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Kuipers, Prof. Oscar

Oscar Kuipers
Oscar Kuipers

Oscar Kuipers is professor of Molecular Genetics of Prokaryotes at the University of Groningen, and  a member of the department of Molecular Genetics of the Groningen Biomolecular Sciences and Biotechnology Institute.  Prokaryotes are micro-organisms without a nucleus, such as bacteria and Cyanobacteria. The field of molecular genetics studies gene functions and regulation and the interaction between genes. This research results, for example, in increasing knowledge about the gene modification of bacteria and is very important to biotechnology. Kuipers  studied Biology at Utrecht University and in 1990 gained his PhD in the department of Biochemistry of the same university. After that, he  worked at NIZO Food Research in Ede and the Wageningen Centre for Food Sciences.

Each year Kuipers supervises the (always successful) University of Groningen student team that competes in the iGEM competition in Boston. In 2012 this team became world champion, with a biological detection system to check how fresh meat is. In 2011 Kuipers received the ‘Simon Stevin Master' Award by the Technical Sciences Foundation (STW) and a grant of EUR 500,000 to spend on research. In the same year he became member of the prestigious Royal Netherlands Academy of Arts and Sciences (KNAW).  

At the end of May 2013, the EU awarded Kuipers a grant of € 1 million to make synthetic peptides, with particular attention to the development of new antibiotics.

Previously in the news


Guo, L., Stoffels, K., Broos, J., & Kuipers, O. P. (2024). Altering Specificity and Enhancing Stability of the Antimicrobial Peptides Nisin and Rombocin through Dehydrated Amino Acid Residue Engineering. Peptides, 174, Article 171152.
Yi, Y., Liang, L., de Jong, A., & Kuipers, O. P. (2024). A systematic comparison of natural product potential, with an emphasis on RiPPs, by mining of bacteria of three large ecosystems. GENOMICS, 116(4), Article 110880.
Lilge, L., & Kuipers, O. P. (2024). A two-step regulatory circuit involving Spo0A-AbrB activates mersacidin biosynthesis in Bacillus subtilis. International journal of antimicrobial agents, 63(5), Article 107155.
Liu, F., van Heel, A. J., & Kuipers, O. P. (2024). Engineering circular bacteriocins: structural and functional effects of α-helix exchanges and disulfide introductions in circularin A. Frontiers in Microbiology, 15, Article 1337647.
Guo, L., Stoffels, K., Broos, J., & Kuipers, O. P. (2024). Engineering hybrid lantibiotics yields the highly stable and bacteriocidal peptide cerocin V. Microbiological Research, 282, Article 127640.
Ariza, J. J., García-López, J. D., Aguinaga-Casañas, M. A., Baños, A., García, F., Kuipers, O. P., & Cebrián, R. (2024). Enhancing food preservation and safety: Synergistic effects of Allium-derived organosulfur compounds and outer membrane permeabilization peptide L-11. Food control, 165, Article 110691. Advance online publication.
Guo, L., Kuipers, O. P., & Broos, J. (2024). Facile Halogenation of Antimicrobial Peptides As Demonstrated by Producing Bromotryptophan-Labeled Nisin Variants with Enhanced Antimicrobial Activity. Journal of Natural Products, Article jnatprod.4c00118. Advance online publication.
Fernandez-Cantos, M. V., Babu, A. F., Hanhineva, K., & Kuipers, O. P. (2024). Identification of metabolites produced by six gut commensal Bacteroidales strains using non-targeted LC-MS/MS metabolite profiling. Microbiological Research, 283, Article 127700.
Garcia-Morena, D., Fernandez-Cantos, M. V., Escalera, S. L., Lok, J., Iannone, V., Cancellieri, P., Maathuis, W., Panagiotou, G., Aranzamendi, C., Aidy, S. E., Kolehmainen, M., El-Nezami, H., Wellejus, A., & Kuipers, O. P. (2024). In Vitro Influence of Specific Bacteroidales Strains on Gut and Liver Health Related to Metabolic Dysfunction-Associated Fatty Liver Disease. Probiotics and Antimicrobial Proteins. Advance online publication.
Guo, L., Wambui, J., Wang, C., Broos, J., Stephan, R., & Kuipers, O. P. (2024). Rombocin, a Short Stable Natural Nisin Variant, Displays Selective Antimicrobial Activity against Listeria monocytogenes and Employs a Dual Mode of Action to Kill Target Bacterial Strains. ACS Synthetic Biology, 13(1), 370–383. Article 3c00612.
Vargiu, M., Xu, Y., Kuipers, O., & Roelfes, G. (2024). Selective Aza-Michael Addition to Dehydrated Amino Acids in Natural Antimicrobial Peptides. ChemBioChem, 25(7), Article e202400043.
Van Eldijk, T. J. B., Sheridan, E. A., Martin, G., Weissing, F. J., Kuipers, O. P., & Van Doorn, G. S. (2024). Temperature dependence of the mutation rate towards antibiotic resistance. JAC-Antimicrobial Resistance, 6(3), Article dlae085.
Arias-Orozco, P., Zhou, L., Yi, Y., Cebrián, R., & Kuipers, O. P. (2024). Uncovering the diversity and distribution of biosynthetic gene clusters of prochlorosins and other putative RiPPs in marine Synechococcus strains. Microbiology Spectrum, 12(1), 1-19.


Cebrián, R., Martínez-García, M., Fernández, M., García, F., Martínez-Bueno, M., Valdivia, E., Kuipers, O. P., Montalbán-López, M., & Maqueda, M. (2023). Advances in the preclinical characterization of the antimicrobial peptide AS-48. Frontiers in Microbiology, 14, Article 1110360.
Fernandez-Cantos, M. V., Garcia de la Morena, D., Yi, Y., Liang, L., Gomez Vazquez, E., & Kuipers, O. (2023). Bioinformatic mining for RiPP biosynthetic gene clusters in Bacteroidales reveals possible new subfamily architectures and novel natural products. Frontiers in Microbiology, 14, Article 1219272.
Morawska, L. P., & Kuipers, O. P. (2023). Cell-to-cell non-conjugative plasmid transfer between Bacillus subtilis and lactic acid bacteria. Microbial Biotechnology, 16(4), 784-798.
Guo, L., Wambui, J., Wang, C., Muchaamba, F., Fernandez-Cantos, M. V., Broos, J., Tasara, T., Kuipers, O. P., & Stephan, R. (2023). Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles. Microbiology Spectrum, 11(5), Article e0531922.
Fu, Y., Zhou, L., & Kuipers, O. P. (2023). Discovery, biosynthesis, and characterization of a lanthipeptide from Bacillus subtilis EH11 with a unique lanthionine ring pattern. Cell Reports Physical Science, 4(8), Article 101524.
Zhao, X., Zhong, X., Yang, S., Deng, K., Liu, L., Song, X., Zou, Y., Li, L., Zhou, X., Jia, R., Lin, J., Tang, H., Ye, G., Yang, J., Zhao, S., Lang, Y., Wan, H., Yin, Z., & Kuipers, O. P. (2023). Elucidating the Mechanism of Action of the Gram-Negative-Pathogen-Selective Cyclic Antimicrobial Lipopeptide Brevicidine. Antimicrobial Agents and Chemotherapy, 67(5).
Fu, Y., Xu, Y., Ruijne, F., & Kuipers, O. P. (2023). Engineering lanthipeptides by introducing a large variety of RiPP modifications to obtain new-to-nature bioactive peptides. FEMS Microbiology Reviews, 47(3), Article fuad017.
Hammad, M., Ali, H., Hassan, N., Tawab, A., Salman, M., Jawad, I., de Jong, A., Moreno, C. M., Kuipers, O. P., Feroz, Y., & Rashid, M. H. (2023). Food safety and biological control; genomic insights and antimicrobial potential of Bacillus velezensis FB2 against agricultural fungal pathogens. PLoS ONE, 18(11), Article e0291975.
Liu, F., van Heel, A. J., & Kuipers, O. P. (2023). Leader- and Terminal Residue Requirements for Circularin A Biosynthesis Probed by Systematic Mutational Analyses. ACS Synthetic Biology, 12(3), 852-862.
Guo, L., Wang, C., Broos, J., & Kuipers, O. P. (2023). Lipidated variants of the antimicrobial peptide nisin produced via incorporation of methionine analogs for click chemistry show improved bioactivity. The Journal of Biological Chemistry, 229(7), Article 104845.
Li, L., Zhang, L., Zhang, T., Liu, Y., Lü, X., Kuipers, O. P., & Yi, Y. (2023). (Meta)genomics -assisted screening of novel antibacterial lactic acid bacteria strains from traditional fermented milk from Western China and their bioprotective effects on cheese. LWT, 175, Article 114507.
Abraham Versloot, R. C., Arias-Orozco, P., Tadema, M. J., Rudolfus Lucas, F. L., Zhao, X., Marrink, S. J., Kuipers, O. P., & Maglia, G. (2023). Seeing the Invisibles: Detection of Peptide Enantiomers, Diastereomers, and Isobaric Ring Formation in Lanthipeptides Using Nanopores. Journal of the American Chemical Society, 145(33), 18355-18365. Article 4076.
Cebrián Castillo, R., Xia, Y., & Kuipers, O. (2023). Synergistic composition against pseudomonas aeruginosa. (Patent No. WO2023063827).
Cebrián, R., Lucas, R., Fernández-Cantos, M. V., Slot, K., Peñalver, P., Martínez-García, M., Párraga-Leo, A., de Paz, M. V., García, F., Kuipers, O. P., & Morales, J. C. (2023). Synthesis and antimicrobial activity of aminoalkyl resveratrol derivatives inspired by cationic peptides. Journal of enzyme inhibition and medicinal chemistry, 38(1), 267-281.
Cacace, E., Kim, V., Varik, V., Knopp, M., Tietgen, M., Brauer-Nikonow, A., Inecik, K., Mateus, A., Milanese, A., Mårli, M. T., Mitosch, K., Selkrig, J., Brochado, A. R., Kuipers, O. P., Kjos, M., Zeller, G., Savitski, M. M., Göttig, S., Huber, W., & Typas, A. (2023). Systematic analysis of drug combinations against Gram-positive bacteria. Nature Microbiology, 8(11), 2196-2212.


Arias-Orozco, P., Yi, Y., Ruijne, F., Cebrián, R., & Kuipers, OP. (2023). Investigating the Specificity of the Dehydration and Cyclization Reactions in Engineered Lanthipeptides by Synechococcal SyncM. ACS Synthetic Biology, 12, 164–177.
Muñoz, C. Y., Zhou, L., Yi, Y., & Kuipers, O. P. (2022). Biocontrol properties from phyllospheric bacteria isolated from Solanum lycopersicum and Lactuca sativa and genome mining of antimicrobial gene clusters. BMC Genomics, 23(1), Article 152.
Cebrián, R., Li, Q., Peñalver, P., Belmonte-Reche, E., Andrés-Bilbao, M., Lucas, R., de Paz, M. V., Kuipers, O. P., & Morales, J. C. (2022). Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. Journal of Natural Products, 85(6), 1459-1473. Article 1c01107.
Farooq, S. A., de Jong, A., Khaliq, S., & Kuipers, O. P. (2022). Draft Genome Sequences of Bacillus velezensis Strains AF_3B and OS2, Bacillus amyloliquefaciens Strain BS9, Bacillus halotolerans Strain A1, and Bacillus sp. Strain BS3, Producing Biosurfactants with Antimicrobial Potential. Microbiology resource announcements, 11(10), Article e0048222.
Bustamante Ordonez, M., van Doorn, S., Weissing, F., Daras, I., Kuipers, O., & de Vos, M. (2022). Eco-evolutionary interactions and the spread of antimicrobial resistance in pathogenic microbial communities. Poster session presented at Netherlands Society for Evolutionary Biology Meeting 2022, Ede, Netherlands.
Mordhorst, S., Ruijne, F., Vagstad, A. L., Kuipers, O. P., & Piel, J. (2022). Emulating nonribosomal peptides with ribosomal biosynthetic strategies. RSC Chemical Biology, 4, 7-36.
de Jong, A., Kuipers, O. P., & Kok, J. (2022). FUNAGE-Pro: comprehensive web server for gene set enrichment analysis of prokaryotes. Nucleic Acids Research, 50(W1), 330-336. Article gkac441.
Liu, F., van Heel, A. J., Chen, J., & Kuipers, O. P. (2022). Functional production of clostridial circularin A in Lactococcus lactis NZ9000 and mutational analysis of its aromatic and cationic residues. Frontiers in Microbiology, 13, Article 1026290.
Pinto, J. P. C., Brouwer, R., Zeyniyev, A., Kuipers, O. P., & Kok, J. (2022). High-Resolution Chrono-Transcriptome of Lactococcus lactis Reveals That It Expresses Proteins with Adapted Size and pI upon Acidification and Nutrient Starvation. Applied and environmental microbiology, 88(9), Article e0247621.
Viel, J. H., & Kuipers, O. P. (2022). Modular Use of the Uniquely Small Ring A of Mersacidin Generates the Smallest Ribosomally Produced Lanthipeptide. ACS Synthetic Biology, 11(9), 3078-3087. Article 2c00343.
Viel, J. H., & Kuipers, O. P. (2022). Mutational Studies of the Mersacidin Leader Reveal the Function of Its Unique Two-Step Leader Processing Mechanism. ACS Synthetic Biology, 11(5), 1949–1957 .
Schouten, G. K., Paulussen, F. M., Kuipers, O. P., Bitter, W., Grossmann, T. N., & van Ulsen, P. (2022). Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo. Antibiotics , 11(2), Article 11020273.
Morawska, L. P., Detert Oude Weme, R. G. J., Frenzel, E., Dirkzwager, M., Hoffmann, T., Bremer, E., & Kuipers, O. P. (2022). Stress-induced activation of the proline biosynthetic pathway in Bacillus subtilis: A population-wide and single-cell study of the osmotically controlled proHJ promoter. Microbial Biotechnology, 15(9), 2411-2425.
Ekkers, D. M., Tusso, S., Moreno-Gamez, S., Rillo, M. C., Kuipers, O. P., & van Doorn, G. S. (2022). Trade-offs predicted by metabolic network structure give rise to evolutionary specialization and phenotypic diversification. Molecular Biology and Evolution, 39(6), Article msac124.
Morawska, L. P., & Kuipers, O. P. (2022). Transcriptome analysis and prediction of the metabolic state of stress-induced viable but non-culturable Bacillus subtilis cells. Scientific Reports, 12(1), Article 18015.


Chen, J., & Kuipers, O. P. (2022). Analysis of cross-functionality within LanBTC synthetase complexes from different bacterial sources with respect to production of fully modified lanthipeptides. Applied and environmental microbiology, 88(2), Article AEM0161821.
Morawska, L. P., Hernandez-Valdes, J. A., & Kuipers, O. P. (2022). Diversity of bet-hedging strategies in microbial communities-Recent cases and insights. Wires mechanisms of disease, 14(2), Article e1544.
Cebrián, R., Belmonte-Reche, E., Pirota, V., de Jong, A., Morales, J. C., Freccero, M., Doria, F., & Kuipers, O. P. (2022). G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action. Journal of Medicinal Chemistry, 65(6), 4752-4766.
van Tilburg, A. Y., Warmer, P., van Heel, A. J., Sauer, U., & Kuipers, O. P. (2022). Membrane composition and organization of Bacillus subtilis 168 and its genome-reduced derivative miniBacillus PG10. Microbial Biotechnology, 15(5), 1633-1651. Article 13978.
Zhou, L., Song, C., Li, Z., & Kuipers, O. P. (2021). Antimicrobial activity screening of rhizosphere soil bacteria from tomato and genome-based analysis of their antimicrobial biosynthetic potential. BMC Genomics, 22(1), Article 29.
Fu, Y., Jaarsma, A. H., & Kuipers, O. P. (2021). Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs). Cellular and molecular life sciences, 78, 3921–3940 .
Zhou, L., Song, C., Muñoz, C. Y., & Kuipers, O. P. (2021). Bacillus cabrialesii BH5 Protects Tomato Plants Against Botrytis cinerea by Production of Specific Antifungal Compounds. Frontiers in Microbiology, 12, Article 707609.
Zhao, X., Wang, X., Shukla, R., Kumar, R., Weingarth, M., Breukink, E., & Kuipers, O. P. (2021). Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an Exceptionally Low Hemolytic Activity. Frontiers in Microbiology, 12, Article 693725.
Zhao, X., Wang, X., Shukla, R., Kumar, R., Weingarth, M., Breukink, E., & Kuipers, O. P. (2021). Brevibacillin 2V Exerts Its Bactericidal Activity via Binding to Lipid II and Permeabilizing Cellular Membranes. Frontiers in Microbiology, 12, Article 694847.
Zhao, X., & Kuipers, O. P. (2021). BrevicidineB, a New Member of the Brevicidine Family, Displays an Extended Target Specificity. Frontiers in Microbiology, 12, Article 693117.
Viel, J. H., van Tilburg, A. Y., & Kuipers, O. P. (2021). Characterization of Leader Processing Shows That Partially Processed Mersacidin Is Activated by AprE After Export. Frontiers in Microbiology, 12, Article 765659.
Ruijne, F., & Kuipers, O. P. (2021). Combinatorial biosynthesis for the generation of new-to-nature peptide antimicrobials. Biochemical Society Transactions, 49(1), 203-215. Article BST20200425.
Muñoz, C. Y., de Jong, A., & Kuipers, O. P. (2021). Draft Genome Sequences of a Bacillus subtilis Strain, a Bacillus velezensis Strain, a Paenibacillus Strain, and an Acinetobacter baumannii Strain, All Isolated from the Phyllosphere of Lactuca sativa or Solanum lycopersicum. Microbiology resource announcements, 10(4), Article e01092-20.
Arias-Orozco, P., Yi, Y., & Kuipers, O. P. (2021). Draft Genome Sequences of Four Bacterial Strains of Heterotrophic Alteromonas macleodii and Marinobacter, Isolated from a Nonaxenic Culture of Two Marine Synechococcus Strains. Microbiology resource announcements, 10(19), Article e00116-21.
Xia, Y., Cebrián, R., Xu, C., Jong, A. D., Wu, W., & Kuipers, O. P. (2021). Elucidating the mechanism by which synthetic helper peptides sensitize Pseudomonas aeruginosa to multiple antibiotics. PLoS Pathogens, 17(9), Article e1009909.
Arias-Orozco, P., Inklaar, M., Lanooij, J., Cebrián, R., & Kuipers, O. P. (2021). Functional Expression and Characterization of the Highly Promiscuous Lanthipeptide Synthetase SyncM, Enabling the Production of Lanthipeptides with a Broad Range of Ring Topologies. ACS Synthetic Biology, 10(10), 2579-2591. Article acssynbio.1c00224.
Gazioglu, O., Kareem, B. O., Afzal, M., Shafeeq, S., Kuipers, O. P., Ulijasz, A. T., Andrew, P. W., & Yesilkaya, H. (2021). Glutamate Dehydrogenase (GdhA) of Streptococcus pneumoniae Is Required for High Temperature Adaptation. Infection and Immunity, 89(12), Article IAI0040021.
Viel, J. H., Jaarsma, A. H., & Kuipers, O. P. (2021). Heterologous Expression of Mersacidin in Escherichia coli Elucidates the Mode of Leader Processing. ACS Synthetic Biology, 10(3), 600-608. Article acssynbio.0c00601.
Zhou, L., de Jong, A., Yi, Y., & Kuipers, O. P. (2021). Identification, Isolation, and Characterization of Medipeptins, Antimicrobial Peptides From Pseudomonas mediterranea EDOX. Frontiers in Microbiology, 12, Article 732771.
Chen, J., & Kuipers, O. P. (2021). Isolation and Analysis of the Nisin Biosynthesis Complex NisBTC: Further Insights into Their Cooperative Action. mBio, 12(5), Article e02585-21.
Lauxen, A. I., Kobauri, P., Wegener, M., Hansen, M. J., Galenkamp, N. S., Maglia, G., Szymanski, W., Feringa, B. L., & Kuipers, O. P. (2021). Mechanism of Resistance Development in E. coli against TCAT, a Trimethoprim-Based Photoswitchable Antibiotic. Pharmaceuticals, 14(5), Article ph14050392.
Zhao, X., & Kuipers, O. P. (2021). Nisin- and Ripcin-Derived Hybrid Lanthipeptides Display Selective Antimicrobial Activity against Staphylococcus aureus. ACS Synthetic Biology, 10(7), 1703–1714.
Li, Q., Cebrián, R., Montalbán-López, M., Ren, H., Wu, W., & Kuipers, O. P. (2021). Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens. Communications biology, 4(1), Article 31.
Luo, Y., Korza, G., DeMarco, A. M., Kuipers, O. P., Li, Y.-Q., & Setlow, P. (2021). Properties of spores of Bacillus subtilis with or without a transposon that decreases spore germination and increases spore wet heat resistance. Journal of Applied Microbiology, 131(6), 2918-2928.
Fernandez-Cantos, M. V., Garcia-Morena, D., Iannone, V., El-Nezami, H., Kolehmainen, M., & Kuipers, O. P. (2021). Role of microbiota and related metabolites in gastrointestinal tract barrier function in NAFLD. Tissue Barriers, 9(3), Article e1879719.
Zhao, X., Xu, Y., Viel, J. H., & Kuipers, O. P. (2021). Semisynthetic Macrocyclic Lipo-lanthipeptides Display Antimicrobial Activity Against Bacterial Pathogens. ACS Synthetic Biology, 10(8), 1980-1991.
Zhao, X., & Kuipers, O. P. (2021). Synthesis of silver-nisin nanoparticles with low cytotoxicity as antimicrobials against biofilm-forming pathogens. Colloids and Surfaces B: Biointerfaces, 206, Article 111965.
Michalik, S., Reder, A., Richts, B., Faßhauer, P., Mäder, U., Pedreira, T., Poehlein, A., van Heel, A. J., van Tilburg, A. Y., Altenbuchner, J., Klewing, A., Reuß, D. R., Daniel, R., Commichau, F. M., Kuipers, O. P., Hamoen, L. W., Völker, U., & Stülke, J. (2021). The Bacillus subtilis Minimal Genome Compendium. ACS Synthetic Biology, 10(10), 2767-2771. Article acssynbio.1c00339.
Cebrián, R., Xu, C., Xia, Y., Wu, W., & Kuipers, O. P. (2021). The cathelicidin-derived close-to-nature peptide D-11 sensitizes Klebsiella pneumoniae to a range of antibiotics in vitro, ex vivo and in vivo. International journal of antimicrobial agents, 58(5), Article 106434.
Shlla, B., Gazioglu, O., Shafeeq, S., Manzoor, I., Kuipers, O. P., Ulijasz, A., Hiller, N. L., Andrew, P. W., & Yesilkaya, H. (2021). The Rgg1518 transcriptional regulator is a necessary facet of sugar metabolism and virulence in Streptococcus pneumoniae. Molecular Microbiology, 116(3), 996-1008.
van Tilburg, A. Y., Fülleborn, J. A., Reder, A., Völker, U., Stülke, J., van Heel, A. J., & Kuipers, O. P. (2021). Unchaining miniBacillus PG10: Relief of FlgM-mediated repression of autolysin genes. Applied and environmental microbiology, 87(18), Article e01123-21.
Chen, J., van Heel, A. J., & Kuipers, O. P. (2021). Visualization and Analysis of the Dynamic Assembly of a Heterologous Lantibiotic Biosynthesis Complex in Bacillus subtilis. mBio, 12(4), Article e01219-21.


van Tatenhove-Pel, R. J., Rijavec, T., Lapanje, A., van Swam, I., Zwering, E., Hernandez-Valdes, J. A., Kuipers, O. P., Picioreanu, C., Teusink, B., & Bachmann, H. (2021). Microbial competition reduces metabolic interaction distances to the low µm-range. The ISME journal, 15, 688–701.
Montalbán-López, M., Scott, T. A., Ramesh, S., Rahman, I. R., van Heel, A. J., Viel, J. H., Bandarian, V., Dittmann, E., Genilloud, O., Goto, Y., Grande Burgos, M. J., Hill, C., Kim, S., Koehnke, J., Latham, J. A., Link, A. J., Martínez, B., Nair, S. K., Nicolet, Y., ... van der Donk, W. A. (2021). New developments in RiPP discovery, enzymology and engineering. Natural product reports, 38(1), 130-239. Article D0NP00027B.
de Vries, R. H., Viel, J. H., Kuipers, O. P., & Roelfes, G. (2021). Rapid and selective chemical editing of Ribosomally synthesized and Post-translationally modified Peptides (RiPPs) via Cu(II)-catalyzed β-borylation of dehydroamino acids. Angewandte Chemie (International ed. in English), 60(8), 3946-3950.
Teusink, B., Kuipers, O. P., & Moineau, S. (2021). Symposium on Lactic Acid Bacteria-reading while waiting for a meeting. FEMS Microbiology Reviews, 45(2), Article fuaa049.
Xia, Y., Xu, C., Wang, D., Weng, Y., Jin, Y., Bai, F., Cheng, Z., Kuipers, O. P., & Wu, W. (2021). YbeY controls the type III and type VI secretion systems and biofilm formation through RetS in Pseudomonas aeruginosa. Applied and environmental microbiology, 87(5).
Boonstra, M., Schaffer, M., Sousa, J., Morawska, L., Holsappel, S., Hildebrandt, P., Sappa, P. K., Rath, H., de Jong, A., Lalk, M., Mäder, U., Völker, U., & Kuipers, O. P. (2020). Analyses of competent and non-competent subpopulations of Bacillus subtilis reveal yhfW, yhxC and ncRNAs as novel players in competence. Environmental Microbiology, 22(6), 2312-2328.
Zhao, X., Yin, Z., Breukink, E., Moll, G. N., & Kuipers, O. P. (2020). An Engineered Double Lipid II Binding Motifs-Containing Lantibiotic Displays Potent and Selective Antimicrobial Activity against Enterococcus faecium. Antimicrobial Agents and Chemotherapy, 64(6), Article e02050-19.
Hernandez-Valdes, J. A., Huang, C., Kok, J., & Kuipers, O. P. (2020). Another Breaker of the Wall: the Biological Function of the Usp45 Protein of Lactococcus lactis. Applied and environmental microbiology, 86(16), 1-14. Article e00903-20.
Hernandez-Valdes, J. A., van Gestel, J., & Kuipers, O. P. (2020). A riboswitch gives rise to multi-generational phenotypic heterogeneity in an auxotrophic bacterium. Nature Communications, 11(1), Article 1203.
Caro-Astorga, J., Frenzel, E., Perkins, J. R., Álvarez-Mena, A., de Vicente, A., Ranea, J. A. G., Kuipers, O. P., & Romero, D. (2020). Biofilm formation displays intrinsic offensive and defensive features of Bacillus cereus. NPJ biofilms and microbiomes, 6(1), Article 3.
Li, Z., Song, C., Yi, Y., & Kuipers, O. P. (2020). Characterization of plant growth-promoting rhizobacteria from perennial ryegrass and genome mining of novel antimicrobial gene clusters. BMC Genomics, 21(1), Article 157.
Li, Z., Chakraborty, P., de Vries, R. H., Song, C., Zhao, X., Roelfes, G., Scheffers, D.-J., & Kuipers, O. P. (2020). Characterization of two relacidines belonging to a novel class of circular lipopeptides that act against Gram-negative bacterial pathogens. Environmental Microbiology, 22(12), 5125-5136.
Marcelli, B., de Jong, A., Janzen, T., Serrano, M., Kok, J., & Kuipers, O. P. (2020). Complete Genome Sequences of 28 Lactococcal Bacteriophages Isolated from Failed Dairy Fermentation Processes. Microbiology resource announcements, 9(12), Article e01535-19.
Deng, J., Viel, J. H., Kubyshkin, V., Budisa, N., & Kuipers, O. P. (2020). Conjugation of Synthetic Polyproline Moietes to Lipid II Binding Fragments of Nisin Yields Active and Stable Antimicrobials. Frontiers in Microbiology, 11, Article 575334.
Hernandez-Valdes, J. A., Solopova, A., & Kuipers, O. P. (2020). Development of Lactococcus lactis Biosensors for Detection of Diacetyl. Frontiers in Microbiology, 11, Article 1032.
Hernandez-Valdes, J. A., Dalglish, M. M., Hermans, J., & Kuipers, O. P. (2020). Development of Lactococcus lactis Biosensors for Detection of Sulfur-Containing Amino Acids. Frontiers in Microbiology, 11, Article 1654.
Hernandez-Valdes, J. A., de Jong, A., Kok, J., & Kuipers, O. P. (2020). Draft Genome Sequences of Three Amino Acid-Secreting Lactococcus lactis Strains. Microbiology resource announcements, 9(16), Article e00158.
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Hernandez-Valdes, J. A., Aan de Stegge, M., Hermans, J., Teunis, J., van Tatenhove-Pel, R. J., Teusink, B., Bachmann, H., & Kuipers, O. P. (2020). Enhancement of amino acid production and secretion by Lactococcus lactis using a droplet-based biosensing and selection system. Metabolic Engineering Communications, 11, Article e00133.
Zhao, X., Cebrian, R., Fu, Y., Rink, R., Bosma, T., Moll, G. N., & Kuipers, O. P. (2020). High-throughput screening for substrate specificity-adapted mutants of the nisin dehydratase NisB. ACS Synthetic Biology, 9(6), 1468-1478.
Hernandez-Valdes, J. A., Zhou, L., de Vries, M. P., & Kuipers, O. P. (2020). Impact of spatial proximity on territoriality among human skin bacteria. NPJ biofilms and microbiomes, 6(1), Article 30.
Huang, C., Hernandez-Valdes, J. A., Kuipers, O. P., & Kok, J. (2020). Lysis of a Lactococcus lactis dipeptidase mutant and rescue by mutation in the pleiotropic regulator cody. Applied and environmental microbiology, 86(8), Article 2937.
Zhao, X., Li, Z., & Kuipers, O. P. (2020). Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification. Cell Chemical Biology, 27(10), 1262-1271.


van Tatenhove-Pel, R. J., Hernandez-Valdes, J. A., Teusink, B., Kuipers, O. P., Fischlechner, M., & Bachmann, H. (2020). Microdroplet screening and selection for improved microbial production of extracellular compounds. Current Opinion in Biotechnology, 61, 72-81.
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