During the Dutch Longdagen 2016, Dr. Loes Kistemaker, research group Molecular Pharmacology of the Groningen Research Institute of Pharmacy (GRIP), was awarded the NRS Swieringa Thesis Award. Loes Kistemaker received the award together with a price of € 4.500,-. The
Swieringa Thesis Awarded
is granted annually to the best thesis in the field of lung diseases, diagnostics and therapy.
obtained her PhD
in March 2015 and was rewarded the classification cum laude.
She graduated under the supervision of Prof. R. Gosens, Prof. H. Meurs (GRIP) and
Prof. H. Kerstjens (UMCG).
The studies Loes Kistemaker described in her thesis have revealed that acetylcholine contributes to airway
inflammation and remodeling in asthma and Chronic Obstructive Pulmonary Disease (COPD) specifically via M3 muscarinic receptors. In addition, she provided the first evidence that inflammation in COPD is in part mediated by the neurotransmitter acetylcholine. This suggests that patients with asthma or COPD might benefit from M3-selective antagonists to a much larger extent than previously appreciated.
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