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Topography-mediated control of cellular response: migration, intracellular crowding, and gene-delivery

PhD ceremony:L. Ge
When:December 07, 2020
Supervisor:dr. P. (Patrick) van Rijn
Co-supervisor:dr. T.G. (Theo) van Kooten
Where:Academy building RUG
Faculty:Medical Sciences / UMCG

With the vigorous development and major breakthroughs of regenerative medicine technology, biomaterials occupy a very important position for providing a suitable therapeutic option for obtaining a higher quality of life. The cell-material interactions, especially the physicochemical (topography and stiffness) effects of materials, determines cell functions like cell adhesion, spreading, proliferation, alignment, migration, and differentiation. In this thesis, to explore topography-mediated alterations and investigate subcellular behaviors, we demonstrate the important role of topography modulating cell migration and identify the topography influence on macromolecular crowding in living cells. Furthermore, the topography stimuli were investigated for the control and enhancement of gene delivery capacity of stem cells.