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Next-generation regenerative therapy for tissue restoration

Organ-derived extracellular matrix hydrogels with secretome components of adipose stem cells
PhD ceremony:V. GetovaWhen:April 29, 2026 Start:14:30Supervisors:prof. dr. M.C. Harmsen, prof. dr. J.K. (Janette) BurgessWhere:Academy building UGFaculty:Medical Sciences / UMCG
Next-generation regenerative therapy for tissue restoration

Next-generation regenerative therapy for tissue restoration

When the body gets injured, it tries to heal itself. But sometimes this healing is not complete. For example, wounds in people with diabetes may not heal well, and heart damage can leave permanent scars.

In this research of Vasilena Getova, we explored new ways to help the body heal more effectively. We used natural materials from tissues and helpful substances released by special cells from fat tissue. These substances can send signals that support healing.

We created a soft gel from natural tissue that can hold and slowly release these healing signals. In our experiments, this helped cells grow, move, and align as they would when new blood vessels form. Blood vessels are very important because they bring oxygen and nutrients needed for healing.

We also built a simple layered model that looks more like real human tissue. This makes it easier to study how healing works and how we can improve it.

The results show that combining natural materials with these cell molecules can improve the body’s repair process. This method does not need living cells, which makes it safer and easier to use.

In the future, this approach could help treat wounds, heart damage, and other injuries more effectively.

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