Melgert, Prof. Barbro
Barbro Melgert is Professor of Respiratory Immunology at the Faculty of Science and Engineering. She studies how immune cells in the lungs respond to harmful environmental influences, including microplastics. Since 2018, she has received grants to investigate the effects of microplastics on the lungs.
When clothing made of synthetic fabrics is worn, washed, or dried, invisible, tiny plastic particles are released into the air: microplastics. With her team, Melgert demonstrated that nylon fibers from clothing disrupt the development of airways in lab-grown mini-lungs.
Melgert stresses that exposure to microplastics is an issue that must be addressed not only by consumers, but also by industry and government. Still, individuals can take steps to protect themselves. Her practical advice: vacuum regularly, ventilate your home well, and opt for more sustainable clothing instead of fast fashion.
Previously in the news
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A healthy planet means healthy people (in Dutch)
2025
Inno4Vac
respiratory models team, Ekanger, C. T., Dinesh Kumar,
N., Koutstaal, R. W., Zhou, F., Beukema, M.,
Waldock, J., Jochems, S. P., Mulder, N., van Els, C. A. C. M.,
Engelhardt, O. G., Mantel, N., Buno, K. P., Brokstad, K. A.,
Engelsen, A. S. T., Cox, R. J., Melgert, B. N.,
Huckriede, A. L. W., & van Kasteren, P. B. (2025).
Comparison of air-liquid interface transwell and airway
organoid models for human respiratory virus infection
studies. Frontiers in Immunology,
16, Article 1532144. https://doi.org/10.3389/fimmu.2025.1532144
Xiao,
Z., Osipyan, A., Song, S.,
Chen, D., Schut, R. A., van Merkerk, R.,
van der Wouden, P. E., Cool, R. H., Quax,
W. J., Melgert, B. N., Poelarends, G.
J., & Dekker, F. J. (2025).
Correction to “Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Derivative Inhibits d-Dopachrome Tautomerase Activity and
Suppresses the Proliferation of Non-Small Cell Lung Cancer
Cells”Article link copied! Journal of
Medicinal Chemistry, 68(6), 6844-6845. https://doi.org/10.1021/acs.jmedchem.5c00406
Liu,
Y., Papagianis, P. C., de Kuijper, Z. S. C., Chitty, J. G.,
Thomas, B., Borghuis, T., Jongman, R.
M., Pillay, J., Richards, E. A., Melgert,
B. N., Burgess, J. K., & Bourke, J. E.
(2025). Generation of a novel lung fibrosis model using
precision cut lung slices from transgenic TGFβ1 mice.
American Journal of Physiology - Cell
Physiology. Advance online publication. https://doi.org/10.1152/ajpcell.00015.2025
Rae,
B., Bood, V., Dijk, H.-J., Vasse, G.
F., Melgert, B. N., Nagelkerke,
A., Burgess, J. K., Slebos,
D.-J., Heijink, I. H., & Pouwels, S.
D. (2025). Interorgan Communication Between Lung and
Colorectal Epithelial Cells Studied Using a Novel
Multi-Organ-On-Chip System. Comprehensive
Physiology, 15(5), Article e70051. https://doi.org/10.1002/cph4.70051
van
der Ploeg, E., Faiz, A., Teitsma, G. J.,
Brotons, A. S., Govorukhina, N., Sand, J. M.
B., Leeming, D. J., Melgert, B. N., Horvatovich,
P., Burgess, J. K., & Gan, C.
T. (2025). It takes two: Aberrant repair and low-grade
inflammation characterize bronchiolitis obliterans syndrome after
lung transplantation in serum proteomic analysis.
JHLT Open, 9, 100303. https://doi.org/10.1016/j.jhlto.2025.100303
Habibie,
H., Putri, K. S. S., Boorsma, C. E., Brass, D. M., Heukels,
P., Wijsenbeek, M., Kool, M., van den Berge, M.,
Borghuis, T., Vaughan, A., Corte, T., Liu, G.,
Brandsma, C.-A., Gan, C. T., Olinga,
P., Timens, W., Kahn, N., Hansbro, P. M.,
Kreuter, M., ... Melgert, B. N. (2025).
Osteoprotegerin is elevated in pulmonary fibrosis and
associates with IPF progression: a pilot study.
Respiration. Advance online publication. https://doi.org/10.1159/000547439
Li,
D., van der Veen, T. A., de Groot, L. E. S., de Jager,
M. H., Lan, A., Baarsma, H. A., Lutter, R., van
der Graaf, K., Gosens, R., Schmidt,
M., & Melgert, B. N. (2025).
Pre-Existing Allergic Inflammation Alters Both Innate and
Adaptive Immune Responses in Mice Co-Infected with Influenza
Virus. International Journal of Molecular
Sciences, 26(8), Article 3483. https://doi.org/10.3390/ijms26083483
Joglekar,
M. M., Sand, J. M. B., Borghuis, T., Leeming,
D. J., Karsdal, M., Klont, F., Bowler, R. P.,
Melgert, B. N., Burgess, J. K., &
Pouwels, S. D. (2025). The Calprotectin Fragment,
CPa9-HNE, Is a Plasma Biomarker of Mild Chronic Obstructive
Pulmonary Disease. Cells,
14(15), Article 1155. https://doi.org/10.3390/cells14151155
Willems,
S. H., Qian, S., Lång, P., Overtoom, B.
E., Alimostafazadeh, S., Fuentes-Mateos, R.,
Vasse, G. F., van der Veen, T. A., Vlasma,
J., De Jager, M. H., Guryev, V.,
Fejer, G., Andersson, G., & Melgert, B. N. (2025).
TRAPping the effects of tobacco smoking: the regulation and
function of Acp5 expression in lung macrophages.
American journal of physiology. Lung cellular and
molecular physiology, 328(4), L497-L511. https://doi.org/10.1152/ajplung.00157.2024
2024
Dragunas,
G., Koster, C. S., de Souza Xavier Costa,
N., Melgert, B. N., Munhoz, C. D., Gosens,
R., & Mauad, T. (2025). Neuroplasticity and
neuroimmune interactions in fatal asthma.
Allergy, 80(2), 462-473. https://doi.org/10.1111/all.16373
Vlasma,
J. R., van der Veen, T. A., De Jager, M.
H., Nawijn, M. C., Brandsma,
C.-A., & Melgert, B. N. (2024).
Cigarette smoking prolongs inflammation associated with
influenza infection and delays its clearance in mice.
American Journal of Physiology - Lung Cellular and
Molecular Physiology, 327(5), L634-L645. https://doi.org/10.1152/ajplung.00369.2023
Vasse,
G. F., & Melgert, B. N. (2024).
Microplastic and plastic pollution: impact on respiratory
disease and health. European respiratory review :
an official journal of the European Respiratory
Society, 33(172), Article 230226. https://doi.org/10.1183/16000617.0226-2023
Putri,
K. S. S., Adhyatmika, A., Boorsma, C. E., Habibie,
H., Ruigrok, M. J. R., Heukels, P.,
Timens, W., de Jager, M. H., Hinrichs, W.
L. J., Olinga, P., & Melgert, B.
N. (2024). Osteoprotegerin is an Early Marker of the
Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo
Lung Fibrosis. Lung, 202,
331–342. https://doi.org/10.1007/s00408-024-00691-5
Joglekar,
M. M., Bekker, N. J., Koloko Ngassie, M.
L., Vonk, J. M., Borghuis,
T., Reinders-Luinge, M., Bakker, J.,
Woldhuis, R. R., Pouwels, S. D., Melgert,
B. N., Timens, W., Brandsma,
C.-A., & Burgess, J. K. (2024). The
lung extracellular matrix protein landscape in severe early-onset
and moderate chronic obstructive pulmonary disease.
American Journal of Physiology - Lung Cellular and
Molecular Physiology, 327(3), L304-L318. https://doi.org/10.1152/ajplung.00332.2023
Nizamoglu,
M., Alleblas, F., Koster,
T., Borghuis, T., Vonk, J. M.,
Thomas, M. J., White, E. S., Watson, C. K., Timens,
W., El Kasmi, K. C., Melgert, B. N.,
Heijink, I. H., & Burgess, J. K. (2024).
Three dimensional fibrotic extracellular matrix directs
microenvironment fiber remodeling by fibroblasts.
Acta Biomaterialia, 177, 118-131. https://doi.org/10.1016/j.actbio.2024.02.008
Li,
D., Kortekaas, R. K., Douglas, K. B. I.,
Douwenga, W., Eisel, U. L. M., Melgert,
B. N., Gosens, R., & Schmidt,
M. (2024). TNF signaling mediates
lipopolysaccharide-induced lung epithelial progenitor cell
responses in mouse lung organoids. Biomedicine
& pharmacotherapy = Biomedecine &
pharmacotherapie, 181, Article 117704. https://doi.org/10.1016/j.biopha.2024.117704
2023
Russo,
S., Kwiatkowski, M., Wolters, J. C.,
Gerding, A., Hermans, J., Govorukhina,
N., Bischoff, R., & Melgert, B.
N. (2024). Effects of lysine deacetylase inhibitor
treatment on LPS responses of alveolar-like macrophages.
Journal of Leukocyte Biology,
115(3), 435–449. https://doi.org/10.1093/jleuko/qiad121
Song,
S., van Dijk, F., Vasse, G. F.,
Liu, Q., Gosselink, I. F., Weltjens, E., Remels, A. H., de
Jager, M. H., Bos, S., Li, C., Stoeger, T.,
Rehberg, M., Kutschke, D., van Eck, G., Wu, X.,
Willems, S. H., Boom, D., Kooter, I. M., Spierings,
D., ... Melgert, B. N. (2024). Inhalable
Textile Microplastic Fibers Impair Airway Epithelial
Differentiation. American Journal of Respiratory
and Critical Care Medicine, 209(4), 427 - 443.
https://doi.org/10.1164/rccm.202211-2099OC
Vasse,
G. F., Russo, S., Barcaru,
A., Oun, A. A. A., Dolga, A.
M., van Rijn, P., Kwiatkowski, M.,
Govorukhina, N., Bischoff, R., &
Melgert, B. N. (2023). Collagen type I alters the
proteomic signature of macrophages in a collagen
morphology-dependent manner. Scientific
Reports, 13(1), Article 5670. https://doi.org/10.1038/s41598-023-32715-0
Nizamoglu,
M., Koloko Ngassie, M. L., Meuleman, R.
A., Banchero, M., Borghuis, T.,
Timens, W., Nawijn, M. C., Melgert, B.
N., Heijink, I. H., Brandsma,
C.-A., & Burgess, J. K. (2023).
Collagen type XIV is proportionally lower in the lung tissue
of patients with IPF. Scientific
Reports, 13, Article 19393. https://doi.org/10.1038/s41598-023-46733-5
Melgert,
B., & van den Berge, M. (2023).
Handboek Sekse- en Gendersensitieve geneeskunde: COPD.
In T. Lagro, L. Visser, & A. Bos (Eds.), Handboek Sekse- en
Gendersensitieve geneeskunde: COPD Prelum Uitgevers. https://www.prelum.nl/product/sekse-en-gendersensitieve-geneeskunde/?gad_source=1&gclid=EAIaIQobChMIre6E0Pq2hAMVNZiDBx2a7gVbEAQYBCABEgIr7fD_BwE
Hofstede,
L. T., Vasse, G. F., & Melgert, B.
N. (2023). Microplastics: A threat for developing and
repairing organs? Cambridge Prisms:
Plastics, 1, Article e19. https://doi.org/10.1017/plc.2023.19
Moes,
C. A., Gan, C. T., Venema, L.
H., Hoffmann, R. F., Melgert, B.
N., Kerstjens, H. A. M., Olinga,
P., & Ruigrok, M. J. R. (2023).
Modelling Acid-Induced Lung Damage in Precision-Cut Lung
Slices: An Ex Vivo Animal Model.
Transplantology, 4(4), 185-196. https://doi.org/10.3390/transplantology4040018
Türk,
Y., Witte, J. A., van Huisstede, A., Melgert, B. N.,
van Schadewijk, A., Taube, C., Hiemstra, P. S., Kappen, J. H.,
& Braunstahl, G. J. (2023). Visceral adipose tissue: A
relevant inflammatory compartment in obesity-related asthma?
Clinical and Experimental Allergy,
53(12), 1295-1297. https://doi.org/10.1111/cea.14395
2022
Nizamoglu,
M., Koster, T., Thomas, M. J., Timens,
W., Koss, C. K., El Kasmi, K. C., Melgert,
B., Heijink, I., & Burgess, J.
(2022). 3D Fibrotic Lung Extracellular Matrix Hydrogels
Trigger Pro-Fibrotic Responses in Primary Lung
Fibroblasts. A5245-A5245. https://doi.org/10.1164/ajrccm-conference.2022.205.1_MeetingAbstracts.A5245
Donkers,
J. M., Höppener, E., Grigoriev, I., Will, L., Melgert,
B., van der Zaan, B., van de Steeg, E., & Kooter, I. M.
(2022). Advanced epithelial lung and gut barrier models
demonstrate passage of microplastic particles.
Microplastics and Nanoplastics,
2(6). https://doi.org/10.1186/s43591-021-00024-w
Draijer,
C., Florez-Sampedro, L., Reker-Smit,
C., Post, E., van Dijk, F.,
& Melgert, B. N. (2022). Explaining the polarized
macrophage pool during murine allergic lung inflammation.
Frontiers in Immunology, 13, Article
1056477. https://doi.org/10.3389/fimmu.2022.1056477
Nizamoglu,
M., Schlepütz, M., Heijink, I.,
Blokland, K., Thomas, M. J., Melgert, B.,
& Burgess, J. (2022). Fibroblast-seeded lung
extracellular matrix (ecm)-derived hydrogels as an in vitro model
for stromal bed in idiopathic pulmonary fibrosis (ipf).
S123-S123.
Joglekar,
M. M., Nizamoglu, M., Fan, Y.,
Nemani, S. S. P., Weckmann, M., Pouwels, S. D.,
Heijink, I. H., Melgert, B. N., Pillay,
J., & Burgess, J. K. (2022). Highway
to heal: Influence of altered extracellular matrix on infiltrating
immune cells during acute and chronic lung diseases.
Frontiers in Pharmacology, 13,
Article 995051. https://doi.org/10.3389/fphar.2022.995051
Song,
S., Xiao, Z., Dekker, F. J.,
Poelarends, G. J., & Melgert, B. N. (2022).
Macrophage migration inhibitory factor family proteins are
multitasking cytokines in tissue injury. Cellular
and molecular life sciences, 79(2), Article
105. https://doi.org/10.1007/s00018-021-04038-8
Adhyatmika,
A., Putri, K. S. S., Gore, E., Mangnus, K. A., Reker-Smit,
C., Schuppan, D., Beljaars, L., Olinga,
P., & Melgert, B. N. (2022).
Osteoprotegerin Expression in Liver is Induced by IL13
through TGFβ. Cellular physiology and
biochemistry, 56(1), 28-38. https://doi.org/10.33594/000000492
Ruigrok,
M. J. R., Roest, M. A. P., Frijlink, H.
W., Olinga, P., Hinrichs, W. L.
J., & Melgert, B. N. (2022). RANKL
confers protection against cell death in precision-cut lung
slices. Frontiers in Physiology,
13, Article 1029697. https://doi.org/10.3389/fphys.2022.1029697
Blokland,
K. E. C., Nizamoglu, M., Habibie,
H., Borghuis, T., Schuliga, M., Melgert,
B. N., Knight, D. A., Brandsma, C.-A.,
Pouwels, S. D., & Burgess, J. K. (2022).
Substrate stiffness engineered to replicate disease
conditions influence senescence and fibrotic responses in primary
lung fibroblasts. Frontiers in
Pharmacology, 13, Article 989169. https://doi.org/10.3389/fphar.2022.989169
2021
Xiao,
Z., Chen, D., Mulder, F., Song,
S., van der Wouden, P. E., Cool, R.
H., Melgert, B. N., Poelarends, G.
J., & Dekker, F. J. (2022).
4-Iodopyrimidine labeling reveals nuclear translocation and
nuclease activity for both MIF and MIF2.
Chemistry, 28(1), Article
e202103030. https://doi.org/10.1002/chem.202103030
Xiao,
Z., Osipyan, A., Song, S.,
Chen, D., Schut, R. A., van Merkerk, R.,
van der Wouden, P. E., Cool, R. H., Quax,
W. J., Melgert, B. N., Poelarends, G.
J., & Dekker, F. J. (2022).
Thieno[2,3- d]pyrimidine-2,4(1 H,3 H)-dione Derivative
Inhibits d -Dopachrome Tautomerase Activity and Suppresses the
Proliferation of Non-Small Cell Lung Cancer Cells.
Journal of Medicinal Chemistry,
65(3), 2059-2077. https://doi.org/10.1021/acs.jmedchem.1c01598
Vasse,
G. F., Van Os, L., De Jager, M., Jonker,
M. R., Borghuis, T., Van Den Toorn, L. T.,
Jellema, P., White, E. S., Van Rijn, P.,
Harmsen, M. C., Heijink, I. H., Melgert,
B. N., & Burgess, J. K. (2021).
Adipose Stromal Cell-Secretome Counteracts Profibrotic
Signals From IPF Lung Matrices. Frontiers in
Pharmacology, 12, Article 669037. https://doi.org/10.3389/fphar.2021.669037
van
Pijkeren, A., Dietze, J., Brotons, A. S.,
Egger, A.-S., Lijster, T., Barcaru, A., Hotze, M.,
Kobler, P., Dekker, F. J., Horvatovich,
P., Melgert, B. N., Ziegler, M.,
Thedieck, K., Heiland, I., Bischoff, R., &
Kwiatkowski, M. (2021). Combined Metabolic and Chemical
(CoMetChem) Labeling Using Stable Isotopes—a Strategy to
Reveal Site-Specific Histone Acetylation and Deacetylation Rates by
LC-MS. Analytical Chemistry,
93(38), 12872-12880. https://doi.org/10.1021/acs.analchem.1c01359
Song,
S., Liu, B., Habibie, H., Van den Bor, J.,
Smit, M. J., Gosens, R., Wu, X.,
Brandsma, C.-A., Cool, R. H., Haisma, H.
J., Poelarends, G. J., & Melgert, B.
N. (2021). D-dopachrome tautomerase contributes to
lung epithelial repair via ACKR3-dependent Akt signaling.
European Respiratory Journal, 58. https://doi.org/10.1183/13993003.congress-2021.OA2700
Song,
S., Liu, B., Habibie, H., van den Bor, J.,
Smit, M. J., Gosens, R., Wu, X.,
Brandsma, C.-A., Cool, R. H., Haisma, H.
J., Poelarends, G. J., & Melgert, B.
N. (2021). D-dopachrome tautomerase contributes to
lung epithelial repair via atypical chemokine receptor 3-dependent
Akt signaling. EBioMedicine,
68, Article 103412. https://doi.org/10.1016/j.ebiom.2021.103412
Ruigrok,
M. J. R., Frijlink, H. W., Melgert, B.
N., Olinga, P., & Hinrichs, W. L.
J. (2021). Gene therapy strategies for idiopathic
pulmonary fibrosis: recent advances, current challenges, and future
directions. Molecular Therapy - Methods &
Clinical Development, 20, 483-496. https://doi.org/10.1016/j.omtm.2021.01.003
van
Dijk, F., Song, S., van Eck, G. W. A.,
Wu, X., Bos, I. S. T., Boom, D. H. A., Kooter,
I. M., Spierings, D., Wardenaar, R.,
Cole, M., Salvati, A., Gosens, R.,
& Melgert, B. (2021). Inhalable textile
microplastic fibers impair airway epithelial growth.
(bioRxiv). BioRxiv. https://doi.org/10.1101/2021.01.25.428144
Vasse,
G. F., Nizamoglu, M., Heijink, I.
H., Schlepütz, M., van Rijn, P., Thomas,
M. J., Burgess, J. K., & Melgert, B.
N. (2021). Macrophage-stroma interactions in fibrosis:
Biochemical, biophysical, and cellular perspectives.
The Journal of Pathology, 254(4),
344-357. https://doi.org/10.1002/path.5632
Russo,
S., Kwiatkowski, M., Govorukhina, N.,
Bischoff, R., & Melgert, B. N. (2021).
Meta-Inflammation and Metabolic Reprogramming of Macrophages
in Diabetes and Obesity: The Importance of Metabolites.
Frontiers in Immunology, 12, Article
746151. https://doi.org/10.3389/fimmu.2021.746151
Turan,
N., van der Veen, T. A., Draijer, C., Fattahi,
F., Ten Hacken, N. H., Timens,
W., van Oosterhout, A. J., van den Berge,
M., & Melgert, B. N. (2021).
Neutrophilic Asthma Is Associated With Smoking, High Numbers
of IRF5+, and Low Numbers of IL10+ Macrophages.
Frontiers in allergy, 2, 676930. https://doi.org/10.3389/falgy.2021.676930
Xiao,
Z., Song, S., Chen, D., van
Merkerk, R., van der Wouden, P., Cool,
R., Quax, W., Poelarends,
G., Melgert, B., & Dekker, F.
J. (2021). Proteolysis Targeting Chimera (PROTAC) for
Macrophage Migration Inhibitory Factor (MIF) Has Anti-Proliferative
Activity in Lung Cancer Cells. Angewandte Chemie
(International ed. in English), 60(32),
17514-17521. https://doi.org/10.1002/anie.202101864
Blokland,
K. E. C., Habibie, H., Borghuis,
T., Teitsma, G. J., Schuliga, M., Melgert, B.
N., Knight, D. A., Brandsma, C.-A., Pouwels, S.
D., & Burgess, J. K. (2021). Regulation of
Cellular Senescence Is Independent from Profibrotic
Fibroblast-Deposited ECM. Cells,
10(7), 1-18. Article 1628. https://doi.org/10.3390/cells10071628
Vasse,
G. F., Buzon, P., Melgert, B.
N., Roos, W. H., & van Rijn,
P. (2021). Single Cell Reactomics: Real-Time
Single-Cell Activation Kinetics of Optically Trapped
Macrophages. Small methods,
5(4), e2000849. Article 2000849. https://doi.org/10.1002/smtd.202000849
van
der Ploeg, E. A., Melgert, B. N.,
Burgess, J. K., & Gan, C. T. (2021).
The potential of biomarkers of fibrosis in chronic lung
allograft dysfunction. Transplantation
Reviews, 35(3), Article 100626. https://doi.org/10.1016/j.trre.2021.100626
Habibie,
H., Adhyatmika, A., Schaafsma, D., & Melgert, B.
N. (2021). The role of osteoprotegerin (OPG) in
fibrosis: its potential as a biomarker and/or biological target for
the treatment of fibrotic diseases. Pharmacology
& Therapeutics, 228, Article 107941. https://doi.org/10.1016/j.pharmthera.2021.107941
2020
Xiao,
Z., Chen, D., Song, S., van der
Vlag, R., van der Wouden, P. E., van Merkerk,
R., Cool, R., Hirsch, A. K.
H., Melgert, B., Quax, W.
J., Poelarends, G. J., & Dekker, F.
J. (2020). 7-Hydroxycoumarins are Affinity-based
Fluorescent Probes for Competitive Binding Studies of Macrophage
Migration Inhibitory Factor. Journal of Medicinal
Chemistry, 63(20), 11920-11933. https://doi.org/10.1021/acs.jmedchem.0c01160
Florez-Sampedro,
L., Brandsma, C.-A., de Vries,
M., Timens, W., Bults, R., Vermeulen, C.
J., van den Berge, M., Obeidat, M., Joubert,
P., Nickle, D. C., Poelarends, G. J., Faiz,
A., & Melgert, B. N. (2020). Genetic
regulation of gene expression of MIF family members in lung
tissue. Scientific Reports,
10(1), Article 16980. https://doi.org/10.1038/s41598-020-74121-w
Adhyatmika,
A., Beljaars, L., Putri, K. S. S., Habibie,
H., Boorsma, C. E., Reker-Smit, C.,
Luangmonkong, T., Guney, B., Haak, A., Mangnus, K. A., Post,
E., Poelstra, K., Ravnskjaer, K., Olinga,
P., & Melgert, B. N. (2020).
Osteoprotegerin Is more than a Possible Serum Marker in Liver
Fibrosis: A Study into Its Function in Human and Murine
Liver. Pharmaceutics, 12(5),
Article 471. https://doi.org/10.3390/pharmaceutics12050471
Lkhagvadorj,
K., Zeng, Z., Song, J., Reinders-Luinge,
M., Kooistra, W., Song, S.,
Krauss-Etschmann, S., Melgert, B. N., Cao, J.,
& Hylkema, M. N. (2020). Prenatal smoke exposure
dysregulates lung epithelial cell differentiation in mouse
offspring - Role for AREG-induced EGFR signaling.
American Journal of Physiology - Lung Cellular and
Molecular Physiology, 319(4), L742-L751. https://doi.org/10.1152/ajplung.00209.2020
Habibie,
H., Song, S., Putri, K., Boorsma, C.,
Cool, R., Wu, X., Gosens,
R., Wang, Y., Quax, W.,
Olinga, P., Brandsma, C.-A., Timens,
W., Burgess, J., & Melgert, B.
(2020). RANKL contributes to lung tissue repair via promoting
type II epithelial cell proliferation. European
Respiratory Journal, 56. https://doi.org/10.1183/13993003.congress-2020.5029
Florez-Sampedro,
L., Soto-Gamez, A., Poelarends, G.
J., & Melgert, B. N. (2020). The role
of MIF in chronic lung diseases: Looking beyond
inflammation. American Journal of Physiology -
Lung Cellular and Molecular Physiology,
318(6), L1183-L1197. https://doi.org/10.1152/ajplung.00521.2019
Bartucci,
R., Åberg, C., Melgert, B.
N., Boersma, Y. L., Olinga, P., &
Salvati, A. (2020). Time-Resolved Quantification of
Nanoparticle Uptake, Distribution, and Impact in Precision-Cut
Liver Slices. Small, 16(21),
Article e1906523. https://doi.org/10.1002/smll.201906523
2019
van
der Veen, T. A., de Groot, L. E. S., & Melgert, B.
N. (2020). The different faces of the macrophage in
asthma. Current Opinion in Pulmonary
Medicine, 26(1), 62-68. https://doi.org/10.1097/MCP.0000000000000647
Liu,
B., Song, S., Setroikromo, R.,
Chen, S., Hu, W., Chen, D., van der Wekken, A.
J., Melgert, B. N., Timens,
W., van den Berg, A., Saber, A., &
Haisma, H. J. (2019). CX Chemokine Receptor 7
Contributes to Survival of KRAS-Mutant Non-Small Cell Lung Cancer
upon Loss of Epidermal Growth Factor Receptor.
Cancers, 11(4), Article 455. https://doi.org/10.3390/cancers11040455
Van
der Graaf, K., Adel, S., Plat, L., & Melgert, B.
(2019). Detection of Mollicute species (Mycoplasma) in House
Dust Mites. Allergy, 74,
658-659.
Heukels,
P., van Hulst, J. A. C., van Nimwegen, M., Boorsma, C. E.,
Melgert, B. N., von der Thusen, J. H., van den Blink, B.,
Hoek, R. A. S., Miedema, J. R., Neys, S. F. H., Corneth, O. B. J.,
Hendriks, R. W., Wijsenbeek, M. S., & Kool, M. (2019).
Enhanced Bruton's tyrosine kinase in B-cells and autoreactive
IgA in patients with idiopathic pulmonary fibrosis.
Respiratory Research, 20(1), Article
232. https://doi.org/10.1186/s12931-019-1195-7
van
der Veen, A., Roffel, M. P., Brandsma, C.-A., De
Jager, M., Post, E., Van den Berge,
M., Boudewijn, I., De Groot, L., Lutter, R., Bracke, K.,
Maes, T., Melgert, B., & Heijink, I.
(2019). LSC-2019-Dysfunctional macrophage polarization in
murine COPD exacerbation. European Respiratory
Journal, 54. https://doi.org/10.1183/13993003.congress-2019.PA1667
Habibie,
H., Burgess, J., Wisman, M.,
Jonker, M., Kool, M., Wijsenbeek, M., Kahn, N., Kreuter,
M., & Melgert, B. N. (2019). Serum
osteoprotegerin and fibulin-1 levels negatively correlate with DLCO
in IPF. European Respiratory Journal,
54(63), Article PA4702. https://doi.org/10.1183/13993003.congress-2019.PA4702
Sampedro,
L. F., Brandsma, C. A., De Vries,
M., Timens, W., Obeidat, M., Joubert, P.,
Nickle, D. C., Poelarends, G. J., Faiz,
A., & Melgert, B. N. (2019). Shared
Single Nucleotide Polymorphisms Regulate Gene Expression of
Macrophage Migration Inhibitory Factor and D-Dopachrome
Tautomerase-Like Protein in Lung Tissue. American
Journal of Respiratory and Critical Care Medicine,
199.
Ruigrok,
M., Tomar, J., Frijlink, H. W., Melgert,
B., Hinrichs, W., & Olinga, P.
(2019). The effects of oxygen concentration on cell death,
anti-oxidant transcription, acute inflammation, and cell
proliferation in precision-cut lung slices.
Scientific Reports, 9(1), Article
16239. https://doi.org/10.1038/s41598-019-52813-2
2018
de
Groot, L. E. S., van der Veen, T. A., Martinez, F. O., Hamann, J.,
Lutter, R., & Melgert, B. N. (2019).
Oxidative stress and macrophages: driving forces behind
exacerbations of asthma and chronic obstructive pulmonary
disease? American Journal of Physiology - Lung
Cellular and Molecular Physiology, 316(2),
L369-L384. https://doi.org/10.1152/ajplung.00456.2018
Vasse,
G. F., Kühn, P. T., Zhou, Q., Bhusari, S. A.,
Reker-Smit, C., Melgert, B. N., & van
Rijn, P. (2018). Collagen morphology influences
macrophage shape and marker expression in vitro.
Journal of Immunology and Regenerative
Medicine, 1, 13-20. https://doi.org/10.1016/j.regen.2018.01.002
Draijer,
C., Robbe, P., Boorsma, C. E., Hylkema, M. N.,
& Melgert, B. N. (2018). Dual role of YM1+ M2
macrophages in allergic lung inflammation.
Scientific Reports, 8(1), Article
5105. https://doi.org/10.1038/s41598-018-23269-7
Heukels,
P., van Hulst, J. A. C., van Nimwegen, M., Boorsma, C. E.,
Melgert, B. N., van den Toorn, L. M., Boomars, K. A. T.,
Wijsenbeek, M. S., Hoogsteden, H., von der Thüsen, J. H.,
Hendriks, R. W., Kool, M., & van den Blink, B. (2018).
Fibrocytes are increased in lung and peripheral blood of
patients with idiopathic pulmonary fibrosis.
Respiratory Research, 19(1), Article
90. https://doi.org/10.1186/s12931-018-0798-8
Utari,
P. D., Setroikromo, R., Melgert, B.
N., & Quax, W. J. (2018). PvdQ Quorum
Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a
Mouse Model of Pulmonary Infection. Frontiers in
Cellular and Infection Microbiology, 8,
Article 119. https://doi.org/10.3389/fcimb.2018.00119
Ruigrok,
M. J. R., Xian, J.-L., Frijlink, H. W.,
Melgert, B. N., Hinrichs, W. L. J., &
Olinga, P. (2018). siRNA-mediated protein knockdown in
precision-cut lung slices. European Journal of
Pharmaceutics and Biopharmaceutics, 133,
339-348. https://doi.org/10.1016/j.ejpb.2018.11.005
Ruigrok,
M., Xian, J. L., Frijlink, H. W.,
Melgert, B., Hinrichs, W., & Olinga,
P. (2018). siRNA-mediated protein knockdown in
precision-cut lung slices. Poster session presented at
AAPS PharmSci360, Washington, District of Columbia, United
States.
Ruigrok,
M., Maggan, N., Frijlink, H. W., Melgert,
B., Olinga, P., & Hinrichs, W.
(2018). siRNA-mediated RNA interference in precision-cut
tissue slices prepared from mouse lung. Poster session
presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics
and Pharmaceutical Technology, Granada, Spain.
Kok,
T., Wasiel, A. A., Cool, R. H., Melgert, B.
N., Poelarends, G. J., & Dekker, F.
J. (2018). Small-molecule inhibitors of macrophage
migration inhibitory factor (MIF) as an emerging class of
therapeutics for immune disorders. Drug Discovery
Today, 23(11), 1910-1918. https://doi.org/10.1016/j.drudis.2018.06.017
Florez-Sampedro,
L., Song, S., & Melgert, B. N.
(2018). The diversity of myeloid immune cells shaping wound
repair and fibrosis in the lung. Regeneration
(Oxford, England), 5(1), 3-25. https://doi.org/10.1002/reg2.97
2017
Boorsma,
C. E., van der Veen, T. A., Putri, K. S. S., de
Almeida, A., Draijer, C., Mauad, T., Fejer, G., Brandsma,
C.-A., van den Berge, M., Bossé, Y., Sin,
D., Hao, K., Reithmeier, A., Andersson, G., Olinga,
P., Timens, W., Casini, A., &
Melgert, B. N. (2017). A Potent Tartrate Resistant
Acid Phosphatase Inhibitor to Study the Function of TRAP in
Alveolar Macrophages. Scientific
Reports, 7(1), Article 12570. https://doi.org/10.1038/s41598-017-12623-w
Turk,
Y., van Huisstede, A., van Schadewijk, A., Melgert,
B., Hiemstra, P., & Braunstahl, G.-J. (2017).
Characterization of adipose tissue inflammation in morbidly
obese asthmatics. European Respiratory
Journal, 50(Supplement 61). https://doi.org/10.1183/1393003.congress-2017.PA3908
Melgert,
B. N., & Casini, A. (2017). Gold(III) compounds as tartrate resistant acid
phosphatase inhibitors, and therapeutic uses thereof.
(Patent No. WO2017058012). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2017058012A1&KC=A1&FT=D&ND=3&date=20170406&DB=&locale=en_EP
Draijer,
C., Boorsma, C. E., Robbe, P., Timens, W.,
Hylkema, M. N., Ten Hacken, N. H., van
den Berge, M., Postma, D. S., &
Melgert, B. N. (2017). Human asthma is characterized
by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like
macrophages around airways compared with healthy airways.
Journal of Allergy and Clinical Immunology,
140(1), 280-283. https://doi.org/10.1016/j.jaci.2016.11.020
Ruigrok,
M. J. R., Maggan, N., Willaert, D., Frijlink, H.
W., Melgert, B. N., Olinga,
P., & Hinrichs, W. L. J. (2017).
siRNA-mediated RNA interference in precision-cut tissue
slices prepared from mouse lung and kidney. The
AAPS Journal, 19(6), 1855-1863. https://doi.org/10.1208/s12248-017-0136-y
2016
Draijer,
C., Boorsma, C. E., Reker-Smit, C., Post,
E., Poelstra, K., & Melgert, B.
N. (2016). PGE(2)-treated macrophages inhibit
development of allergic lung inflammation in mice.
Journal of Leukocyte Biology,
100(1), 95-102. https://doi.org/10.1189/jlb.3MAB1115-505R
Draijer,
C., Boorsma, C. E., Reker-Smit, C., Post,
E., Poelstra, K., & Melgert, B.
N. (2016). PGE2-treated macrophages inhibit
development of allergic lung inflammation in mice.
American Journal of Respiratory and Critical Care
Medicine, 193.
Draijer,
C., Boorsma, C. E., Post, E., Dijk, van,
F., & Melgert, B. N. (2016).
Recruitment And Proliferation Of Macrophage Polarization
States During Allergic Lung Inflammation. American
Journal of Respiratory and Critical Care Medicine,
193.
Draijer,
C., Hylkema, M. N., Boorsma, C. E., Klok, P.
A., Robbe, P., Timens, W., Postma, D.
S., Greene, C. M., & Melgert, B. N. (2016).
Sexual maturation protects against development of lung
inflammation through estrogen. American Journal of
Physiology - Lung Cellular and Molecular Physiology,
310(2), L166-L174. https://doi.org/10.1152/ajplung.00119.2015
Postma,
D. S., Wijkstra, P. J., Hiemstra, P. S.,
Melgert, B. N., Braunstahl, G.-J., Hylkema, M.
N., & Sterk, P. J. (2016). The Dutch National
Program for Respiratory Research. The Lancet.
Respiratory Medicine, 4(5), 356-357. https://doi.org/10.1016/S2213-2600(16)30035-2
2015
Robbe,
P., Draijer, C., Rebelo Borg, T., Luinge, M.,
Timens, W., Wouters, I. M., Melgert, B.
N., & Hylkema, M. N. (2015). Distinct
macrophage phenotypes in allergic and nonallergic lung
inflammation. American Journal of Physiology -
Lung Cellular and Molecular Physiology,
308(4), L358-L367. https://doi.org/10.1152/ajplung.00341.2014
Draijer,
C., Gonçalves Dias Pereira, P., Boorsma, C., Hylkema,
M., & Melgert, B. (2015). Dual
role of M2 macrophages in asthma. Poster session
presented at 25th International Congress of the European
Respiratory Society, Amsterdam, Netherlands.
Gonçalves
Dias Pereira, P., Draijer, C., Borg, T. R., Luinge,
M., Timens, W., Wouters, I. M., Melgert,
B., & Hylkema, M. (2015). Farm dust
directs phenotype-specific macrophage activation which may
contribute to protection against Th2-related disorders. In
Farming exposure and asthma phenotypes in mice and men
(pp. 139-147). Rijksuniversiteit Groningen.
Gonçalves
Dias Pereira, P., Draijer, C., Brandsma, C.-A.,
Hesse, L., Luinge, M., Melgert,
B., Timens, W., Wouters, I. M., &
Hylkema, M. (2015). Fluticasone propionate suppresses
farm dust-induced airway hyperresponsiveness in mice but has no
effect on lung neutrophils. In Farming exposure and
asthma phenotypes in mice and men (pp. 77-97).
Rijksuniversiteit Groningen.
Heukels,
P., Van Hulst, J., Wijsenbeek, M. S., Boorsma, C. E.,
Melgert, B. N., Hoogsteden, H. C., Hendriks, R. W., Corneth,
O. B. J., Kool, M., & Van den Blink, B. (2015). Linking
Cellular Immunity To B Cell (auto) immunity In Idiopathic Pulmonary
Fibrosis. American Journal of Respiratory and
Critical Care Medicine, 191.
Heukels,
P., Van Hulst, J., Wijsenbeek, M. S., Boorsma, C., Melgert,
B., Hoogsteden, H. C., Hendriks, R. W., Corneth, O. B. J.,
Kool, M., & van den Blink, B. (2015). Linking cellular
immunity to B cell (auto)immunity in idiopatic pulmonary
fibrosis. American Journal of Respiratory and
Critical Care Medicine, 191(Meeting
Abstracts), Article A6127.
Draijer,
C., Boorsma, C., Gonçalves Dias Pereira, P., Hylkema,
M., Timens, W., van den Berge,
M., Postma, D. S., & Melgert,
B. (2015). Macrophage subsets in lung tissue of
healthy controls and asthma patients. Abstract from
Free Communications Sessions Longdagen 2015, Utrecht,
Netherlands.
Draijer,
C., Boorsma, C., Robbe, P., Hylkema, M., Timens,
W., Van den Berge, M., Postma,
D., & Melgert, B. (2015). Macrophage
subsets in lung tissue of healthy controls and asthma
patients. European Respiratory
Journal, 46. https://doi.org/10.1183/13993003.congress-2015.PA2544
Adhyatmika,
A., Putri, K. S. S., Beljaars, L., &
Melgert, B. N. (2015). The Elusive Antifibrotic
Macrophage. Frontiers in Medicine,
2(81), Article 81. https://doi.org/10.3389/fmed.2015.00081
Boorsma,
C., Draijer, C., Cool, R., Brandsma,
C.-A., Nossent, G., Heukels, P., van den Blink,
B., Timens, W., & Melgert, B. (2015).
The RANKL-OPG balance in pulmonary fibrosis.
Poster session presented at 25th International Congress of the
European Respiratory Society, Amsterdam, Netherlands. http://www.ersnet.org/component/flexicontent/items/item/4838-ers-international-congress-2015.html#
Boorsma,
C., Draijer, C., Cool, R., Brandsma,
C.-A., Nossent, G., Heukels, P., Van den Blink,
B., Brass, D., Timens, W., & Melgert,
B. (2015). The RANKL-OPG balance in pulmonary
fibrosis. European Respiratory
Journal, 46. https://doi.org/10.1183/13993003.congress-2015.PA3809
2014
Beljaars,
L., Boorsma, C. E., Guney, B., Poelstra,
K., & Melgert, B. N. (2014). A new
communication system regulating extracellular matrix in liver
fibrosis: RANK/RANKL/OPG. Hepatology,
60(Supplement 1), 584A-584A. https://doi.org/10.1002/hep.27412
Boorsma,
C. E., Draijer, C., Cool, R., Brandsma,
C., Nossent, G., Brass, D. M., Timens,
W., & Melgert, B. N. (2014). A
Possible Role For The Rank/rankl/opg Axis In Pulmonary
Fibrosis. American Journal of Respiratory and
Critical Care Medicine, 189.
van
de Garde, M. D. B., Martinez, F. O., Melgert, B.
N., Hylkema, M. N., Jonkers, R. E., &
Hamann, J. (2014). Chronic exposure to glucocorticoids shapes
gene expression and modulates innate and adaptive activation
pathways in macrophages with distinct changes in leukocyte
attraction. Journal of Immunology,
192(3), 1196-1208. https://doi.org/10.4049/jimmunol.1302138
Draijer,
C., Robbe, P., Boorsma, C. E., Hylkema, M. N.,
Timens, W., Postma, D., Ten Hacken, N. H.
T., & Melgert, B. N. (2014).
Differential Macrophage Subsets In Males And Females With
Asthma. American Journal of Respiratory and
Critical Care Medicine, 189.
Spaans,
F., Melgert, B. N., Borghuis, T.,
Klok, P. A., de Vos, P., Bakker, W. W.,
van Goor, H., & Faas, M. (2014).
Extracellular Adenosine Triphosphate Affects Systemic and
Kidney Immune Cell Populations in Pregnant Rats.
American Journal of Reproductive Immunology,
72(3), 305-316. https://doi.org/10.1111/aji.12267
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