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dr. W.L.J. (Wouter) Hinrichs

Profielfoto van dr. W.L.J. (Wouter) Hinrichs

Working experience

Oct. 1998-Present

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, The Netherlands, headed by Prof. Dr. H.W. Frijlink.

Main research subjects:

- Sugar glasses for the stabilization of biopharmaceuticals.

- Solid dispersions for the stabilization and improved bioavailability of lipophilic drugs.

- Powders for pulmonary delivery and tablets for oral administration.

- Controlled release of biopharmaceuticals from biodegradable polymeric matrices



Title thesis

Date PhD defense

Yu Tian

Blends of trehalose and pullulan to stabilize biopharmaceuticals in alternative dosage forms: Orodispersible films and dissolving microneedles

23 October 2020

Max Beugeling

Biodegradable implants for the biphasic pulsatile delivery of antigens: Towards single-injection vaccines

16 October 2020

Mitchel JR Ruigrok

siRNA in precision-cut lung slices: knocking down fibrosis?

20 December 2019

Kurnia S.S. Putri

Osteoprotegerin in organ fibrosis: biomarker, actor and target of therapy?

17 June 2019

Jasmine Tomar

Paving the way for pulmonary influenza vaccines: Exploring formulations, models and site of deposition

7 December 2018

Yoshita Bhide

Towards improved and broadly protective influenza vaccines; Focus on delivery systems, routes of administration and animal models

8 October 2018

Naomi Teekamp

Protein delivery from polymeric matrices: From pre-formulation stabilization studies to site-specific delivery

20 April 2018

Fransien van Dijk

Delivery of biologicals: Sustained release of cell-specific proteins in fibrosis

23 March 2018

Maarten A. Mensink

Solid state stabilization of proteins by sugars: Why size and flexibility matter

2 June 2017

Dewi Setyaningsiha

Development of solid dispersion formulation containing curcumin/curcuma longa standardized extract to improve curcumin dissolution rate and absorption

3 February 2016

Niels Grasmeijer

Improving protein stabilization by spray drying: Formulation and process development

11 January 2016

Milica Stanković

Innovative platform technologies for stabilization and controlled release of proteins from polymer depots

8 December 2014

Wouter F. Tonnis

Powder to the people; The storage stability, handling, and administration advantages of powder formulations for pulmonary vaccination

5 December 2014

Senthil Murugappan

New strategies for simplifying influenza vaccination

9 May 2014

Harshad P. Patil

Development of adjuvanted influenza vaccines for pulmonary delivery

15 February 2014

Christina Avanti

Innovative strategies for stabilization of therapeutic peptides in aqueous formulations

2 July 2012

Parinda Srinarong

Improved dissolution behavior of lipophilic drugs by solid dispersions: a matter of composition

18 April 2011

Hans de Waard

A novel bottom-up process to prepare drug nanocrystals: The art of the soluble

11 March 2011

Vinay Saluja

Novel perspectives for influenza vaccine formulation and administration: L. lactis cell wall derived adjuvant, stable dry powder vaccines and mucosal vaccine delivery

3 December 2010

Gerrit S. Zijlstra

Dry powder inhalation of biopharmaceuticals: From formulation to proof of concept

11 December 2009

Jean-Pierre Amorij

The development of stable influenza vaccine powder

formulations for new needle-free dosage forms

4 January 2008

Dirk-Jan van Drooge

Combining the incompatible: Inulin glass dispersions for fast dissolution, stabilization and formulation of lipophilic drugs

28 April 2006

H. Jonas C. Eriksson

Analytical techniques and formulation strategies for the therapeutic protein alkaline phosphatase

5 July 2004

  1. Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia



Theoretical courses:

- Thermodynamics (1998-present)

- Transport through membranes (2003- 2007)

- Physical chemistry of colloids, suspensions and emulsions (2000-present)

- Formulation proteins and lipophilic drugs (2011-present)

Practical courses:

- Technology and Biopharmacy (1998-2008)

- Dispensing and Dosage Forms (1998-2008)

- Pharmaceutical Technology and Biopharmacy (2008-present)


- Editorial board/academic editor “Pharmaceutics” (2018-present).

- Scientific coordinator “Biopharmacy Day”: (bi)annual meeting of the Belgium and Dutch Society for Pharmaceutical Technology and Biopharmaceutical Sciences (2005-2008 and 2012-present).

- Theoretical course entitled “Physicochemical aspects related to dosage form development” for master students Industrial Pharmacy. Facultas Farmasi, Universitas Surabaya, Indonesia (2014-present).

- Member of the board of the Dutch Federation for Pharmaceutical Sciences (2005-2012).

- Principal investigator Top Institute Pharma project entitled: “Hot Medicines: breaking the cold chain requirement for polypeptide-based priority medicines (2008-2012).

- Principle investigator of W.J. Kolff Institute, UMCG, Groningen, The Netherlands (2011-present).

- Principle investigator of ANDDI program, UMCG, Groningen, The Netherlands (2011-2013).

- Advanced course on pharmaceutical technology: Application of dispersion system on improving drug stability. Facultas Farmaci, Universitas Surabaya, Indonesia, July 20-22, 2006.

- Reviewer for journals:

  • AapsPharmSciTech
  • ACS Applied Materials & Interfaces
  • ACS Biomaterials Science & Engineering
  • Applied Microbiology and Biotechnology
  • Applied Science
  • Biochimica et Biophysica Acta
  • Biophysical Journal
  • Coatings
  • Colloids and Surfaces A
  • Current Research in Pharmacology and Drug Discovery
  • Drug Development and Industrial Pharmacy
  • Drying Technology
  • Enzyme and Microbial Technology
  • European Journal of Pharmaceutics and Biopharmaceutics
  • European Journal of Pharmaceutical Sciences
  • Expert Opinion on Drug Delivery
  • Expert Reviews on Vaccines
  • Industrial & Engineering Chemistry Research
  • International Journal of Biological Macromolecules
  • International Journal of Inflammation
  • International Journal of Nanomedicine
  • International Journal of Pharmaceutics
  • Journal of Biomaterials Science: Polymer Edition
  • Journal of Controlled Release
  • Journal of Food Engineering
  • Journal of Drug Delivery Science and Technology
  • Journal of Peptide Science
  • Molecular Pharmaceutics
  • Molecules
  • Pharmaceutical Research
  • Pharmaceuticals
  • Pharmaceutics
  • Polymers
  • Polymers International
  • Powder Technology
  • Therapeutic Delivery
  • Vaccine
  • Vaccines

January 2004 - June 2004

Sabbatical leave. Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Belgium, headed by Prof. Dr. S.C. De Smedt and Prof. Dr. J. Demeester.    

Research subject:

- Sugar glasses for the stabilization of nanoparticles (liposomes and gene delivery systems).

November 1996 - September 1998

Department of Biopharmacy and Pharmaceutical Technology, Utrecht University, The Netherlands, headed by Prof. Dr. Ir. W.E. Hennink.

Research subjects:

- Thermosensitive polymers as carriers for DNA delivery

- Polymers as adhesives for oral prostheses

- Thermosensitive hydrogels for the controlled release of proteins


- Theoretical course “Thermodynamics and Kinetics”

November 1992 - October 1996

Institute for Biomedical Technology, University of Twente, The Netherlands, headed by Prof. Dr. J. Feijen.

Research subject:

- Improved biocompatibility of heamodialysis membranes by covalent coupling of heparin.


Doctorate study

January 1987 - November 1992

Institute for Biomedical Technology, University of Twente, The Netherlands, under supervision of Prof. Dr. J. Feijen and Department of Experimental Cardiopulmonary Surgery, University Hospital of Groningen, The Netherlands under supervision of Prof. Dr. Ch.R.H. Wildevuur.

Title of PhD thesis: Porous Polymer Structures for Tissue Regeneration.

Masters study        

September 1977 - January 1985

Chemistry at the University of Groningen, The Netherlands. Main subjects: inorganic chemistry and human genetics.

Laatst gewijzigd:25 juni 2022 16:18