G. (Giovanni) Maglia, Prof

Telefoon:

E-mail:

giovanni.maglia rug.nl

Research interests

The main focus of our group is on the chemistry and biophysics of nanopores. We are engineering, modifying and redesigning these protein systems for applications in NanoBioTechnology and Single-Molecule Biophysics.

We are using biological nanopores in:

• Single-molecule enzymology

• Single-molecule sensing and DNA analysis

• Protein components for nanomachines

Research Group Webpage -Google pages

Research Group RUG Webpage

Publicaties

Assembly and the gating mechanism of the Pel exopolysaccharide export complex PelBC of Pseudomonas aeruginosa

Benedens, M., Rosales-Hernandez, C., Straathof, S. A. P., Loschwitz, J., Berninghausen, O., Maglia, G., Beckmann, R. & Kedrov, A., 5-jun.-2025, In: Nature Communications. 16, 1, 16 blz., 5249.

Onderzoeksoutput: Article › › peer review

Balancing Permeability and Stability: A Study of Hybrid Membranes for Synthetic Cells Using Lipids and PBd-b-PEO Block Copolymers

Presutti, C., Vreeker, E., Sasidharan, S., Ferdinando, Z., Stuart, M., Juhaniewicz-Dębińska, J., Maglia, G., Roos, W. H. & Poolman, B., 8-apr.-2025, (E-pub ahead of print) In: Biomacromolecules. 14 blz., 4c01651.

Onderzoeksoutput: Article › › peer review

Nanopore-Functionalized Hybrid Lipid-Block Copolymer Membranes Allow Efficient Single-Molecule Sampling and Stable Sensing of Human Serum

Vreeker, E., Grünewald, F., van der Heide, N. J., Bonini, A., Marrink, S. J., Tych, K. K. & Maglia, G., apr.-2025, In: Advanced materials. 37, 15, 15 blz., e2418462.

Onderzoeksoutput: Article › › peer review

Nanopores with an Engineered Selective Entropic Gate Detect Proteins at Nanomolar Concentration in Complex Biological Sample

Straathof, S., Di Muccio, G. & Maglia, G., 7-mei-2025, In: Journal of the American Chemical Society. 147, 18, blz. 15050-15065 16 blz., 4c17147.

Onderzoeksoutput: Article › › peer review

Alle (111) publicaties

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G. (Giovanni) Maglia, Prof

Research interests

Publicaties

Assembly and the gating mechanism of the Pel exopolysaccharide export complex PelBC of Pseudomonas aeruginosa

Balancing Permeability and Stability: A Study of Hybrid Membranes for Synthetic Cells Using Lipids and PBd-b-PEO Block Copolymers

Nanopore-Functionalized Hybrid Lipid-Block Copolymer Membranes Allow Efficient Single-Molecule Sampling and Stable Sensing of Human Serum

Nanopores with an Engineered Selective Entropic Gate Detect Proteins at Nanomolar Concentration in Complex Biological Sample

Toward single-molecule protein sequencing using nanopores

Allostery can convert binding free energies into concerted domain motions in enzymes

Blobs form during the single-file transport of proteins across nanopores

Controlled Translocation of Proteins through a Biological Nanopore for Single-Protein Fingerprint Identification

Controlling Electroosmosis in Nanopores Without Altering the Nanopore Sensing Region

Engineered nanopores for exopeptidase protein sequencing

Pers/media

Current Approaches to Protein Sequencing

ERC Proof of Concept subsidie om monitoren van patiënten met hartfalen te verbeteren

ERC Proof of Concept Grant to improve monitoring heart failure patients

Breakthrough: Protein Triumphantly Transmitted Through Nanopore!

Protein Successfully Transported Through a Nanopore

Engineered Nanopore Translocates Full Length Proteins

The Final Piece Required for Easy Protein Sequencing

The missing link to make easy protein sequencing possible?

Is There a Missing Link that Can Simplify Protein Sequencing?

Missing Link Discovered for Simplified Protein Sequencing