya, E. A., van der Graaf, A., Lanting, P., van der Geest, M., Fu, J., Swertz, M., Franke, L., Wijmenga, C., Deelen, P., Zhernakova, A., & Sanna, S. (2020). Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes. Frontiers in Genetics, 11, [613].
BIOS Consortium, van der Graaf, A., Claringbould, A., Rimbert, A., Westra, H-J., Li, Y., Wijmenga, C., Sanna, S., & Franke, L. (2020). Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids. Nature Communications, 11(1), [4930].
Lanting, P., Drenth, E., Boven, L., van Hoek, A., Hijlkema, A., Poot, E., van der Vries, G., Schoevers, R., Horwitz, E., Gans, R., Kosterink, J., Plantinga, M., van Langen, I., Ranchor, A., Wijmenga, C., Franke, L., Wilffert, B., & Sijmons, R. (2020). Practical Barriers and Facilitators Experienced by Patients, Pharmacists and Physicians to the Implementation of Pharmacogenomic Screening in Dutch Outpatient Hospital Care-An Explorative Pilot Study. Journal of personalized medicine, 10(4), 1-13. [293].
Bangma, A., Voskuil, M. D., Uniken Venema, W. T. C., Brugge, H., Hu, S., Lanting, P., Franke, L., Dijkstra, G., Festen, E. A. M., & Weersma, R. K. (2020). Predicted efficacy of a pharmacogenetic passport for inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 51(11), 1105-1115.
Van Der Wijst, M. G. P., De Vries, D. H., Groot, H. E., Trynka, G., Hon, C. C., Bonder, M. J., Stegle, O., Nawijn, M. C., Idaghdour, Y., Van Der Harst, P., Ye, C. J., Powell, J., Theis, F. J., Mahfouz, A., Heing, M., & Franke, L. (2020). The single-cell eQTLGen consortium. eLife, 9, [52155].


BIOS Consortium (2019). A linear mixed-model approach to study multivariate gene-environment interactions. Nature Genetics, 51(1), 180-186.
BIOS Consortium (2019). Allele specific expression identifies rare variants as cause for extreme allelic imbalance. European Journal of Human Genetics, 27, 601.
Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., ... Wilson, J. F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10(1), [4957].
Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., Mujagic, Z., Masclee, A. A. M., Jonkers, D. M. A. E., Oosting, M., Joosten, L. A. B., Netea, M. G., Franke, L., Zhernakova, A., Fu, J., Wijmenga, C., & McCarthy, M. I. (2019). Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nature Genetics, 51(4), 600-605.
Zeng, B., Lloyd-Jones, L. R., Montgomery, G. W., Metspalu, A., Esko, T., Franke, L., Vosa, U., Claringbould, A., Brigham, K. L., Quyyumi, A. A., Idaghdour, Y., Yang, J., Visscher, P. M., Powell, J. E., & Gibson, G. (2019). Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation. Genetics, 212(3), 905-918.
BIOS Consortium, van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran, D. L., Moffitt, T. E., Poulton, R., Franke, B., & Boomsma, D. (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biological Psychiatry, 86(8), 599-607.
BIOS Consortium, van Rooij, J., Mandaviya, P. R., Claringbould, A., Felix, J. F., van Dongen, J., Jansen, R., Franke, L., 't Hoen, P. A. C., Heijmans, B., & van Meurs, J. B. J. (2019). Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies. Genome Biology, 20(1), [235].
CommonMind Consortium, Psychiat Genomics Consortium, iPSYCH-GEMS Schizophrenia Working, Huckins, L. M., Dobbyn, A., Ruderfer, D. M., Hoffman, G., Wang, W., Pardinas, A. F., Rajagopal, V. M., Als, T. D., Nguyen, H. T., Girdhar, K., Boocock, J., Roussos, P., Fromer, M., Kramer, R., Purcell, S., Demontis, D., ... Stahl, E. A. (2019). Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51(4), 659-674.
23and Me Res Team, eQTLgen Consortium, Int Cannabis Consortium, & Soc Sci Genetic Association Con (2019). Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51(2), 245-257.
eQTLgen Consortium, Timmers, P. R., Mounier, N., Lall, K., Fischer, K., Ning, Z., Feng, X., Bretherick, A. D., & Clark, D. W. (2019). Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. eLife, 8, [39856].
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