prof. dr. B.N. Melgert
Open positions: We are looking for a talented postdoc to complete our team. We have funding for a pioneering project studying the impact of microplastic (textile) fibers on lung tissue.
Project summary: Indoor dust contains vast amounts of small plastic fibers. These microfibers are small enough to be inhaled and plastic fibers have been detected in all samples of lung tissue of patients investigated for lung cancer. Owing to their size, shape and resistance to biological degradation, these microfibers have the potential to cause respiratory disease. Other types of air pollution (diesel exhaust, cigarette smoke) can adhere to microfibers and these chemicals may cause additional stress or toxicity to lung cells, making it harder for these patients to fight respiratory infections. At present, no studies have explored whether microfibers can affect cells in lung tissue. In this project, we aim to investigate the effects of microfibers, with and without adhered pollutants, on the cells that line the airways, because these are the first to come into contact with inhaled microfibers. We will be using lung organoids of epithelial cells, fibroblasts, and macrophages as our main model.
Details: project is for one year and candidate needs to start before May 2019. Experience with cell culture, lung science, and organoid culture is preferred. Please contact me by email for more info or to apply directly.
Ongoing Research Support
2019-2020 ZONMW Microplastics grant together with Prof Reinoud Gosens (GRIP), Dr Anna Salvati (GRIP), and Dr Matthew Cole (Plymouth Marine Laboratory). Coordinating PI: Barbro N. Melgert. Title: What is the impact of microplastic fibers on our lungs?
2017-2019 RESPIRE ERS/EU fellowship for Dr M. Kwiatkowski. Title: Proteomics-based Pharmacological Biochemistry (P2B2)” - A strategy to identify protein species and signaling pathways regulating inflammatory responses of pulmonary macrophages in NFκB-mediated inflammation and COPD.
2015 - 2020 Consortium grant from the Dutch Lung Fund together with Lutter of AMC and Martinez of Oxford University. Coordinating PI: Barbro N. Melgert. Title: Does high baseline oxidative stress attenuate macrophage function during exacerbations of COPD and asthma?
2014 - 2020 Grant from the Penderfonds of the Organisation of Dutch Pulmonary Fibrosis Patients to fund the exchange of human fibrotic lung tissue between RUG/UMCG and Erasmus MC in Rotterdam. PIs: Barbro N. Melgert and Bernt van der Blink.
Completed Research Support
2016- 2017 Grant from Roche for fibrosis research together with Olinga (GRIP) and Faber/Dijkstra (UMCG)
2011 – 2015 Start up grant from the Faculty of Mathematics and Natural Sciences of the University of Groningen. PI: Barbro N. Melgert. Title: The role of macrophages in the development of pulmonary fibrosis and COPD.
2011 – 2015 Research grant from the Netherlands Asthma Foundation. PI: Barbro N. Melgert. Title: The role of alternatively activated macrophages in the pathogenesis of asthma.
2006 – 2009 The role of sex hormones in the pathogenesis of asthma, funded by Netherlands Asthma Foundation, PI: Barbro N. Melgert
|Laatst gewijzigd:||03 maart 2019 18:43|