Targeted delivery of TRAIL for immunotherapy of ovarian cancer
PhD ceremony: Mr. M. de Bruyn, 11.00 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Targeted delivery of TRAIL for immunotherapy of ovarian cancer
Promotor(s): prof. A.G.J. van der Zee, prof. L.F.H.M. de Leij
Faculty: Medical Sciences
In this thesis, the concept of tumour-targeted delivery of sTRAIL was further developed in preclinical studies with an emphasis on eliminating metastasis and disseminated disease. In addition, this tumour cell-targeted approach was adapted to an immune cell-targeted approach with the goal of augmenting anti-tumour activity of T-cells. Selective delivery of high levels of TRAIL to the cell surface of T-cells, a key tumoricidal immune effector cell population, strongly augments their anti-tumour activity. This novel approach proved to be highly effective towards a host of different tumour cell types, including ovarian cancer.
Last modified: | 13 March 2020 01.02 a.m. |
More news
-
29 April 2024
Tactile sensors
Every two weeks, UG Makers puts the spotlight on a researcher who has created something tangible, ranging from homemade measuring equipment for academic research to small or larger products that can change our daily lives. That is how UG...
-
29 April 2024
Royal Decoration awarded to Gerard van den Berg
The Faculty of Economics and Business is very proud to announce that Professor Gerard van den Berg has been appointed Officer of the Order of Orange-Nassau. The decoration was presented to him by Mayor Koen Schuiling of the Municipality of...
-
18 April 2024
PET-scan expert Jan Pruim benoemd tot Officier in Orde van Oranje Nassau
Hoogleraar medische beeldvorming Jan Pruim is bij zijn afscheid van het UMCG benoemd tot Officier in de Orde van Oranje Nassau. De koninklijke versierselen werden hem op woensdag 17 april uitgereikt door burgemeester Koen Schuiling van de gemeente...