prof. dr. A.P. (Alexandra/Sasha) Zhernakova

Rosalind Franklin Fellow

Faculty of Medical Sciences

Telephone:

+31 50 361 7100

E-mail:

a.zhernakova umcg.nl

ORCID Research Portal

Publications

Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility

Díaz-Muñoz, C., Bozzarelli, I., Lopera-Maya, E. A., Belbasis, L., Lo Faro, V., Camargo Tavares, L., Heredia-Fernández, F., Di Lorenzo, B., Sinha, T., Esteban Blanco, C., Favé, M.-J., Awadalla, P., Walters, R. G., Bonfiglio, F., Zhernakova, A., Sanna, S. & D'Amato, M., 20-Jan-2026, (E-pub ahead of print) In: Gut.

Research output: Contribution to journal › Article › Academic › peer-review

Approaches toward understanding human immunity

Brodin, P., Wang, F., Zhu, B., Hammond, T., Lu, C. P., Wimmers, F., Zhernakova, A., Liu, W., Nadeau, K. & Prlic, M., 9-Sept-2025, In: Immunity. 58, 9, p. 2139-2143 5 p.

Research output: Contribution to journal › Article › Academic

A reconceptualized framework for human microbiome transmission in early life

Rakoff-Nahoum, S., Debelius, J., Valles-Colomer, M., Noordzij, H. T., Esteban-Torres, M., Zhernakova, A., Brusselaers, N. & Pettersen, V. K., 14-Aug-2025, In: Nature Communications. 16, 14 p., 7546.

Research output: Contribution to journal › Review article › peer-review

Association between gut microbiome profiles and host metabolic health across the life course: a population-based study

Li, R., Kurilshikov, A., Yang, S., van Oortmerssen, J. A. E., van Hilten, A., Ahmadizar, F., Roshchupkin, G., Kraaij, R., Duijts, L., Fu, J., Ikram, M. K., Jaddoe, V. W. V., Uitterlinden, A. G., Rivadeneira, F., Kavousi, M., Zhernakova, A. & Medina-Gomez, C., Mar-2025, In: The Lancet Regional Health - Europe. 50, 14 p., 101195.

Research output: Contribution to journal › Article › Academic › peer-review

Correction to: Examining the healthy human microbiome concept (Nature Reviews Microbiology, (2024), 10.1038/s41579-024-01107-0)

Human Microbiome Action Consortium, Joos, R., Boucher, K., Lavelle, A., Arumugam, M., Blaser, M. J., Claesson, M. J., Clarke, G., Cotter, P. D., De Sordi, L., Dominguez-Bello, M. G., Dutilh, B. E., Ehrlich, S. D., Ghosh, T. S., Hill, C., Junot, C., Lahti, L., Lawley, T. D., Licht, T. R. & Maguin, E., Makhalanyane, T. P., Marchesi, J. R., Matthijnssens, J., Raes, J., Ravel, J., Salonen, A., Scanlan, P. D., Shkoporov, A., Stanton, C., Thiele, I., Tolstoy, I., Walter, J., Yang, B., Yutin, N., Zhernakova, A., Zwart, H., Derosa, L., Zitvogel, L., Veiga, P., Vecchi, C., Trebicka, J., Serra, D., Segata, N., Schierwagen, R., Sarati, A., Rodriguez, J., Rhimi, M., Ravaud, P., Prost, P. L., Pons, N., Pinto, F., Doré, J. & Ross, R. P., Mar-2025, In: Nature Reviews Microbiology. 23, 1 p., 206.

Research output: Contribution to journal › Erratum

Crohn’s disease and ulcerative colitis exhibit prediagnostic antibody signatures with shared and divergent changes towards disease onset

Bourgonje, A. R., Andreu Sánchez, S., Gacesa, R., Innocenti, G., Kalka, I. N., Klompus, S., Leviatan, S., Schlesinger, Y., Krongauz, D., Weinberger, A., van der Vegt, B., Fu, J., Segal, E., Zhernakova, A., Vogl, T. & Weersma, R. K., 10-Nov-2025, In: Gut. 74, p. 1977-1988 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease

Sinke, L., Delerue, T., Wilson, R., Lu, X., Xia, Y., Costeira, R., Nasr, M. K., Beekman, M., Franke, L., Zhernakova, A., Fu, J., Gieger, C., Herder, C., Koenig, W., Peters, A., Ordovas, J. M., Dörr, M., Grabe, H. J., Nauck, M. & Bell, J. T., Teumer, A., Snieder, H., Waldenberger, M., Slagboom, P. E. & Heijmans, B. T., 8-Oct-2025, (E-pub ahead of print) In: Diabetologia.

Research output: Contribution to journal › Article › Academic › peer-review

Early-life development of the gut virome and plasmidome: A longitudinal study in cesarean-born infants

Fernández-Pato, A., Sinha, T., Garmaeva, S., Gulyaeva, A., Kuzub, N., Roux, S., Fu, J., Kurilshikov, A. & Zhernakova, A., 24-Jun-2025, In: Cell reports. 44, 6, 20 p., 115731.

Research output: Contribution to journal › Article › Academic › peer-review

Examining the healthy human microbiome concept

Human Microbiome Action Consortium, Joos, R., Boucher, K., Lavelle, A., Arumugam, M., Blaser, M. J., Claesson, M. J., Clarke, G., Cotter, P. D., De Sordi, L., Dominguez-Bello, M. G., Dutilh, B. E., Ehrlich, S. D., Ghosh, T. S., Hill, C., Junot, C., Lahti, L., Lawley, T. D., Licht, T. R. & Maguin, E., Makhalanyane, T. P., Marchesi, J. R., Matthijnssens, J., Raes, J., Ravel, J., Salonen, A., Scanlan, P. D., Shkoporov, A., Stanton, C., Thiele, I., Tolstoy, I., Walter, J., Yang, B., Yutin, N., Zhernakova, A., Zwart, H., Doré, J. & Ross, R. P., Mar-2025, In: Nature Reviews Microbiology. 23, p. 192–205 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Global genetic structure of human gut microbiome species is related to geographic location and host health

Andreu-Sánchez, S., Blanco-Míguez, A., Wang, D., Golzato, D., Manghi, P., Heidrich, V., Fackelmann, G., Zhernakova, D. V., Kurilshikov, A., Valles-Colomer, M., Weersma, R. K., Zhernakova, A., Fu, J. & Segata, N., 24-Jul-2025, In: Cell. 188, 15, p. 3942-3959.e9 28 p.

Research output: Contribution to journal › Article › Academic › peer-review