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Kuipers, Prof. Oscar

Oscar Kuipers
Oscar Kuipers

Oscar Kuipers is professor of Molecular Genetics of Prokaryotes at the University of Groningen, and  a member of the department of Molecular Genetics of the Groningen Biomolecular Sciences and Biotechnology Institute.  Prokaryotes are micro-organisms without a nucleus, such as bacteria and Cyanobacteria. The field of molecular genetics studies gene functions and regulation and the interaction between genes. This research results, for example, in increasing knowledge about the gene modification of bacteria and is very important to biotechnology. Kuipers  studied Biology at Utrecht University and in 1990 gained his PhD in the department of Biochemistry of the same university. After that, he  worked at NIZO Food Research in Ede and the Wageningen Centre for Food Sciences.

Each year Kuipers supervises the (always successful) University of Groningen student team that competes in the iGEM competition in Boston. In 2012 this team became world champion, with a biological detection system to check how fresh meat is. In 2011 Kuipers received the ‘Simon Stevin Master' Award by the Technical Sciences Foundation (STW) and a grant of EUR 500,000 to spend on research. In the same year he became member of the prestigious Royal Netherlands Academy of Arts and Sciences (KNAW).  

At the end of May 2013, the EU awarded Kuipers a grant of € 1 million to make synthetic peptides, with particular attention to the development of new antibiotics.

Previously in the news

2021

Zhou, L., Song, C., Li, Z., & Kuipers, O. P. (2021). Antimicrobial activity screening of rhizosphere soil bacteria from tomato and genome-based analysis of their antimicrobial biosynthetic potential. BMC Genomics, 22(1), [29]. https://doi.org/10.1186/s12864-020-07346-8
Fu, Y., Jaarsma, A. H., & Kuipers, O. P. (2021). Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs). Cellular and molecular life sciences, [s00018-021-03759-0]. https://doi.org/10.1007/s00018-021-03759-0
Zhao, X., Wang, X., Shukla, R., Kumar, R., Weingarth, M., Breukink, E., & Kuipers, O. P. (2021). Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an Exceptionally Low Hemolytic Activity. Frontiers in Microbiology, 12, [693725]. https://doi.org/10.3389/fmicb.2021.693725
Zhao, X., & Kuipers, O. P. (2021). BrevicidineB, a New Member of the Brevicidine Family, Displays an Extended Target Specificity. Frontiers in Microbiology, 12, [693117]. https://doi.org/10.3389/fmicb.2021.693117
Ruijne, F., & Kuipers, O. P. (2021). Combinatorial biosynthesis for the generation of new-to-nature peptide antimicrobials. Biochemical Society Transactions, 49(1), 203-215. [ BST20200425]. https://doi.org/10.1042/BST20200425
Muñoz, C. Y., de Jong, A., & Kuipers, O. P. (2021). Draft Genome Sequences of a Bacillus subtilis Strain, a Bacillus velezensis Strain, a Paenibacillus Strain, and an Acinetobacter baumannii Strain, All Isolated from the Phyllosphere of Lactuca sativa or Solanum lycopersicum. Microbiology resource announcements, 10(4), [e01092-20]. https://doi.org/10.1128/MRA.01092-20
Arias-Orozco, P., Yi, Y., & Kuipers, O. P. (2021). Draft Genome Sequences of Four Bacterial Strains of Heterotrophic Alteromonas macleodii and Marinobacter, Isolated from a Nonaxenic Culture of Two Marine Synechococcus Strains. Microbiology resource announcements, 10(19), [e00116-21]. https://doi.org/10.1128/MRA.00116-21
Viel, J. H., Jaarsma, A. H., & Kuipers, O. P. (2021). Heterologous Expression of Mersacidin in Escherichia coli Elucidates the Mode of Leader Processing. ACS Synthetic Biology, 10(3), 600-608. [acssynbio.0c00601]. https://doi.org/10.1021/acssynbio.0c00601
Lauxen, A. I., Kobauri, P., Wegener, M., Hansen, M. J., Galenkamp, N. S., Maglia, G., Szymanski, W., Feringa, B. L., & Kuipers, O. P. (2021). Mechanism of Resistance Development in E. coli against TCAT, a Trimethoprim-Based Photoswitchable Antibiotic. Pharmaceuticals, 14(5), [ph14050392]. https://doi.org/10.3390/ph14050392
Zhao, X., & Kuipers, O. P. (2021). Nisin- and Ripcin-Derived Hybrid Lanthipeptides Display Selective Antimicrobial Activity against Staphylococcus aureus. ACS Synthetic Biology, [00080]. https://doi.org/10.1021/acssynbio.1c00080
Li, Q., Cebrián, R., Montalbán-López, M., Ren, H., Wu, W., & Kuipers, O. P. (2021). Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens. Communications biology, 4(1), [31]. https://doi.org/10.1038/s42003-020-01511-1
Luo, Y., Korza, G., DeMarco, A. M., Kuipers, O. P., Li, Y-Q., & Setlow, P. (2021). Properties of spores of Bacillus subtilis with or without a transposon that decreases spore germination and increases spore wet heat resistance. Journal of Applied Microbiology, [jam.15163]. https://doi.org/10.1111/jam.15163
Fernandez-Cantos, M. V., Garcia-Morena, D., Iannone, V., El-Nezami, H., Kolehmainen, M., & Kuipers, O. P. (2021). Role of microbiota and related metabolites in gastrointestinal tract barrier function in NAFLD. Tissue Barriers, [e1879719]. https://doi.org/10.1080/21688370.2021.1879719
Zhao, X., & Kuipers, O. P. (2021). Synthesis of silver-nisin nanoparticles with low cytotoxicity as antimicrobials against biofilm-forming pathogens. Colloids and Surfaces B: Biointerfaces, 206, [111965]. https://doi.org/10.1016/j.colsurfb.2021.111965
van Tilburg, A. Y., Fülleborn, J. A., Reder, A., Völker, U., Stülke, J., van Heel, A. J., & Kuipers, O. P. (2021). Unchaining miniBacillus PG10: Relief of FlgM-mediated repression of autolysin genes. Applied and environmental microbiology, [AEM0112321]. https://doi.org/10.1128/AEM.01123-21

2020

van Tatenhove-Pel, R. J., Rijavec, T., Lapanje, A., van Swam, I., Zwering, E., Hernandez-Valdes, J. A., Kuipers, O. P., Picioreanu, C., Teusink, B., & Bachmann, H. (2021). Microbial competition reduces metabolic interaction distances to the low µm-range. The ISME journal, 15, 688–701. https://doi.org/10.1038/s41396-020-00806-9
Montalbán-López, M., Scott, T. A., Ramesh, S., Rahman, I. R., van Heel, A. J., Viel, J. H., Bandarian, V., Dittmann, E., Genilloud, O., Goto, Y., Grande Burgos, M. J., Hill, C., Kim, S., Koehnke, J., Latham, J. A., Link, A. J., Martínez, B., Nair, S. K., Nicolet, Y., ... van der Donk, W. A. (2021). New developments in RiPP discovery, enzymology and engineering. Natural product reports, 38(1), 130-239. [D0NP00027B]. https://doi.org/10.1039/d0np00027b
de Vries, R. H., Viel, J. H., Kuipers, O. P., & Roelfes, G. (2021). Rapid and selective chemical editing of Ribosomally synthesized and Post-translationally modified Peptides (RiPPs) via Cu(II)-catalyzed β-borylation of dehydroamino acids. Angewandte Chemie (International ed. in English), 60(8), 3946-3950. https://doi.org/10.1002/anie.202011460
Teusink, B., Kuipers, O. P., & Moineau, S. (2021). Symposium on Lactic Acid Bacteria-reading while waiting for a meeting. FEMS Microbiology Reviews, 45(2), [fuaa049]. https://doi.org/10.1093/femsre/fuaa049
Xia, Y., Xu, C., Wang, D., Weng, Y., Jin, Y., Bai, F., Cheng, Z., Kuipers, O. P., & Wu, W. (2021). YbeY controls the type III and type VI secretion systems and biofilm formation through RetS in Pseudomonas aeruginosa. Applied and environmental microbiology, 87(5). https://doi.org/10.1128/AEM.02171-20
Hernandez-Valdes, J. A., van Gestel, J., & Kuipers, O. P. (2020). A riboswitch gives rise to multi-generational phenotypic heterogeneity in an auxotrophic bacterium. Nature Communications, 11(1), [1203]. https://doi.org/10.1038/s41467-020-15017-1
Zhao, X., Yin, Z., Breukink, E., Moll, G. N., & Kuipers, O. P. (2020). An Engineered Double Lipid II Binding Motifs-Containing Lantibiotic Displays Potent and Selective Antimicrobial Activity against Enterococcus faecium. Antimicrobial Agents and Chemotherapy, 64(6), [ e02050-19]. https://doi.org/10.1128/AAC.02050-19
Boonstra, M., Schaffer, M., Sousa, J., Morawska, L., Holsappel, S., Hildebrandt, P., Sappa, P. K., Rath, H., de Jong, A., Lalk, M., Mäder, U., Völker, U., & Kuipers, O. P. (2020). Analyses of competent and non-competent subpopulations of Bacillus subtilis reveal yhfW, yhxC and ncRNAs as novel players in competence. Environmental Microbiology, 22(6), 2312-2328. https://doi.org/10.1111/1462-2920.15005
Hernandez-Valdes, J. A., Huang, C., Kok, J., & Kuipers, O. P. (2020). Another Breaker of the Wall: the Biological Function of the Usp45 Protein of Lactococcus lactis. Applied and environmental microbiology, 86(16), 1-14. [e00903-20]. https://doi.org/10.1128/AEM.00903-20
Caro-Astorga, J., Frenzel, E., Perkins, J. R., Álvarez-Mena, A., de Vicente, A., Ranea, J. A. G., Kuipers, O. P., & Romero, D. (2020). Biofilm formation displays intrinsic offensive and defensive features of Bacillus cereus. NPJ biofilms and microbiomes, 6(1), [3]. https://doi.org/10.1038/s41522-019-0112-7
Li, Z., Song, C., Yi, Y., & Kuipers, O. P. (2020). Characterization of plant growth-promoting rhizobacteria from perennial ryegrass and genome mining of novel antimicrobial gene clusters. BMC Genomics, 21(1), [157]. https://doi.org/10.1186/s12864-020-6563-7
Li, Z., Chakraborty, P., de Vries, R. H., Song, C., Zhao, X., Roelfes, G., Scheffers, D-J., & Kuipers, O. P. (2020). Characterization of two relacidines belonging to a novel class of circular lipopeptides that act against Gram-negative bacterial pathogens. Environmental Microbiology, 22(12), 5125-5136. https://doi.org/10.1111/1462-2920.15145
Marcelli, B., de Jong, A., Janzen, T., Serrano, M., Kok, J., & Kuipers, O. P. (2020). Complete Genome Sequences of 28 Lactococcal Bacteriophages Isolated from Failed Dairy Fermentation Processes. Microbiology resource announcements, 9(12), [e01535-19]. https://doi.org/10.1128/MRA.01535-19
Deng, J., Viel, J. H., Kubyshkin, V., Budisa, N., & Kuipers, O. P. (2020). Conjugation of Synthetic Polyproline Moietes to Lipid II Binding Fragments of Nisin Yields Active and Stable Antimicrobials. Frontiers in Microbiology, 11, [575334]. https://doi.org/10.3389/fmicb.2020.575334
Hernandez-Valdes, J. A., Solopova, A., & Kuipers, O. P. (2020). Development of Lactococcus lactis Biosensors for Detection of Diacetyl. Frontiers in Microbiology, 11, [1032]. https://doi.org/10.3389/fmicb.2020.01032
Hernandez-Valdes, J. A., Dalglish, M. M., Hermans, J., & Kuipers, O. P. (2020). Development of Lactococcus lactis Biosensors for Detection of Sulfur-Containing Amino Acids. Frontiers in Microbiology, 11, [1654]. https://doi.org/10.3389/fmicb.2020.01654
Hernandez-Valdes, J. A., de Jong, A., Kok, J., & Kuipers, O. P. (2020). Draft Genome Sequences of Three Amino Acid-Secreting Lactococcus lactis Strains. Microbiology resource announcements, 9(16), [e00158]. https://doi.org/10.1128/MRA.00158-20
Marcelli, B., Karsens, H., Nijland, M., Oudshoorn, R., Kuipers, O. P., & Kok, J. (2020). Employing lytic phage-mediated horizontal gene transfer in Lactococcus lactis. PLoS ONE, 15(9 ), [e0238988]. https://doi.org/10.1371/journal.pone.0238988
Xia, Y., Weng, Y., Xu, C., Wang, D., Pan, X., Tian, Z., Xia, B., Li, H., Chen, R., Liu, C., Jin, Y., Bai, F., Cheng, Z., Kuipers, O. P., & Wu, W. (2020). Endoribonuclease YbeY Is Essential for RNA Processing and Virulence in Pseudomonas aeruginosa. Mbio, 11(3), 1-21. [e00659-20]. https://doi.org/10.1128/mBio.00659-20
Hernandez-Valdes, J. A., Aan de Stegge, M., Hermans, J., Teunis, J., van Tatenhove-Pel, R. J., Teusink, B., Bachmann, H., & Kuipers, O. P. (2020). Enhancement of amino acid production and secretion by Lactococcus lactis using a droplet-based biosensing and selection system. Metabolic Engineering Communications, 11, [e00133]. https://doi.org/10.1016/j.mec.2020.e00133
Zhao, X., Cebrian, R., Fu, Y., Rink, R., Bosma, T., Moll, G. N., & Kuipers, O. P. (2020). High-throughput screening for substrate specificity-adapted mutants of the nisin dehydratase NisB. ACS Synthetic Biology, 9(6), 1468-1478. https://doi.org/10.1021/acssynbio.0c00130
Hernandez-Valdes, J. A., Zhou, L., de Vries, M. P., & Kuipers, O. P. (2020). Impact of spatial proximity on territoriality among human skin bacteria. NPJ biofilms and microbiomes, 6(1), [30]. https://doi.org/10.1038/s41522-020-00140-0
Huang, C., Hernandez-Valdes, J. A., Kuipers, O. P., & Kok, J. (2020). Lysis of a Lactococcus lactis dipeptidase mutant and rescue by mutation in the pleiotropic regulator cody. Applied and environmental microbiology, 86(8), [2937]. https://doi.org/10.1128/AEM.02937-19
Zhao, X., Li, Z., & Kuipers, O. P. (2020). Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification. Cell Chemical Biology, 27(10), 1262-1271. https://doi.org/10.1016/j.chembiol.2020.07.005
van Tilburg, A. Y., van Heel, A. J., Stülke, J., de Kok, N. A. W., Rueff, A-S., & Kuipers, O. P. (2020). MiniBacillus PG10 as a Convenient and Effective Production Host for Lantibiotics. ACS Synthetic Biology, 9(7), 1833-1842. [acssynbio.0c00194]. https://doi.org/10.1021/acssynbio.0c00194
Li, Z., de Vries, R. H., Chakraborty, P., Song, C., Zhao, X., Scheffers, D-J., Roelfes, G., & Kuipers, O. P. (2020). Novel modifications of nonribosomal peptides from Brevibacillus laterosporus MG64 and investigation of their mode of action. Applied and environmental microbiology, 86(24), 1-14. [e01981-20]. https://doi.org/10.1128/AEM.1981-20
Chen, J., van Heel, A. J., & Kuipers, O. P. (2020). Subcellular Localization and Assembly Process of the Nisin Biosynthesis Machinery in Lactococcus lactis. Mbio, 11(6), 1-22. [e02825-20]. https://doi.org/10.1128/mBio.02825-20
Deng, J., Viel, J. H., Chen, J., & Kuipers, O. P. (2020). Synthesis and Characterization of Heterodimers and Fluorescent Nisin Species by Incorporation of Methionine Analogues and Subsequent Click Chemistry. ACS Synthetic Biology, 9(9), 2525-2536. https://doi.org/10.1021/acssynbio.0c00308

2019

van Tatenhove-Pel, R. J., Hernandez-Valdes, J. A., Teusink, B., Kuipers, O. P., Fischlechner, M., & Bachmann, H. (2020). Microdroplet screening and selection for improved microbial production of extracellular compounds. Current Opinion in Biotechnology, 61, 72-81. https://doi.org/10.1016/j.copbio.2019.10.007
Marcelli, B., de Jong, A., Karsens, H., Janzen, T., Kok, J., & Kuipers, O. P. (2019). A specific sugar moiety in the Lactococcus lactis cell wall pellicle is required for infection by CHPC971, a member of the rare 1706 phage species. Applied and environmental microbiology, 85(19), [e01224-19]. https://doi.org/10.1128/AEM.01224-19
Price, C. E., Branco Dos Santos, F., Hesseling, A., Uusitalo, J. J., Bachmann, H., Benavente, V., Goel, A., Berkhout, J., Bruggeman, F. J., Marrink, S-J., Montalban-Lopez, M., de Jong, A., Kok, J., Molenaar, D., Poolman, B., Teusink, B., & Kuipers, O. P. (2019). Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength. BMC Evolutionary Biology, 19(1), [15]. https://doi.org/10.1186/s12862-018-1331-x
van Tatenhove-Pel, R. J., Zwering, E., Solopova, A., Kuipers, O. P., & Bachmann, H. (2019). Ampicillin-treated Lactococcus lactis MG1363 populations contain persisters as well as viable but non-culturable cells. Scientific Reports, 9(1), [9867]. https://doi.org/10.1038/s41598-019-46344-z
Schmitt, S., Montalbán-López, M., Peterhoff, D., Deng, J., Wagner, R., Held, M., Kuipers, O. P., & Panke, S. (2019). Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale. Nature Chemical Biology, 15(5), 437-443. https://doi.org/10.1038/s41589-019-0250-5
Perez, M., Calles-Enríquez, M., Del Rio, B., Redruello, B., de Jong, A., Kuipers, O. P., Kok, J., Martin, M. C., Ladero, V., Fernandez, M., & Alvarez, M. A. (2019). Construction and characterization of a double mutant of Enterococcus faecalis that does not produce biogenic amines. Scientific Reports, 9(1), [16881]. https://doi.org/10.1038/s41598-019-53175-5
Cebrian, R., Macia-Valero, A., Jati, A. P., & Kuipers, O. P. (2019). Design and Expression of Specific Hybrid Lantibiotics Active Against Pathogenic Clostridium spp. Frontiers in Microbiology, 10, [2154]. https://doi.org/10.3389/fmicb.2019.02154
Li, Z., Song, C., de Jong, A., & Kuipers, O. P. (2019). Draft Genome Sequences of Six Bacillus Strains and One Brevibacillus Strain Isolated from the Rhizosphere of Perennial Ryegrass (Lolium perenne). Microbiology resource announcements, 8(4), [ARTN e01586-18]. https://doi.org/10.1128/MRA.01586-18
Zhou, L., Song, C., de Jong, A., & Kuipers, O. P. (2019). Draft Genome Sequences of 10 Paenibacillus and Bacillus sp. Strains Isolated from Healthy Tomato Plants and Rhizosphere Soil. Microbiology resource announcements, 8(12), [e00055-19]. https://doi.org/10.1128/MRA.00055-19
Solopova, A., van Tilburg, A. Y., Foito, A., Allwood, J. W., Stewart, D., Kulakauskas, S., & Kuipers, O. P. (2019). Engineering Lactococcus lactis for the production of unusual anthocyanins using tea as substrate. Metabolic Engineering, 54, 160-169. https://doi.org/10.1016/j.ymben.2019.04.002
Li, Q., Montalban-Lopez, M., & Kuipers, O. P. (2019). Feasability of Introducing a Thioether Ring in Vasopressin by nisBTC Co-expression in Lactococcus lactis. Frontiers in Microbiology, 10, [1508]. https://doi.org/10.3389/fmicb.2019.01508
Kaunietis, A., Buivydas, A., Čitavičius, D. J., & Kuipers, O. P. (2019). Heterologous biosynthesis and characterization of a glycocin from a thermophilic bacterium. Nature Communications, 10(1), [1115]. https://doi.org/10.1038/s41467-019-09065-5
van Tilburg, A. Y., Cao, H., van der Meulen, S. B., Solopova, A., & Kuipers, O. P. (2019). Metabolic engineering and synthetic biology employing Lactococcus lactis and Bacillus subtilis cell factories. Current Opinion in Biotechnology, 59, 1-7. https://doi.org/10.1016/j.copbio.2019.01.007
Morabbi Heravi, K., Manzoor, I., Watzlawick, H., de Jong, A., Kuipers, O. P., & Altenbuchner, J. (2019). Phosphosugar stress in Bacillus subtilis: Intracellular accumulation of mannose 6-phosphate derepresed the glcR-phoC operon from repression by GlcR. Journal of Bacteriology, 201(9), [e00732-18]. https://doi.org/10.1128/JB.00732-18
de Vries, R., Viel, J., Oudshoorn, R., Kuipers, O., & Roelfes, G. (2019). Selective Modification of RiPPs via Diels-Alder Cycloadditions on Dehydroalanine Residues. Chemistry, 25(55), 12698–12702. https://doi.org/10.1002/chem.201902907
Motib, A. S., Al-Bayati, F. A. Y., Manzoor, I., Shafeeq, S., Kadam, A., Kuipers, O. P., Hiller, N. L., Andrew, P. W., & Yesilkaya, H. (2019). TprA/PhrA Quorum Sensing System Has a Major Effect on Pneumococcal Survival in Respiratory Tract and Blood, and Its Activity Is Controlled by CcpA and GInR. Frontiers in Cellular and Infection Microbiology, 9, [326]. https://doi.org/10.3389/fcimb.2019.00326

2018

Bron, P. A., Marcelli, B., Mulder, J., van der Els, S., Morawska, L. P., Kuipers, O. P., Kok, J., & Kleerebezem, M. (2019). Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria. Current Opinion in Biotechnology, 56, 61-68. https://doi.org/10.1016/j.copbio.2018.09.004
Kuipers, O. P., & Li, Q. (2018). Antimicrobial peptides and admixtures thereof showing antimicrobial activity against gram-negative pathogens. (Patent No. WO2018231058). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2018231058A2&KC=A2&FT=D&ND=3&date=20181220&DB=&locale=en_EP
Nickling, J. H., Baumann, T., Schmitt, F-J., Bartholomae, M., Kuipers, O. P., Friedrich, T., & Budisa, N. (2018). Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids. Journal of visualized experiments : JoVE, (135), [57551]. https://doi.org/10.3791/57551, https://doi.org/10.3791/57551
Dudnik, A., Almeida, A. F., Andrade, R., Avila, B., Banados, P., Barbay, D., Bassard, J-E., Benkoulouche, M., Bott, M., Braga, A., Breitel, D., Brennan, R., Bulteau, L., Chanforan, C., Costa, I., Costa, R. S., Doostmohammadi, M., Faria, N., Feng, C., ... Solopova, A. (2018). BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits. Phytochemistry reviews, 17(2), 291-326. https://doi.org/10.1007/s11101-017-9532-2
van Heel, A. J., de Jong, A., Song, C., Viel, J. H., Kok, J., & Kuipers, O. P. (2018). BAGEL4: a user-friendly web server to thoroughly mine RiPPs and bacteriocins. Nucleic Acids Research, 46(W1), W278-W281. https://doi.org/10.1093/nar/gky383
Cao, H., Villatoro-Hernandez, J., Weme, R. D. O., Frenzel, E., & Kuipers, O. P. (2018). Boosting heterologous protein production yield by adjusting global nitrogen and carbon metabolic regulatory networks in Bacillus subtilis. Metabolic Engineering, 49, 143-152. https://doi.org/10.1016/j.ymben.2018.08.001
Fu, Y., Mu, D., Qiao, W., Zhu, D., Wang, X., Liu, F., Xu, H., Saris, P., Kuipers, O. P., & Qiao, M. (2018). Co-expression of Nisin Z and Leucocin C as a Basis for Effective Protection Againstin Pasteurized Milk. Frontiers in Microbiology, 9, [547]. https://doi.org/10.3389/fmicb.2018.00547
Omony, J., de Jong, A., Krawczyk, A. O., Eijlander, R. T., & Kuipers, O. P. (2018). Dynamic sporulation gene co-expression networks for Bacillus subtilis 168 and the food-borne isolate Bacillus amyloliquefaciens: a transcriptomic model. Microbial genomics, 4(2), [mgen.0.000157]. https://doi.org/10.1099/mgen.0.000157
Bartholomae, M., Baumann, T., Nickling, J. H., Peterhoff, D., Wagner, R., Budisa, N., & Kuipers, O. P. (2018). Expanding the Genetic Code of and to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics. Frontiers in Microbiology, 9, 1-11. [657]. https://doi.org/10.3389/fmicb.2018.00657
Yi, Y., Li, Z., Song, C., & Kuipers, O. P. (2018). Exploring plant-microbe interactions of the rhizobacteria Bacillus subtilis and Bacillus mycoides by use of the CRISPR-Cas9 system. Environmental Microbiology, 20(12), 4245-4260. https://doi.org/10.1111/1462-2920.14305
Boonstra, M., Vesel, N., & Kuipers, O. P. (2018). Fluorescently Labeled DNA Interacts with Competence and Recombination Proteins and Is Integrated and Expressed Following Natural Transformation of Bacillus subtilis. Mbio, 9(5), [e01161-18]. https://doi.org/10.1128/mBio.01161-18
Solopova, A., Bachmann, H., Teusink, B., Kok, J., & Kuipers, O. P. (2018). Further Elucidation of Galactose Utilization in MG1363. Frontiers in Microbiology, 9, [1803]. https://doi.org/10.3389/fmicb.2018.01803
Mu, D., Lu, J., Qiao, M., Kuipers, O. P., Zhu, J., Li, X., Yang, P., Zhao, Y., Luo, S., Wu, X., Jiang, S., & Zheng, Z. (2018). Heterologous signal peptides-directing secretion of Streptomyces mobaraensis transglutaminase by Bacillus subtilis. Applied Microbiology and Biotechnology, 102(13), 5533-5543. https://doi.org/10.1007/s00253-018-9000-y
Frenzel, E., Legebeke, J., van Stralen, A., van Kranenburg, R., & Kuipers, O. P. (2018). In vivo selection of sfGFP variants with improved and reliable functionality in industrially important thermophilic bacteria. Biotechnology for Biofuels, 11, [8]. https://doi.org/10.1186/s13068-017-1008-5
Li, Q., Montalban-Lopez, M., & Kuipers, O. P. (2018). Increasing Antimicrobial Activity of Nisin-based Lantibiotics Against Gram-negative Pathogens. Applied and environmental microbiology, 84(12), [UNSP e00052-18]. https://doi.org/10.1128/AEM.00052-18
Mulder, J., Wels, M., Kuipers, O. P., Kleerebezem, M., & Bron, P. A. (2018). Induction of Natural Competence in Genetically-modified Lactococcus lactis. Bio-Protocol, 8(13), [2922]. https://doi.org/10.21769/BioProtoc.2922
Cao, H., & Kuipers, O. P. (2018). Influence of global gene regulatory networks on single cell heterogeneity of green fluorescent protein production in Bacillus subtilis. Microbial Cell Factories, 17(1), [134]. https://doi.org/10.1186/s12934-018-0985-9
Carvalho, S. M., Kloosterman, T. G., Manzoor, I., Caldas, J., Vinga, S., Martinussen, J., Saraiva, L. M., Kuipers, O. P., & Neves, A. P. (2018). Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39. Frontiers in Microbiology, 9, [321]. https://doi.org/10.3389/fmicb.2018.00321
Afzal, M., Shafeeq, S., & Kuipers, O. P. (2018). NADH-Mediated Gene Expression in Streptococcus pneumoniae and Role of Rex as a Transcriptional Repressor of the Rex-Regulon. Frontiers in Microbiology, 9, 1-9. [fmicb.2018.01300]. https://doi.org/10.3389/fmicb.2018.01300
Yi, Y., Li, Z., & Kuipers, O. P. (2018). Plant-Microbe Interaction: Transcriptional Response of Bacillus Mycoides to Potato Root Exudates. Journal of visualized experiments : JoVE, (137), [57606]. https://doi.org/10.3791/57606
Zhi, X., Abdullah, I. T., Gazioglu, O., Manzoor, I., Shafeeq, S., Kuipers, O. P., Hiller, N. L., Andrew, P. W., & Yesilkaya, H. (2018). Rgg-Shp regulators are important for pneumococcal colonization and invasion through their effect on mannose utilization and capsule synthesis. Scientific Reports, 8(1), [6369]. https://doi.org/10.1038/s41598-018-24910-1
Montalban-Lopez, M., Deng, J., van Heel, A. J., & Kuipers, O. P. (2018). Specificity and Application of the Lantibiotic Protease NisP. Frontiers in Microbiology, 9. https://doi.org/10.3389/fmicb.2018.00160
Carvalho, S. M., Freitas, C. S., Kuipers, O. P., & Saraiva, L. M. (2018). Staphylococcus aureus metabolic strategies to survive nitrosative stress. Free Radical Biology and Medicine, 120, S149-S150. https://doi.org/10.1016/j.freeradbiomed.2018.04.493

2017

Yi, Y., Frenzel, E., Spoelder, J., Elzenga, J. T. M., van Elsas, J. D., & Kuipers, O. P. (2018). Optimized fluorescent proteins for the rhizosphere-associated bacterium Bacillus mycoides with endophytic and biocontrol agent potential. Environmental microbiology reports, 10(1), 57-74. https://doi.org/10.1111/1758-2229.12607
Kuipers, O., & Kovacs, A. (2017). Bacterial gangs: United and strong by means of quorum sensing. In J. van Doorn, J. Luirink, J. van der Oost, B. Oudega, L. Robertson, H. Smit, P. Willemsen, & C. Biemans (Eds.), MIGHTY MICROBES: THE AMAZING WORLD OF MICROORGANISMS (1 ed., Vol. 1, pp. 71-73). Microcanon Foundation.
Cao, H., van Heel, A. J., Ahmed, H., Mols, M., & Kuipers, O. P. (2017). Cell surface engineering of Bacillus subtilis improves production yields of heterologously expressed α-amylases. Microbial Cell Factories, 16(1), 1-9. [56]. https://doi.org/10.1186/s12934-017-0674-0
Hajaj, B., Yesilkaya, H., Shafeeq, S., Zhi, X., Benisty, R., Tchalah, S., Kuipers, O. P., & Porat, N. (2017). CodY Regulates Thiol Peroxidase Expression as Part of the Pneumococcal Defense Mechanism against H2O2 Stress. Frontiers in Cellular and Infection Microbiology, 7, 1-13. [210]. https://doi.org/10.3389/fcimb.2017.00210
Yi, Y., de Jong, A., Frenzel, E., & Kuipers, O. P. (2017). Comparative Transcriptomics of Bacillus mycoides Strains in Response to Potato-Root Exudates Reveals Different Genetic Adaptation of Endophytic and Soil Isolates. Frontiers in Microbiology, 8, 1-14. [1487]. https://doi.org/10.3389/fmicb.2017.01487
Solopova, A., Kok, J., & Kuipers, O. P. (2017). Disruption of a transcriptional repressor by an IS-element integration leads to the activation of a novel silent cellobiose transporter in Lactococcus lactis MG1363. Applied and environmental microbiology, 83(23), [e01279-17]. https://doi.org/10.1128/AEM.01279-17
Kleerebezem, M., Kuipers, O. P., & Smid, E. J. (2017). Editorial: Lactic acid bacteria-a continuing journey in science and application. FEMS Microbiology Reviews, 41(Supp_1), S1-S2. https://doi.org/10.1093/femsre/fux036
Banin, E., Hughes, D., & Kuipers, O. P. (2017). Editorial: Bacterial pathogens, antibiotics and antibiotic resistance. FEMS Microbiology Reviews, 41(3), 450-452. [016]. https://doi.org/10.1093/femsre/fux016
Montalbán-López, M., van Heel, A. J., & Kuipers, O. P. (2017). Employing the promiscuity of lantibiotic biosynthetic machineries to produce novel antimicrobials. FEMS Microbiology Reviews, 41(1), 5-18. [fuw034]. https://doi.org/10.1093/femsre/fuw034
Visweswaran, G. R. R., Kurek, D., Szeliga, M., Pastrana, F. R., Kuipers, O. P., Kok, J., & Buist, G. (2017). Expression of prophage-encoded endolysins contributes to autolysis of Lactococcus lactis. Applied Microbiology and Biotechnology, 101(3), 1099-1110. https://doi.org/10.1007/s00253-016-7822-z
van den Esker, M. H., Kovács, Á. T., & Kuipers, O. P. (2017). From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions. Mbio, 8(6), 1-5. [e01963-17]. https://doi.org/10.1128/mBio.01963-17
van Heel, A. J., Montalban-Lopez, M., Oliveau, Q., & Kuipers, O. P. (2017). Genome-guided identification of novel head-to-tail cyclized antimicrobial peptides, exemplified by the discovery of pumilarin. Microbial genomics, 3(10), 1-9. [mgen.0.000134]. https://doi.org/10.1099/mgen.0.000134
Bartholomae, M., Buivydas, A., Viel, J. H., Montalban-Lopez, M., & Kuipers, O. P. (2017). Major gene-regulatory mechanisms operating in ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthesis. Molecular Microbiology, 106(2), 186-206. https://doi.org/10.1111/mmi.13764
Tracanna, V., de Jong, A., Medema, M. H., & Kuipers, O. P. (2017). Mining prokaryotes for antimicrobial compounds: From diversity to function. FEMS Microbiology Reviews, 41(3), 417-429. [014]. https://doi.org/10.1093/femsre/fux014
Motib, A., Guerreiro, A., Al-Bayati, F., Piletska, E., Manzoor, I., Shafeeq, S., Kadam, A., Kuipers, O., Hiller, L., Cowen, T., Piletsky, S., Andrew, P., & Yesilkaya, H. (2017). Modulation of Quorum Sensing in a Gram Positive Pathogen by Linear Imprinted Copolymers with anti-Infective Properties. Angewandte Chemie - International Edition, 56(52), 16555-16558. [anie.201709313]. https://doi.org/10.1002/anie.201709313
Afzal, M., Kuipers, O. P., & Shafeeq, S. (2017). Niacin-mediated Gene Expression and Role of NiaR as a Transcriptional Repressor of niaX, nadC, and pnuC in Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology, 7, 1-11. [70]. https://doi.org/10.3389/fcimb.2017.00070
Al-Bayati, F. A. Y., Kahya, H. F. H., Damianou, A., Shafeeq, S., Kuipers, O. P., Andrew, P. W., & Yesilkaya, H. (2017). Pneumococcal galactose catabolism is controlled by multiple regulators acting on pyruvate formate lyase. Scientific Reports, 7, 1-17. [43587 ]. https://doi.org/10.1038/srep43587

2016

Yi, Y., & Kuipers, O. P. (2017). Development of an efficient electroporation method for rhizobacterial Bacillus mycoides strains. Journal of microbiological methods, 133, 82-86. https://doi.org/10.1016/j.mimet.2016.12.022
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