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Research projects Health and Food

Below an overview of all research within the flagship Health and Food.

2021

Sizoo, D., de Heide, L. J. M., Emous, M., van Zutphen, T., Navis, G., & van Beek, A. P. (2021). Measuring Muscle Mass and Strength in Obesity: A Review of Various Methods. Obesity Surgery, 31(1), 384-393. https://doi.org/10.1007/s11695-020-05082-2
van den Broek, M., de Heide, L. J. M., Sips, F. L. P., Koehorst, M., van Zutphen, T., Emous, M., van Faassen, M., Groen, A. K., van Riel, N. A. W., de Boer, J. F., van Beek, A. P., & Kuipers, F. (2021). Altered bile acid kinetics contribute to postprandial hypoglycaemia after Roux-en-Y gastric bypass surgery. International Journal of Obesity. https://doi.org/10.1038/s41366-020-00726-w

2020

Beumeler, L., van Wieren, A., Buter, H., van Zutphen, T., Bruins, N., de Jager, C., Koopmans, M., Navis, G., & Boerma, C. (2020). Patient-reported physical functioning is limited in almost half of critical illness survivors 1-year after ICU-admission: A retrospective single-centre study. PLoS ONE, 15(12), [e0243981]. https://doi.org/10.1371/journal.pone.0243981
de Boer, J. F., de Vries, H. D., Palmiotti, A., Li, R., Doestzada, M., Hoogerland, J. A., Fu, J., La Rose, A. M., Westerterp, M., Mulder, N. L., Hovingh, M. V., Koehorst, M., Kloosterhuis, N. J., Wolters, J. C., Bloks, V. W., Haas, J. T., Dombrowicz, D., Staels, B., van de Sluis, B., & Kuipers, F. (2020). Cholangiopathy and biliary fibrosis in Cyp2c70-deficient mice are fully reversed by ursodeoxycholic acid. Cellular and molecular gastroenterology and hepatology. https://doi.org/10.1016/j.jcmgh.2020.12.004
Visser, E., Geleijnse, J. M., & de Roos, B. (2020). Inter-individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: a Critical Review. Molecular Nutrition & Food Research, 64(7), [e1900479]. https://doi.org/10.1002/mnfr.201900479

2019

Beumeler, L., Bruins, N., de Jager, C., Buter, H., Koopmans, M., van Zutphen, T., & Boerma, C. (2019). Long-term physical recovery after critical illness is limited. 55-55. Poster session presented at 32nd Annual Congress of the European Society of Intensive Care Medicine (ESICM LIVES 2019), Berlijn, Germany. https://icm-experimental.springeropen.com/track/pdf/10.1186/s40635-019-0265-y
de Boer, J. F., Verkade, E., Mulder, N. L., de Vries, H. D., Huijkman, N. C., Koehorst, M., Boer, T., Wolters, J. C., Bloks, V. W., van de Sluis, B., & Kuipers, F. (2020). A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]. Journal of Lipid Research, 61(3), 291-305. https://doi.org/10.1194/jlr.RA119000243
de Boer, J. F., Verkade, E., Mulder, N. L., de Vries, H. D., Huijkman, N., Koehorst, M., Boer, T., Wolters, J. C., Bloks, V. W., van de Sluis, B., & Kuipers, F. (2019). A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice. Journal of Hepatology, 70, E25-E26.
De Boer, J. F., de Vries, H. D., Palmiotti, A., Li, R., Mulder, N. L., Hovingh, M. V., Koehorst, M., Kloosterhuis, N. J., Bloks, V. W., van de Sluis, B., & Kuipers, F. (2019). A HUMAN-LIKE COMPOSITION OF THE CIRCULATING BILE ACID POOL IMPACTS ON PLASMA LDL CHOLESTEROL IN MICE. ATHEROSCLEROSIS, 287, E14-E14. https://doi.org/10.1016/j.atherosclerosis.2019.06.038
van Zutphen, T., Bertolini, A., de Vries, H. D., Bloks, V. W., de Boer, J. F., Jonker, J. W., & Kuipers, F. (2019). Potential of Intestine-Selective FXR Modulation for Treatment of Metabolic Disease. In Bile Acids and Their Receptors (pp. 207-234). (Handbook of Experimental Pharmacology). Springer. https://doi.org/10.1007/164_2019_233
Heeman, W., Dijkstra, K., Hoff, C., Koopal, S., Pierie, J-P., Bouma, H., & Boerma, E. C. (2019). Application of laser speckle contrast imaging in laparoscopic surgery. Biomedical optics express, 10(4), 2010-2019. https://doi.org/10.1364/BOE.10.002010
Heeman, W., Steenbergen, W., van Dam, G., & Boerma, E. C. (2019). Clinical applications of laser speckle contrast imaging: a review. Journal of Biomedical Optics, 24(8), 1-11. https://doi.org/10.1117/1.JBO.24.8.080901
van Zutphen, T., Stroeve, J. H. M., Yang, J., Bloks, V. W., Jurdzinski, A., Roelofsen, H., Huijkman, N. C. A., van Dijk, T. H., Vonk, R. J., van Deursen, J., Staels, B., Groen, A. K., & Kuipers, F. (2019). FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements[S]. Journal of Lipid Research, 60(9), 1547-1561. https://doi.org/10.1194/jlr.M094508
Zwarts, I., van Zutphen, T., Kruit, J. K., Liu, W., Oosterveer, M. H., Verkade, H. J., Uhlenhaut, N. H., & Jonker, J. W. (2019). Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR. Scientific Reports, 9(1), [9299]. https://doi.org/10.1038/s41598-019-45803-x

2018

Beumeler, L. F. E., Waarsenburg, E. C., Booij, S. H., Scheurink, A., & Hoenders, H. J. R. (2018). Evaluation of a lifestyle intervention program in primary care on physical and mental health and quality of life of cancer survivors: A pilot study. European Journal of Integrative Medicine, 23, 1-5. https://doi.org/10.1016/j.eujim.2018.08.007
Visser, E., de Roos, N. M., Oosting, E., Endenburg, S. C., & Dronkers, J. J. (2018). Association Between Preoperative Vitamin D Status and Short-Term Physical Performance after Total Hip Arthroplasty: A Prospective Study. Annals of nutrition and metabolism, 73(3), 252-260. https://doi.org/10.1159/000492938

2017

Doktorova, M., Zwarts, I., van Zutphen, T., van Dijk, T. H., Bloks, V. W., Harkema, L., de Bruin, A., Downes, M., Evans, R. M., Verkade, H. J., & Jonker, J. W. (2017). Intestinal PPARĪ“ protects against diet-induced obesity, insulin resistance and dyslipidemia. Scientific Reports, 7(1), [846]. https://doi.org/10.1038/s41598-017-00889-z

2016

Liu, W., Struik, D., Nies, V. J. M., Jurdzinski, A., Harkema, L., de Bruin, A., Verkade, H. J., Downes, M., Evans, R. M., van Zutphen, T., & Jonker, J. W. (2016). Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. Proceedings of the National Academy of Sciences of the United States of America, 113(8), 2288-2293. https://doi.org/10.1073/pnas.1525093113
Nies, V. J. M., Sancar, G., Liu, W., van Zutphen, T., Struik, D., Yu, R. T., Atkins, A. R., Evans, R. M., Jonker, J. W., & Downes, M. R. (2016). Fibroblast Growth Factor Signaling in Metabolic Regulation. Frontiers in endocrinology, 6, [193]. https://doi.org/10.3389/fendo.2015.00193
van Zutphen, T., Ciapaite, J., Bloks, V. W., Ackereley, C., Gerding, A., Jurdzinski, A., de Moraes, R. A., Zhang, L., Wolters, J. C., Bischoff', R., Wanders, R. J., Houten, S. M., Bronte-Tinkew, D., Shatseva, T., Lewis, G. F., Groen, A. K., Reijngoud, D-J., Bakker, B. M., Jonker, J. W., ... Bandsma, R. H. J. (2016). Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. Journal of Hepatology, 65(6), 1198-1208. https://doi.org/10.1016/j.jhep.2016.05.046
Sargent, G., van Zutphen, T., Shatseva, T., Zhang, L., Di Giovanni, V., Bandsma, R., & Kim, P. K. (2016). PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation. The Journal of Cell Biology, 214(6), 677-690. https://doi.org/10.1083/jcb.201511034

2015

Bandsma, R. H. J., Ackerley, C., Koulajian, K., Zhang, L., van Zutphen, T., van Dijk, T. H., Xiao, C., Giacca, A., & Lewis, G. F. (2015). A low-protein diet combined with low-dose endotoxin leads to changes in glucose homeostasis in weanling rats. American Journal of Physiology - Endocrinology and Metabolism, 309(5), E466-E473. https://doi.org/10.1152/ajpendo.00090.2015

2014

van Zutphen, T., Todde, V., de Boer, R., Kreim, M., Hofbauer, H. F., Wolinski, H., Veenhuis, M., Klei, I. J. V. D., & Kohlwein, S. D. (2014). Lipid droplet autophagy in the yeast Saccharomyces cerevisiae. Molecular Biology of the Cell, 25(2), 290-301. https://doi.org/10.1091/mbc.E13-08-0448

2011

van Zutphen, T., Veenhuis, M., & van der Klei, I. J. (2011). Damaged peroxisomes are subject to rapid autophagic degradation in the yeast Hansenula polymorpha. Autophagy, 7(8), 863-872. https://doi.org/10.4161/auto.7.8.15697
van Zutphen, T., & van der Klei, I. J. (2011). Quantitative analysis of organelle abundance, morphology and dynamics. Current Opinion in Biotechnology, 22(1), 127-132. https://doi.org/10.1016/j.copbio.2010.10.015

2010

van Zutphen, T., Baerends, R. J. S., Susanna, K., de Jong, A., Kuipers, O. P., Veenhuis, M., & van der Klei, I. J. (2010). Adaptation of Hansenula polymorpha to methanol: A transcriptome analysis. BMC Genomics, 11(1). https://doi.org/10.1186/1471-2164-11-1
Zutphen, T. V. (2010). Proliferation and autophagic degradation of peroxisomes in Hansenula polymorpha. s.n.

2009

Zutphen, T. V., Klei, I. J. V. D., & Kiel, J. A. K. W. (2009). Pexophagy in Hansenula polymorpha. In D. J. Klionsky (Ed.), Autophagy: Lower Eukaryotes and non-Mammalian Systems (Vol. 1, pp. 197-125). (Methods in Enzymology; Vol. 451). Elsevier.

2008

van Zutphen, T., van der Klei, I. J., & Kiel, J. A. K. W. (2008). Pexophagy in Hansenula polymorpha. In DJ. Klionsky (Ed.), AUTOPHAGY: LOWER EUKARYOTES AND NON-MAMMALIAN SYSTEMS, PT A (pp. 197-215). (Methods in Enzymology; Vol. 451). Academic Press. https://doi.org/10.1016/S0076-6879(08)03214-X
van Zutphen, T., van der Klei, I. J., & Kiel, J. A. K. W. (2008). Pexophagy in Hansenula polymorpha. Methods Enzymol., 451, 197 - 215.
Zutphen, T. V., Veenhuis, M., & Klei, I. J. V. D. (2008). Pex14 is the sole component of the peroxisomal translocon that is required for pexophagy. Autophagy, 4(1), 63-66.

2007

Stasyk, O. G., Van Zutphen, T., Kang, H. A., Stasyk, O. V., Veenhuis, M., & Sibirny, A. A. (2007). The role of Hansenula polymorpha MIG1 homologues in catabolite repression and pexophagy. Fems Yeast Research, 7(7), 1103-1113. https://doi.org/10.1111/j.1567-1364.2007.00286.x
Last modified:21 April 2021 08.59 a.m.