Interfaculty Mass Spectrometry Center
Interfaculty Mass Spectrometry Center (IMSC)
Mass spectrometry services and infrastructure for LC-MS/MS analysis, proteomics, and metabolomics.
Our facility supports all research groups at the University of Groningen (UG) and the University Medical Center Groningen (UMCG) as well as external academic and commercial customers in their efforts to characterize or quantify molecules of chemical, biological, and pharmaceutical interest.
Our facility has drawn up standard protocols for proteomics analysis and offers scientific expertise in collaborative research aimed at developing new sample preparation methods, analytical techniques, and specific bioinformatics analysis approaches for proteomics and metabolomics analysis.
We support the full process of sample preparation, LC-MS analysis, and data analysis and provide expertise in experimental design, data processing and analysis, and multi-omics data integration.
The available equipment includes:
A wide range of mass spectrometers (MSs):
- Orbitraps
- QTOFs
- Triple quadrupoles
- MALDI-TOF & Mass spectrometry imaging
Sample preparation and separation systems:
- Liquid chromatography (HPLC, UPLC, NanoLC)
- Capillary electrophoresis (CE)
- Automated liquid-handling
Freely available and commercial data processing tools:
- Spectronaut, PEAKS, Proteome Discoverer, MSFragger, MaxQuant
- Skyline, MSDIAL, MZmine
- GlycoGenius, PASTAQ
- SCiLS