Site-selective modification of aminoglycoside antibiotics for therapeutic and diagnostic applications
|PhD ceremony:||Ms E.M. (Eliza) Warszawik|
|When:||January 08, 2021|
|Supervisor:||prof. dr. A. Herrmann|
|Co-supervisor:||dr. P. (Patrick) van Rijn|
|Where:||Academy building RUG|
|Faculty:||Science and Engineering|
The rising levels of antimicrobial resistance and lack of treatment options, especially to multidrug-resistant Gram-negative bacteria are a serious threat to human health.
Aminoglycosides are a potent class of broad-spectrum bactericidal antibiotics, which have been in use for the last few decades. This class of drugs is especially valuable in the treatment of bacterial infections caused by aerobic Gram-negative pathogens and promising starting building blocks for the development of new leads. Aminoglycosides and their derivatives showed great potential for the development of new compounds with antimicrobial activity against resistant bacteria. However, the further use of aminoglycosides and the development of new leads requires a better understanding of the drug modes of action and their derivatives and getting more insights into mechanisms of bacterial resistance.
In this work, we applied chemo- and regioselective modification methods to produce novel aminoglycosides derivatives to for therapeutic and diagnostic applications.