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Moving signature of frailty

From physical activity patterns as behavioral biomarkers to digital-assisted intervention
PhD ceremony:Ms X. (Xin) ZhangWhen:April 15, 2026 Start:09:00Supervisors:prof. dr. C.J.C. (Claudine ) Lamoth, prof. dr. B.C. (Barbara) van Munster, prof. dr. L. Feng LiCo-supervisor:J.S.M. HobbelenWhere:Academy building UGFaculty:Medical Sciences / UMCG
Moving signature of frailty

Moving signature of frailty

As our society ages, supporting older adults in maintaining their vitality and preventing functional decline has become an important public health priority. Frailty, a condition that makes people more vulnerable to loss of independence, can often be slowed or even reversed if caught early. Current assessment tools often lack sensitivity to provide specific insights needed for personalized prevention.

To address this gap, the research of Xin Zhang monitored older adults' daily movements (from walking to turning in bed) using wearable sensors. We combined this continuous digital tracking data with traditional health measures to gain a fuller picture of both physical behavior and how people perceive their own health.

The study revealed that early signs of frailty may include a "fragmented" pattern of daily physical activity, alongside slight declines in physical function. More importantly, we found that how older adults feel about their health is a strong driver of their ability to stay active. After all, even those who appear active may still be frail if they perceive their health as poor.

We also developed a personalized activity program that adapts to each individual's physical capacity and personal preferences assisted by digital technology. Early results indicate this tailored approach is both feasible and promising.

Inspired by the ancient wisdom of "treating disease before it arises" (上工治未病), our work demonstrates that digital-assisted monitoring and intervention offer a practical approach for frailty management and promoting healthy aging.

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