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OnderzoekVan Swinderen Institute

Prof.dr. Patrick Onck, University of Groningen, The Netherlands

20 June 2013

Speaker: Prof.dr. P. Onck
Affiliation: Zernike Institute for Advanced Materials, University of Groningen
Title: Biophysics of Natively Unfolded Proteins
Date: 20 June 2013
Start: 16:00 (Doors open and coffee available at 15:30)
Location: FWN-Building 51.11.0080
Host: T.L.C. Jansen

Abstract:

Although it has long been assumed that proteins only inherit their function from folding into a specific structure, there is now increasing evidence that natively unfolded proteins play an important role in many biological functions, such as nuclear transport. Transport of molecules in and out of the nucleus of eukaryotic cells is controlled by large protein complexes, called ‘nuclear pore complexes’ (NPCs), that are embedded in the nuclear membrane. The actual transport is mediated by natively unfolded proteins, FG-nucleoporins (FG-nups), forming a low-density cloud of flexible filaments that line the core region of the NPC. To explore how these FG-nups mediate transport we have developed a coarsegrained molecular dynamics model. I will discuss some recent results on the predicted spatial conformation of the FG-nups inside the transport channel and how this is encoded in the amino-acid sequence.

Last modified:12 September 2014 11.22 a.m.

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