The Membrane Enzymology group focuses on the molecular mechanisms of transport across biological membranes and the biogenesis of membrane (transport) proteins. In other words: How do molecules permeate biological membranes, how and where are the transport proteins synthesized and how do they travel to specific locations? We develop and use state-of-the-art approaches to probe the activity, position and traffic of individual molecules in the cell, and we combine the ‘ensemble’ enzymology and X-ray crystallography studies with (single-molecule) microscopy to yield mechanistic insight in membrane transport.
Our main website is at http://www.membraneenzymology.com
Recent research highlights:
- Dr Albert Guskov has been awarded NWO Vidi grant of 800.000 euro for his research project about structure and function of Co/Ni transporters
- Professor Poolman has been awarded ERC advanced grant of 2.5 million euro for his research project "ABCVolume: The ABC of Cell Volume Regulation"
- The first vizualiton of how ABC-transporter works at the single molecule level (see also the press-release here)
- The first crystal structure of membrane transporter with 3+1+3 toplogy (see also the press-release here)
The group is embedded in the research schools Groningen Biomolecular Sciences and Biotechnology Institute (GBB) and the Zernike Institute for Advanced Materials. The group also is part of the Centre for Synthetic Biology (CSB) and participates in the Netherlands Proteomics Centre (NPC).
|Last modified:||19 May 2015 3.01 p.m.|