Although it has long been assumed that proteins only inherit their function from folding into a specific structure, there is now increasing evidence that natively unfolded proteins play an important role in many biological functions, such as nuclear transport. Transport of molecules in and out of the nucleus of eukaryotic cells is controlled by large protein complexes, called ‘nuclear pore complexes’ (NPCs), that are embedded in the nuclear membrane. The actual transport is mediated by natively unfolded proteins, FG-nucleoporins (FG-nups), forming a low-density cloud of flexible filaments that line the core region of the NPC. To explore how these FG-nups mediate transport we have developed a coarsegrained molecular dynamics model. I will discuss some recent results on the predicted spatial conformation of the FG-nups inside the transport channel and how this is encoded in the amino-acid sequence.
The Royal Netherlands Academy of Arts and Sciences (KNAW) has appointed Professor Maria Loi and Professor Dirk Slotboom from the Faculty of Science and Engineering as members of the Academy.
The Dutch Research Council (NWO) has awarded three Vici grants, worth €1.5 million each, to three UG researchers. Prof. J.W Romeijn, Prof. S. Hoekstra, Prof. K.I. Caputi can use this money to develop an innovative line of research and to set up...
Reaching out to sustainable business owners is what Gjalt de Jong is all about. He sees the University as a director of innovation. An independent arbiter who can expedite the shift to a circular economy. To this end, he first needed to change...
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