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Chemical approaches for quantitative proteomics

PhD ceremony:Mr X. (Xiaobo) Tian
When:September 24, 2021
Start:14:30
Supervisor:prof. dr. R.P.H. (Rainer) Bischoff
Co-supervisor:dr. H.P. (Hjalmar) Permentier
Where:Academy building RUG
Faculty:
Chemical approaches for quantitative proteomics

Xiaobo focuses on developing novel isotope labeling-based tags for quantitative proteomics along two lines of research: (1) In data-dependent acquisition (DDA) mode, eliminating the ratio distortion caused by peptide cofragmentation and increasing the multiplexing capacity. (2) In data-independent acquisition (DIA) mode, achieving multiplexed quantification with general DIA LC-MS settings. The representative work, Ac-IP tag that specifically suitable for the multiplexing in DIA mode, attracted much attention from peers.