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About us Faculty of Science and Engineering Our Research GRIP PharmacoTherapy, -Epidemiology & -Economics (PTEE)

Master projects

Master projects may concern any of the elements in PTEE: Pharmaco therapy, - epidemiology and - economy. Also connections to Nivel, Lareb and (hospital) pharmacies exist, allowing for interesting research projects.

For more information on requirements and procedures concerning master projects, please consult the study info for Pharmacy: https://student.portal.rug.nl/infonet/studenten/fse/programmes/msc-far/curriculum/masterproject,

or MPS: https://student.portal.rug.nl/infonet/studenten/fse/programmes/msc-bms/curriculum/research-project

To find a suitable project, please contact the available supervisors below. This works best via email, with a short description of your background and interests.

Eelko Hak :

Prof Hak's group is involved in real-world data-analysis of drug effects and safety as well as in trends in drug use. His interest is in applying novel designs and analytical strategies to deal with confounding by indication. Topics include drugs in diabetes, pregnancy, ashtma/COPD, infections, cardiovascular and neurological diseases. Most studies are done with the in-house IADB.nl prescription database sometimes in combination with the Lifelines database (PharmLines). Questionnaire studies, focus group interviews or audits are infrequently applied.

Katja Taxis :

Talitha Feenstra:

The Pharmaco-eocnomics group at PTEE is lead by Professor Dr Feenstra. Talitha Feenstra does research on economic evaluations of personalized care by precision medicine. In ongoing projects, she supports adaptive and targeted prevention and treatment using patient level modelling in diabetes mellitus (RHAPSODY, DIAMANT, PROMINENT) and mental health care (IMPROVE). Observational data, mostly based on routine data from daily clinical practice are available for analysis as part of these projects.

Next to this, she performs methodological research on the role of pharmaco-economic decision models. For more information you can visit her MEPA page: https://www.rug.nl/staff/t.l.feenstra/

Master thesis projects are available mostly in two research lines:

A. Diabetes related work

B. Mental illnesses related work

Projects in pharmacoeconomics mostly concern a substantial amount of statistics and require students with analytical skills and an interest in working in a multidisciplinary team.

Nynke Schuiling-Veninga :

As a senior lecturer, Dr Nynke Schuiling-Veninga is involved in education and research within the fields of pharmacoepidemiology, pharmacotherapy and pharmacy practice research. She supervises bachelor- and master research projects done with the in-house IADB.nl prescription database focusing on the effects and safety of drugs use and trends in the utilization of drugs. Especially the use and safety of drugs during pregnancy and use and safety of psychotropic drugs have her interest. Besides this, many other topics have her interest too like the treatment of neurological disorders (migraine, epilepsy), prescribing of antibiotics and utilization of drugs among children and adolescents.

Liset van Dijk :

Liset van Dijk is professor of Pharmacy Health services research (https://www.nivel.nl/nl/medewerker/l-liset-van-dijk). Her work concentrates on pharmacy practice and policy research. Main research areas include: adherence tot medication, patient-pharmacist communication, the patient perspective on medication use, organisation of primary care, implementation research and e-health solutions to support medication use. In Liset's research line a wide variety of research methods are applied: quantitative (survey, database analyses) and qualitative (interviews, focus groups, video observations) and mixed-method. Liset works together with different organisations and connects students with these organisations. In 2019-2021 students worked together with Nivel, Pharmi, Radboudumc, Health Base and Harteraad. Liset is the coordinator of the Make It consortium that studies implementation of medication adherence interventions (https://makeitconsortium.nl/). For this project, several master projects will become available the upcoming years

Eric van Roon :

Prof van Roon offers possibilities tot conduct your master research project in het hospital setting. In cooperation with PhD students ((hospital) pharmacists, medical specialists) you work on projects that have a very close relation to daily clinical practice in the intramural setting. The research questions are characterized by a high level of direct clinical relevance. The fields of research are very diverse, for example within the field of haemato-oncology, anticoagulation, bariatric pharmacology and hospital psychiatry. Locations are large teaching or peripheral hospitals in the Northern part of The Netherlands. Besides the focus on your research project all hospitals offer the possibility to dive deeper into the intramural care setting. This facilitates the development of your idea whether to pursue a career as hospital pharmacist.

Eugène van Puijenbroek :

Pharmacovigilance is the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other medicine-related problem. It is one of the topics addressed by the Pharmacy, PharmacoTherapy, - Epidemiology & -Economics. Group. Prof Dr van Puijenbroek is endowed professor of pharmacovigilance and head Science and research at Pharmacovigilance Centre Lareb. His field of attention is the development of signal detection methodologies by means of collecting and interpreting information about adverse reactions of drugs used in daily practice. See also: https://www.rug.nl/staff/e.p.van.puijenbroek/

Master thesis projects focus on the following topics:

1. Methodological development is signal detection strategies

2. Study of specific drug safety signals in the post-marketing phase

3. Adverse events associated with drug exposure during pregnancy

Methods apply may vary and entail the analysis the (inter-) national pharmacovigilance database(s), observational studies or surveys. For most studies, affinity with data-analysis and epidemiology, basic knowledge of medical terminology is needed

Frank Jansman:

Research internship Deventer Teaching Hospital:

The effect of antiandrogens on the pharmacokinetics of

analgesics in men with prostate cancer

Background

Prostate cancer is the second most diagnosed cancer in men worldwide, with an incidence of 29.3

per 100,000 men. The treatment of prostate cancer depends on the severity of the disease and the

condition of the patient. Hormonal treatment is effective for a long time, but in most patients cancer

cells find other ways to feed and the tumor starts to grow again over time. Agents that are often

used are anti-androgens. In metastatic prostate cancer, in 90% of the cases, metastasis occurs in the

bones. Analgesic drugs are often used for these metastases. However, some analgesics have clinically

relevant interactions with antiandrogens due to CYP induction. The pharmacokinetics of the

combination have never been studied and may be of great added value in the pain management of

prostate cancer patients.

Objective of research

To investigate the effect of antiandrogens on the pharmacokinetics of analgesics in men with

prostate cancer.

What are you going to do?

As a research student, you will include patients, collect data on co-medication, co-morbidities and

other relevant data, help the analysts with the analysis of the plasma and ultimately investigate the

possible effect of antiandrogens on the pharmacokinetics of painkillers. In addition, the assignment

can be expanded with other relevant studies into knowledge gaps within oncology and/or pain relief.

What does it yield?

During this internship you will learn a lot about the collaboration between hospital pharmacy,

urology and oncology, the different analytical methods of medicines and the perception of patients

with cancer. You will also have the opportunity to gain clinical experience. In addition, you will be

introduced to working in a hospital pharmacy and you will participate in team meetings, you will be

able to attend substantive presentations and you will meet nice colleagues. Do you have any specific

learning goals in the hospital? Let us know and we can see what we can do for you!

What are we looking for?

An enthusiastic master pharmacy student with an interest in hospital pharmacy, who has good

communication skills, is critical and can work independently.

When?

The entire study will take place from July 2021 to December 2022 as part of the registration as a

hospital pharmacist of one of our residents. For this research assignment we are looking for a master

pharmacy student from September-December 2021 to February-May 2022. Enthusiastic, but just

looking for other dates? Feel free to give us a call, then we can look at suitable dates together!

Interested in this assignment?

Do you have any questions or are you interested in carrying out this assignment? Please contact prof

Frank Jansman or Suzan Detert Oude Weme via: f.jansman@dz.nl, s.detertoudeweme@dz.nl or

0570-536000.

Last modified:30 August 2021 2.30 p.m.
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