dr. J.T.M.L. (Judith) Paridaen

When making decisions on division mode and cell fates, stem cell integrate cell-intrinsic and -extrinsic signals and factors. Although several of these signals and factors have been identified, it is not clear how and when a stem cell selects its division mode and daughter cell fates. In our lab, we aim to understand how single stem cells make decisions on division mode and cell fates, and how these decisions affect developing and adult tissues. We employ single cell analyses, lineage tracing techniques and computational modeling to look at single stem cell behaviour in the developing and adult brain. We use the zebrafish and mouse as our main model systems. In particular, we are interested in the role of fate-determining factors such as signalling pathways and subcellular structures in symmetric and asymmetric stem cell divisions.

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