Kuipers, Prof. Oscar
Oscar Kuipers is professor of Molecular Genetics of Prokaryotes at the University of Groningen, and a member of the department of Molecular Genetics of the Groningen Biomolecular Sciences and Biotechnology Institute. Prokaryotes are micro-organisms without a nucleus, such as bacteria and Cyanobacteria. The field of molecular genetics studies gene functions and regulation and the interaction between genes. This research results, for example, in increasing knowledge about the gene modification of bacteria and is very important to biotechnology. Kuipers studied Biology at Utrecht University and in 1990 gained his PhD in the department of Biochemistry of the same university. After that, he worked at NIZO Food Research in Ede and the Wageningen Centre for Food Sciences.
Each year Kuipers supervises the (always successful) University of Groningen student team that competes in the iGEM competition in Boston. In 2012 this team became world champion, with a biological detection system to check how fresh meat is. In 2011 Kuipers received the ‘Simon Stevin Master' Award by the Technical Sciences Foundation (STW) and a grant of EUR 500,000 to spend on research. In the same year he became member of the prestigious Royal Netherlands Academy of Arts and Sciences (KNAW).
At the end of May 2013, the EU awarded Kuipers a grant of € 1 million to make synthetic peptides, with particular attention to the development of new antibiotics.
Previously in the news
2023
Morawska,
L. P., & Kuipers, O. P. (2023).
Cell-to-cell non-conjugative plasmid transfer between
Bacillus subtilis and lactic acid bacteria.
Microbial Biotechnology, 16(4),
784-798. https://doi.org/10.1111/1751-7915.14195
Guo,
L., Wambui, J., Wang, C., Muchaamba, F.,
Fernandez-Cantos, M. V., Broos, J., Tasara,
T., Kuipers, O. P., & Stephan, R. (2023).
Cesin, a short natural variant of nisin, displays potent
antimicrobial activity against major pathogens despite lacking two
C-terminal macrocycles. Microbiology
Spectrum, Article e0531922. Advance online publication.
https://doi.org/10.1128/spectrum.05319-22
Guo,
L., Wang, C., Broos, J.,
& Kuipers, O. P. (2023). Lipidated variants of the
antimicrobial peptide nisin produced via incorporation of
methionine analogs for click chemistry show improved
bioactivity. The Journal of Biological
Chemistry, 229(7), Article 104845. Advance
online publication. https://doi.org/10.1016/j.jbc.2023.104845
Abraham
Versloot, R. C., Arias-Orozco, P.,
Tadema, M. J., Rudolfus Lucas, F. L.,
Zhao, X., Marrink, S. J., Kuipers, O.
P., & Maglia, G. (2023). Seeing the
Invisibles: Detection of Peptide Enantiomers, Diastereomers, and
Isobaric Ring Formation in Lanthipeptides Using Nanopores.
Journal of the American Chemical Society,
145(33), 18355-18365. Article 4076. https://doi.org/10.1021/jacs.3c04076
Cebrián
Castillo, R., Xia, Y., & Kuipers,
O. (2023). Synergistic composition
against pseudomonas aeruginosa. (Patent No.
WO2023063827).
2022
Arias-Orozco,
P., Yi, Y., Ruijne, F., Cebrián, R.,
& Kuipers, OP. (2023). Investigating the
Specificity of the Dehydration and Cyclization Reactions in
Engineered Lanthipeptides by Synechococcal SyncM.
ACS Synthetic Biology, 12,
164–177. Advance online publication. https://doi.org/10.1021/acssynbio.2c00455
Muñoz,
C. Y., Zhou, L., Yi, Y.,
& Kuipers, O. P. (2022). Biocontrol properties
from phyllospheric bacteria isolated from Solanum lycopersicum and
Lactuca sativa and genome mining of antimicrobial gene
clusters. BMC Genomics,
23(1), Article 152. https://doi.org/10.1186/s12864-022-08392-0
Cebrián,
R., Li, Q., Peñalver, P., Belmonte-Reche, E.,
Andrés-Bilbao, M., Lucas, R., de Paz, M. V., Kuipers, O.
P., & Morales, J. C. (2022). Chemically Tuning
Resveratrol for the Effective Killing of Gram-Positive
Pathogens. Journal of Natural
Products, 85(6), 1459-1473. Article 1c01107.
Advance online publication. https://doi.org/10.1021/acs.jnatprod.1c01107
Farooq,
S. A., de Jong, A., Khaliq, S., & Kuipers,
O. P. (2022). Draft Genome Sequences of Bacillus
velezensis Strains AF_3B and OS2, Bacillus amyloliquefaciens Strain
BS9, Bacillus halotolerans Strain A1, and Bacillus sp. Strain BS3,
Producing Biosurfactants with Antimicrobial Potential.
Microbiology resource announcements,
11(10), Article e0048222. Advance online publication. https://doi.org/10.1128/mra.00482-22
Bustamante
Ordonez, M., van Doorn, S., Weissing,
F., Daras, I., Kuipers, O.,
& de Vos, M. (2022). Eco-evolutionary
interactions and the spread of antimicrobial resistance in
pathogenic microbial communities. Poster session
presented at Netherlands Society for Evolutionary Biology Meeting
2022, Ede, Netherlands.
Mordhorst,
S., Ruijne, F., Vagstad, A. L., Kuipers, O.
P., & Piel, J. (2022). Emulating nonribosomal
peptides with ribosomal biosynthetic strategies.
RSC Chemical Biology, 4, 7-36. https://doi.org/10.1039/d2cb00169a
de
Jong, A., Kuipers, O. P., & Kok,
J. (2022). FUNAGE-Pro: comprehensive web server for
gene set enrichment analysis of prokaryotes.
Nucleic Acids Research, 50(W1),
330-336. Article gkac441. Advance online publication. https://doi.org/10.1093/nar/gkac441
Liu,
F., van Heel, A. J., Chen,
J., & Kuipers, O. P. (2022).
Functional production of clostridial circularin A in
Lactococcus lactis NZ9000 and mutational analysis of its aromatic
and cationic residues. Frontiers in
Microbiology, 13, Article 1026290. https://doi.org/10.3389/fmicb.2022.1026290
Pinto,
J. P. C., Brouwer, R., Zeyniyev, A., Kuipers, O.
P., & Kok, J. (2022). High-Resolution
Chrono-Transcriptome of Lactococcus lactis Reveals That It
Expresses Proteins with Adapted Size and pI upon Acidification and
Nutrient Starvation. Applied and environmental
microbiology, 88(9), Article e0247621. Advance
online publication. https://doi.org/10.1128/aem.02476-21
Viel,
J. H., & Kuipers, O. P. (2022).
Modular Use of the Uniquely Small Ring A of Mersacidin
Generates the Smallest Ribosomally Produced Lanthipeptide.
ACS Synthetic Biology, 11(9),
3078-3087. Article 2c00343. Advance online publication. https://doi.org/10.1021/acssynbio.2c00343
Viel,
J. H., & Kuipers, O. P. (2022).
Mutational Studies of the Mersacidin Leader Reveal the
Function of Its Unique Two-Step Leader Processing Mechanism.
ACS Synthetic Biology, 11(5),
1949–1957 . Advance online publication. https://doi.org/10.1021/acssynbio.2c00088
Schouten,
G. K., Paulussen, F. M., Kuipers, O. P., Bitter, W.,
Grossmann, T. N., & van Ulsen, P. (2022). Stapling of
Peptides Potentiates the Antibiotic Treatment of Acinetobacter
baumannii In Vivo. Antibiotics ,
11(2), Article 11020273. https://doi.org/10.3390/antibiotics11020273
Morawska,
L. P., Detert Oude Weme, R. G. J., Frenzel, E., Dirkzwager,
M., Hoffmann, T., Bremer, E., & Kuipers, O. P.
(2022). Stress-induced activation of the proline biosynthetic
pathway in Bacillus subtilis: A population-wide and single-cell
study of the osmotically controlled proHJ promoter.
Microbial Biotechnology, 15(9),
2411-2425. Advance online publication. https://doi.org/10.1111/1751-7915.14073
Ekkers,
D. M., Tusso, S., Moreno-Gamez, S., Rillo, M.
C., Kuipers, O. P., & van Doorn, G.
S. (2022). Trade-offs predicted by metabolic network
structure give rise to evolutionary specialization and phenotypic
diversification. Molecular Biology and
Evolution, 39(6), Article msac124. https://doi.org/10.1093/molbev/msac124
Morawska,
L. P., & Kuipers, O. P. (2022).
Transcriptome analysis and prediction of the metabolic state
of stress-induced viable but non-culturable Bacillus subtilis
cells. Scientific Reports,
12(1), Article 18015. https://doi.org/10.1038/s41598-022-21102-w
2021
Chen,
J., & Kuipers, O. P. (2022). Analysis
of cross-functionality within LanBTC synthetase complexes from
different bacterial sources with respect to production of fully
modified lanthipeptides. Applied and environmental
microbiology, 88(2), Article AEM0161821.
Advance online publication. https://doi.org/10.1128/AEM.01618-21
Morawska,
L. P., Hernandez-Valdes, J. A., &
Kuipers, O. P. (2022). Diversity of bet-hedging
strategies in microbial communities-Recent cases and
insights. Wires mechanisms of disease,
14(2), Article e1544. Advance online publication. https://doi.org/10.1002/wsbm.1544
Cebrián,
R., Belmonte-Reche, E., Pirota, V., de Jong,
A., Morales, J. C., Freccero, M., Doria, F., &
Kuipers, O. P. (2022). G-Quadruplex DNA as a Target in
Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide
Ligand and Its Mode of Action. Journal of
Medicinal Chemistry, 65(6), 4752-4766. Advance
online publication. https://doi.org/10.1021/acs.jmedchem.1c01905
van
Tilburg, A. Y., Warmer, P., van Heel, A. J.,
Sauer, U., & Kuipers, O. P. (2022). Membrane
composition and organization of Bacillus subtilis 168 and its
genome-reduced derivative miniBacillus PG10.
Microbial Biotechnology, 15(5),
1633-1651. Article 13978. Advance online publication. https://doi.org/10.1111/1751-7915.13978
Zhou,
L., Song, C., Li, Z., & Kuipers, O. P.
(2021). Antimicrobial activity screening of rhizosphere soil
bacteria from tomato and genome-based analysis of their
antimicrobial biosynthetic potential. BMC
Genomics, 22(1), Article 29. Advance online
publication. https://doi.org/10.1186/s12864-020-07346-8
Fu,
Y., Jaarsma, A. H., & Kuipers, O. P.
(2021). Antiviral activities and applications of ribosomally
synthesized and post-translationally modified peptides
(RiPPs). Cellular and molecular life
sciences, 78, 3921–3940 . Advance online
publication. https://doi.org/10.1007/s00018-021-03759-0
Zhou,
L., Song, C., Muñoz, C. Y., &
Kuipers, O. P. (2021). Bacillus cabrialesii BH5
Protects Tomato Plants Against Botrytis cinerea by Production of
Specific Antifungal Compounds. Frontiers in
Microbiology, 12, Article 707609. https://doi.org/10.3389/fmicb.2021.707609
Zhao,
X., Wang, X., Shukla, R., Kumar, R., Weingarth, M.,
Breukink, E., & Kuipers, O. P. (2021).
Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an
Exceptionally Low Hemolytic Activity. Frontiers in
Microbiology, 12, Article 693725. https://doi.org/10.3389/fmicb.2021.693725
Zhao,
X., Wang, X., Shukla, R., Kumar, R., Weingarth, M.,
Breukink, E., & Kuipers, O. P. (2021).
Brevibacillin 2V Exerts Its Bactericidal Activity via Binding
to Lipid II and Permeabilizing Cellular Membranes.
Frontiers in Microbiology, 12,
Article 694847. https://doi.org/10.3389/fmicb.2021.694847
Zhao,
X., & Kuipers, O. P. (2021).
BrevicidineB, a New Member of the Brevicidine Family,
Displays an Extended Target Specificity. Frontiers
in Microbiology, 12, Article 693117. https://doi.org/10.3389/fmicb.2021.693117
Viel,
J. H., van Tilburg, A. Y., & Kuipers,
O. P. (2021). Characterization of Leader Processing
Shows That Partially Processed Mersacidin Is Activated by AprE
After Export. Frontiers in
Microbiology, 12, Article 765659. https://doi.org/10.3389/fmicb.2021.765659
Ruijne,
F., & Kuipers, O. P. (2021).
Combinatorial biosynthesis for the generation of
new-to-nature peptide antimicrobials. Biochemical
Society Transactions, 49(1), 203-215. Article
BST20200425. Advance online publication. https://doi.org/10.1042/BST20200425
Muñoz,
C. Y., de Jong, A., & Kuipers, O.
P. (2021). Draft Genome Sequences of a Bacillus
subtilis Strain, a Bacillus velezensis Strain, a Paenibacillus
Strain, and an Acinetobacter baumannii Strain, All Isolated from
the Phyllosphere of Lactuca sativa or Solanum lycopersicum.
Microbiology resource announcements,
10(4), Article e01092-20. https://doi.org/10.1128/MRA.01092-20
Arias-Orozco,
P., Yi, Y., & Kuipers, O. P.
(2021). Draft Genome Sequences of Four Bacterial Strains of
Heterotrophic Alteromonas macleodii and Marinobacter, Isolated from
a Nonaxenic Culture of Two Marine Synechococcus Strains.
Microbiology resource announcements,
10(19), Article e00116-21. https://doi.org/10.1128/MRA.00116-21
Xia,
Y., Cebrián, R., Xu, C., Jong, A.
D., Wu, W., & Kuipers, O. P. (2021).
Elucidating the mechanism by which synthetic helper peptides
sensitize Pseudomonas aeruginosa to multiple antibiotics.
PLoS Pathogens, 17(9), Article
e1009909. https://doi.org/10.1371/journal.ppat.1009909
Arias-Orozco,
P., Inklaar, M., Lanooij, J., Cebrián,
R., & Kuipers, O. P. (2021).
Functional Expression and Characterization of the Highly
Promiscuous Lanthipeptide Synthetase SyncM, Enabling the Production
of Lanthipeptides with a Broad Range of Ring Topologies.
ACS Synthetic Biology, 10(10),
2579-2591. Article acssynbio.1c00224. Advance online publication.
https://doi.org/10.1021/acssynbio.1c00224
Gazioglu,
O., Kareem, B. O., Afzal, M., Shafeeq, S., Kuipers, O.
P., Ulijasz, A. T., Andrew, P. W., & Yesilkaya, H.
(2021). Glutamate Dehydrogenase (GdhA) of Streptococcus
pneumoniae Is Required for High Temperature Adaptation.
Infection and Immunity, 89(12),
Article IAI0040021. Advance online publication. https://doi.org/10.1128/IAI.00400-21
Viel,
J. H., Jaarsma, A. H., & Kuipers, O. P.
(2021). Heterologous Expression of Mersacidin in Escherichia
coli Elucidates the Mode of Leader Processing. ACS
Synthetic Biology, 10(3), 600-608. Article
acssynbio.0c00601. Advance online publication. https://doi.org/10.1021/acssynbio.0c00601
Zhou,
L., de Jong, A., Yi, Y.,
& Kuipers, O. P. (2021). Identification,
Isolation, and Characterization of Medipeptins, Antimicrobial
Peptides From Pseudomonas mediterranea EDOX.
Frontiers in Microbiology, 12,
Article 732771. https://doi.org/10.3389/fmicb.2021.732771
Chen,
J., & Kuipers, O. P. (2021).
Isolation and Analysis of the Nisin Biosynthesis Complex
NisBTC: Further Insights into Their Cooperative Action.
mBio, 12(5), Article e02585-21. https://doi.org/10.1128/mBio.02585-21
Lauxen,
A. I., Kobauri, P., Wegener, M., Hansen, M.
J., Galenkamp, N. S., Maglia, G.,
Szymanski, W., Feringa, B. L., &
Kuipers, O. P. (2021). Mechanism of Resistance
Development in E. coli against TCAT, a Trimethoprim-Based
Photoswitchable Antibiotic.
Pharmaceuticals, 14(5), Article
ph14050392. https://doi.org/10.3390/ph14050392
Zhao,
X., & Kuipers, O. P. (2021). Nisin-
and Ripcin-Derived Hybrid Lanthipeptides Display Selective
Antimicrobial Activity against Staphylococcus aureus.
ACS Synthetic Biology, 10(7),
1703–1714. Advance online publication. https://doi.org/10.1021/acssynbio.1c00080
Li,
Q., Cebrián, R., Montalbán-López, M., Ren, H., Wu,
W., & Kuipers, O. P. (2021).
Outer-membrane-acting peptides and lipid II-targeting
antibiotics cooperatively kill Gram-negative pathogens.
Communications biology, 4(1),
Article 31. https://doi.org/10.1038/s42003-020-01511-1
Luo,
Y., Korza, G., DeMarco, A. M., Kuipers, O. P., Li,
Y-Q., & Setlow, P. (2021). Properties of spores of
Bacillus subtilis with or without a transposon that decreases spore
germination and increases spore wet heat resistance.
Journal of Applied Microbiology,
131(6), 2918-2928. Advance online publication. https://doi.org/10.1111/jam.15163
Fernandez-Cantos,
M. V., Garcia-Morena, D., Iannone, V.,
El-Nezami, H., Kolehmainen, M., & Kuipers, O. P.
(2021). Role of microbiota and related metabolites in
gastrointestinal tract barrier function in NAFLD.
Tissue Barriers, 9(3), Article
e1879719. Advance online publication. https://doi.org/10.1080/21688370.2021.1879719
Zhao,
X., Xu, Y., Viel, J. H.,
& Kuipers, O. P. (2021). Semisynthetic Macrocyclic
Lipo-lanthipeptides Display Antimicrobial Activity Against
Bacterial Pathogens. ACS Synthetic
Biology, 10(8), 1980-1991. https://doi.org/10.1021/acssynbio.1c00161
Zhao,
X., & Kuipers, O. P. (2021).
Synthesis of silver-nisin nanoparticles with low cytotoxicity
as antimicrobials against biofilm-forming pathogens.
Colloids and Surfaces B: Biointerfaces,
206, Article 111965. Advance online publication. https://doi.org/10.1016/j.colsurfb.2021.111965
Michalik,
S., Reder, A., Richts, B., Faßhauer, P., Mäder, U.,
Pedreira, T., Poehlein, A., van Heel, A. J., van
Tilburg, A. Y., Altenbuchner, J., Klewing, A., Reuß, D.
R., Daniel, R., Commichau, F. M., Kuipers, O. P.,
Hamoen, L. W., Völker, U., & Stülke, J. (2021).
The Bacillus subtilis Minimal Genome Compendium.
ACS Synthetic Biology, 10(10),
2767-2771. Article acssynbio.1c00339. Advance online publication.
https://doi.org/10.1021/acssynbio.1c00339
Cebrián,
R., Xu, C., Xia, Y., Wu, W., &
Kuipers, O. P. (2021). The cathelicidin-derived
close-to-nature peptide D-11 sensitizes Klebsiella pneumoniae to a
range of antibiotics in vitro, ex vivo and in vivo.
International journal of antimicrobial
agents, 58(5), Article 106434. Advance online
publication. https://doi.org/10.1016/j.ijantimicag.2021.106434
Shlla,
B., Gazioglu, O., Shafeeq, S., Manzoor, I., Kuipers, O.
P., Ulijasz, A., Hiller, N. L., Andrew, P. W., &
Yesilkaya, H. (2021). The Rgg1518 transcriptional regulator
is a necessary facet of sugar metabolism and virulence in
Streptococcus pneumoniae. Molecular
Microbiology, 116(3), 996-1008. Advance online
publication. https://doi.org/10.1111/mmi.14788
van
Tilburg, A. Y., Fülleborn, J. A., Reder,
A., Völker, U., Stülke, J., van Heel, A.
J., & Kuipers, O. P. (2021).
Unchaining miniBacillus PG10: Relief of FlgM-mediated
repression of autolysin genes. Applied and
environmental microbiology, 87(18), Article
e01123-21. Advance online publication. https://doi.org/10.1128/AEM.01123-21
Chen,
J., van Heel, A. J., & Kuipers, O.
P. (2021). Visualization and Analysis of the Dynamic
Assembly of a Heterologous Lantibiotic Biosynthesis Complex in
Bacillus subtilis. mBio,
12(4), Article e01219-21. https://doi.org/10.1128/mBio.01219-21
2020
van
Tatenhove-Pel, R. J., Rijavec, T., Lapanje, A., van Swam, I.,
Zwering, E., Hernandez-Valdes, J. A., Kuipers,
O. P., Picioreanu, C., Teusink, B., & Bachmann, H.
(2021). Microbial competition reduces metabolic interaction
distances to the low µm-range. The ISME
journal, 15, 688–701. Advance online
publication. https://doi.org/10.1038/s41396-020-00806-9
Montalbán-López,
M., Scott, T. A., Ramesh, S., Rahman, I. R., van Heel, A.
J., Viel, J. H., Bandarian, V., Dittmann, E.,
Genilloud, O., Goto, Y., Grande Burgos, M. J., Hill, C., Kim, S.,
Koehnke, J., Latham, J. A., Link, A. J., Martínez, B., Nair,
S. K., Nicolet, Y., ... van der Donk, W. A. (2021). New
developments in RiPP discovery, enzymology and engineering.
Natural product reports, 38(1),
130-239. Article D0NP00027B. Advance online publication. https://doi.org/10.1039/d0np00027b
de
Vries, R. H., Viel, J. H., Kuipers, O.
P., & Roelfes, G. (2021). Rapid and
selective chemical editing of Ribosomally synthesized and
Post-translationally modified Peptides (RiPPs) via Cu(II)-catalyzed
β-borylation of dehydroamino acids.
Angewandte Chemie (International ed. in
English), 60(8), 3946-3950. Advance online
publication. https://doi.org/10.1002/anie.202011460
Teusink,
B., Kuipers, O. P., & Moineau, S. (2021).
Symposium on Lactic Acid Bacteria-reading while waiting for a
meeting. FEMS Microbiology Reviews,
45(2), Article fuaa049. Advance online publication. https://doi.org/10.1093/femsre/fuaa049
Xia,
Y., Xu, C., Wang, D., Weng, Y., Jin, Y., Bai,
F., Cheng, Z., Kuipers, O. P., & Wu, W. (2021).
YbeY controls the type III and type VI secretion systems and
biofilm formation through RetS in Pseudomonas aeruginosa.
Applied and environmental microbiology,
87(5). Advance online publication. https://doi.org/10.1128/AEM.02171-20
Boonstra,
M., Schaffer, M., Sousa, J., Morawska, L.,
Holsappel, S., Hildebrandt, P., Sappa, P. K., Rath,
H., de Jong, A., Lalk, M., Mäder, U.,
Völker, U., & Kuipers, O. P. (2020).
Analyses of competent and non-competent subpopulations of
Bacillus subtilis reveal yhfW, yhxC and ncRNAs as novel players in
competence. Environmental
Microbiology, 22(6), 2312-2328. Advance online
publication. https://doi.org/10.1111/1462-2920.15005
Zhao,
X., Yin, Z., Breukink, E., Moll, G. N.,
& Kuipers, O. P. (2020). An Engineered Double
Lipid II Binding Motifs-Containing Lantibiotic Displays Potent and
Selective Antimicrobial Activity against Enterococcus
faecium. Antimicrobial Agents and
Chemotherapy, 64(6), Article e02050-19.
Advance online publication. https://doi.org/10.1128/AAC.02050-19
Hernandez-Valdes,
J. A., Huang, C., Kok, J., & Kuipers,
O. P. (2020). Another Breaker of the Wall: the
Biological Function of the Usp45 Protein of Lactococcus
lactis. Applied and environmental
microbiology, 86(16), 1-14. Article e00903-20.
Advance online publication. https://doi.org/10.1128/AEM.00903-20
Hernandez-Valdes,
J. A., van Gestel, J., & Kuipers, O. P.
(2020). A riboswitch gives rise to multi-generational
phenotypic heterogeneity in an auxotrophic bacterium.
Nature Communications, 11(1),
Article 1203. https://doi.org/10.1038/s41467-020-15017-1
Caro-Astorga,
J., Frenzel, E., Perkins, J. R., Álvarez-Mena, A., de Vicente,
A., Ranea, J. A. G., Kuipers, O. P., & Romero, D.
(2020). Biofilm formation displays intrinsic offensive and
defensive features of Bacillus cereus. NPJ
biofilms and microbiomes, 6(1), Article 3. https://doi.org/10.1038/s41522-019-0112-7
Li,
Z., Song, C., Yi, Y., & Kuipers, O. P. (2020).
Characterization of plant growth-promoting rhizobacteria from
perennial ryegrass and genome mining of novel antimicrobial gene
clusters. BMC Genomics,
21(1), Article 157. https://doi.org/10.1186/s12864-020-6563-7
Li,
Z., Chakraborty, P., de Vries, R. H.,
Song, C., Zhao, X., Roelfes, G.,
Scheffers, D-J., & Kuipers, O. P. (2020).
Characterization of two relacidines belonging to a novel
class of circular lipopeptides that act against Gram-negative
bacterial pathogens. Environmental
Microbiology, 22(12), 5125-5136. Advance
online publication. https://doi.org/10.1111/1462-2920.15145
Marcelli,
B., de Jong, A., Janzen, T., Serrano, M., Kok,
J., & Kuipers, O. P. (2020). Complete
Genome Sequences of 28 Lactococcal Bacteriophages Isolated from
Failed Dairy Fermentation Processes. Microbiology
resource announcements, 9(12), Article
e01535-19. https://doi.org/10.1128/MRA.01535-19
Deng,
J., Viel, J. H., Kubyshkin, V., Budisa, N.,
& Kuipers, O. P. (2020). Conjugation of Synthetic
Polyproline Moietes to Lipid II Binding Fragments of Nisin Yields
Active and Stable Antimicrobials. Frontiers in
Microbiology, 11, Article 575334. https://doi.org/10.3389/fmicb.2020.575334
Hernandez-Valdes,
J. A., Solopova, A., & Kuipers, O. P.
(2020). Development of Lactococcus lactis Biosensors for
Detection of Diacetyl. Frontiers in
Microbiology, 11, Article 1032. https://doi.org/10.3389/fmicb.2020.01032
Hernandez-Valdes,
J. A., Dalglish, M. M., Hermans, J.,
& Kuipers, O. P. (2020). Development of
Lactococcus lactis Biosensors for Detection of Sulfur-Containing
Amino Acids. Frontiers in
Microbiology, 11, Article 1654. https://doi.org/10.3389/fmicb.2020.01654
Hernandez-Valdes,
J. A., de Jong, A., Kok, J.,
& Kuipers, O. P. (2020). Draft Genome Sequences of
Three Amino Acid-Secreting Lactococcus lactis Strains.
Microbiology resource announcements,
9(16), Article e00158. https://doi.org/10.1128/MRA.00158-20
Marcelli,
B., Karsens, H., Nijland, M., Oudshoorn,
R., Kuipers, O. P., & Kok, J. (2020).
Employing lytic phage-mediated horizontal gene transfer in
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Xia,
Y., Weng, Y., Xu, C., Wang, D., Pan, X., Tian, Z., Xia, B.,
Li, H., Chen, R., Liu, C., Jin, Y., Bai, F., Cheng, Z.,
Kuipers, O. P., & Wu, W. (2020). Endoribonuclease
YbeY Is Essential for RNA Processing and Virulence in Pseudomonas
aeruginosa. mBio, 11(3),
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Hernandez-Valdes,
J. A., Aan de Stegge, M., Hermans, J.,
Teunis, J., van Tatenhove-Pel, R. J., Teusink, B., Bachmann,
H., & Kuipers, O. P. (2020). Enhancement of
amino acid production and secretion by Lactococcus lactis using a
droplet-based biosensing and selection system.
Metabolic Engineering Communications,
11, Article e00133. https://doi.org/10.1016/j.mec.2020.e00133
Zhao,
X., Cebrian, R., Fu, Y., Rink, R., Bosma,
T., Moll, G. N., & Kuipers, O. P.
(2020). High-throughput screening for substrate
specificity-adapted mutants of the nisin dehydratase NisB.
ACS Synthetic Biology, 9(6),
1468-1478. Advance online publication. https://doi.org/10.1021/acssynbio.0c00130
Hernandez-Valdes,
J. A., Zhou, L., de Vries, M.
P., & Kuipers, O. P. (2020). Impact
of spatial proximity on territoriality among human skin
bacteria. NPJ biofilms and
microbiomes, 6(1), Article 30. https://doi.org/10.1038/s41522-020-00140-0
Huang,
C., Hernandez-Valdes, J. A., Kuipers, O.
P., & Kok, J. (2020). Lysis of a
Lactococcus lactis dipeptidase mutant and rescue by mutation in the
pleiotropic regulator cody. Applied and
environmental microbiology, 86(8), Article
2937. Advance online publication. https://doi.org/10.1128/AEM.02937-19
Zhao,
X., Li, Z., & Kuipers, O. P. (2020).
Mimicry of a Non-ribosomally Produced Antimicrobial,
Brevicidine, by Ribosomal Synthesis and Post-translational
Modification. Cell Chemical Biology,
27(10), 1262-1271. Advance online publication. https://doi.org/10.1016/j.chembiol.2020.07.005
van
Tilburg, A. Y., van Heel, A. J., Stülke,
J., de Kok, N. A. W., Rueff, A-S., &
Kuipers, O. P. (2020). MiniBacillus PG10 as a
Convenient and Effective Production Host for Lantibiotics.
ACS Synthetic Biology, 9(7),
1833-1842. Article acssynbio.0c00194. Advance online publication.
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Li,
Z., de Vries, R. H., Chakraborty, P.,
Song, C., Zhao, X., Scheffers,
D-J., Roelfes, G., & Kuipers, O.
P. (2020). Novel modifications of nonribosomal
peptides from Brevibacillus laterosporus MG64 and investigation of
their mode of action. Applied and environmental
microbiology, 86(24), 1-14. Article e01981-20.
Advance online publication. https://doi.org/10.1128/AEM.01981-20
Chen,
J., van Heel, A. J., & Kuipers, O.
P. (2020). Subcellular Localization and Assembly
Process of the Nisin Biosynthesis Machinery in Lactococcus
lactis. mBio, 11(6), 1-22.
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Deng,
J., Viel, J. H., Chen, J., &
Kuipers, O. P. (2020). Synthesis and Characterization
of Heterodimers and Fluorescent Nisin Species by Incorporation of
Methionine Analogues and Subsequent Click Chemistry.
ACS Synthetic Biology, 9(9),
2525-2536. Advance online publication. https://doi.org/10.1021/acssynbio.0c00308
2019
van
Tatenhove-Pel, R. J., Hernandez-Valdes, J. A.,
Teusink, B., Kuipers, O. P., Fischlechner, M., &
Bachmann, H. (2020). Microdroplet screening and selection for
improved microbial production of extracellular compounds.
Current Opinion in Biotechnology,
61, 72-81. Advance online publication. https://doi.org/10.1016/j.copbio.2019.10.007
Price,
C. E., Branco Dos Santos, F., Hesseling, A., Uusitalo, J. J.,
Bachmann, H., Benavente, V., Goel, A., Berkhout, J., Bruggeman, F.
J., Marrink, S-J., Montalban-Lopez, M., de Jong,
A., Kok, J., Molenaar, D., Poolman,
B., Teusink, B., & Kuipers, O. P. (2019).
Adaption to glucose limitation is modulated by the pleotropic
regulator CcpA, independent of selection pressure strength.
BMC Evolutionary Biology, 19(1),
Article 15. https://doi.org/10.1186/s12862-018-1331-x
van
Tatenhove-Pel, R. J., Zwering, E., Solopova, A., Kuipers, O.
P., & Bachmann, H. (2019). Ampicillin-treated
Lactococcus lactis MG1363 populations contain persisters as well as
viable but non-culturable cells. Scientific
Reports, 9(1), Article 9867. https://doi.org/10.1038/s41598-019-46344-z
Schmitt,
S., Montalbán-López, M., Peterhoff, D., Deng, J., Wagner,
R., Held, M., Kuipers, O. P., & Panke, S. (2019).
Analysis of modular bioengineered antimicrobial
lanthipeptides at nanoliter scale. Nature Chemical
Biology, 15(5), 437-443. Advance online
publication. https://doi.org/10.1038/s41589-019-0250-5
Marcelli,
B., de Jong, A., Karsens, H., Janzen,
T., Kok, J., & Kuipers, O. P. (2019).
A specific sugar moiety in the Lactococcus lactis cell wall
pellicle is required for infection by CHPC971, a member of the rare
1706 phage species. Applied and environmental
microbiology, 85(19), Article e01224-19.
Advance online publication. https://doi.org/10.1128/AEM.01224-19
Skirl,
A-M., Kuipers, O. P., & van Doorn, G.
S. (2019). Characterization of controllable
mutator strains. Poster session presented at
Netherlands Society for Evolutionary Biology Meeting 2019, Ede,
Netherlands.
Perez,
M., Calles-Enríquez, M., Del Rio, B., Redruello, B., de
Jong, A., Kuipers, O. P., Kok, J.,
Martin, M. C., Ladero, V., Fernandez, M., & Alvarez, M. A.
(2019). Construction and characterization of a double mutant
of Enterococcus faecalis that does not produce biogenic
amines. Scientific Reports,
9(1), Article 16881. https://doi.org/10.1038/s41598-019-53175-5
Cebrian,
R., Macia-Valero, A., Jati, A. P., &
Kuipers, O. P. (2019). Design and Expression of
Specific Hybrid Lantibiotics Active Against Pathogenic Clostridium
spp. Frontiers in Microbiology,
10, Article 2154. https://doi.org/10.3389/fmicb.2019.02154
Zhou,
L., Song, C., de Jong, A., & Kuipers,
O. P. (2019). Draft Genome Sequences of 10
Paenibacillus and Bacillus sp. Strains Isolated from Healthy Tomato
Plants and Rhizosphere Soil. Microbiology resource
announcements, 8(12), Article e00055-19. https://doi.org/10.1128/MRA.00055-19
Li,
Z., Song, C., de Jong, A., & Kuipers, O.
P. (2019). Draft Genome Sequences of Six Bacillus
Strains and One Brevibacillus Strain Isolated from the Rhizosphere
of Perennial Ryegrass (Lolium perenne).
Microbiology resource announcements,
8(4), Article ARTN e01586-18. https://doi.org/10.1128/MRA.01586-18
Solopova,
A., van Tilburg, A. Y., Foito, A., Allwood, J. W.,
Stewart, D., Kulakauskas, S., & Kuipers, O. P.
(2019). Engineering Lactococcus lactis for the production of
unusual anthocyanins using tea as substrate.
Metabolic Engineering, 54, 160-169.
Advance online publication. https://doi.org/10.1016/j.ymben.2019.04.002
Li,
Q., Montalban-Lopez, M., & Kuipers, O. P. (2019).
Feasability of Introducing a Thioether Ring in Vasopressin by
nisBTC Co-expression in Lactococcus lactis.
Frontiers in Microbiology, 10,
Article 1508. https://doi.org/10.3389/fmicb.2019.01508
Kaunietis,
A., Buivydas, A., Čitavičius, D. J., & Kuipers,
O. P. (2019). Heterologous biosynthesis and
characterization of a glycocin from a thermophilic
bacterium. Nature Communications,
10(1), Article 1115. https://doi.org/10.1038/s41467-019-09065-5
van
Tilburg, A. Y., Cao, H., van der Meulen, S. B., Solopova,
A., & Kuipers, O. P. (2019). Metabolic
engineering and synthetic biology employing Lactococcus lactis and
Bacillus subtilis cell factories. Current Opinion
in Biotechnology, 59, 1-7. Advance online
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Morabbi
Heravi, K., Manzoor, I., Watzlawick, H., de Jong,
A., Kuipers, O. P., & Altenbuchner, J.
(2019). Phosphosugar stress in Bacillus subtilis:
Intracellular accumulation of mannose 6-phosphate derepresed the
glcR-phoC operon from repression by GlcR. Journal
of Bacteriology, 201(9), Article e00732-18.
Advance online publication. https://doi.org/10.1128/JB.00732-18
de
Vries, R., Viel, J., Oudshoorn, R.,
Kuipers, O., & Roelfes, G. (2019).
Selective Modification of RiPPs via Diels-Alder
Cycloadditions on Dehydroalanine Residues.
Chemistry, 25(55),
12698–12702. Advance online publication. https://doi.org/10.1002/chem.201902907
Motib,
A. S., Al-Bayati, F. A. Y., Manzoor, I., Shafeeq, S., Kadam,
A., Kuipers, O. P., Hiller, N. L., Andrew, P. W.,
& Yesilkaya, H. (2019). TprA/PhrA Quorum Sensing System
Has a Major Effect on Pneumococcal Survival in Respiratory Tract
and Blood, and Its Activity Is Controlled by CcpA and GInR.
Frontiers in Cellular and Infection
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2018
Bron,
P. A., Marcelli, B., Mulder, J., van der Els, S., Morawska,
L. P., Kuipers, O. P., Kok, J.,
& Kleerebezem, M. (2019). Renaissance of traditional DNA
transfer strategies for improvement of industrial lactic acid
bacteria. Current Opinion in
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O. P., & Li, Q. (2018). Antimicrobial peptides and admixtures thereof
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J. H., Baumann, T., Schmitt, F-J., Bartholomae, M., Kuipers,
O. P., Friedrich, T., & Budisa, N. (2018).
Antimicrobial Peptides Produced by Selective Pressure
Incorporation of Non-canonical Amino Acids.
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