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Lipids and apolipoproteins in cardiovascular disease

PhD ceremony:Mr P.J.W.H. (Paul) Kappelle
When:December 14, 2016
Supervisor:prof. dr. B.H.R. (Bruce) Wolffenbuttel
Co-supervisors:dr. R.P.F. Dullaart, dr. G.M. Dallinga-Thie
Where:Academy building RUG
Faculty:Medical Sciences / UMCG

The first part of this thesis describes the role of cholesterol particles and associated proteins, and their role in the development of cardiovascular disease. There seems to be an advantage in determining the balance between good and bad cholesterol, as compared to the separate measures when attempting to predict the development of cardiovascular disease. Certain genes that have an influence on proteins transporting cholesterol from one particle to the other, do not seem to have an effect on the predictive value of these measures. The inhibition of this protein does increase the level of the good cholesterol, but this does not seem to result in any survival benefit.

The second part of this thesis describes the effect of cholesterol lowering agents on different cholesterol particles and associated proteins. Cholesterol lowering agents seem to affect the number of particles less than their cholesterol content. This could lead to a lack of intensive cholesterol treatment when only the cholesterol concentration is considered.