Molecular heterogeneity and angiogenesis in glioblastoma
| PhD ceremony: | Ms S. (Siobhan) Conroy |
| When: | November 27, 2017 |
| Start: | 11:00 |
| Supervisors: | prof. dr. W. (Wim) Timens, prof. dr. F.A.E. (Frank ) Kruyt |
| Co-supervisors: | dr. W.F.A. (Wilfred) den Dunnen, dr. K.P.L. Bhat |
| Where: | Academy building RUG |
| Faculty: | Medical Sciences / UMCG |
The aim of this thesis was the assessment of the differential molecular characteristics and functional responses of glioblastomas with dissimilar phenotypes. The characteristics of transcriptional subclasses were studied in detail through the definition of molecular subclasses at protein level and the assessment of kinase activity profiles and vascularization patterns. In addition, the plasticity or interchangeability of these molecular phenotypes was studied, and the second part of the thesis then focused on the role of angiogenesis in glioblastoma in general. The thesis is concluded with the exploration of the druggability of the vascular compartment in glioblastoma.