Chemical approaches for quantitative proteomics
|PhD ceremony:||Mr X. (Xiaobo) Tian|
|When:||September 24, 2021|
|Supervisor:||prof. dr. R.P.H. (Rainer) Bischoff|
|Co-supervisor:||dr. H.P. (Hjalmar) Permentier|
|Where:||Academy building RUG|
Xiaobo focuses on developing novel isotope labeling-based tags for quantitative proteomics along two lines of research: (1) In data-dependent acquisition (DDA) mode, eliminating the ratio distortion caused by peptide cofragmentation and increasing the multiplexing capacity. (2) In data-independent acquisition (DIA) mode, achieving multiplexed quantification with general DIA LC-MS settings. The representative work, Ac-IP tag that specifically suitable for the multiplexing in DIA mode, attracted much attention from peers.