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Glucose (monitoring): from bench to real world experiences

PhD ceremony:Ms M.J. (Marion) Fokkert
When:April 04, 2022
Supervisors:prof. dr. H.J.G. (Henk) Bilo, R.O.B. (Reinold) Gans
Co-supervisors:dr. R.J. Slingerland, P.R. van Dijk
Where:Academy building RUG
Faculty:Medical Sciences / UMCG
Glucose (monitoring): from bench to real world experiences

Glucose monitoring systems emerged as an option to measure glucose concentrations in the interstitial fluid using a sensor. Main findings of this thesis are:• To achieve a glucose measurement with the smallest measurement uncertainty when diagnosing (gestational) diabetes, measurements should be performed using a FC-Mix blood collection tube instead of the standard NaF-EDTA or NaF-oxalate blood collection tube.• When using the FreeStyle Libre Flash Glucose Monitoring System (FSL-FGM) in daily life, it should be taken in account that readings in the lower range are likely to be lower than the actual glucose reading. Furthermore, after ingestion of a meal, FSL-FGM measured glucose lag behind the blood measured glucose. As a result, there is a risk of underestimating the effect of a meal on the glucose response• One-year use of FSL-FGM in people with diabetes resulted in improved well-being and decreased disease burden, as well as improvement of glycemic control, especially at those users with initially the poorest metabolic control. From a user perspective, the beneficial influence on the frequency and severity of hypoglycemia’s was also of great importance.• In a considerable percentage of people with diabetes, HbA1c levels reported by themselves are not accurate enough to be useful in research.• In case the glucose outcome derived from a glucose monitoring system does not match with the expected outcome by the user, a capillary glucose measurement should be performed. This is of particular importance during exercise.