Pediatric and Congenital Cardiology

cardiology/electrophysiology

Heart Failure
Translational cardiology

Medical Technology Assessment comprises economic evaluation in health care, ethical and legal issues as well as issues regarding implementation and reimbursement of innovative technologies.

Molecular Biology
Ageing Biology
Stem Cell Biology
Cardiovascular Regenerative Medicine

Clinical Pharmacology, Drug Utilization Research, diabetes & cardiovascular risk factor treatment.

Cardiology with special attention for electrophysiology and arrhythmias

I am an interventional cardiologist and scientist. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction.

My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website: www.cardiomics.net

In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/mHealth to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; www.early-synergy.nl) studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies.

Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Vascular remodeling in chronic diseases such as chronic kidney disease, diabetes, and solid organ transplants

Obesity, aging and associated diseases (insulin resistance, type 2 Diabetes, Nonalcoholic fatty liver disease, diabetic cardiomyopathy) with specific emphasis on the role of fatty acid metabolism and metabolic inflammation in mice.

Insulin resistance and related disorders.
Development and conduct of long term randomized controlled trials in patients with insulin resistance during early and advanced type 2 diabetes (POEM and HOME studies) to improve clinically relevant, metabolic and vascular outcomes.
Healthy aging, and early healthy aging.

Endothelial cells, endothelial dysfunction, endothelial-mesenchymal transition, mitochondrial dysfunction, mitochondrial medicines, microRNA, epigenetics,  inflammation, heart failure, cardiac fibrosis, atherosclerosis, vascular calcification, (diabetic) retinopathy, kidney disease.

Vasculaire Geneeskunde:
- Hypertensie
- Diabetes Mellitus
- Hypercholesterolemie
- Premature atherosclerose
- Perifeer vaatlijden
- Cardiovasculaire schade door kankerbehandeling

Vascular Grafts
Regenerative Medicine
Tissue Engineering
Mesenchymal Stem/Stromal Cells
Extracellular Matrix
Hydrogels
Biomaterials

Coronary artery disease
Myocardial infarction
Interventional cardiology

hartfalen
implanteerbare cardiale devices

General adult cardiac surgery. Specific interest in minimally invasive techniques, valve-sparing surgery, complex aortic surgery, rhythm surgery and thoracic transplantations (heart, lung and heart-lung). Main research field are the developement of new surgical tools, in collaboration with TU Twente and mechatronic companies, and pre-habilitation program for cardiac surgery. Founder of the pre-habilitation program in Beatrixoord and PI of the related the Heart-ROCQ study.

Hartfalen
Experimentele cardiologie

Professor Oudkerk is professor of Radiology at the University of Groningen, Chief Scientific Officer of the Institute for Diagnostic Accuracy- iDNA (formerly of the Center of Medical Imaging Norht East Netherlands (CMI-NEN) , NWO research Center of Exellence) and the principal investigator for Radiology of the NELSON lung cancer detection study. Founder and past president of the European Society of Cardiac Radiology and former Chairman of Radiology departments of DDHK Erasmus MC Rotterdam and University Medical Center Groningen. Prof. Oudkerk has a broad insight into new imaging modalities, algorithms and strategies. He is ranked as one the most influential researchers in Radiology in Europe (2019). For his research work he received prestigious grants such as ERC advanced grant, Royal Academy of Sciences of the Netherlands (KNAW), Ministry of Science and Technology of China, NWO, KWF, NKB grants etc.He is lead investigator of the NELSON lungcancer detection study, the ROBINSCA study for coronary disease detection, NELCIN B3 study in China focusing on Lungcancer , coronary artery disease and pulmonary disease  in one imaging test. Many of the current and new guidelines are derived from his original work. For example- Diagnostic management strategies for pulmonary embolism, lungcancer screening, imaging of the myocardial ischaemic cascade etc-furthermore the introduction of High Power Gradient Magnetic Resonance Imaging and body MRI in Europe- Introduction of the first continuous rotating spiral computed tomography scanner. Prof. Oudkerk was invited as a member of the medical advisory board of Siemens AG, Germany for development of the first continuous rotating spiral CT and has been part of this board until the development of the current volume multi-detector CT scanners pushing forward the need for higher temporal resolutions in CT scanning comparable with EBT. With his researchteam he initiated the field of CT coronary imaging; / EBT coronary angiography- use of volume rendering for cardiac CT- fly-through coronary arteries on CT (CT angioscopy)- MDCT coronary angiography- 4D MDCT coronary visualization- MDCT thrombus detection in ACS- and he initiated in the field of CT lung cancer screening new management strategies for early lung cancer detection of the prospective multi-center lung cancer screening study (NELSON) since 2000. Other research activities are non-invasive testing of coronary atherosclerosis ( by- passing more than 20 indirect tests), imaging of  liver metastasis, coronary calcium scoring, vena cava stenting, MR infarct imaging, CT recognition of acute aortic dissection, infusion rate of contrast agents in small bowel imaging /, as well as the concept of high power gradient body MR generating many spin-off scientific publications. He has an influential vision on the future of imaging and health care, which has been rewarded with international awards and invitations to lecture on (inter-)national platforms Prof. Oudkerk has achieved to independently receive external financing for several research projects.  Cooperation with international partners throughout the world (among others, England, Poland, USA, China) in multidisciplinary multi-center studies. Prof. Oudkerk is inspiring many (inter-)national students to start their PhD research in his department, resulting in several PhD defenses per year.Prof Oudkerk published more than 555 peer reviewed articles, is cited over 20,000 times with an H-index >70 (Scopus June 2019). Key publications in NEJM, Lancet, Thorax, Circulation, JACC, Eur Heart, Radiology, Lancet Oncology, etc.

Arrhythmias, in particular Atrial fibrillation; Heart failure; Implantable cardiac devices

Cardiovasculair
Botdichtheid

Genetic Epidemiology of (risk factors for) cardiovascular disease and type 2 diabetes

Heart Failure, Cardiovascular Risk and Primary Prevention

Cardiac Fibrosis
Regenerative Medicine
Tissue Engineering
Mesenchymal Stem/Stromal Cells
Endothelial-to-Mesenchymal Transition
Fibroblast Differentiation
Extracellular Matrix
Hydrogels

Epidemiology of chronic kidney disease
Socio-demographic determinants of chronic kidney disease
Causality in observational studies
Estimation of the burden of disease

Heart failure

Cardiovascular Diseases, Atherosclerosis, Lipoprotein Metabolism, Cholestrol Efflux Pathways, Inflammation

Clinical Pharmacology, Albuminuria, Renal function, Clinical Trials