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Kuipers, Prof. Oscar

Oscar Kuipers
Oscar Kuipers

Oscar Kuipers is professor of Molecular Genetics of Prokaryotes at the University of Groningen, and  a member of the department of Molecular Genetics of the Groningen Biomolecular Sciences and Biotechnology Institute.  Prokaryotes are micro-organisms without a nucleus, such as bacteria and Cyanobacteria. The field of molecular genetics studies gene functions and regulation and the interaction between genes. This research results, for example, in increasing knowledge about the gene modification of bacteria and is very important to biotechnology. Kuipers  studied Biology at Utrecht University and in 1990 gained his PhD in the department of Biochemistry of the same university. After that, he  worked at NIZO Food Research in Ede and the Wageningen Centre for Food Sciences.

Each year Kuipers supervises the (always successful) University of Groningen student team that competes in the iGEM competition in Boston. In 2012 this team became world champion, with a biological detection system to check how fresh meat is. In 2011 Kuipers received the ‘Simon Stevin Master' Award by the Technical Sciences Foundation (STW) and a grant of EUR 500,000 to spend on research. In the same year he became member of the prestigious Royal Netherlands Academy of Arts and Sciences (KNAW).  

At the end of May 2013, the EU awarded Kuipers a grant of € 1 million to make synthetic peptides, with particular attention to the development of new antibiotics.

Previously in the news


Muñoz, C. Y., Zhou, L., Yi, Y., & Kuipers, O. P. (2022). Biocontrol properties from phyllospheric bacteria isolated from Solanum lycopersicum and Lactuca sativa and genome mining of antimicrobial gene clusters. BMC Genomics, 23(1), [152].
Cebrián, R., Li, Q., Peñalver, P., Belmonte-Reche, E., Andrés-Bilbao, M., Lucas, R., de Paz, M. V., Kuipers, O. P., & Morales, J. C. (2022). Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. Journal of Natural Products, 85(6), 1459-1473. [1c01107].
Farooq, S. A., de Jong, A., Khaliq, S., & Kuipers, O. P. (2022). Draft Genome Sequences of Bacillus velezensis Strains AF_3B and OS2, Bacillus amyloliquefaciens Strain BS9, Bacillus halotolerans Strain A1, and Bacillus sp. Strain BS3, Producing Biosurfactants with Antimicrobial Potential. Microbiology resource announcements, 11(10), [e0048222].
Bustamante Ordonez, M., van Doorn, S., Weissing, F., Daras, I., Kuipers, O., & de Vos, M. (2022). Eco-evolutionary interactions and the spread of antimicrobial resistance in pathogenic microbial communities. Poster session presented at Netherlands Society for Evolutionary Biology Meeting 2022, Ede, Netherlands.
de Jong, A., Kuipers, O. P., & Kok, J. (2022). FUNAGE-Pro: comprehensive web server for gene set enrichment analysis of prokaryotes. Nucleic Acids Research, 50(W1), 330-336. [gkac441].
Pinto, J. P. C., Brouwer, R., Zeyniyev, A., Kuipers, O. P., & Kok, J. (2022). High-Resolution Chrono-Transcriptome of Lactococcus lactis Reveals That It Expresses Proteins with Adapted Size and pI upon Acidification and Nutrient Starvation. Applied and environmental microbiology, [e0247621].
Viel, J. H., & Kuipers, O. P. (2022). Modular Use of the Uniquely Small Ring A of Mersacidin Generates the Smallest Ribosomally Produced Lanthipeptide. ACS Synthetic Biology, 11(9), 3078-3087. [2c00343].
Viel, J. H., & Kuipers, O. P. (2022). Mutational Studies of the Mersacidin Leader Reveal the Function of Its Unique Two-Step Leader Processing Mechanism. ACS Synthetic Biology.
Schouten, G. K., Paulussen, F. M., Kuipers, O. P., Bitter, W., Grossmann, T. N., & van Ulsen, P. (2022). Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo. Antibiotics , 11(2), [11020273].
Morawska, L. P., Detert Oude Weme, R. G. J., Frenzel, E., Dirkzwager, M., Hoffmann, T., Bremer, E., & Kuipers, O. P. (2022). Stress-induced activation of the proline biosynthetic pathway in Bacillus subtilis: A population-wide and single-cell study of the osmotically controlled proHJ promoter. Microbial Biotechnology, 15(9), 2411-2425.
Ekkers, D. M., Tusso, S., Moreno-Gamez, S., Rillo, M. C., Kuipers, O. P., & van Doorn, G. S. (2022). Trade-offs predicted by metabolic network structure give rise to evolutionary specialization and phenotypic diversification. Molecular Biology and Evolution, 39(6), [msac124].
Morawska, L. P., & Kuipers, O. P. (2022). Transcriptome analysis and prediction of the metabolic state of stress-induced viable but non-culturable Bacillus subtilis cells. Scientific Reports, 12(1), [18015].


Chen, J., & Kuipers, O. P. (2022). Analysis of cross-functionality within LanBTC synthetase complexes from different bacterial sources with respect to production of fully modified lanthipeptides. Applied and environmental microbiology, 88(2), [AEM0161821].
Morawska, L. P., Hernandez-Valdes, J. A., & Kuipers, O. P. (2022). Diversity of bet-hedging strategies in microbial communities-Recent cases and insights. Wires mechanisms of disease, 14(2), [e1544].
Cebrián, R., Belmonte-Reche, E., Pirota, V., de Jong, A., Morales, J. C., Freccero, M., Doria, F., & Kuipers, O. P. (2022). G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action. Journal of Medicinal Chemistry, 65(6), 4752-4766.
van Tilburg, A. Y., Warmer, P., van Heel, A. J., Sauer, U., & Kuipers, O. P. (2022). Membrane composition and organization of Bacillus subtilis 168 and its genome-reduced derivative miniBacillus PG10. Microbial Biotechnology, 15(5), 1633-1651. [13978].
Zhou, L., Song, C., Li, Z., & Kuipers, O. P. (2021). Antimicrobial activity screening of rhizosphere soil bacteria from tomato and genome-based analysis of their antimicrobial biosynthetic potential. BMC Genomics, 22(1), [29].
Fu, Y., Jaarsma, A. H., & Kuipers, O. P. (2021). Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs). Cellular and molecular life sciences, 78, 3921–3940 .
Zhou, L., Song, C., Muñoz, C. Y., & Kuipers, O. P. (2021). Bacillus cabrialesii BH5 Protects Tomato Plants Against Botrytis cinerea by Production of Specific Antifungal Compounds. Frontiers in Microbiology, 12, [707609].
Zhao, X., Wang, X., Shukla, R., Kumar, R., Weingarth, M., Breukink, E., & Kuipers, O. P. (2021). Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an Exceptionally Low Hemolytic Activity. Frontiers in Microbiology, 12, [693725].
Zhao, X., Wang, X., Shukla, R., Kumar, R., Weingarth, M., Breukink, E., & Kuipers, O. P. (2021). Brevibacillin 2V Exerts Its Bactericidal Activity via Binding to Lipid II and Permeabilizing Cellular Membranes. Frontiers in Microbiology, 12, [694847].
Zhao, X., & Kuipers, O. P. (2021). BrevicidineB, a New Member of the Brevicidine Family, Displays an Extended Target Specificity. Frontiers in Microbiology, 12, [693117].
Viel, J. H., van Tilburg, A. Y., & Kuipers, O. P. (2021). Characterization of Leader Processing Shows That Partially Processed Mersacidin Is Activated by AprE After Export. Frontiers in Microbiology, 12, [765659].
Ruijne, F., & Kuipers, O. P. (2021). Combinatorial biosynthesis for the generation of new-to-nature peptide antimicrobials. Biochemical Society Transactions, 49(1), 203-215. [ BST20200425].
Muñoz, C. Y., de Jong, A., & Kuipers, O. P. (2021). Draft Genome Sequences of a Bacillus subtilis Strain, a Bacillus velezensis Strain, a Paenibacillus Strain, and an Acinetobacter baumannii Strain, All Isolated from the Phyllosphere of Lactuca sativa or Solanum lycopersicum. Microbiology resource announcements, 10(4), [e01092-20].
Arias-Orozco, P., Yi, Y., & Kuipers, O. P. (2021). Draft Genome Sequences of Four Bacterial Strains of Heterotrophic Alteromonas macleodii and Marinobacter, Isolated from a Nonaxenic Culture of Two Marine Synechococcus Strains. Microbiology resource announcements, 10(19), [e00116-21].
Xia, Y., Cebrián, R., Xu, C., Jong, A. D., Wu, W., & Kuipers, O. P. (2021). Elucidating the mechanism by which synthetic helper peptides sensitize Pseudomonas aeruginosa to multiple antibiotics. PLoS Pathogens, 17(9), [e1009909].
Arias-Orozco, P., Inklaar, M., Lanooij, J., Cebrián, R., & Kuipers, O. P. (2021). Functional Expression and Characterization of the Highly Promiscuous Lanthipeptide Synthetase SyncM, Enabling the Production of Lanthipeptides with a Broad Range of Ring Topologies. ACS Synthetic Biology, 10(10), 2579-2591. [acssynbio.1c00224].
Gazioglu, O., Kareem, B. O., Afzal, M., Shafeeq, S., Kuipers, O. P., Ulijasz, A. T., Andrew, P. W., & Yesilkaya, H. (2021). Glutamate Dehydrogenase (GdhA) of Streptococcus pneumoniae Is Required for High Temperature Adaptation. Infection and Immunity, 89(12), [IAI0040021].
Viel, J. H., Jaarsma, A. H., & Kuipers, O. P. (2021). Heterologous Expression of Mersacidin in Escherichia coli Elucidates the Mode of Leader Processing. ACS Synthetic Biology, 10(3), 600-608. [acssynbio.0c00601].
Zhou, L., de Jong, A., Yi, Y., & Kuipers, O. P. (2021). Identification, Isolation, and Characterization of Medipeptins, Antimicrobial Peptides From Pseudomonas mediterranea EDOX. Frontiers in Microbiology, 12, [732771].
Chen, J., & Kuipers, O. P. (2021). Isolation and Analysis of the Nisin Biosynthesis Complex NisBTC: Further Insights into Their Cooperative Action. Mbio, 12(5), [e02585-21].
Lauxen, A. I., Kobauri, P., Wegener, M., Hansen, M. J., Galenkamp, N. S., Maglia, G., Szymanski, W., Feringa, B. L., & Kuipers, O. P. (2021). Mechanism of Resistance Development in E. coli against TCAT, a Trimethoprim-Based Photoswitchable Antibiotic. Pharmaceuticals, 14(5), [ph14050392].
Zhao, X., & Kuipers, O. P. (2021). Nisin- and Ripcin-Derived Hybrid Lanthipeptides Display Selective Antimicrobial Activity against Staphylococcus aureus. ACS Synthetic Biology, 10(7), 1703–1714.
Li, Q., Cebrián, R., Montalbán-López, M., Ren, H., Wu, W., & Kuipers, O. P. (2021). Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens. Communications biology, 4(1), [31].
Luo, Y., Korza, G., DeMarco, A. M., Kuipers, O. P., Li, Y-Q., & Setlow, P. (2021). Properties of spores of Bacillus subtilis with or without a transposon that decreases spore germination and increases spore wet heat resistance. Journal of Applied Microbiology, 131(6), 2918-2928.
Fernandez-Cantos, M. V., Garcia-Morena, D., Iannone, V., El-Nezami, H., Kolehmainen, M., & Kuipers, O. P. (2021). Role of microbiota and related metabolites in gastrointestinal tract barrier function in NAFLD. Tissue Barriers, 9(3), [e1879719].
Zhao, X., Xu, Y., Viel, J. H., & Kuipers, O. P. (2021). Semisynthetic Macrocyclic Lipo-lanthipeptides Display Antimicrobial Activity Against Bacterial Pathogens. ACS Synthetic Biology, 10(8), 1980-1991.
Zhao, X., & Kuipers, O. P. (2021). Synthesis of silver-nisin nanoparticles with low cytotoxicity as antimicrobials against biofilm-forming pathogens. Colloids and Surfaces B: Biointerfaces, 206, [111965].
Michalik, S., Reder, A., Richts, B., Faßhauer, P., Mäder, U., Pedreira, T., Poehlein, A., van Heel, A. J., van Tilburg, A. Y., Altenbuchner, J., Klewing, A., Reuß, D. R., Daniel, R., Commichau, F. M., Kuipers, O. P., Hamoen, L. W., Völker, U., & Stülke, J. (2021). The Bacillus subtilis Minimal Genome Compendium. ACS Synthetic Biology, 10(10), 2767-2771. [acssynbio.1c00339].
Cebrián, R., Xu, C., Xia, Y., Wu, W., & Kuipers, O. P. (2021). The cathelicidin-derived close-to-nature peptide D-11 sensitizes Klebsiella pneumoniae to a range of antibiotics in vitro, ex vivo and in vivo. International journal of antimicrobial agents, 58(5), [106434].
Shlla, B., Gazioglu, O., Shafeeq, S., Manzoor, I., Kuipers, O. P., Ulijasz, A., Hiller, N. L., Andrew, P. W., & Yesilkaya, H. (2021). The Rgg1518 transcriptional regulator is a necessary facet of sugar metabolism and virulence in Streptococcus pneumoniae. Molecular Microbiology, 116(3), 996-1008.
van Tilburg, A. Y., Fülleborn, J. A., Reder, A., Völker, U., Stülke, J., van Heel, A. J., & Kuipers, O. P. (2021). Unchaining miniBacillus PG10: Relief of FlgM-mediated repression of autolysin genes. Applied and environmental microbiology, 87(18), [e01123-21].
Chen, J., van Heel, A. J., & Kuipers, O. P. (2021). Visualization and Analysis of the Dynamic Assembly of a Heterologous Lantibiotic Biosynthesis Complex in Bacillus subtilis. Mbio, 12(4), [e01219-21].


van Tatenhove-Pel, R. J., Rijavec, T., Lapanje, A., van Swam, I., Zwering, E., Hernandez-Valdes, J. A., Kuipers, O. P., Picioreanu, C., Teusink, B., & Bachmann, H. (2021). Microbial competition reduces metabolic interaction distances to the low µm-range. The ISME journal, 15, 688–701.
Montalbán-López, M., Scott, T. A., Ramesh, S., Rahman, I. R., van Heel, A. J., Viel, J. H., Bandarian, V., Dittmann, E., Genilloud, O., Goto, Y., Grande Burgos, M. J., Hill, C., Kim, S., Koehnke, J., Latham, J. A., Link, A. J., Martínez, B., Nair, S. K., Nicolet, Y., ... van der Donk, W. A. (2021). New developments in RiPP discovery, enzymology and engineering. Natural product reports, 38(1), 130-239. [D0NP00027B].
de Vries, R. H., Viel, J. H., Kuipers, O. P., & Roelfes, G. (2021). Rapid and selective chemical editing of Ribosomally synthesized and Post-translationally modified Peptides (RiPPs) via Cu(II)-catalyzed β-borylation of dehydroamino acids. Angewandte Chemie (International ed. in English), 60(8), 3946-3950.
Teusink, B., Kuipers, O. P., & Moineau, S. (2021). Symposium on Lactic Acid Bacteria-reading while waiting for a meeting. FEMS Microbiology Reviews, 45(2), [fuaa049].
Xia, Y., Xu, C., Wang, D., Weng, Y., Jin, Y., Bai, F., Cheng, Z., Kuipers, O. P., & Wu, W. (2021). YbeY controls the type III and type VI secretion systems and biofilm formation through RetS in Pseudomonas aeruginosa. Applied and environmental microbiology, 87(5).
Boonstra, M., Schaffer, M., Sousa, J., Morawska, L., Holsappel, S., Hildebrandt, P., Sappa, P. K., Rath, H., de Jong, A., Lalk, M., Mäder, U., Völker, U., & Kuipers, O. P. (2020). Analyses of competent and non-competent subpopulations of Bacillus subtilis reveal yhfW, yhxC and ncRNAs as novel players in competence. Environmental Microbiology, 22(6), 2312-2328.
Zhao, X., Yin, Z., Breukink, E., Moll, G. N., & Kuipers, O. P. (2020). An Engineered Double Lipid II Binding Motifs-Containing Lantibiotic Displays Potent and Selective Antimicrobial Activity against Enterococcus faecium. Antimicrobial Agents and Chemotherapy, 64(6), [ e02050-19].
Hernandez-Valdes, J. A., Huang, C., Kok, J., & Kuipers, O. P. (2020). Another Breaker of the Wall: the Biological Function of the Usp45 Protein of Lactococcus lactis. Applied and environmental microbiology, 86(16), 1-14. [e00903-20].
Hernandez-Valdes, J. A., van Gestel, J., & Kuipers, O. P. (2020). A riboswitch gives rise to multi-generational phenotypic heterogeneity in an auxotrophic bacterium. Nature Communications, 11(1), [1203].
Caro-Astorga, J., Frenzel, E., Perkins, J. R., Álvarez-Mena, A., de Vicente, A., Ranea, J. A. G., Kuipers, O. P., & Romero, D. (2020). Biofilm formation displays intrinsic offensive and defensive features of Bacillus cereus. NPJ biofilms and microbiomes, 6(1), [3].
Li, Z., Song, C., Yi, Y., & Kuipers, O. P. (2020). Characterization of plant growth-promoting rhizobacteria from perennial ryegrass and genome mining of novel antimicrobial gene clusters. BMC Genomics, 21(1), [157].
Li, Z., Chakraborty, P., de Vries, R. H., Song, C., Zhao, X., Roelfes, G., Scheffers, D-J., & Kuipers, O. P. (2020). Characterization of two relacidines belonging to a novel class of circular lipopeptides that act against Gram-negative bacterial pathogens. Environmental Microbiology, 22(12), 5125-5136.
Marcelli, B., de Jong, A., Janzen, T., Serrano, M., Kok, J., & Kuipers, O. P. (2020). Complete Genome Sequences of 28 Lactococcal Bacteriophages Isolated from Failed Dairy Fermentation Processes. Microbiology resource announcements, 9(12), [e01535-19].
Deng, J., Viel, J. H., Kubyshkin, V., Budisa, N., & Kuipers, O. P. (2020). Conjugation of Synthetic Polyproline Moietes to Lipid II Binding Fragments of Nisin Yields Active and Stable Antimicrobials. Frontiers in Microbiology, 11, [575334].
Hernandez-Valdes, J. A., Solopova, A., & Kuipers, O. P. (2020). Development of Lactococcus lactis Biosensors for Detection of Diacetyl. Frontiers in Microbiology, 11, [1032].
Hernandez-Valdes, J. A., Dalglish, M. M., Hermans, J., & Kuipers, O. P. (2020). Development of Lactococcus lactis Biosensors for Detection of Sulfur-Containing Amino Acids. Frontiers in Microbiology, 11, [1654].
Hernandez-Valdes, J. A., de Jong, A., Kok, J., & Kuipers, O. P. (2020). Draft Genome Sequences of Three Amino Acid-Secreting Lactococcus lactis Strains. Microbiology resource announcements, 9(16), [e00158].
Marcelli, B., Karsens, H., Nijland, M., Oudshoorn, R., Kuipers, O. P., & Kok, J. (2020). Employing lytic phage-mediated horizontal gene transfer in Lactococcus lactis. PLoS ONE, 15(9 ), [e0238988].
Xia, Y., Weng, Y., Xu, C., Wang, D., Pan, X., Tian, Z., Xia, B., Li, H., Chen, R., Liu, C., Jin, Y., Bai, F., Cheng, Z., Kuipers, O. P., & Wu, W. (2020). Endoribonuclease YbeY Is Essential for RNA Processing and Virulence in Pseudomonas aeruginosa. Mbio, 11(3), [e00659-20].
Hernandez-Valdes, J. A., Aan de Stegge, M., Hermans, J., Teunis, J., van Tatenhove-Pel, R. J., Teusink, B., Bachmann, H., & Kuipers, O. P. (2020). Enhancement of amino acid production and secretion by Lactococcus lactis using a droplet-based biosensing and selection system. Metabolic Engineering Communications, 11, [e00133].
Zhao, X., Cebrian, R., Fu, Y., Rink, R., Bosma, T., Moll, G. N., & Kuipers, O. P. (2020). High-throughput screening for substrate specificity-adapted mutants of the nisin dehydratase NisB. ACS Synthetic Biology, 9(6), 1468-1478.
Hernandez-Valdes, J. A., Zhou, L., de Vries, M. P., & Kuipers, O. P. (2020). Impact of spatial proximity on territoriality among human skin bacteria. NPJ biofilms and microbiomes, 6(1), [30].
Huang, C., Hernandez-Valdes, J. A., Kuipers, O. P., & Kok, J. (2020). Lysis of a Lactococcus lactis dipeptidase mutant and rescue by mutation in the pleiotropic regulator cody. Applied and environmental microbiology, 86(8), [2937].
Zhao, X., Li, Z., & Kuipers, O. P. (2020). Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification. Cell Chemical Biology, 27(10), 1262-1271.
van Tilburg, A. Y., van Heel, A. J., Stülke, J., de Kok, N. A. W., Rueff, A-S., & Kuipers, O. P. (2020). MiniBacillus PG10 as a Convenient and Effective Production Host for Lantibiotics. ACS Synthetic Biology, 9(7), 1833-1842. [acssynbio.0c00194].
Li, Z., de Vries, R. H., Chakraborty, P., Song, C., Zhao, X., Scheffers, D-J., Roelfes, G., & Kuipers, O. P. (2020). Novel modifications of nonribosomal peptides from Brevibacillus laterosporus MG64 and investigation of their mode of action. Applied and environmental microbiology, 86(24), 1-14. [e01981-20].
Chen, J., van Heel, A. J., & Kuipers, O. P. (2020). Subcellular Localization and Assembly Process of the Nisin Biosynthesis Machinery in Lactococcus lactis. Mbio, 11(6), 1-22. [e02825-20].
Deng, J., Viel, J. H., Chen, J., & Kuipers, O. P. (2020). Synthesis and Characterization of Heterodimers and Fluorescent Nisin Species by Incorporation of Methionine Analogues and Subsequent Click Chemistry. ACS Synthetic Biology, 9(9), 2525-2536.


van Tatenhove-Pel, R. J., Hernandez-Valdes, J. A., Teusink, B., Kuipers, O. P., Fischlechner, M., & Bachmann, H. (2020). Microdroplet screening and selection for improved microbial production of extracellular compounds. Current Opinion in Biotechnology, 61, 72-81.
Price, C. E., Branco Dos Santos, F., Hesseling, A., Uusitalo, J. J., Bachmann, H., Benavente, V., Goel, A., Berkhout, J., Bruggeman, F. J., Marrink, S-J., Montalban-Lopez, M., de Jong, A., Kok, J., Molenaar, D., Poolman, B., Teusink, B., & Kuipers, O. P. (2019). Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength. BMC Evolutionary Biology, 19(1), [15].
van Tatenhove-Pel, R. J., Zwering, E., Solopova, A., Kuipers, O. P., & Bachmann, H. (2019). Ampicillin-treated Lactococcus lactis MG1363 populations contain persisters as well as viable but non-culturable cells. Scientific Reports, 9(1), [9867].
Schmitt, S., Montalbán-López, M., Peterhoff, D., Deng, J., Wagner, R., Held, M., Kuipers, O. P., & Panke, S. (2019). Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale. Nature Chemical Biology, 15(5), 437-443.
Marcelli, B., de Jong, A., Karsens, H., Janzen, T., Kok, J., & Kuipers, O. P. (2019). A specific sugar moiety in the Lactococcus lactis cell wall pellicle is required for infection by CHPC971, a member of the rare 1706 phage species. Applied and environmental microbiology, 85(19), [e01224-19].
Skirl, A-M., Kuipers, O. P., & van Doorn, G. S. (2019). Characterization of controllable mutator strains. Poster session presented at Netherlands Society for Evolutionary Biology Meeting 2019, Ede, Netherlands.
Perez, M., Calles-Enríquez, M., Del Rio, B., Redruello, B., de Jong, A., Kuipers, O. P., Kok, J., Martin, M. C., Ladero, V., Fernandez, M., & Alvarez, M. A. (2019). Construction and characterization of a double mutant of Enterococcus faecalis that does not produce biogenic amines. Scientific Reports, 9(1), [16881].
Cebrian, R., Macia-Valero, A., Jati, A. P., & Kuipers, O. P. (2019). Design and Expression of Specific Hybrid Lantibiotics Active Against Pathogenic Clostridium spp. Frontiers in Microbiology, 10, [2154].
Zhou, L., Song, C., de Jong, A., & Kuipers, O. P. (2019). Draft Genome Sequences of 10 Paenibacillus and Bacillus sp. Strains Isolated from Healthy Tomato Plants and Rhizosphere Soil. Microbiology resource announcements, 8(12), [e00055-19].
Li, Z., Song, C., de Jong, A., & Kuipers, O. P. (2019). Draft Genome Sequences of Six Bacillus Strains and One Brevibacillus Strain Isolated from the Rhizosphere of Perennial Ryegrass (Lolium perenne). Microbiology resource announcements, 8(4), [ARTN e01586-18].
Solopova, A., van Tilburg, A. Y., Foito, A., Allwood, J. W., Stewart, D., Kulakauskas, S., & Kuipers, O. P. (2019). Engineering Lactococcus lactis for the production of unusual anthocyanins using tea as substrate. Metabolic Engineering, 54, 160-169.
Li, Q., Montalban-Lopez, M., & Kuipers, O. P. (2019). Feasability of Introducing a Thioether Ring in Vasopressin by nisBTC Co-expression in Lactococcus lactis. Frontiers in Microbiology, 10, [1508].
Kaunietis, A., Buivydas, A., Čitavičius, D. J., & Kuipers, O. P. (2019). Heterologous biosynthesis and characterization of a glycocin from a thermophilic bacterium. Nature Communications, 10(1), [1115].
van Tilburg, A. Y., Cao, H., van der Meulen, S. B., Solopova, A., & Kuipers, O. P. (2019). Metabolic engineering and synthetic biology employing Lactococcus lactis and Bacillus subtilis cell factories. Current Opinion in Biotechnology, 59, 1-7.
Morabbi Heravi, K., Manzoor, I., Watzlawick, H., de Jong, A., Kuipers, O. P., & Altenbuchner, J. (2019). Phosphosugar stress in Bacillus subtilis: Intracellular accumulation of mannose 6-phosphate derepresed the glcR-phoC operon from repression by GlcR. Journal of Bacteriology, 201(9), [e00732-18].
de Vries, R., Viel, J., Oudshoorn, R., Kuipers, O., & Roelfes, G. (2019). Selective Modification of RiPPs via Diels-Alder Cycloadditions on Dehydroalanine Residues. Chemistry, 25(55), 12698–12702.
Motib, A. S., Al-Bayati, F. A. Y., Manzoor, I., Shafeeq, S., Kadam, A., Kuipers, O. P., Hiller, N. L., Andrew, P. W., & Yesilkaya, H. (2019). TprA/PhrA Quorum Sensing System Has a Major Effect on Pneumococcal Survival in Respiratory Tract and Blood, and Its Activity Is Controlled by CcpA and GInR. Frontiers in Cellular and Infection Microbiology, 9, [326].


Bron, P. A., Marcelli, B., Mulder, J., van der Els, S., Morawska, L. P., Kuipers, O. P., Kok, J., & Kleerebezem, M. (2019). Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria. Current Opinion in Biotechnology, 56, 61-68.
Kuipers, O. P., & Li, Q. (2018). Antimicrobial peptides and admixtures thereof showing antimicrobial activity against gram-negative pathogens. (Patent No. WO2018231058).
Nickling, J. H., Baumann, T., Schmitt, F-J., Bartholomae, M., Kuipers, O. P., Friedrich, T., & Budisa, N. (2018). Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids. Journal of visualized experiments : JoVE, (135), [57551].,
Dudnik, A., Almeida, A. F., Andrade, R., Avila, B., Banados, P., Barbay, D., Bassard, J-E., Benkoulouche, M., Bott, M., Braga, A., Breitel, D., Brennan, R., Bulteau, L., Chanforan, C., Costa, I., Costa, R. S., Doostmohammadi, M., Faria, N., Feng, C., ... Solopova, A. (2018). BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits. Phytochemistry reviews, 17(2), 291-326.
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