Skip to ContentSkip to Navigation
About us Faculty of Science and Engineering Our Research GRIP News and activities

Pharmacokinetics and optimal exposure of antifungal drugs in critically ill patients

01 June 2015

In her thesis Kim van der Elst has evaluated the behavior and the exposure of antifungal drugs and established the relation with the treatment outcome in critically ill adults and children. Furthermore, she has developed noninvasive sampling methods to facilitate monitoring of drug concentrations in blood/body fluids. She has shown that the antifungal drug exposure in critically ill adults and children is often inadequate with the standard dose.

With the growing number of immunocompromised and critically ill patients, as the result of aggressive cancer treatment and immunosuppressive treatment after organ transplantation, the incidence of invasive fungal disease has increased in recent years. However, the behavior of a drug in the body and the blood concentration of the drug can be altered in critically ill patients compared to healthy people.

Adequate exposure is essential for an effective treatment, and ultimately, for improved outcome. The findings of Van der Elst call for the development of a more personalized therapy for patients with invasive fungal disease. This treatment should be based on the characteristics of the fungus and on the characteristics of the patient (underlying disease and treatment of the disease, leading to altered drug behavior). With this strategy, adequate antifungal treatment can be achieved with the current arsenal of antifungal drugs.

PhD defence:


June 05, 2015




prof. dr. J.G.W. (Jos) Kosterink , prof. dr. T.S. (Tjip) van der Werf


Academy building RUG


Mathematics and Natural Sciences

Kim van der Elst
Kim van der Elst
Last modified:17 June 2019 5.39 p.m.
View this page in: Nederlands

More news

  • 04 March 2024

    A plant-based sensor

    Every two weeks, UG Makers puts the spotlight on a researcher who has created something tangible, ranging from homemade measuring equipment for academic research to small or larger products that can change our daily lives. That is how UG...

  • 11 December 2023

    Join the 'Language and AI' community

    As a part of the Jantina Tammes School, the 'Language and AI' theme is an interdisciplinary initiative that aims to encourage collaboration among academics, PhD candidates, students, and industry representatives who share a keen interest in the...

  • 13 October 2023

    Moniek Tromp appointed Captain of Science of the Top Sector Chemistry

    Prof. Moniek Tromp has been appointed Captain of Science of the Chemistry Top Sector by the Minister of Economic Affairs and Climate Policy. As from 1 July 2023, she succeeded Prof. Bert Weckhuysen from Utrecht University.