Prof. Oscar Kuipers and Dr. Auke van Heel have set up the spin-off company Omnicin Therapeutics to develop new antibiotics against resistant bacteria. In their research into new possibilities for combating multi-resistant bacteria, the researchers have discovered substances that improve the functioning of existing antibiotics. An important discovery, given the worldwide increase in the percentage of bacteria that is resistant to antibiotics.
There exist Gram-negative bacteria and Gram-positive bacteria that cause diseases. In contrast to Gram-positive bacteria, the Gram-negative bacteria have an extra layer – outer membrane – on the outside. As a result, some antibiotics that work on Gram-positive bacteria, but aren’t active on Gram-negative bacteria. The newly discovered substances act as gate-openers that allow antibiotics to pass the outer membrane of Gram-negative bacteria. The substances thus enable the treatment diseases caused by Gram-negative bacteria, with antibiotics that are normally only used for Gram-positive pathogens.
The worldwide percentage of bacteria that are resistant to one or more antibiotics is rising. Many organizations, including WHO, have called for action for this problem. The invention of Prof. Kuipers and PhD student Qian Li is using two compounds that show no or very little antibiotic activity by themselves and only show good efficacy when combined. This makes it a new class of antibiotic strategy.
With the newly established Omnicin Therapeutics, the researchers want to ensure that the new class of antibiotics are accepted and registered. Dr. Auke van Heel is CEO of Omnicin Therapeutics, Dr. Herman Steen is the CBO and Prof. Oscar Kuipers the scientific advisor. The researchers have a patent on behalf of the University of Groningen. There is also support from the Netherlands Antibiotic Development Platform (NADP) and the NWO. Omnicin Therapeutics also offers a unique opportunity for current and future investors.
Carlijn van Beek has won the 2021 Golden Master Award for her Master’s research. She is Master’s student in Chemistry at the University of Groningen (UG). The award has been granted by the Royal Netherlands Chemical Society (KNCV) since 2009.
The Vikings were active in North America in the year 1021 AD. This now represents the earliest – and only – known year in which Europeans were present in the Americas prior to the arrival of Columbus in 1492 AD. It also represents a definitive point...
Every year, the University of Groningen composes a multidisciplinary team of students who compete in the international Genetically Engineered Machine (iGEM) competition. iGEM is an international competition in biotechnology aimed at finding new...
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether or not you want to accept other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information