The Membrane Enzymology group focuses on the molecular mechanisms of transport across biological membranes and the biogenesis of membrane (transport) proteins. In other words: How do molecules permeate biological membranes, how and where are the transport proteins synthesized and how do they travel to specific locations? We develop and use state-of-the-art approaches to probe the activity, position and traffic of individual molecules in the cell, and we combine the ‘ensemble’ enzymology and X-ray crystallography studies with (single-molecule) microscopy to yield mechanistic insight in membrane transport.
Our main website is at http://www.membraneenzymology.com
Recent research highlights:
- Dr Albert Guskov has been awarded NWO Vidi grant of 800.000 euro for his research project about structure and function of Co/Ni transporters
- Professor Poolman has been awarded ERC advanced grant of 2.5 million euro for his research project "ABCVolume: The ABC of Cell Volume Regulation"
- The first vizualiton of how ABC-transporter works at the single molecule level (see also the press-release here)
- The first crystal structure of membrane transporter with 3+1+3 toplogy (see also the press-release here)
|Last modified:||29 May 2019 2.57 p.m.|